Article(id=1322627038184329901, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322627025303622144, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1590595200000, acceptedDateStr=2020-05-28, onlineDate=1793268459124, onlineDateStr=2026-10-29, pubDate=1613318400000, pubDateStr=2021-02-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793268459124, onlineIssueDateStr=2026-10-29, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793268459124, creator=13701087609, updateTime=1793268459124, updator=13701087609, issue=Issue{id=1322627025303622144, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='3', pageStart='193', pageEnd='288', issueExtLink='null', onlineDate='null', pubDate='1613318400000', pubDateStr='2021-02-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793268456054, creator='13701087609', updateTime=1793269130792, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322629855401857146, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322627025303622144, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322629855406051451, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322627025303622144, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=267, endPage=273, ext={EN=ArticleExt(id=1322627038364684974, articleId=1322627038184329901, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Synthesis and biological evaluation of twin drug of tetramethylpyrazine and scutellarein for ischemic stroke, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To design and synthesize twin drug of tetramethylpyrazine and scutellarein for ischemic stroke.
Methods: Based upon the theory of twin drug, six targeted compounds were synthesized and their structures were confirmed by 1H-NMR and HRMS. The antioxidant and anticoagulant activities of the target compounds were studied in vitro, and the selected compound was further evaluated for cerebral ischemia/reperfusion protection using middle cerebral artery occlusion (MCAO) model.
Results: All the tested compounds showed good effect against oxidative damage and anticoagulant activity, and the volume ratio of cerebral infarction in the high dose group of compound 4 was reduced to 23.7% compared with the MCAO group.
Conclusion: The twin drug strategy has certain reference value for the treatment of ischemic stroke.
, authors=Ming-ji LIU, Shu-xia WU, Dan-dan LEI, Qing-yan ZHANG, Li DONG, Yong-xi DONG, authorsList=Ming-ji LIU, Shu-xia WU, Dan-dan LEI, Qing-yan ZHANG, Li DONG, Yong-xi DONG, authorCompany=null, correspAuthors=Yong-xi DONG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322627038620537519, articleId=1322627038184329901, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=川芎嗪灯盏乙素苷元抗缺血性脑卒中孪药的合成及活性研究, columnId=1236330556003242277, journalTitle=中国新药杂志, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的： 设计合成川芎嗪灯盏乙素苷元孪药，研究其对于缺血性脑卒中的治疗作用。
方法： 以川芎嗪和灯盏乙素苷元为原药，通过共价键将其拼合，并对所合成目标化合物进行体外抗氧化损伤、抗凝血活性研究，筛选得到目标化合物4进行体内缺血再灌注损伤保护作用研究。
结果： 设计合成得到6个川芎嗪灯盏乙素苷元孪药，受试化合物均表现出良好的抗氧化损伤及抗凝血活性，化合物4高剂量组脑梗死体积比减小为23.7%（与模型组相比）。
结论： 孪药策略对于治疗缺血性脑卒中具有一定的参考价值。
, authors=刘明吉, 吴淑霞, 雷丹丹, 张青艳, 董莉, 董永喜, authorsList=刘明吉, 吴淑霞, 雷丹丹, 张青艳, 董莉, 董永喜, authorCompany=null, correspAuthors=董永喜, authorNote=
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刘明吉，女，硕士研究生，主要从事天然药物结构修饰研究。联系电话：（0851）88416153，E-mail：1506207004@qq.com。
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刘明吉，女，硕士研究生，主要从事天然药物结构修饰研究。联系电话：（0851）88416153，E-mail：1506207004@qq.com。
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