Article(id=1322627352929095892, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322627316266680781, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1597852800000, acceptedDateStr=2020-08-20, onlineDate=1793268534165, onlineDateStr=2026-10-29, pubDate=1611936000000, pubDateStr=2021-01-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793268534165, onlineIssueDateStr=2026-10-29, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793268534165, creator=13701087609, updateTime=1793268534165, updator=13701087609, issue=Issue{id=1322627316266680781, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='2', pageStart='97', pageEnd='192', issueExtLink='null', onlineDate='null', pubDate='1611936000000', pubDateStr='2021-01-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793268525425, creator='13701087609', updateTime=1793269089393, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322629681875108722, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322627316266680781, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322629681879303027, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322627316266680781, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=132, endPage=138, ext={EN=ArticleExt(id=1322627354640371925, articleId=1322627352929095892, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Research progress in redox sensitive targeting nano drug delivery systems, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

The ideal tumor targeting drug delivery system should be highly accumulated in the tumor site and release the drug quickly, while there is no leakage in the blood circulation. The accurate tumor targeting can be realized by taking advantage of the changed redox state in tumor environment and the difference of intracellular and extracellular glutathione levels, combined with the nano drug delivery system. This review introduced the principles of redox-sensitive nano drug delivery systems, redox-sensitive bond and their construction methods, also analyzed and summarized the application of different redox-sensitive nano-drug delivery systems based on liposomes, nanoparticles, nanomicelles and nanogels in tumor targeting therapy, which can provide a reference for further study of tumor targeting drug delivery.

, authors=Yi-lin ZHOU, Shu-lan LIU, Xin-hua XIA, Man-shu ZOU, Li-li ZHOU, authorsList=Yi-lin ZHOU, Shu-lan LIU, Xin-hua XIA, Man-shu ZOU, Li-li ZHOU, authorCompany=null, correspAuthors=Xin-hua XIA, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322627355173048534, articleId=1322627352929095892, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=氧化还原敏感型靶向纳米给药系统的研究进展, columnId=1236330553964810454, journalTitle=中国新药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

理想的肿瘤靶向给药系统应在肿瘤部位高度累积且快速释放药物，而在血液循环中无泄漏，利用肿瘤环境改变的氧化还原状态及细胞内外的谷胱甘肽差异，结合纳米给药系统，可实现精准肿瘤靶向。本文对氧化还原敏感型靶向纳米给药系统的原理、氧化还原敏感键及其构建方法进行了介绍，并对基于脂质体、纳米粒、纳米胶束、纳米凝胶4种载体的不同氧化还原敏感型纳米给药系统在肿瘤靶向治疗中的应用进行了分析和总结，可为肿瘤靶向给药的进一步研究提供参考。

, authors=周艺林, 刘淑兰, 夏新华, 邹蔓姝, 周莉莉, authorsList=周艺林, 刘淑兰, 夏新华, 邹蔓姝, 周莉莉, authorCompany=null, correspAuthors=夏新华, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=kiQHt4VVNrFpenvh6r9DCQ==, magXml=oZCUXONAIUSWYx4U+0dtTQ==, pdfUrl=null, pdf=pIVPgWAWy2q63GjAev46lw==, pdfFileSize=1161001, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=g7ZE1POb0MOgOXaixyQrRA==, mapNumber=null, fund=null)}, authors=[Author(id=1322627356817215708, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=382761882@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322627357056291038, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, authorId=1322627356817215708, language=EN, stringName=Yi-lin ZHOU, firstName=Yi-lin, middleName=null, lastName=ZHOU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Hunan University of Chinese Medicine, School of Pharmacy, Changsha 410208, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322627357123399903, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, authorId=1322627356817215708, language=CN, stringName=周艺林, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=湖南中医药大学药学院，长沙　410208, bio={"content":"

周艺林，女，硕士研究生，主要从事中药新制剂及制剂质量标准的研究。E-mail：382761882@qq.com。

"}, bioImg=null, bioContent=

周艺林，女，硕士研究生，主要从事中药新制剂及制剂质量标准的研究。E-mail：382761882@qq.com。

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322627356720746712, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, xref=null, ext=[AuthorCompanyExt(id=1322627356729135321, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, companyId=1322627356720746712, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Hunan University of Chinese Medicine, School of Pharmacy, Changsha 410208, China), AuthorCompanyExt(id=1322627356737523930, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, companyId=1322627356720746712, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=湖南中医药大学药学院，长沙　410208)])]), Author(id=1322627357186314465, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322627357253423331, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, authorId=1322627357186314465, language=EN, stringName=Shu-lan