Article(id=1322627043028751090, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322627025303622144, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1583683200000, acceptedDateStr=2020-03-09, onlineDate=1793268460280, onlineDateStr=2026-10-29, pubDate=1613318400000, pubDateStr=2021-02-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793268460280, onlineIssueDateStr=2026-10-29, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793268460280, creator=13701087609, updateTime=1793268460280, updator=13701087609, issue=Issue{id=1322627025303622144, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='3', pageStart='193', pageEnd='288', issueExtLink='null', onlineDate='null', pubDate='1613318400000', pubDateStr='2021-02-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793268456054, creator='13701087609', updateTime=1793269130792, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322629855401857146, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322627025303622144, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322629855406051451, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322627025303622144, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=285, endPage=288, ext={EN=ArticleExt(id=1322627043192328947, articleId=1322627043028751090, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Literature analysis of tigecycline-induced blood coagulation dysfunction, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To analyze the general patterns and characteristics of blood coagulation dysfunction induced by tigecycline and provide reference for clinical use.
Methods: Blood coagulation dysfunction induced by tigecycline reported in foreign and domestic academic journals were collected from China National Knowledge Infrastructure (CNKI), VIP, PubMed, Embase and SCI, and analyzed in depth.
Results: A total of 17 patients, including 12 males and 5 females, were retrieved, and 5 of whom with abnormal liver function. Among them, 10 patients appear coagulation dysfunction in 10 d of treatment. The clinical manifestations of blood coagulation dysfunction induced by tigecycline were the significant prolongation of prothrombin time (PT), activated partial thromboplastin time (APTT) and fibrinogen (FIB) significantly decreased. After treatment, 16 patients recovered and 1 died.
Conclusion: Clinicians and pharmacists should familiarize the pauem and characteristics of blood coagulation dysfunction induced by tigecycline, which should be used strictly in accordance with the instructions. Drug monitoring should be strengthened.
, authors=Ming ZHANG
1, Jin WANG
2, Rui WANG
2, Nan BAI
2, Chao AI
1, authorsList=Ming ZHANG, Jin WANG, Rui WANG, Nan BAI, Chao AI, authorCompany=null, correspAuthors=Chao AI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322627043423015668, articleId=1322627043028751090, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=替加环素致凝血功能障碍文献分析, columnId=1236331163573342670, journalTitle=中国新药杂志, columnName=药物安全与合理应用, runingTitle=null, highlight=null, articleAbstract=
目的： 分析替加环素致凝血功能障碍的发生规律及特点，为临床安全用药提供参考。
方法： 检索中国学术期刊全文数据库、维普中文科技期刊数据库、PubMed、Embase及SCI数据库收载的替加环素致凝血功能障碍的个案报道，进行分析。
结果： 共检索到替加环素致凝血功能障碍病例17例，男性12例，女性5例，其中合并肝功能异常的患者5例。10例在用药10 d内发生凝血功能障碍。临床表现主要为凝血酶原时间（prothrombin time，PT）和部分凝血活酶时间（activated partial thromboplastin time，APTT）的明显延长及纤维蛋白原（fibrinogen，FIB）的下降。经对症处理后，16例患者好转，1例患者死亡。
结论： 临床医师和药师应了解替加环素致凝血功能障碍的规律和特点，严格按照药品说明书的要求使用，加强用药监护。
, authors=张明
1, 王瑾
2, 王睿
2, 白楠
2, 艾超
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