Article(id=1322627026062782794, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322627025303622144, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1586966400000, acceptedDateStr=2020-04-16, onlineDate=1793268456234, onlineDateStr=2026-10-29, pubDate=1613318400000, pubDateStr=2021-02-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793268456234, onlineIssueDateStr=2026-10-29, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793268456234, creator=13701087609, updateTime=1793268456234, updator=13701087609, issue=Issue{id=1322627025303622144, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='3', pageStart='193', pageEnd='288', issueExtLink='null', onlineDate='null', pubDate='1613318400000', pubDateStr='2021-02-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793268456054, creator='13701087609', updateTime=1793269130792, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322629855401857146, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322627025303622144, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322629855406051451, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322627025303622144, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=246, endPage=253, ext={EN=ArticleExt(id=1322627026226360651, articleId=1322627026062782794, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Research progress of oncolytic virus combined with other drugs in cancer therapy, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Oncolytic virus, as a biological agent of cancer, plays an anti-tumor role by selectively infecting and lyses tumor cells in the treatment of cancer, increasing the exposure of tumor antigens, remolding the tumor microenvironment, increasing the infiltration of immune cells in the tumor microenvironment, and activating the immune system. Because the therapeutic effect of using oncolytic virus alone is not satisfactory, and many clinical trials on the combination of oncolytic virus and other anti-cancer drugs have shown good anti-tumor effect, the application of combination of the two is expected to release the enormous potential of oncolytic virus therapy against cancer. This article reviews the anti-tumor mechanisms, application types, clinical trial status and important progress of combined therapy of oncolytic virus.

, authors=Jiao-yan CUI, Shi-jie CAI, authorsList=Jiao-yan CUI, Shi-jie CAI, authorCompany=null, correspAuthors=Shi-jie CAI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322627026473824588, articleId=1322627026062782794, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=溶瘤病毒联合其他药物用于肿瘤治疗的研究进展, columnId=1236330553964810454, journalTitle=中国新药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

溶瘤病毒作为一种抗肿瘤生物制剂，在肿瘤治疗中选择性地感染裂解肿瘤细胞，增加肿瘤抗原暴露，重塑肿瘤微环境，增加肿瘤微环境中免疫细胞浸润，激活免疫系统，发挥抗肿瘤作用。由于溶瘤病毒单药治疗效果不佳，而溶瘤病毒与其他抗癌药物联用的多个临床研究均表现出良好的抗肿瘤效果，联合用药有望释放溶瘤病毒疗法抗肿瘤方面的巨大潜能。本文从溶瘤病毒抗肿瘤机制、应用类型、联合治疗的临床研究现状、重要进展等进行综述。

, authors=崔姣艳, 蔡世杰, authorsList=崔姣艳, 蔡世杰, authorCompany=null, correspAuthors=蔡世杰, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=E5rhbNCKn+XuDz/4m825Vg==, magXml=wxcOmrzINPepSoUsLbSyHw==, pdfUrl=null, pdf=HKIO/hlyGaj1k4gZV7x5yw==, pdfFileSize=2141606, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=ZCyzVo4wQsL7K23cmMzxGw==, mapNumber=null, fund=null)}, authors=[Author(id=1322627026775814481, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627026062782794, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=cuijiaoyan@126.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322627026859700563, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627026062782794, authorId=1322627026775814481, language=EN, stringName=Jiao-yan CUI, firstName=Jiao-yan, middleName=null, lastName=CUI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Xi'an New Chang'an Regenerative Medicine Technology Research and Development Co., Ltd., Xi'an 710065, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322627026931003732, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322627026062782794, authorId=1322627026775814481, language=CN, stringName=崔姣艳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=西安新长安再生医学科技研发有限公司，西安　710065, bio={"content":"

崔姣艳，女，硕士研究生，研究方向：肿瘤生物治疗。E-mail：cuijiaoyan@126.com。

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崔姣艳，女，硕士研究生，研究方向：肿瘤生物治疗。E-mail：cuijiaoyan@126.com。

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