Article(id=1322627317218783969, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322627316266680781, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1576771200000, acceptedDateStr=2019-12-20, onlineDate=1793268525652, onlineDateStr=2026-10-29, pubDate=1611936000000, pubDateStr=2021-01-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793268525652, onlineIssueDateStr=2026-10-29, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793268525652, creator=13701087609, updateTime=1793268525652, updator=13701087609, issue=Issue{id=1322627316266680781, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='2', pageStart='97', pageEnd='192', issueExtLink='null', onlineDate='null', pubDate='1611936000000', pubDateStr='2021-01-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793268525425, creator='13701087609', updateTime=1793269089393, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322629681875108722, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322627316266680781, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322629681879303027, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322627316266680781, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=170, endPage=177, ext={EN=ArticleExt(id=1322627317617242850, articleId=1322627317218783969, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Preparation and evaluation of betastatin ethosomes, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To study the optimal formulation process of betastin ethosomes and investigate its transdermal permeation in vitro.
Methods: Betastine ethosomes were prepared by ethanol injection method. The dosage of soybean lecithin, ethanol and water bath temperature were taken as investigation factors, particle size and entrapment efficiency were determined as evaluation indexes, and the formulation was optimized by central composite design-response surface methodology. The preliminary stability of the preparation was also investigated. Transdermal absorption test in vitro was carried out by using Franz diffusion cell to compare the effects of different ways of administration on the transdermal penetration of betastine.
Results: The optimum prescription conditions were as follows: betastine 100 mg, soybean lecithin 311 mg, ethanol 4.1 mL, water bath temperature 39 ℃. The preparation was clear liquid with blue light, the encapsulation rate was (67.1±2.23)%, the particle size was (59.6±4.81) nm, and the difference between the actual value and the predicted value was less than 5%. The transdermal permeation rate of betastin (10.76 μg·cm-2·h-1) was 8.47 times of that of aqueous solution, 3.09 times of that of ordinary liposomes, and 1.63 times of that of 45% ethanol solution.
Conclusion: The prepared betastol ethosomes has the advantages of small particle size, uniform distribution, high stability and good transdermal absorption.
, authors=Hao WANG, Run-ze LIU, Jun-feng DONG, Jian-wen ZHOU, Chun-yan HUANG, Yu-meng CHU, Cui-yan HAN, authorsList=Hao WANG, Run-ze LIU, Jun-feng DONG, Jian-wen ZHOU, Chun-yan HUANG, Yu-meng CHU, Cui-yan HAN, authorCompany=null, correspAuthors=Cui-yan HAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322627318040867555, articleId=1322627317218783969, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=倍他司汀醇质体的制备与评价, columnId=1236330556003242277, journalTitle=中国新药杂志, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的： 研究倍他司汀醇质体最佳处方工艺，并考察其体外透皮特性。
方法： 采用乙醇注入法制备倍他司汀醇质体，以大豆卵磷脂用量、乙醇用量和水浴温度作为考察因素，粒径、包封率为测定指标，采用星点设计-效应面法优化处方，并考察该制剂的初步稳定性；应用Franz扩散池进行体外透皮吸收试验，比较不同给药形式对倍他司汀经皮渗透的影响。
结果： 最佳处方工艺为倍他司汀100 mg、大豆卵磷脂311 mg、乙醇4.1 mL、水浴温度为39 ℃，制备的倍他司汀醇质体外观为泛有蓝光的澄清液体，包封率为（67.1±2.23）%，粒径为（59.6±4.81）nm，与预测值相差比例均<5%。倍他司汀醇质体的经皮渗透速率为10.76 μg·cm-2·h-1，是水溶液的8.47倍、普通脂质体的3.09倍、体积分数为45%乙醇溶液的1.63倍。
结论： 制备的倍他司汀醇质体粒径小、分布均匀、稳定性较高，具有良好的透皮吸收特性。
, authors=王皓, 刘润泽, 董俊峰, 周建文, 黄春燕, 初雨萌, 韩翠艳, authorsList=王皓, 刘润泽, 董俊峰, 周建文, 黄春燕, 初雨萌, 韩翠艳, authorCompany=null, correspAuthors=韩翠艳, authorNote=
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王皓，男，硕士研究生，研究方向：药物制剂新技术、新剂型。联系电话：（0452）2663382，E-mail：1354935327@qq.com。
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王皓，男，硕士研究生，研究方向：药物制剂新技术、新剂型。联系电话：（0452）2663382，E-mail：1354935327@qq.com。
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