Article(id=1322901644438012749, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322901641049015115, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1606752000000, acceptedDateStr=2020-12-01, onlineDate=1793333930347, onlineDateStr=2026-10-30, pubDate=1626278400000, pubDateStr=2021-07-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793333930347, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793333930347, creator=13701087609, updateTime=1793333930347, updator=13701087609, issue=Issue{id=1322901641049015115, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='13', pageStart='1153', pageEnd='1248', issueExtLink='null', onlineDate='null', pubDate='1626278400000', pubDateStr='2021-07-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793333929460, creator='13701087609', updateTime=1793333989426, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322901892623376986, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322901641049015115, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322901892627571291, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322901641049015115, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1192, endPage=1199, ext={EN=ArticleExt(id=1322901645323010894, articleId=1322901644438012749, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=The current research status and progress in universal chimeric antigen receptor T-cell immunotherapy, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Universal CAR-T cell technology belongs to the universal T cell technology based on gene editing in general CAR-T. It knocks out the signal receptor factor of T cell through gene editing, and produces CAR-T cell by using modified T cell from healthy volunteers; therefore it will not cause immune rejection such as graft versus host disease (GvHD) and host versus graft reaction (HvGR) after infusion. In animal experiments and early clinical trials, UCAR-T technology shows significant anti-tumor effect, wide applicability and tremendous application potentials. In terms of industrialization, UCAR-T cell technology is expected to solve the problems of high cost in designing and culturing autologous CAR-T preparations, of long preparation cycle, difficult quality control, insufficient cell quantity and expansion capacity, because of its unique features such as quality controllable, off-the-shelf, and easy for large-scale preparation, etc. This paper introduces the current research progress and existing problems of UCAR-T cells, and conducts a preliminary analysis of the existing problems, providing a reference for the fundamental research and clinical trials of UCAR-T cells.

, authors=Fang-ming ZHU, Xiao-qing CAI, Chang CUI, Hong-xi GUO, Ting-ting LU, Dao-jun XU, authorsList=Fang-ming ZHU, Xiao-qing CAI, Chang CUI, Hong-xi GUO, Ting-ting LU, Dao-jun XU, authorCompany=null, correspAuthors=Dao-jun XU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322901646900069199, articleId=1322901644438012749, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=通用型嵌合抗原受体T细胞的研究现状及进展, columnId=1236330552693944345, journalTitle=中国新药杂志, columnName=生物医药前沿, runingTitle=null, highlight=null, articleAbstract=

通用型嵌合抗原受体T细胞（universal chimeric antigen receptor T-cell immunotherapy，UCAR-T）属于通用型CAR-T中基于基因编辑的通用T细胞技术，通过基因编辑技术敲除T细胞信号受体因子，并使用经过改造的健康志愿者的T细胞制备CAR-T细胞，输注后不会引起移植物抗宿主病（graft versus host disease，GvHD）和宿主抗移植物反应（host versus graft reaction，HvGR）等免疫排斥反应。在动物实验和早期临床试验研究方面，UCAR-T技术显示出了良好的抗瘤效果、广泛的适用性和不可估量的应用潜力；在产业化方面，UCAR-T细胞技术显示出了质量可控、off-the-shelf、容易规模化制备等特点，解决了自体CAR-T的设计及培养制备成本过高、制备周期长、质量控制不易、细胞数量及扩增能力不足等问题。本文介绍了目前UCAR-T细胞的研究现状、进展及存在问题，并就存在问题进行了初步分析，为UCAR-T细胞的基础研究、产业化研究以及临床应用提供参考。

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朱芳明，女，硕士研究生，主要从事免疫细胞产品的研究及开发工作。E-mail：CANPLT@163.com。

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朱芳明，女，硕士研究生，主要从事免疫细胞产品的研究及开发工作。E-mail：CANPLT@163.com。

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