Article(id=1322627827455865652, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322627786464936095, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1609171200000, acceptedDateStr=2020-12-29, onlineDate=1793268647301, onlineDateStr=2026-10-29, pubDate=1615737600000, pubDateStr=2021-03-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793268647301, onlineIssueDateStr=2026-10-29, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793268647301, creator=13701087609, updateTime=1793268647301, updator=13701087609, issue=Issue{id=1322627786464936095, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='5', pageStart='385', pageEnd='480', issueExtLink='null', onlineDate='null', pubDate='1615737600000', pubDateStr='2021-03-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793268637529, creator='13701087609', updateTime=1793269201588, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322630152530539005, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322627786464936095, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322630152530539006, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322627786464936095, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=394, endPage=398, ext={EN=ArticleExt(id=1322627827606860597, articleId=1322627827455865652, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Discussion on the container closure integrity of rubber stopper/glass container, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Research on container closure integrity (CCI) is an important part of drug development. This article focuses on the CCI research of the life cycle of the rubber stopper/glass container, including packaging design, production, and stability research, and discusses the MALL establishment of rubber stopper/glass container.

, authors=Jun-wei MA, Di-liang GUO, Juan LIU, Yong-hui LIU, authorsList=Jun-wei MA, Di-liang GUO, Juan LIU, Yong-hui LIU, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322627827829158710, articleId=1322627827455865652, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=胶塞/玻璃瓶容器密封完整性研究的探讨, columnId=1236331159400018080, journalTitle=中国新药杂志, columnName=新药注册与审评技术, runingTitle=null, highlight=null, articleAbstract=

容器密封完整性（container closure integrity，CCI）研究是药物开发的重要组成部分。本文重点论述了胶塞/玻璃瓶容器生命周期的CCI研究，包括包装设计、产品生产、稳定性研究3个方面。对胶塞/玻璃瓶容器最大允许泄漏限度建立进行探讨。

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马骏威，男，主要从事药品审评工作。E-mail：mjw2007@126.com。

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马骏威，男，主要从事药品审评工作。E-mail：mjw2007@126.com。

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