LIU, firstName=Shu-lan, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Hunan University of Chinese Medicine, School of Pharmacy, Changsha 410208, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322627357534441700, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, authorId=1322627357186314465, language=CN, stringName=刘淑兰, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=湖南中医药大学药学院，长沙　410208, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322627356720746712, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, xref=null, ext=[AuthorCompanyExt(id=1322627356729135321, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, companyId=1322627356720746712, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Hunan University of Chinese Medicine, School of Pharmacy, Changsha 410208, China), AuthorCompanyExt(id=1322627356737523930, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, companyId=1322627356720746712, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=湖南中医药大学药学院，长沙　410208)])]), Author(id=1322627357928706278, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=xiaxinhua001@163.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1322627358029369576, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, authorId=1322627357928706278, language=EN, stringName=Xin-hua XIA, firstName=Xin-hua, middleName=null, lastName=XIA, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Hunan University of Chinese Medicine, School of Pharmacy, Changsha 410208, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322627358310387945, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, authorId=1322627357928706278, language=CN, stringName=夏新华, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=湖南中医药大学药学院，长沙　410208, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322627356720746712, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, xref=null, ext=[AuthorCompanyExt(id=1322627356729135321, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, companyId=1322627356720746712, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Hunan University of Chinese Medicine, School of Pharmacy, Changsha 410208, China), AuthorCompanyExt(id=1322627356737523930, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, companyId=1322627356720746712, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=湖南中医药大学药学院，长沙　410208)])]), Author(id=1322627358398468331, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322627358478160109, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, authorId=1322627358398468331, language=EN, stringName=Man-shu ZOU, firstName=Man-shu, middleName=null, lastName=ZOU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Hunan University of Chinese Medicine, School of Pharmacy, Changsha 410208, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322627358784344302, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, authorId=1322627358398468331, language=CN, stringName=邹蔓姝, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=湖南中医药大学药学院，长沙　410208, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322627356720746712, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, xref=null, ext=[AuthorCompanyExt(id=1322627356729135321, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, companyId=1322627356720746712, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Hunan University of Chinese Medicine, School of Pharmacy, Changsha 410208, China), AuthorCompanyExt(id=1322627356737523930, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, companyId=1322627356720746712, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=湖南中医药大学药学院，长沙　410208)])]), Author(id=1322627359153443057, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322627359233134835, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, authorId=1322627359153443057, language=EN, stringName=Li-li ZHOU, firstName=Li-li, middleName=null, lastName=ZHOU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Hunan University of Chinese Medicine, School of Pharmacy, Changsha 410208, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322627359296049396, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, authorId=1322627359153443057, language=CN, stringName=周莉莉, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=湖南中医药大学药学院，长沙　410208, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322627356720746712, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, xref=null, ext=[AuthorCompanyExt(id=1322627356729135321, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, companyId=1322627356720746712, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Hunan University of Chinese Medicine, School of Pharmacy, Changsha 410208, China), AuthorCompanyExt(id=1322627356737523930, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, companyId=1322627356720746712, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=湖南中医药大学药学院，长沙　410208)])])], keywords=[Keyword(id=1322627359673536757, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, language=EN, orderNo=1, keyword=redox