首页 期刊 论文 学科刊群 资讯 加盟 关于
EN
image
Article(id=1322627838986007460, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322627786464936095, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1604246400000, acceptedDateStr=2020-11-02, onlineDate=1793268650051, onlineDateStr=2026-10-29, pubDate=1615737600000, pubDateStr=2021-03-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793268650051, onlineIssueDateStr=2026-10-29, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793268650051, creator=13701087609, updateTime=1793268650051, updator=13701087609, issue=Issue{id=1322627786464936095, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='5', pageStart='385', pageEnd='480', issueExtLink='null', onlineDate='null', pubDate='1615737600000', pubDateStr='2021-03-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793268637529, creator='13701087609', updateTime=1793269201588, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322630152530539005, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322627786464936095, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322630152530539006, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322627786464936095, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=424, endPage=433, ext={EN=ArticleExt(id=1322627840768586661, articleId=1322627838986007460, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=The anti-diabetic chronic inflammation mechanism of berberine based on transcriptomics and proteomics analysis, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective:

LPS induces RAW264.7 cells to become an inflammation model, and uses transcriptomics and proteomics techniques to explore the anti-diabetic chronic inflammation mechanism of berberine.

Methods:

After RAW264.7 cells induced by LPS (0.1 μg·mL-1) were incubated with berberine (1 μg·mL-1), protein and RNA were extracted, and proteomics and transcriptomics analysis were performed. Proteins and genes that were differentially expressed were found, and gene ontology (GO) enrichment analysis and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis were performed. STRING was used to draw interaction diagrams (PPI) to perform real-time fluorescence quantification of common differentially expressed proteins and genes PCR for verification.

Results:

By comparing the model group with the berberine group, there are a total of 1 801 differentially expressed genes in transcriptomics, and 11 differentially expressed genes, such as Pdia4, Itgam, Hsp90b1, Prdx5, Pdia6, Myc, Fosl1, Il10, Ccl2, Lpin2 and Pik3r2, are related to inflammation. Proteomics obtained a total of 83 differentially expressed proteins, and 10 differentially expressed proteins were found, including Hsp90b1, Pdia6, Prdx5, Pdia4, Itgam, Stat1, Pgm2, Ptgs1, Nos2, Actb, are related to inflammation. There are 5 common differentially expressed proteins and genes.

Conclusion:

Berberine may achieve anti-inflammatory effects by reducing the release of inflammatory factors, while reducing Hsp90b1, Pdia6, Prdx5, Pdia4, Itgam, PTGS1, NOS2 and IL-10, and increasing the production of Pik3r2 and LPIN 2 genes to further relieve abnormal metabolism and insulin resistance as well as reducing oxidative damage to the endoplasmic reticulum to treat diabetes.

, authors=Ying-qian CAO1, Li-fen ZHOU2, Hong YU3, Ya-nan XUE1, Zhi-fu AI4, Xiao-quan LUO4, Chang-hua ZHANG1, authorsList=Ying-qian CAO, Li-fen ZHOU, Hong YU, Ya-nan XUE, Zhi-fu AI, Xiao-quan LUO, Chang-hua ZHANG, authorCompany=null, correspAuthors=Chang-hua ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322627841028633510, articleId=1322627838986007460, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=基于转录组学和蛋白质组学分析小檗碱抗糖尿病慢性炎症机制, columnId=1236330556003242277, journalTitle=中国新药杂志, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的：

通过LPS诱导的RAW264.7细胞炎症模型，应用转录组学和蛋白质组学技术探究小檗碱抗糖尿病慢性炎症机制。

方法：

RAW264.7细胞通过LPS（0.1 μg·mL-1）诱导，给予小檗碱（1 μg·mL-1），分别提取蛋白和RNA，进行蛋白质组学和转录组学分析，分别找出差异表达蛋白和差异表达基因，并进行基因本体（GO）富集分析和京都基因与基因组百科全书（KEGG）通路富集分析，并运用STRING进行绘制相互作用图（PPI），对共同差异表达蛋白和基因进行实时荧光定量PCR进行验证。

结果：

通过模型组与小檗碱组相比较，转录组学共有1 801个差异表达基因，找出11种差异表达基因Pdia4，Itgam，Hsp90b1，Prdx5，Pdia6，Myc，Fosl1，Il10，Ccl2，Lpin2，Pik3r2与炎症相关；蛋白质组学共得到83个差异表达蛋白，找出10个差异表达蛋白Hsp90b1，Pdia6，Prdx5，Pdia4，Itgam，Stat1，Pgm2，Ptgs1，Nos2，Actb与炎症相关；共同差异表达蛋白和基因共有5个。

结论：

小檗碱可能是通过减少炎症因子释放，同时减少Hsp90b1，Pdia6，Prdx5，Pdia4，Itgam，PTGS1，NOS2和IL-10及增加Pik3r2和LPIN 2基因的生成来达到抗炎作用，进一步缓解异常代谢和胰岛素抵抗以及减轻内质网氧化损伤来治疗糖尿病。

, authors=操映倩1, 周立分2, 余宏3, 薛亚楠1, 艾志福4, 罗小泉4, 章常华1, authorsList=操映倩, 周立分, 余宏, 薛亚楠, 艾志福, 罗小泉, 章常华, authorCompany=null, correspAuthors=章常华, authorNote=

