Article(id=1322626734831284377, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322626690153562922, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1589212800000, acceptedDateStr=2020-05-12, onlineDate=1793268386799, onlineDateStr=2026-10-29, pubDate=1610640000000, pubDateStr=2021-01-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793268386799, onlineIssueDateStr=2026-10-29, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793268386799, creator=13701087609, updateTime=1793268386799, updator=13701087609, issue=Issue{id=1322626690153562922, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='1', pageStart='1', pageEnd='93', issueExtLink='null', onlineDate='null', pubDate='1610640000000', pubDateStr='2021-01-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793268376148, creator='13701087609', updateTime=1793269030229, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322629433626837820, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322626690153562922, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322629433626837821, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322626690153562922, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=17, endPage=24, ext={EN=ArticleExt(id=1322626735045193882, articleId=1322626734831284377, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Development of background data on repeated toxicity studies in juvenile SD rats, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To summarize the indexes of juvenile SD rats in control group of the 4-week repeated administration toxicity test in our laboratory, and to establish the background data of our laboratory so as to provide reference for the evaluation of non-clinical safety of pediatric drugs.
Methods: From repeated administration toxicity test of pediatrics between 2015 and 2019, the indexes of juvenile SD rats were selected and analyzed, including body weight, feed consumptions, reproductive development (preputial separation and vaginal patency), skeletal development (crown-rump length, tibia length and bone density), hematology, blood biochemistry, immunization and viscera index.
Results: The mean value, standard deviation, maximum and minimum values, 95% confidence interval as well as coefficient of variation of all indicators from juvenile SD rats in different genders were obtained through statistical analysis.
Conclusion: The reference ranges of normal values of juvenile SD rats for different genders and ages were established.
, authors=Li-ming CHONG
1, 2, 3, Yang YANG
1, 2, 3, Li-fen CHEN
1, 2, 3, Li XU
1, 2, 3, Ding-shi CHEN
1, 2, 3, Zhong-hui WANG
1, 2, 3, Li ZHOU
1, 2, 3, Zu-yue SUN
1, 2, 3, authorsList=Li-ming CHONG, Yang YANG, Li-fen CHEN, Li XU, Ding-shi CHEN, Zhong-hui WANG, Li ZHOU, Zu-yue SUN, authorCompany=null, correspAuthors=Li ZHOU, Zu-yue SUN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322626735431069851, articleId=1322626734831284377, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=幼龄SD大鼠重复给药毒性试验背景数据的建立, columnId=1236331161786569054, journalTitle=中国新药杂志, columnName=重大新药创制专项巡礼, runingTitle=null, highlight=null, articleAbstract=
目的： 对本研究室幼龄SD大鼠4周重复给药毒性试验中正常对照组的各项指标进行统计整理，建立本研究室的数据背景资料，为儿科药物非临床安全性评价提供参考。
方法： 从本研究室2015—2019年进行的儿科药物重复给药毒性试验中，选取全部正常对照组幼龄SD大鼠的数据，包括体重、摄食量、生殖发育（龟头包皮腺裂开和阴道张开时间）、骨骼发育（顶臀长、胫骨长度和密度）、血液学、血生化、免疫和脏器指标进行统计分析。
结果： 经过数据统计分析，得出不同性别幼龄SD大鼠各项指标的均值、标准差、最大值、最小值、95%置信区间和变异系数。
结论： 初步建立了不同性别和年龄的幼龄SD大鼠各项指标的正常值参考范围。
, authors=崇立明
1, 2, 3, 杨阳
1, 2, 3, 陈丽芬
1, 2, 3, 许丽
1, 2, 3, 陈丁实
1, 2, 3, 王忠辉
1, 2, 3, 周莉
1, 2, 3, 孙祖越
1, 2, 3, authorsList=崇立明, 杨阳, 陈丽芬, 许丽, 陈丁实, 王忠辉, 周莉, 孙祖越, authorCompany=null, correspAuthors=周莉, 孙祖越, authorNote=
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1Shanghai Institute of Planned Parenthood Research, National Evaluation Center for Toxicology of Fertility Regulating Drugs, Shanghai 200032, China
2NHC Key Lab. of Reproduction Regulation, Shanghai 200032, China
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1上海市计划生育科学研究所药理毒理学研究室，中国生育调节药物毒理检测中心，上海 200032
2国家人口和计划生育委员会计划生育药具重点实验室，上海 200032
3复旦大学生殖与发育研究院，上海 200032, bio={"content":"
崇立明，男，助理研究员，主要从事药物生殖与发育毒理学研究。E-mail：chonglm@163.com。
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崇立明，男，助理研究员，主要从事药物生殖与发育毒理学研究。E-mail：chonglm@163.com。
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1Shanghai Institute of Planned Parenthood Research, National Evaluation Center for Toxicology of Fertility Regulating Drugs, Shanghai 200032, China
2NHC Key Lab. of Reproduction Regulation, Shanghai 200032, China
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1, 2, 3, address=
1上海市计划生育科学研究所药理毒理学研究室，中国生育调节药物毒理检测中心，上海 200032
2国家人口和计划生育委员会计划生育药具重点实验室，上海 200032
3复旦大学生殖与发育研究院，上海 200032, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322626735640785052, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322626734831284377, xref=1, ext=[AuthorCompanyExt(id=1322626735649173661, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322626734831284377, companyId=1322626735640785052, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1Shanghai Institute of Planned Parenthood Research, National Evaluation Center for Toxicology of Fertility Regulating Drugs, Shanghai 200032, China), AuthorCompanyExt(id=1322626735661756574, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322626734831284377, companyId=1322626735640785052, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1上海市计划生育科学研究所药理毒理学研究室，中国生育调节药物毒理检测中心，上海 200032)]), AuthorCompany(id=1322626735833723039, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322626734831284377, xref=2, ext=[AuthorCompanyExt(id=1322626735846305952, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322626734831284377, companyId=1322626735833723039, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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1, 2, 3, address=