sensitive), Keyword(id=1322627359992303862, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, language=EN, orderNo=2, keyword=nano drug delivery system), Keyword(id=1322627360071995639, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, language=EN, orderNo=3, keyword=tumor targeting), Keyword(id=1322627360134910200, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, language=EN, orderNo=4, keyword=disulfide bond), Keyword(id=1322627360197824761, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, language=EN, orderNo=5, keyword=glutathione (GSH)), Keyword(id=1322627360399151354, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, language=CN, orderNo=1, keyword=氧化还原敏感), Keyword(id=1322627360495620347, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, language=CN, orderNo=2, keyword=纳米给药系统), Keyword(id=1322627360566923516, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, language=CN, orderNo=3, keyword=肿瘤靶向), Keyword(id=1322627360638226685, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, language=CN, orderNo=4, keyword=二硫键), Keyword(id=1322627360822776062, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, language=CN, orderNo=5, keyword=谷胱甘肽)], refs=[Reference(id=1322627361414172930, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=null, journalName=null, refType=null, unstructuredReference=WANG Z, ZHI K, DING Z, et al. Emergence in protein derived nanomedicine as anticancer therapeutics: more than a tour de force[J]. Semin Cancer Biol, 2020, published online ahead of print., articleTitle=null, refAbstract=null), Reference(id=1322627361737134339, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=TRAN PHL, XIANG D, TRAN TTD, et al. Exosomes and nanoengineering: a match made for precision therapeutics[J]. Adv Mater, 2020, 32(18): e1904040., articleTitle=null, refAbstract=null), Reference(id=1322627361816826116, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=AGRAWAL M, SARAF S, SARAF S, et al. Recent strategies and advances in the fabrication of nano lipid carriers and their application towards brain targeting[J]. J Control Release, 2020, 321: 372-415., articleTitle=null, refAbstract=null), Reference(id=1322627361904906501, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=RIAZ MK, RIAZ MA, ZHANG X, et al. Surface Functionalization and Targeting Strategies of Liposomes in Solid Tumor Therapy: A Review[J]. Int J Mol Sci, 2018, 19(1): 195., articleTitle=null, refAbstract=null), Reference(id=1322627362139787526, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=MÜLLER LK, LANDFESTER K. Natural liposomes and synthetic polymeric structures for biomedical applications[J]. Biochem Biophys Res Commun, 2015, 468(3): 411-418., articleTitle=null, refAbstract=null), Reference(id=1322627362232062215, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=ARYASOMAYAJULA B, SALZANO G, TORCHILIN VP. Multifunctional Liposomes[J]. Methods Mol Biol, 2017, 1530: 41-61., articleTitle=null, refAbstract=null), Reference(id=1322627362290782473, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHANG YH, CAO J, YUAN Z. Strategies and challenges to improve the performance of tumor-associated active targeting[J]. J Mater Chem B, 2020, 8(18): 3959-3971., articleTitle=null, refAbstract=null), Reference(id=1322627362500497674, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=JAIN A, JAIN SK. Stimuli-responsive smart liposomes in cancer targeting[J]. Curr Drug Targets, 2018, 19(3): 259-270., articleTitle=null, refAbstract=null), Reference(id=1322627362617938187, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=AĞARDAN NBM, TORCHILIN VP. Chapter 1-Engineering of stimuli-sensitive nanopreparations to overcome physiological barriers and cancer multidrug resistance[M]. 2016: 1-28., articleTitle=null, refAbstract=null), Reference(id=1322627362706018572, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=王小巍, 张红艳, 刘锐, 等. 谷胱甘肽的研究进展[J]. 中国药剂学杂志(网络版), 2019, 17(4): 141-148., articleTitle=null, refAbstract=null), Reference(id=1322627362936705294, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=RAZA A, HAYAT U, RASHEED T, et al. Redox-responsive nano-carriers as tumor-targeted drug delivery systems[J]. Eur J Med Chem, 2018, 157: 705-715., articleTitle=null, refAbstract=null), Reference(id=1322627363003814159, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=SUFI SA, PAJANIRADJE S, MUKHERJEE V, et al. Redox nano-architectures: perspectives and implications in diagnosis and treatment of human diseases[J]. Antioxid Redox Signal, 2019, 30(5): 762-785., articleTitle=null, refAbstract=null), Reference(id=1322627363339358480, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=LI RR, PENG FF, CAI J, et al. Redox dual-stimuli responsive drug delivery systems for improving tumor-targeting ability and reducing adverse side effects[J]. Asian J Pharm Sci, 2020, 15(3): 311-325., articleTitle=null, refAbstract=null), Reference(id=1322627363419050257, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=null, journalName=null, refType=null, unstructuredReference=LEE