操映倩，女，硕士研究生，主要从事中药及天然产物药理学研究。E-mail：。

, correspAuthorsNote=
章常华，男，博士，副教授，硕士研究生导师，主要从事中药及天然产物药理学研究。E-mail：。
, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=36XQ0raKLpDF74DQdztQ6g==, magXml=uBAB2xJIhRAf1KqZ5p+j2Q==, pdfUrl=null, pdf=ufjcMSbym5RDxGzmYO+alQ==, pdfFileSize=2865955, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=QtJBCfvf/IJkwoByntPOaw==, mapNumber=null, fund=null)}, authors=[Author(id=1322627841649390516, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=18178945787@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322627841724887990, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627841649390516, language=EN, stringName=Ying-qian CAO, firstName=Ying-qian, middleName=null, lastName=CAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322627841791996855, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627841649390516, language=CN, stringName=操映倩, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1江西中医药大学药学院，南昌　330004, bio={"content":"

操映倩，女，硕士研究生，主要从事中药及天然产物药理学研究。E-mail：。

"}, bioImg=null, bioContent=

操映倩，女，硕士研究生，主要从事中药及天然产物药理学研究。E-mail：。

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322627841276097447, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, xref=1, ext=[AuthorCompanyExt(id=1322627841284486056, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841276097447, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China), AuthorCompanyExt(id=1322627841292874665, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841276097447, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1江西中医药大学药学院，南昌　330004)])]), Author(id=1322627841854911417, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322627841926214587, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627841854911417, language=EN, stringName=Li-fen ZHOU, firstName=Li-fen, middleName=null, lastName=ZHOU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2Large Precision Instrument Sharing Service Center of Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322627842014294972, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627841854911417, language=CN, stringName=周立分, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2江西中医药大学大型精密仪器共享服务中心，南昌　330004, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322627841368372138, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, xref=2, ext=[AuthorCompanyExt(id=1322627841376760747, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841368372138, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2Large Precision Instrument Sharing Service Center of Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China), AuthorCompanyExt(id=1322627841385149356, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841368372138, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2江西中医药大学大型精密仪器共享服务中心，南昌　330004)])]), Author(id=1322627842085598142, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322627842156901312, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627842085598142, language=EN, stringName=Hong YU, firstName=Hong, middleName=null, lastName=YU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=3, address=3School of Mathematics and Computer, Yuzhang Normal University, Nanchang 330004, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322627842224010177, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627842085598142, language=CN, stringName=余宏, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=3, address=3豫章师范学院数学与计算机学院，南昌　330004, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322627841481618349, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, xref=3, ext=[AuthorCompanyExt(id=1322627841490006958, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841481618349, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3School of Mathematics and Computer, Yuzhang Normal University, Nanchang 330004, China), AuthorCompanyExt(id=1322627841498395567, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841481618349, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3豫章师范学院数学与计算机学院，南昌　330004)])]), Author(id=1322627842286924739, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322627842362422213, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627842286924739, language=EN, stringName=Ya-nan XUE, firstName=Ya-nan, middleName=null, lastName=XUE, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322627842425336774, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627842286924739, language=CN, stringName=薛亚楠, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1江西中医药大学药学院，南昌　330004, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322627841276097447, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, xref=1, ext=[AuthorCompanyExt(id=1322627841284486056, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841276097447, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China), AuthorCompanyExt(id=1322627841292874665, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841276097447, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1江西中医药大学药学院，南昌　330004)])]), Author(id=1322627842492445640, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322627842572137418, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627842492445640, language=EN, stringName=Zhi-fu AI, firstName=Zhi-fu, middleName=null, lastName=AI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=4, address=4Experimental Animal Science and Technology Center of Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322627842668606411, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627842492445640, language=CN, stringName=艾志福, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=4, address=4江西中医药大学实验动物科技中心，南昌　330004, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322627841561310128, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, xref=4, ext=[AuthorCompanyExt(id=1322627841573893041, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841561310128, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4Experimental Animal Science and Technology Center of Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China), AuthorCompanyExt(id=1322627841582281650, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841561310128, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4江西中医药大学实验动物科技中心，南昌　330004)])]), Author(id=1322627842735715277, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322627842819601359, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627842735715277, language=EN, stringName=Xiao-quan LUO, firstName=Xiao-quan, middleName=null, lastName=LUO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=4, address=4Experimental Animal Science and Technology Center of Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322627842895098832, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627842735715277, language=CN, stringName=罗小泉, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=4, address=4江西中医药大学实验动物科技中心，南昌　