中国新药杂志

普瑞巴林用于腹腔镜手术后急性疼痛的有效性和安全性系统综述和Meta分析

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耿志宇 ¹ , 宋琳琳 ¹ , 郭镜飞 ²

中国新药杂志 | 药物安全与合理应用 2021,30(5): 454-461

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中国新药杂志 |药物安全与合理应用 2021 , 30 (5) : 454 -461

普瑞巴林用于腹腔镜手术后急性疼痛的有效性和安全性系统综述和Meta分析

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耿志宇，女，博士，主任医师，主要研究方向：临床麻醉与镇痛、麻醉药理及妇产科麻醉。联系电话：（010）83573218，E-mail：gengzhiyu2013@163.com。

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耿志宇¹, 宋琳琳¹, 郭镜飞²

作者信息

¹北京大学第一医院麻醉科，北京　100034

²中国医学科学院附属北京阜外医院麻醉科，北京　100037

作者简介:

耿志宇，女，博士，主任医师，主要研究方向：临床麻醉与镇痛、麻醉药理及妇产科麻醉。联系电话：（010）83573218，E-mail：gengzhiyu2013@163.com。

Efficacy and safety of pregabalin for acute postoperative pain after laparoscopic surgery: a systematic review and Meta-analysis

Zhi-yu GENG¹, Lin-lin SONG¹, Jing-fei GUO²

Affiliations

¹Department of Anesthesiology, First Hospital, Peking University, Beijing 100034, China

²Department of Anesthesiology, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 100037, China

出版时间: 2021-03-15

文章导航

摘要

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目的：

评价普瑞巴林用于腹腔镜手术后的镇痛效果和不良反应。

方法：

计算机检索建库至2019年10月，在Pubmed，Embase，Cochrane library，中国知网、万方数据库和维普中文科技期刊数据库发表的普瑞巴林用于腹腔镜手术后镇痛的随机对照研究。从符合纳入标准的文献中提取数据，采用Revman 5.3软件进行分析。

结果：

共纳入18项研究1 169例患者，镇痛效果方面：普瑞巴林组术后24 h患者疼痛视觉模拟评分（VAS）显著低于对照组（MD=-8.34 mm，95%CI：-11.68~-4.99，P<0.001），术后24 h吗啡用量低于对照组（MD=-5.88 mg，95%CI：-7.66~-4.11，P<0.001）。不良反应方面：普瑞巴林组术后24 h恶心呕吐发生率明显低于对照组（RR=0.75，95%CI：0.62~0.92，P=0.006），术后视物模糊发生率明显高于对照组（RR=2.86，95%CI：1.33~6.18，P=0.007）。两组术后头晕和镇静发生率差异无统计学意义（RR=1.08，95%CI：0.82~1.42，P=0.59；RR=2.41，95%CI：0.44~13.17，P=0.31）。

结论：

普瑞巴林用于不同种类腹腔镜手术后镇痛时，可降低术后疼痛评分，节省阿片用量，并减少术后恶心呕吐发生。推荐术前单次用药模式，以减少视物模糊发生。

关键词

普瑞巴林 / 镇痛 / 腹腔镜 / Meta分析

Abstract

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Objective:

To evaluate the analgesic and adverse effects of pregabalin after laparoscopic surgery.

Methods:

Pubmed, Embase, Cochrane library, China Knowledge Network, Wanfang database and VIP database were searched for randomized controlled trials (RCT) that investigated pregabalin analgesa in adult patients undergoing laparoscopic surgery from inception to October 2019. RevMan 5.3 was used to perform analysis.

Results:

Eighteen RCTs with a total of 1169 subjects were included. Pregabalin was associated with a significant reduction in pain scores and opioid consumption at 24 h compared with placebo (MD=-8.34 mm, 95%CI: -11.68~-4.99, P<0.001 and MD=-5.88 mg, 95%CI: -7.66~-4.11, P<0.001). Patients receiving pregabalin had less postoperative nausea and vomiting compared with placebo (RR=0.75, 95%CI: 0.62~0.92, P=0.006). Visual disturbance was more common in pregabalin group compared with placebo group (RR=2.86, 95%CI: 1.33~6.18, P=0.007). There was no significant difference in the incidence of dizziness and sedation between the two groups (RR=1.08, 95%CI: 0.82~1.42, P=0.59; RR=2.41, 95%CI: 0.44~13.17, P=0.31).

Conclusions:

Perioperative administration of pregabalin may decrease pain scores, opioid consumption, nausea and vomiting when used in different types of laparoscopic surgery. Single preoperative dose is recommended to reduce the occurrence of visual disturbance.

Key words

pregabalin / analgesia / laparoscopic / Meta-analysis

引用本文

耿志宇, 宋琳琳, 郭镜飞. 普瑞巴林用于腹腔镜手术后急性疼痛的有效性和安全性系统综述和Meta分析. 中国新药杂志, 2021 , 30 (5) : 454 -461 .

Zhi-yu GENG, Lin-lin SONG, Jing-fei GUO. Efficacy and safety of pregabalin for acute postoperative pain after laparoscopic surgery: a systematic review and Meta-analysis[J]. Chinese Journal of New Drugs, 2021 , 30 (5) : 454 -461 .

参考文献

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2021年第30卷第5期

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首发时间：2026-10-29
出版时间：2021-03-15

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录用日期：2020-07-30

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¹北京大学第一医院麻醉科，北京　100034

²中国医学科学院附属北京阜外医院麻醉科，北京　100037

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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