Y, THOMPSON DH. Stimuli-responsive liposomes for drug delivery[J]. Nanomedicine, 2017, 9(5): e1450., articleTitle=null, refAbstract=null), Reference(id=1322627363494547730, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=null, journalName=null, refType=null, unstructuredReference=MOVAHEDI F, HU RG, BECKER DL, et al. Stimuli-responsive liposomes for the delivery of nucleic acid therapeutics[J]. Nanomed-Nanotechnol Biol Med, 2015, 11(6): 1575-1584., articleTitle=null, refAbstract=null), Reference(id=1322627363578433811, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=null, journalName=null, refType=null, unstructuredReference=FENG C, ZHU D, CHEN L, et al. Targeted delivery of chlorin e6 via redox sensitive diselenide-containing micelles for improved photodynamic therapy in cluster of differentiation 44-overexpressing breast cancer[J]. Front Pharmacol, 2019, 10: 369., articleTitle=null, refAbstract=null), Reference(id=1322627363842674964, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=null, journalName=null, refType=null, unstructuredReference=孙丙军. 肿瘤微环境氧化还原响应型前药自组装纳米递送系统的研究[D]. 2019., articleTitle=null, refAbstract=null), Reference(id=1322627363897200917, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=null, journalName=null, refType=null, unstructuredReference=CHEN X, ZHANG Y, TANG C, et al. Co-delivery of paclitaxel and anti-survivin siRNA via redox-sensitive oligopeptide liposomes for the synergistic treatment of breast cancer and metastasis[J]. Int J Pharm, 2017, 529(1-2): 102-115., articleTitle=null, refAbstract=null), Reference(id=1322627363968504086, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[19], rfOrder=18, authorNames=null, journalName=null, refType=null, unstructuredReference=XU X, WU J, LIU S, et al. Redox-responsive nanoparticle-mediated systemic RNAi for effective cancer therapy[J]. Small, 2018, 14(41): e1802565., articleTitle=null, refAbstract=null), Reference(id=1322627364031418647, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[20], rfOrder=19, authorNames=null, journalName=null, refType=null, unstructuredReference=WANG X, LIN W, ZHANG W, et al. Amphiphilic redox-sensitive NIR BODIPY nanoparticles for dual-mode imaging and photothermal therapy[J]. J Colloid Interface Sci, 2019, 536: 208-214., articleTitle=null, refAbstract=null), Reference(id=1322627364098527512, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[21], rfOrder=20, authorNames=null, journalName=null, refType=null, unstructuredReference=LUO T, HAN J, ZHAO F, et al. Redox-sensitive micelles based on retinoic acid modified chitosan conjugate for intracellular drug delivery and smart drug release in cancer therapy[J]. Carbohydr Polym, 2019, 215: 8-19., articleTitle=null, refAbstract=null), Reference(id=1322627364182413593, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[22], rfOrder=21, authorNames=null, journalName=null, refType=null, unstructuredReference=DU YW, HE W, ZHOU WY, et al. Disulfide phosphatidylcholines: alternative phospholipids for the preparation of functional liposomes[J]. Chem Commun (Camb), 2019, 55(58): 8434-8437., articleTitle=null, refAbstract=null), Reference(id=1322627364253716762, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[23], rfOrder=22, authorNames=null, journalName=null, refType=null, unstructuredReference=DHAWAN S, GHOSH S, RAVINDER R, et al. Redox Sensitive Self-Assembling Dipeptide for Sustained Intracellular Drug Delivery[J]. Bioconjug Chem, 2019, 30(9): 2458-2468., articleTitle=null, refAbstract=null), Reference(id=1322627364312437019, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[24], rfOrder=23, authorNames=null, journalName=null, refType=null, unstructuredReference=LI M, ZHAO L, ZHANG T, et al. Redox-sensitive prodrug nanoassemblies based on linoleic acid-modified docetaxel to resist breast cancers[J]. Acta Pharm Sin B, 2019, 9(2): 421-432., articleTitle=null, refAbstract=null), Reference(id=1322627364375351580, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[25], rfOrder=24, authorNames=null, journalName=null, refType=null, unstructuredReference=BANALA VT, URANDUR S, SHARMA S, et al. Targeted co-delivery of the aldose reductase inhibitor epalrestat and chemotherapeutic doxorubicin via a redox-sensitive prodrug approach promotes synergistic tumor suppression[J]. Biomater Sci, 2019, 7(7): 2889-2906., articleTitle=null, refAbstract=null), Reference(id=1322627364631204125, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[26], rfOrder=25, authorNames=null, journalName=null, refType=null, unstructuredReference=YANG M, DING HQ, ZHU YX, et al. Co-delivery of paclitaxel and doxorubicin using mixed micelles based on the redox sensitive prodrugs[J]. Colloids Surf B Biointerfaces, 2019, 175: 126-135., articleTitle=null, refAbstract=null), Reference(id=1322627364723478814, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[27], rfOrder=26, authorNames=null, journalName=null, refType=null, unstructuredReference=HE WX, JIANG Y, LI Q, et