330004, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322627841561310128, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, xref=4, ext=[AuthorCompanyExt(id=1322627841573893041, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841561310128, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4Experimental Animal Science and Technology Center of Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China), AuthorCompanyExt(id=1322627841582281650, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841561310128, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4江西中医药大学实验动物科技中心，南昌　330004)])]), Author(id=1322627842953819090, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=20070964@jxutcm.edu.cn, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1322627843025122260, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627842953819090, language=EN, stringName=Chang-hua ZHANG, firstName=Chang-hua, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322627843096425429, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627842953819090, language=CN, stringName=章常华, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1江西中医药大学药学院，南昌　330004, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322627841276097447, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, xref=1, ext=[AuthorCompanyExt(id=1322627841284486056, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841276097447, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China), AuthorCompanyExt(id=1322627841292874665, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841276097447, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1江西中医药大学药学院，南昌　330004)])])], keywords=[Keyword(id=1322627843197088726, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, language=EN, orderNo=1, keyword=transcriptomics), Keyword(id=1322627843264197591, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, language=EN, orderNo=2, keyword=proteomics), Keyword(id=1322627843335500760, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, language=EN, orderNo=3, keyword=berberine), Keyword(id=1322627843415192537, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, language=EN, orderNo=4, keyword=RAW264.7 cells), Keyword(id=1322627843486495706, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, language=EN, orderNo=5, keyword=diabetes), Keyword(id=1322627843553604571, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, language=EN, orderNo=6, keyword=anti-inflammatory), Keyword(id=1322627845206160348, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, language=CN, orderNo=1, keyword=转录组学), Keyword(id=1322627845285852125, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, language=CN, orderNo=2, keyword=蛋白质组学), Keyword(id=1322627845348766686, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, language=CN, orderNo=3, keyword=小檗碱), Keyword(id=1322627845428458463, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, language=CN, orderNo=4, keyword=RAW264.7细胞), Keyword(id=1322627845499761632, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, language=CN, orderNo=5, keyword=糖尿病), Keyword(id=1322627845579453409, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, language=CN, orderNo=6, keyword=抗炎)], refs=[Reference(id=1322627846086964199, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=null, journalName=null, refType=null, unstructuredReference=LIANG YZ, LI JJH, XIAO HB, et al. Identification of stress-related microRNA biomarkers in type 2 diabetes mellitus: a systematic review and meta-analysis[J]. J Diabetes, 2020, 12(9): 633-644., articleTitle=null, refAbstract=null), Reference(id=1322627846175044584, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=郭立新. 糖尿病的流行势态和应对策略[J]. 中国临床保健杂志, 2020, 23(4): 433-436., articleTitle=null, refAbstract=null), Reference(id=1322627846246347753, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=洪小媛, 潘芸芸, 陈吉生. 阿卡波糖仿制药与原研药治疗2型糖尿病的临床综合评价[J]. 今日药学, 2020, 30(10): 715-720., articleTitle=null, refAbstract=null), Reference(id=1322627846313456618, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=袁晓环, 张哲, 王威, 等. 姜黄素类似物的制备及其抑制2型糖尿病小鼠肝脏脂肪变性的活性[J]. 中国医药工业杂志, 2017, 48(2): 179-183, 194., articleTitle=null, refAbstract=null), Reference(id=1322627846384759787, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2017年版)[J]. 中国实用内科杂志, 2018, 38(4): 292-344., articleTitle=null, refAbstract=null), Reference(id=1322627846451868652, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=韩雨薇, 李彩娜, 环奕, 等. 小檗碱配伍水苏糖对糖尿病小鼠糖脂代谢及肠道菌群的影响[J]. 中国临床药理学杂志, 2016, 32(12): 1121-1124., articleTitle=null, refAbstract=null), Reference(id=1322627846527366125, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=XU LY, ZHAO WJ, WANG DM, et al. Chinese medicine in the battle against obesity and metabolic diseases[J]. Front Physiol, 2018, 9: 850., articleTitle=null, refAbstract=null), Reference(id=1322627846602863598, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=HAN YB, MIAO T, WANG XX, et al. Berberine ameliorates obesity-induced chronic inflammation through suppression of ER stress and promotion of macrophage M2 polarization at least partly via downregulating lncRNA Gomafu[J]. Int Immunopharmacol, 2020, 86: doi: 10.1016/j.intimp.2020.106741., articleTitle=null, refAbstract=null), Reference(id=1322627846690943983, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=MENG W, ZHANG JJ, ZHAO HY, et al. Berberine combined with cyclosporine A alleviates acute graft-versus-host disease in murine models[J]. Int Immunopharmacol, 2020, 81: doi: 10.1016/j.intimp.2020.106205., articleTitle=null, refAbstract=null), Reference(id=1322627846753858544, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=PIERCE A, UNWIN RD, EVANS CA, et al. Eight-channel iTRAQ enables comparison of the activity of six leukemogenic tyrosine kinases[J]. Mol Cell Proteom, 2008, 7(5): 853-863., articleTitle=null, refAbstract=null), Reference(id=1322627846833550321, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=杨欣, 李亚辉, 李专, 等. 现代的科学技术与方法在《中药药理学》药性研究中的应用[J]. 