1Shanghai Institute of Planned Parenthood Research, National Evaluation Center for Toxicology of Fertility Regulating Drugs, Shanghai 200032, China
2NHC Key Lab. of Reproduction Regulation, Shanghai 200032, China
3Reproductive and Developmental Research Institute, Fudan University, Shanghai 200032, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322626736802607290, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322626734831284377, authorId=1322626736622252213, language=CN, stringName=陈丽芬, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, 2, 3, address=
1上海市计划生育科学研究所药理毒理学研究室，中国生育调节药物毒理检测中心，上海 200032
2国家人口和计划生育委员会计划生育药具重点实验室，上海 200032
3复旦大学生殖与发育研究院，上海 200032, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322626735640785052, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322626734831284377, xref=1, ext=[AuthorCompanyExt(id=1322626735649173661, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322626734831284377, companyId=1322626735640785052, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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1上海市计划生育科学研究所药理毒理学研究室，中国生育调节药物毒理检测中心，上海 200032)]), AuthorCompany(id=1322626735833723039, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322626734831284377, xref=2, ext=[AuthorCompanyExt(id=1322626735846305952, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322626734831284377, companyId=1322626735833723039, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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3复旦大学生殖与发育研究院，上海 200032)])]), Author(id=1322626736894881980, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322626734831284377, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322626737003933888, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322626734831284377, authorId=1322626736894881980, language=EN, stringName=Li XU, firstName=Li, middleName=null, lastName=XU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, 2, 3, address=
1Shanghai Institute of Planned Parenthood Research, National Evaluation Center for Toxicology of Fertility Regulating Drugs, Shanghai 200032, China
2NHC Key Lab. of Reproduction Regulation, Shanghai 200032, China
3Reproductive and Developmental Research Institute, Fudan University, Shanghai 200032, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322626737083625665, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322626734831284377, authorId=1322626736894881980, language=CN, stringName=许丽, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, 2, 3, address=
1上海市计划生育科学研究所药理毒理学研究室，中国生育调节药物毒理检测中心，上海 200032
2国家人口和计划生育委员会计划生育药具重点实验室，上海 200032
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1上海市计划生育科学研究所药理毒理学研究室，中国生育调节药物毒理检测中心，上海 200032)]), AuthorCompany(id=1322626735833723039, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322626734831284377, xref=2, ext=[AuthorCompanyExt(id=1322626735846305952, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322626734831284377, companyId=1322626735833723039, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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1Shanghai Institute of Planned Parenthood Research, National Evaluation Center for Toxicology of Fertility Regulating Drugs, Shanghai 200032, China
2NHC Key Lab. of Reproduction Regulation, Shanghai 200032, China
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2国家人口和计划生育委员会计划生育药具重点实验室，上海 200032
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1上海市计划生育科学研究所药理毒理学研究室，中国生育调节药物毒理检测中心，上海 200032)]), AuthorCompany(id=1322626735833723039, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322626734831284377, xref=2, ext=[AuthorCompanyExt(id=1322626735846305952, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322626734831284377, companyId=1322626735833723039, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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1Shanghai Institute of Planned Parenthood Research, National Evaluation Center for Toxicology of Fertility Regulating Drugs, Shanghai 200032, China
2NHC Key Lab. of Reproduction Regulation, Shanghai 200032, China
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2国家人口和计划生育委员会计划生育药具重点实验室，上海 200032
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1上海市计划生育科学研究所药理毒理学研究室，中国生育调节药物毒理检测中心，上海 200032)]), AuthorCompany(id=1322626735833723039, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322626734831284377, xref=2, ext=[AuthorCompanyExt(id=1322626735846305952, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322626734831284377, companyId=1322626735833723039, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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1Shanghai Institute of Planned Parenthood Research, National Evaluation Center for Toxicology of Fertility Regulating Drugs, Shanghai 200032, China
2NHC Key Lab. of Reproduction Regulation, Shanghai 200032, China
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2国家人口和计划生育委员会计划生育药具重点实验室，上海 200032
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1上海市计划生育科学研究所药理毒理学研究室，中国生育调节药物毒理检测中心，上海 200032)]), AuthorCompany(id=1322626735833723039, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322626734831284377, xref=2, ext=[AuthorCompanyExt(id=1322626735846305952, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322626734831284377, companyId=1322626735833723039, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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1Shanghai Institute of Planned Parenthood Research, National Evaluation Center for Toxicology of Fertility Regulating Drugs, Shanghai 200032, China
2NHC Key Lab. of Reproduction Regulation, Shanghai 200032, China
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2国家人口和计划生育委员会计划生育药具重点实验室，上海 200032
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