al. A versatile strategy to create an active tumor-targeted chemo-photothermal therapy nanoplatform: a case of an IR-780 derivative co-assembled with camptothecin prodrug[J]. Acta Biomater, 2019, 84: 356-366., articleTitle=null, refAbstract=null), Reference(id=1322627364786393375, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[28], rfOrder=27, authorNames=null, journalName=null, refType=null, unstructuredReference=LING L, ISMAIL M, DU Y, et al. Lipoic acid-derived cross-linked liposomes for reduction-responsive delivery of anticancer drug[J]. Int J Pharm, 2019, 560: 246-260., articleTitle=null, refAbstract=null), Reference(id=1322627364866085152, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[29], rfOrder=28, authorNames=null, journalName=null, refType=null, unstructuredReference=HE W, DU YW, ZHOU WY, et al. Redox-sensitive dimeric camptothecin phosphatidylcholines-based liposomes for improved anticancer efficacy[J]. Nanomedicine (Lond), 2019, 14(23): 3057-3074., articleTitle=null, refAbstract=null), Reference(id=1322627364924805409, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[30], rfOrder=29, authorNames=null, journalName=null, refType=null, unstructuredReference=WANG Z, LING LB, DU YW, et al. Reduction responsive liposomes based on paclitaxel-ss-lysophospholipid with high drug loading for intracellular delivery[J]. Int J Pharm, 2019, 564: 244-255., articleTitle=null, refAbstract=null), Reference(id=1322627364987719970, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[31], rfOrder=30, authorNames=null, journalName=null, refType=null, unstructuredReference=FENG S, WU ZX, ZHAO Z, et al. Engineering of bone- and CD44-dual-targeting redox-sensitive liposomes for the treatment of orthotopic osteosarcoma[J]. ACS Appl Mater Interfaces, 2019, 11(7): 7357-7368., articleTitle=null, refAbstract=null), Reference(id=1322627365063217443, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[32], rfOrder=31, authorNames=null, journalName=null, refType=null, unstructuredReference=FU H, SHI K, HU G, et al. Tumor-targeted paclitaxel delivery and enhanced penetration using TAT-decorated liposomes comprising redox-responsive poly (ethylene glycol)[J]. J Pharm Sci, 2015, 104(3): 1160-1173., articleTitle=null, refAbstract=null), Reference(id=1322627365142909220, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[33], rfOrder=32, authorNames=null, journalName=null, refType=null, unstructuredReference=MERYEM B, RENÉ CG, MARC-ANDRÉ F, et al. Mesoporous silica nanoparticles: selective surface functionalization for optimal relaxometric and drug loading performances[J]. Advanced Functional Materials, 2014, 24(37): 5911-5923., articleTitle=null, refAbstract=null), Reference(id=1322627365260349733, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[34], rfOrder=33, authorNames=null, journalName=null, refType=null, unstructuredReference=HUANG L, LIU J, GAO F, et al. A dual-responsive, hyaluronic acid targeted drug delivery system based on hollow mesoporous silica nanoparticles for cancer therapy[J]. J Mater Chem B, 2018, 6(28): 4618-4629., articleTitle=null, refAbstract=null), Reference(id=1322627365323264294, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[35], rfOrder=34, authorNames=null, journalName=null, refType=null, unstructuredReference=XIAO D, JIA HZ, MA N, et al. A redox-responsive mesoporous silica nanoparticle capped with amphiphilic peptides by self-assembly for cancer targeting drug delivery[J]. Nanoscale, 2015, 7(22): 10071-10077., articleTitle=null, refAbstract=null), Reference(id=1322627365436510503, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[36], rfOrder=35, authorNames=null, journalName=null, refType=null, unstructuredReference=RAJENDRAKUMAR SK, VENU A, REVURI V, et al. Hyaluronan-stabilized redox-sensitive nanoassembly for chemo-gene therapy and dual T1/T2 MR imaging in drug-resistant breast cancer cells[J]. Mol Pharm, 2019, 16(5): 2226-2234., articleTitle=null, refAbstract=null), Reference(id=1322627365503619368, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[37], rfOrder=36, authorNames=null, journalName=null, refType=null, unstructuredReference=LI J, HUO M, WANG J, et al. Redox-sensitive micelles self-assembled from amphiphilic hyaluronic acid-deoxycholic acid conjugates for targeted intracellular delivery of paclitaxel[J]. Biomaterials, 2012, 33(7): 2310-2320., articleTitle=null, refAbstract=null), Reference(id=1322627365604282665, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[38], rfOrder=37, authorNames=null, journalName=null, refType=null, unstructuredReference=XU W, WANG H, DONG L, et al. Hyaluronic acid-decorated redox-sensitive chitosan micelles for tumor-specific intracellular delivery of gambogic acid[J]. Int J Nanomedicine, 2019, 14: 4649-4666., articleTitle=null, refAbstract=null), Reference(id=1322627365671391530, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[39], rfOrder=38, authorNames=null, journalName=null, refType=null, unstructuredReference=JEONG GW, JEONG YI, NAH JW. Triggered doxorubicin