教育教学论坛, 2019(48): 214-215., articleTitle=null, refAbstract=null), Reference(id=1322627846900659186, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHANG CH, XIAO Q, SHENG JQ, et al. Gegen Qinlian Decoction abates nonalcoholic steatohepatitis associated liver injuries via anti-oxidative stress and anti-inflammatory response involved inhibition of toll-like receptor 4 signaling pathways[J]. Biomed Pharmacother, 2020, 126: doi: 10.1016/j.biopha.2020.110076., articleTitle=null, refAbstract=null), Reference(id=1322627846963573747, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=CARR HL, TURNER JD, MAJOR T, et al. New developments in transcriptomic analysis of synovial tissue[J]. Front Med (Lausanne), 2020, 7: doi: 10.3389/fmed.2020.00021., articleTitle=null, refAbstract=null), Reference(id=1322627847026488308, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=null, journalName=null, refType=null, unstructuredReference=MANMONTRI B, SARIAHMETOGLU M, DONKOR J, et al. Glucocorticoids and cyclic AMP selectively increase hepatic lipin-1 expression, and insulin Acts antagonistically[J]. J Lipid Res, 2008, 49(5): 1056-1067., articleTitle=null, refAbstract=null), Reference(id=1322627847089402869, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=null, journalName=null, refType=null, unstructuredReference=PANG B, ZHAO LH, ZHOU Q, et al. Application of berberine on treating type 2 diabetes mellitus[J]. Int J Endocrinol, 2015, 2015: 905749., articleTitle=null, refAbstract=null), Reference(id=1322627847160706038, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=null, journalName=null, refType=null, unstructuredReference=TSUCHIYA Y, TAKAHASHI N, YOSHIZAKI T, et al. A Jak2inhibitor, AG490, reverses lipin-1suppression by TNF-alpha in3T3-L1adipocytes[J]. Biochem Biophys Res Commun, 2009, 382(2): 348-352., articleTitle=null, refAbstract=null), Reference(id=1322627847219426295, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=null, journalName=null, refType=null, unstructuredReference=GRIMSEY N, HAN GS, O'HARA L, et al. Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2[J]. J Biol Chem, 2008, 283(43): 29166-29174., articleTitle=null, refAbstract=null), Reference(id=1322627847286535160, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=null, journalName=null, refType=null, unstructuredReference=陶颖君, 吴洁, 刘畅. 蛋白质组学在糖尿病及其并发症中的应用[J]. 中国药科大学学报, 2020, 51(3): 368-373., articleTitle=null, refAbstract=null), Reference(id=1322627847357838329, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[19], rfOrder=18, authorNames=null, journalName=null, refType=null, unstructuredReference=朱秋爽, 梅仲秋, 刘涛, 等. 新疆圆柏有效成分抑制COX-1/2、5-LO作用及对脂多糖诱导RAW264.7细胞释放TNF-α的影响[J]. 中国药理学通报, 2018, 34(2): 295-296., articleTitle=null, refAbstract=null), Reference(id=1322627847437530106, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[20], rfOrder=19, authorNames=null, journalName=null, refType=null, unstructuredReference=LIU Y, XIAO J, ZHAO Y, et al. microRNA-216a protects against human retinal microvascular endothelial cell injury in diabetic retinopathy by suppressing the NOS2/JAK/STAT axis[J]. Exp Mol Pathol, 2020, 115: doi: 10.1016/j.yexmp.2020.104445., articleTitle=null, refAbstract=null), Reference(id=1322627847504638971, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[21], rfOrder=20, authorNames=null, journalName=null, refType=null, unstructuredReference=马林, 刘小翠, 邓斌. 小檗碱通过影响糖原结构调节肝糖代谢研究[J]. 中草药, 2020, 51(16): 4259-4265., articleTitle=null, refAbstract=null), Reference(id=1322627847588525052, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[22], rfOrder=21, authorNames=null, journalName=null, refType=null, unstructuredReference=HONG F, WU BX, LI ZH. Molecular regulation of macrophages in unleashing cancer-related inflammation[J]. Oncoimmunology, 2014, 3(1): e27659., articleTitle=null, refAbstract=null), Reference(id=1322627847655633917, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[23], rfOrder=22, authorNames=null, journalName=null, refType=null, unstructuredReference=NEGRONI A, PRETE E, VITALI R, et al. Endoplasmic reticulum stress and unfolded protein response are involved in paediatric inflammatory bowel disease[J]. Dig Liver Dis, 2014, 46(9): 788-794., articleTitle=null, refAbstract=null), Reference(id=1322627847735325694, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[24], rfOrder=23, authorNames=null, journalName=null, refType=null, unstructuredReference=FARIDI MH, KHAN SM, ZHAO WP, et al. CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus[J]. J Clin Investig, 2017, 127(4): 1271-1283., articleTitle=null, refAbstract=null), Reference(id=1322627847794045951, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[25], rfOrder=24, authorNames=null, journalName=null, refType=null, unstructuredReference=GRAHAM DB, JASSO GJ, MOK A, et al. Nitric oxide engages an anti-inflammatory feedback loop mediated by peroxiredoxin 5 in phagocytes[J]. Cell Reports, 2018, 24(4): 838-850., articleTitle=null, refAbstract=null)], funds=[Fund(id=1322627845705282530, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, awardId=81774194, language=CN, fundingSource=国家自然科学基金(81774194), fundOrder=null, country=null), Fund(id=1322627845776585699, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, awardId=20192ACBL20027, language=CN, fundingSource=江西省自然科学重点项目联合资助基金(20192ACBL20027), fundOrder=null, country=null), Fund(id=1322627845856277476, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, awardId=20202BABL206142, language=CN, fundingSource=江西省自然科学基金(20202BABL206142), fundOrder=null, country=null), Fund(id=1322627845919192037, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, awardId=GJJ190636, language=CN, fundingSource=江西省教育厅科技计划重点项目(GJJ190636), fundOrder=null, country=null), Fund(id=1322627845990495206, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, awardId=JXSYLXK-ZHYAO118, language=CN, fundingSource=江西省中药学一流学科专项科研基金项目(JXSYLXK-ZHYAO118), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1322627841276097447, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, xref=1, ext=[AuthorCompanyExt(id=1322627841284486056, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841276097447, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China), AuthorCompanyExt(id=1322627841292874665, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841276097447, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1江西中医药大学药学院，南昌　330004)]), AuthorCompany(id=1322627841368372138, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, xref=2, ext=[AuthorCompanyExt(id=1322627841376760747, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841368372138, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2Large Precision Instrument Sharing Service Center of Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China), AuthorCompanyExt(id=1322627841385149356, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841368372138, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2江西中医药大学大型精密仪器共享服务中心，南昌　330004)]), AuthorCompany(id=1322627841481618349, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, xref=3, ext=[AuthorCompanyExt(id=1322627841490006958, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841481618349, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3School of Mathematics and Computer, Yuzhang Normal University, Nanchang 330004, China), AuthorCompanyExt(id=1322627841498395567, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841481618349, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3豫章师范学院数学与计算机学院，南昌　330004)]), AuthorCompany(id=1322627841561310128, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, xref=4, ext=[AuthorCompanyExt(id=1322627841573893041, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841561310128, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4Experimental Animal Science and