Article(id=1322627623470084118, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322627622589280278, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1597852800000, acceptedDateStr=2020-08-20, onlineDate=1793268598667, onlineDateStr=2026-10-29, pubDate=1617033600000, pubDateStr=2021-03-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793268598667, onlineIssueDateStr=2026-10-29, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793268598667, creator=13701087609, updateTime=1793268598667, updator=13701087609, issue=Issue{id=1322627622589280278, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='6', pageStart='481', pageEnd='576', issueExtLink='null', onlineDate='null', pubDate='1617033600000', pubDateStr='2021-03-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793268598458, creator='13701087609', updateTime=1793269229249, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322630268373021321, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322627622589280278, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322630268373021322, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322627622589280278, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=535, endPage=539, ext={EN=ArticleExt(id=1322627623809822743, articleId=1322627623470084118, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Research progress of drugs targeting BAFF/APRIL for systemic lupus erythematosus, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Systemic lupus erythematosus (SLE) is an autoimmune disease caused by the forming of pathogenic autoantibodies and immune complexes which mediate organ and tissue damages. In recent years, many scholars have found that B lymphocytes play an important role in the pathogenesis of SLE. This article mainly reviews the progress of clinical trials of drugs targeting BAFF/APRIL.

, authors=Dan LIU¹, Xiao-xia WANG², Hong WANG², Jia-li HE¹, Pei-han WU¹, Gui-hai LIU¹, authorsList=Dan LIU, Xiao-xia WANG, Hong WANG, Jia-li HE, Pei-han WU, Gui-hai LIU, authorCompany=null, correspAuthors=Xiao-xia WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322627624673849368, articleId=1322627623470084118, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=以BAFF/APRIL为靶点药物治疗系统性红斑狼疮临床研究进展, columnId=1236330553964810454, journalTitle=中国新药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

系统性红斑狼疮（SLE）是一种以致病性自身抗体和免疫复合物形成并介导器官、组织损伤的自身免疫性疾病，近年来不少国内外学者发现B淋巴细胞在SLE的发病中扮演了重要的角色，本文主要对以BAFF/APRIL为靶点的药物治疗SLE的临床试验进展进行综述。

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刘丹，女，硕士研究生，主要从事风湿病诊疗工作。E-mail：18334796300@163.com。

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刘丹，女，硕士研究生，主要从事风湿病诊疗工作。E-mail：18334796300@163.com。

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