release using redox-sensitive hyaluronic acid-g-stearic acid micelles for targeted cancer therapy[J]. Carbohydr Polym, 2019, 209: 161-171., articleTitle=null, refAbstract=null), Reference(id=1322627365906272555, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[40], rfOrder=39, authorNames=null, journalName=null, refType=null, unstructuredReference=TIAN C, ASGHAR S, HU Z, et al. Understanding the cellular uptake and biodistribution of a dual-targeting carrier based on redox-sensitive hyaluronic acid-ss-curcumin micelles for treating brain glioma[J]. Int J Biol Macromol, 2019, 136: 143-153., articleTitle=null, refAbstract=null), Reference(id=1322627365960798508, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[41], rfOrder=40, authorNames=null, journalName=null, refType=null, unstructuredReference=WANG M, ALBERTI K, SUN S, et al. Combinatorially designed lipid-like nanoparticles for intracellular delivery of cytotoxic protein for cancer therapy[J]. Angew Chem Int Ed Engl, 2014, 53(11): 2893-2898., articleTitle=null, refAbstract=null), Reference(id=1322627366019518765, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[42], rfOrder=41, authorNames=null, journalName=null, refType=null, unstructuredReference=LI S, ZHANG J, DENG C, et al. Redox-sensitive and intrinsically fluorescent photoclick hyaluronic acid nanogels for traceable and targeted delivery of cytochrome c to breast tumor in mice[J]. ACS Appl Mater Interfaces, 2016, 8(33): 21155-21162., articleTitle=null, refAbstract=null), Reference(id=1322627366082433326, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[43], rfOrder=42, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHAO XQ, XI YY, ZHANG YM, et al. Redox-sensitive gelatin/silica-aptamer nanogels for targeted siRNA delivery[J]. Nanoscale Res Lett, 2019, 14(1): 273., articleTitle=null, refAbstract=null), Reference(id=1322627366141153583, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[44], rfOrder=43, authorNames=null, journalName=null, refType=null, unstructuredReference=LI F, YANG H, BIE N, et al. Zwitterionic Temperature/Redox-Sensitive Nanogels for Near-Infrared Light-Triggered Synergistic Thermo-Chemotherapy[J]. ACS Appl Mater Interfaces, 2017, 9(28): 23564-23573., articleTitle=null, refAbstract=null), Reference(id=1322627366204068144, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[45], rfOrder=44, authorNames=null, journalName=null, refType=null, unstructuredReference=QU Y, CHU BY, WEI XW, et al. Redox/pH dual-stimuli responsive camptothecin prodrug nanogels for “on-demand” drug delivery[J]. J Control Release, 2019, 296: 93-106., articleTitle=null, refAbstract=null), Reference(id=1322627366271177009, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[46], rfOrder=45, authorNames=null, journalName=null, refType=null, unstructuredReference=MA J, DENG H, ZHAO F, et al. Liposomes-camouflaged redox-responsive nanogels to resolve the dilemma between extracellular stability and intracellular drug release[J]. Macromol Biosci, 2018, 18(7): e1800049., articleTitle=null, refAbstract=null)], funds=[Fund(id=1322627360923439359, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, awardId=81573621, language=CN, fundingSource=国家自然科学基金面上项目(81573621), fundOrder=null, country=null), Fund(id=1322627360998936832, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, awardId=2017SK2122, language=CN, fundingSource=湖南省重点研发计划项目(2017SK2122), fundOrder=null, country=null), Fund(id=1322627361250595073, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, awardId=CX20200756, language=CN, fundingSource=湖南省研究生科研创新项目(CX20200756), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1322627356720746712, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, xref=null, ext=[AuthorCompanyExt(id=1322627356729135321, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, companyId=1322627356720746712, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Hunan University of Chinese Medicine, School of Pharmacy, Changsha 410208, China), AuthorCompanyExt(id=1322627356737523930, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627352929095892, companyId=1322627356720746712, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=湖南中医药大学药学院，长沙　410208)])], figs=null, attaches=null, journal=Journal(id=1235980159023624194, delFlag=0, nameCn=中国新药杂志, nameEn=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, issn=1003-3734, eissn=null, cn=11-2850/R, coden=ZXZHA6, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of New