Technology Center of Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China), AuthorCompanyExt(id=1322627841582281650, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841561310128, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4江西中医药大学实验动物科技中心，南昌　330004)])], figs=null, attaches=null, journal=Journal(id=1235980159023624194, delFlag=0, nameCn=中国新药杂志, nameEn=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, issn=1003-3734, eissn=null, cn=11-2850/R, coden=ZXZHA6, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of New Drugs, journalRemark=null, publicationField=null, createdTime=1772610233314, updatedTime=1788948968376, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=ohPEEN//Vz1tDT3ZBNTp4Q==, picEn=f9WK9bvTM4guTmS/iGhOMg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509780974924039, language=CN, name=中国新药杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948968404, updatedTime=1788948968404, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304509781025255688, language=EN, name=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948968416, updatedTime=1788948968416, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1235980733773295621, websiteList=[Website(id=1235982099191222761, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/CN, language=CN, createTime=1772610695884, createBy=18614031015, updateTime=1772610860397, updateBy=18614031015, name=中国新药杂志-中文, tplId=1146099689490845704, title=中国新药杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983918629966444, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=articleTextType, value=kx, createTime=1772611129672, updateTime=1772611129672, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918604800617, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=banner, value=null, createTime=1772611129666, updateTime=1772611129666, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918655132271, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=grayFlag, value=0, createTime=1772611129678, updateTime=1772611129678, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918596412008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611129664, updateTime=1772611129664, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918667715185, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=minRunFlag, value=0, createTime=1772611129681, updateTime=1772611129681, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918617383531, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic, createTime=1772611129669, updateTime=1772611129669, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918659326576, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=silenceFlag, value=0, createTime=1772611129679, updateTime=1772611129679, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918613189226, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1772611129668, updateTime=1772611129668, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918634160749, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeColor, value=null, createTime=1772611129673, updateTime=1772611129673, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918646743662, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeStyle, value=null, createTime=1772611129676, updateTime=1772611129676, creator=18614031015, updator=18614031015)]), Website(id=1235982099270914542, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/EN, language=EN, createTime=1772610695903, createBy=18614031015, updateTime=1772610875891, updateBy=18614031015, name=中国新药杂志-英文, tplId=1146101810881728533, title=Chinese Journal of New Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983955829248630, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=articleTextType, value=kx, createTime=1772611138541, updateTime=1772611138541, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955804082803, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=banner, value=null, createTime=1772611138535, updateTime=1772611138535, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955854414457, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=grayFlag, value=0, createTime=1772611138547, updateTime=1772611138547, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955795694194, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611138533, updateTime=1772611138533, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955866997371, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=minRunFlag, value=0, createTime=1772611138550, updateTime=1772611138550, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955820860021, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic, createTime=1772611138539, updateTime=1772611138539, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955862803066, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=silenceFlag, value=0, createTime=1772611138549, updateTime=1772611138549, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955812471412, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1772611138537, updateTime=1772611138537, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955837637239, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeColor, value=null, createTime=1772611138543, updateTime=1772611138543, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955846025848, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeStyle, value=null, createTime=1772611138545, updateTime=1772611138545, creator=18614031015, updator=18614031015)])], journalTitle=中国新药杂志, weixinUrl=null, journalUrl=http://www.newdrug.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of New Drugs, journalPhotoCn=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPhotoEn=f9WK9bvTM4guTmS/iGhOMg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/Y2021/V30/I5/424, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/Y2021/V30/I5/424, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/PDF/Y2021/V30/I5/424, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/PDF/Y2021/V30/I5/424, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1615737600000, fullTextJson=null, articleText=null, reference=null)
收藏切换
基于转录组学和蛋白质组学分析小檗碱抗糖尿病慢性炎症机制
收藏切换
PDF下载
操映倩 1 , 周立分 2 , 余宏 3 , 薛亚楠 1 , 艾志福 4 , 罗小泉 4 , 章常华 1
中国新药杂志 | 实验研究 2021,30(5): 424-433
收起
收藏切换
中国新药杂志 |实验研究 2021 , 30 (5) : 424 -433
基于转录组学和蛋白质组学分析小檗碱抗糖尿病慢性炎症机制
全屏
[Author(id=1322627841649390516, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=18178945787@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322627841724887990, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627841649390516, language=EN, stringName=Ying-qian CAO, firstName=Ying-qian, middleName=null, lastName=CAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322627841791996855, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627841649390516, language=CN, stringName=操映倩, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1江西中医药大学药学院，南昌　330004, bio={"content":"

操映倩，女，硕士研究生，主要从事中药及天然产物药理学研究。E-mail：。

"}, bioImg=null, bioContent=

操映倩，女，硕士研究生，主要从事中药及天然产物药理学研究。E-mail：。

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322627841276097447, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, xref=1, ext=[AuthorCompanyExt(id=1322627841284486056, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841276097447, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China), AuthorCompanyExt(id=1322627841292874665, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841276097447, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1江西中医药大学药学院，南昌　330004)])]), Author(id=1322627841854911417, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322627841926214587, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627841854911417, language=EN, stringName=Li-fen ZHOU, firstName=Li-fen, middleName=null, lastName=ZHOU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2Large Precision Instrument Sharing Service Center of Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322627842014294972, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627841854911417, language=CN, stringName=周立分, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2江西中医药大学大型精密仪器共享服务中心，南昌　330004, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322627841368372138, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, xref=2, ext=[AuthorCompanyExt(id=1322627841376760747, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841368372138, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2Large Precision Instrument Sharing Service Center of Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China), AuthorCompanyExt(id=1322627841385149356, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841368372138, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2江西中医药大学大型精密仪器共享服务中心，南昌　330004)])]), Author(id=1322627842085598142, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322627842156901312, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627842085598142, language=EN, stringName=Hong YU, firstName=Hong, middleName=null, lastName=YU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=3, address=3School of Mathematics and Computer, Yuzhang Normal University, Nanchang 330004, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322627842224010177, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627842085598142, language=CN, stringName=余宏, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=3, address=3豫章师范学院数学与计算机学院，南昌　330004, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322627841481618349, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, xref=3, ext=[AuthorCompanyExt(id=1322627841490006958, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841481618349, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3School of Mathematics and Computer, Yuzhang Normal University, Nanchang 330004, China), AuthorCompanyExt(id=1322627841498395567, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841481618349, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3豫章师范学院数学与计算机学院，南昌　330004)])]), Author(id=1322627842286924739, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322627842362422213, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627842286924739, language=EN, stringName=Ya-nan XUE, firstName=Ya-nan, middleName=null, lastName=XUE, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322627842425336774, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627842286924739, language=CN, stringName=薛亚楠, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1江西中医药大学药学院，南昌　330004, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322627841276097447, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, xref=1, ext=[AuthorCompanyExt(id=1322627841284486056, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841276097447, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China), AuthorCompanyExt(id=1322627841292874665, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841276097447, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1江西中医药大学药学院，南昌　330004)])]), Author(id=1322627842492445640, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322627842572137418, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627842492445640, language=EN, stringName=Zhi-fu AI, firstName=Zhi-fu, middleName=null, lastName=AI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=4, address=4Experimental Animal Science and Technology Center of Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322627842668606411, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627842492445640, language=CN, stringName=艾志福, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=4, address=4江西中医药大学实验动物科技中心，南昌　330004, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322627841561310128, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, xref=4, ext=[AuthorCompanyExt(id=1322627841573893041, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841561310128, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4Experimental Animal Science and Technology Center of Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China), AuthorCompanyExt(id=1322627841582281650, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841561310128, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4江西中医药大学实验动物科技中心，南昌　330004)])]), Author(id=1322627842735715277, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322627842819601359, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627842735715277, language=EN, stringName=Xiao-quan LUO, firstName=Xiao-quan, middleName=null, lastName=LUO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=4, address=4Experimental Animal Science and Technology Center of Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322627842895098832, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627842735715277, language=CN, stringName=罗小泉, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=4, address=4江西中医药大学实验动物科技中心，南昌　330004, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322627841561310128, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, xref=4, ext=[AuthorCompanyExt(id=1322627841573893041, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841561310128, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4Experimental Animal Science and Technology Center of Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China), AuthorCompanyExt(id=1322627841582281650, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841561310128, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4江西中医药大学实验动物科技中心，南昌　330004)])]), Author(id=1322627842953819090, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=20070964@jxutcm.edu.cn, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1322627843025122260, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627842953819090, language=EN, stringName=Chang-hua ZHANG, firstName=Chang-hua, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322627843096425429, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, authorId=1322627842953819090, language=CN, stringName=章常华, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1江西中医药大学药学院，南昌　330004, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322627841276097447, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, xref=1, ext=[AuthorCompanyExt(id=1322627841284486056, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841276097447, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China), AuthorCompanyExt(id=1322627841292874665, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627838986007460, companyId=1322627841276097447, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1江西中医药大学药学院，南昌　330004)])])]
操映倩1 , 周立分2, 余宏3, 薛亚楠1, 艾志福4, 罗小泉4, 章常华1
作者信息
  • 1江西中医药大学药学院，南昌　330004
  • 2江西中医药大学大型精密仪器共享服务中心，南昌　330004
  • 3豫章师范学院数学与计算机学院，南昌　330004
  • 4江西中医药大学实验动物科技中心，南昌　330004
通讯作者:
章常华，男，博士，副教授，硕士研究生导师，主要从事中药及天然产物药理学研究。E-mail：。
作者简介:

操映倩，女，硕士研究生，主要从事中药及天然产物药理学研究。E-mail：。

The anti-diabetic chronic inflammation mechanism of berberine based on transcriptomics and proteomics analysis
Ying-qian CAO1 , Li-fen ZHOU2, Hong YU3, Ya-nan XUE1, Zhi-fu AI4, Xiao-quan LUO4, Chang-hua ZHANG1
Affiliations
  • 1School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
  • 2Large Precision Instrument Sharing Service Center of Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
  • 3School of Mathematics and Computer, Yuzhang Normal University, Nanchang 330004, China
  • 4Experimental Animal Science and Technology Center of Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
出版时间: 2021-03-15
文章导航
收藏切换
摘要
收起
目的：

通过LPS诱导的RAW264.7细胞炎症模型，应用转录组学和蛋白质组学技术探究小檗碱抗糖尿病慢性炎症机制。

方法：

RAW264.7细胞通过LPS（0.1 μg·mL-1）诱导，给予小檗碱（1 μg·mL-1），分别提取蛋白和RNA，进行蛋白质组学和转录组学分析，分别找出差异表达蛋白和差异表达基因，并进行基因本体（GO）富集分析和京都基因与基因组百科全书（KEGG）通路富集分析，并运用STRING进行绘制相互作用图（PPI），对共同差异表达蛋白和基因进行实时荧光定量PCR进行验证。