Drugs, journalRemark=null, publicationField=null, createdTime=1772610233314, updatedTime=1788948968376, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=ohPEEN//Vz1tDT3ZBNTp4Q==, picEn=f9WK9bvTM4guTmS/iGhOMg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509780974924039, language=CN, name=中国新药杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948968404, updatedTime=1788948968404, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304509781025255688, language=EN, name=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948968416, updatedTime=1788948968416, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1235980733773295621, websiteList=[Website(id=1235982099191222761, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/CN, language=CN, createTime=1772610695884, createBy=18614031015, updateTime=1772610860397, updateBy=18614031015, name=中国新药杂志-中文, tplId=1146099689490845704, title=中国新药杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983918629966444, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=articleTextType, value=kx, createTime=1772611129672, updateTime=1772611129672, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918604800617, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=banner, value=null, createTime=1772611129666, updateTime=1772611129666, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918655132271, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=grayFlag, value=0, createTime=1772611129678, updateTime=1772611129678, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918596412008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611129664, updateTime=1772611129664, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918667715185, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=minRunFlag, value=0, createTime=1772611129681, updateTime=1772611129681, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918617383531, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic, createTime=1772611129669, updateTime=1772611129669, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918659326576, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=silenceFlag, value=0, createTime=1772611129679, updateTime=1772611129679, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918613189226, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1772611129668, updateTime=1772611129668, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918634160749, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeColor, value=null, createTime=1772611129673, updateTime=1772611129673, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918646743662, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeStyle, value=null, createTime=1772611129676, updateTime=1772611129676, creator=18614031015, updator=18614031015)]), Website(id=1235982099270914542, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/EN, language=EN, createTime=1772610695903, createBy=18614031015, updateTime=1772610875891, updateBy=18614031015, name=中国新药杂志-英文, tplId=1146101810881728533, title=Chinese Journal of New Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983955829248630, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=articleTextType, value=kx, createTime=1772611138541, updateTime=1772611138541, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955804082803, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=banner, value=null, createTime=1772611138535, updateTime=1772611138535, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955854414457, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=grayFlag, value=0, createTime=1772611138547, updateTime=1772611138547, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955795694194, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611138533, updateTime=1772611138533, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955866997371, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=minRunFlag, value=0, createTime=1772611138550, updateTime=1772611138550, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955820860021, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic, createTime=1772611138539, updateTime=1772611138539, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955862803066, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=silenceFlag, value=0, createTime=1772611138549, updateTime=1772611138549, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955812471412, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1772611138537, updateTime=1772611138537, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955837637239, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeColor, value=null, createTime=1772611138543, updateTime=1772611138543, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955846025848, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeStyle, value=null, createTime=1772611138545, updateTime=1772611138545, creator=18614031015, updator=18614031015)])], journalTitle=中国新药杂志, weixinUrl=null, journalUrl=http://www.newdrug.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of New Drugs, journalPhotoCn=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPhotoEn=f9WK9bvTM4guTmS/iGhOMg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/Y2021/V30/I2/132, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/Y2021/V30/I2/132, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/PDF/Y2021/V30/I2/132, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/PDF/Y2021/V30/I2/132, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1611936000000, fullTextJson=null, articleText=null, reference=null)