结果：

通过模型组与小檗碱组相比较，转录组学共有1 801个差异表达基因，找出11种差异表达基因Pdia4，Itgam，Hsp90b1，Prdx5，Pdia6，Myc，Fosl1，Il10，Ccl2，Lpin2，Pik3r2与炎症相关；蛋白质组学共得到83个差异表达蛋白，找出10个差异表达蛋白Hsp90b1，Pdia6，Prdx5，Pdia4，Itgam，Stat1，Pgm2，Ptgs1，Nos2，Actb与炎症相关；共同差异表达蛋白和基因共有5个。

结论：

小檗碱可能是通过减少炎症因子释放，同时减少Hsp90b1，Pdia6，Prdx5，Pdia4，Itgam，PTGS1，NOS2和IL-10及增加Pik3r2和LPIN 2基因的生成来达到抗炎作用，进一步缓解异常代谢和胰岛素抵抗以及减轻内质网氧化损伤来治疗糖尿病。

转录组学  /  蛋白质组学  /  小檗碱  /  RAW264.7细胞  /  糖尿病  /  抗炎
Objective:

LPS induces RAW264.7 cells to become an inflammation model, and uses transcriptomics and proteomics techniques to explore the anti-diabetic chronic inflammation mechanism of berberine.

Methods:

After RAW264.7 cells induced by LPS (0.1 μg·mL-1) were incubated with berberine (1 μg·mL-1), protein and RNA were extracted, and proteomics and transcriptomics analysis were performed. Proteins and genes that were differentially expressed were found, and gene ontology (GO) enrichment analysis and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis were performed. STRING was used to draw interaction diagrams (PPI) to perform real-time fluorescence quantification of common differentially expressed proteins and genes PCR for verification.

Results:

By comparing the model group with the berberine group, there are a total of 1 801 differentially expressed genes in transcriptomics, and 11 differentially expressed genes, such as Pdia4, Itgam, Hsp90b1, Prdx5, Pdia6, Myc, Fosl1, Il10, Ccl2, Lpin2 and Pik3r2, are related to inflammation. Proteomics obtained a total of 83 differentially expressed proteins, and 10 differentially expressed proteins were found, including Hsp90b1, Pdia6, Prdx5, Pdia4, Itgam, Stat1, Pgm2, Ptgs1, Nos2, Actb, are related to inflammation. There are 5 common differentially expressed proteins and genes.

Conclusion:

Berberine may achieve anti-inflammatory effects by reducing the release of inflammatory factors, while reducing Hsp90b1, Pdia6, Prdx5, Pdia4, Itgam, PTGS1, NOS2 and IL-10, and increasing the production of Pik3r2 and LPIN 2 genes to further relieve abnormal metabolism and insulin resistance as well as reducing oxidative damage to the endoplasmic reticulum to treat diabetes.

transcriptomics  /  proteomics  /  berberine  /  RAW264.7 cells  /  diabetes  /  anti-inflammatory
操映倩, 周立分, 余宏, 薛亚楠, 艾志福, 罗小泉, 章常华. 基于转录组学和蛋白质组学分析小檗碱抗糖尿病慢性炎症机制. 中国新药杂志, 2021 , 30 (5) : 424 -433 .
Ying-qian CAO, Li-fen ZHOU, Hong YU, Ya-nan XUE, Zhi-fu AI, Xiao-quan LUO, Chang-hua ZHANG. The anti-diabetic chronic inflammation mechanism of berberine based on transcriptomics and proteomics analysis[J]. Chinese Journal of New Drugs, 2021 , 30 (5) : 424 -433 .
基金
收起
  • 国家自然科学基金(81774194)
  • 江西省自然科学重点项目联合资助基金(20192ACBL20027)
  • 江西省自然科学基金(20202BABL206142)
  • 江西省教育厅科技计划重点项目(GJJ190636)
  • 江西省中药学一流学科专项科研基金项目(JXSYLXK-ZHYAO118)
文献
收起
参考文献 引证文献
排序方式：
[1]
LIANG YZ, LI JJH, XIAO HB, et al. Identification of stress-related microRNA biomarkers in type 2 diabetes mellitus: a systematic review and meta-analysis[J]. J Diabetes, 2020, 12(9): 633-644.
[2]
郭立新. 糖尿病的流行势态和应对策略[J]. 中国临床保健杂志, 2020, 23(4): 433-436.
[3]
洪小媛, 潘芸芸, 陈吉生. 阿卡波糖仿制药与原研药治疗2型糖尿病的临床综合评价[J]. 今日药学, 2020, 30(10): 715-720.
[4]
袁晓环, 张哲, 王威, 等. 姜黄素类似物的制备及其抑制2型糖尿病小鼠肝脏脂肪变性的活性[J]. 中国医药工业杂志, 2017, 48(2): 179-183, 194.
[5]
中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2017年版)[J]. 中国实用内科杂志, 2018, 38(4): 292-344.
[6]
韩雨薇, 李彩娜, 环奕, 等. 小檗碱配伍水苏糖对糖尿病小鼠糖脂代谢及肠道菌群的影响[J]. 中国临床药理学杂志, 2016, 32(12): 1121-1124.
[7]
XU LY, ZHAO WJ, WANG DM, et al. Chinese medicine in the battle against obesity and metabolic diseases[J]. Front Physiol, 2018, 9: 850.
[8]
HAN YB, MIAO T, WANG XX, et al. Berberine ameliorates obesity-induced chronic inflammation through suppression of ER stress and promotion of macrophage M2 polarization at least partly via downregulating lncRNA Gomafu[J]. Int Immunopharmacol, 2020, 86: doi: 10.1016/j.intimp.2020.106741.
[9]
MENG W, ZHANG JJ, ZHAO HY, et al. Berberine combined with cyclosporine A alleviates acute graft-versus-host disease in murine models[J]. Int Immunopharmacol, 2020, 81: doi: 10.1016/j.intimp.2020.106205.
[10]
PIERCE A, UNWIN RD, EVANS CA, et al. Eight-channel iTRAQ enables comparison of the activity of six leukemogenic tyrosine kinases[J]. Mol Cell Proteom, 2008, 7(5): 853-863.
[11]
杨欣, 李亚辉, 李专, 等. 现代的科学技术与方法在《中药药理学》药性研究中的应用[J]. 教育教学论坛, 2019(48): 214-215.
[12]
ZHANG CH, XIAO Q, SHENG JQ, et al. Gegen Qinlian Decoction abates nonalcoholic steatohepatitis associated liver injuries via anti-oxidative stress and anti-inflammatory response involved inhibition of toll-like receptor 4 signaling pathways[J]. Biomed Pharmacother, 2020, 126: doi: 10.1016/j.biopha.2020.110076.
[13]
CARR HL, TURNER JD, MAJOR T, et al. New developments in transcriptomic analysis of synovial tissue[J]. Front Med (Lausanne), 2020, 7: doi: 10.3389/fmed.2020.00021.
[14]
MANMONTRI B, SARIAHMETOGLU M, DONKOR J, et al. Glucocorticoids and cyclic AMP selectively increase hepatic lipin-1 expression, and insulin Acts antagonistically[J]. J Lipid Res, 2008, 49(5): 1056-1067.
[15]
PANG B, ZHAO LH, ZHOU Q, et al. Application of berberine on treating type 2 diabetes mellitus[J]. Int J Endocrinol, 2015, 2015: 905749.
[16]
TSUCHIYA Y, TAKAHASHI N, YOSHIZAKI T, et al. A Jak2inhibitor, AG490, reverses lipin-1suppression by TNF-alpha in3T3-L1adipocytes[J]. Biochem Biophys Res Commun, 2009, 382(2): 348-352.
[17]
GRIMSEY N, HAN GS, O'HARA L, et al. Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2[J]. J Biol Chem, 2008, 283(43): 29166-29174.
[18]
陶颖君, 吴洁, 刘畅. 蛋白质组学在糖尿病及其并发症中的应用[J]. 中国药科大学学报, 2020, 51(3): 368-373.
[19]
朱秋爽, 梅仲秋, 刘涛, 等. 新疆圆柏有效成分抑制COX-1/2、5-LO作用及对脂多糖诱导RAW264.7细胞释放TNF-α的影响[J]. 中国药理学通报, 2018, 34(2): 295-296.
[20]
LIU Y, XIAO J, ZHAO Y, et al. microRNA-216a protects against human retinal microvascular endothelial cell injury in diabetic retinopathy by suppressing the NOS2/JAK/STAT axis[J]. Exp Mol Pathol, 2020, 115: doi: 10.1016/j.yexmp.2020.104445.
[21]
马林, 刘小翠, 邓斌. 小檗碱通过影响糖原结构调节肝糖代谢研究[J]. 中草药, 2020, 51(16): 4259-4265.
[22]
HONG F, WU BX, LI ZH. Molecular regulation of macrophages in unleashing cancer-related inflammation[J]. Oncoimmunology, 2014, 3(1): e27659.
[23]
NEGRONI A, PRETE E, VITALI R, et al. Endoplasmic reticulum stress and unfolded protein response are involved in paediatric inflammatory bowel disease[J]. Dig Liver Dis, 2014, 46(9): 788-794.
[24]
FARIDI MH, KHAN SM, ZHAO WP, et al. CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus[J]. J Clin Investig, 2017, 127(4): 1271-1283.
[25]
GRAHAM DB, JASSO GJ, MOK A, et al. Nitric oxide engages an anti-inflammatory feedback loop mediated by peroxiredoxin 5 in phagocytes[J]. Cell Reports, 2018, 24(4): 838-850.
2021年第30卷第5期
PDF下载
14
5
引用本文
BibTeX
文章信息
  • 首发时间：2026-10-29
  • 出版时间：2021-03-15
补充材料
相关文章
文章信息
作者
出版历史
  • 录用日期：2020-11-02
基金
国家自然科学基金(81774194)
江西省自然科学重点项目联合资助基金(20192ACBL20027)
江西省自然科学基金(20202BABL206142)
江西省教育厅科技计划重点项目(GJJ190636)
江西省中药学一流学科专项科研基金项目(JXSYLXK-ZHYAO118)
作者信息
    1江西中医药大学药学院，南昌　330004
    2江西中医药大学大型精密仪器共享服务中心，南昌　330004
    3豫章师范学院数学与计算机学院，南昌　330004
    4江西中医药大学实验动物科技中心，南昌　330004

通讯作者:

章常华，男，博士，副教授，硕士研究生导师，主要从事中药及天然产物药理学研究。E-mail：。
参考文献
分享链接
https://castjournals.cast.org.cn/joweb/zgxyzz/CN/1322627838986007460
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
相关链接
论文
最新文章
热读文章
热点专题
内参
蓝皮书
产业发展报告
传播力报告
期刊分级目录
资讯
学术新闻
行业新闻
学术会议
行业会议
关于
关于我们
联系我们
北京市海淀区学院南路86号
100081
010-62662699（运营及技术支持）
qkjq@cast.org.cn

中国科学技术协会版权所有 京ICP 备10216604号-4 海淀分局备案 1101084647
科技导报社主办 中国科协信息中心技术支持