Article(id=1322246490249081669, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322246421869346895, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1615824000000, acceptedDateStr=2021-03-16, onlineDate=1793177729426, onlineDateStr=2026-10-28, pubDate=1624982400000, pubDateStr=2021-06-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793177729426, onlineIssueDateStr=2026-10-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793177729426, creator=13701087609, updateTime=1793177729426, updator=13701087609, issue=Issue{id=1322246421869346895, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='12', pageStart='1057', pageEnd='1152', issueExtLink='null', onlineDate='null', pubDate='1624982400000', pubDateStr='2021-06-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793177713123, creator='13701087609', updateTime=1793178158604, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322248290402414824, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322246421869346895, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322248290402414825, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322246421869346895, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1079, endPage=1086, ext={EN=ArticleExt(id=1322246490446213958, articleId=1322246490249081669, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Immunomodulatory effect of lycium barbarum polysaccharide of different molecular weights on macrophage RAW264.7, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To investigate the immunoregulatory effect of Lycium barbarum polysaccharides (LBP) of different molecular weights (Mw) on RAW264.7 macrophages.
Methods: LBP with different Mw was obtained by water extraction, alcohol precipitation and chromatographic column separation. CCK8 method was used to detect the effect of LBP on proliferation of RAW 264.7 cells. The effect of LBP on cell phagocytosis was determined by neutral red method. Real-time quantitative PCR was applied to detect the mRNA expression of TNF-α, IL-6, IL-1β and iNOS. Western blot was used to detect the phosphorylation level of proteins in MAPK signaling pathway.
Results: Two high purity homogeneous components, LBPl (Mw=1 207 kDa) and LBP2 (Mw=125 kDa) were obtained by separation and purification. Compared with the control group, LBP1 and LBP2 at different concentrations significantly promoted the proliferation and phagocytosis of macrophages (P<0.05). LBP1 and LBP2 in the concentration range of 50~200 μg·mL-1 could promote the expression of TNF-α, IL-1β, IL-6 and iNOS mRNA in macrophages in a dose-dependent manner. Western blot analysis showed that LBP1 and LBP2 induced immune response in RAW264.7 cells, which was related to the specific activation of JNK MAPK pathway. In addition, the regulatory effect of LBP1 was better than that of LBP2 on RAW264.7 cells.
Conclusion: The immunoregulatory effect of LBP on RAW264.7 macrophages may be related to its specific activation of JNK MAPK signal transduction pathway, and its activity is closely related to the Mw of LBP.
, authors=Ying WANG
1, Hong-yu JIN
1, Yao-lei LI
1, Xiao-xu DONG
2, Ke ZAN
1, Shuang-cheng MA
1, authorsList=Ying WANG, Hong-yu JIN, Yao-lei LI, Xiao-xu DONG, Ke ZAN, Shuang-cheng MA, authorCompany=null, correspAuthors=Xiao-xu DONG, Ke ZAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322246490735620935, articleId=1322246490249081669, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=不同分子量枸杞多糖对RAW264.7巨噬细胞的免疫调节作用, columnId=1236331161786569054, journalTitle=中国新药杂志, columnName=重大新药创制专项巡礼, runingTitle=null, highlight=null, articleAbstract=
目的： 研究不同分子量枸杞多糖（lycium barbarum polysaccharides，LBP）对小鼠巨噬细胞RAW264.7的免疫调节作用。
方法： 本研究通过水提醇沉及柱分离法以获得不同分子量的LBP成分。运用CCK8法检测不同给药浓度的LBP对RAW 264.7细胞增殖的影响；采用中性红吞噬实验测定LBP对细胞吞噬能力的影响；采用实时荧光定量PCR法检测肿瘤坏死因子α（TNF-α）、白细胞介素（IL）-6、IL-1β和诱导型一氧化氮合酶（iNOS）mRNA的表达情况，采用Western Blot法检测丝裂原活化蛋白激酶（MAPK）信号通路相应蛋白质的磷酸化水平。
结果： 通过分离纯化获得2个高纯度均一组分，分别为LBP1[重均分子量（Mw）=1 207 kDa]和LBP2（Mw=125 kDa）。与对照组相比，不同浓度的LBP1和LBP2组分对巨噬细胞的增殖和吞噬能力均有明显的促进作用（P<0.05）；LBP1和LBP2在50~200 μg·mL-1浓度范围内，可促进巨噬细胞中TNF-α，IL-1β，IL-6和iNOS mRNA的表达，且呈现剂量依赖性。Western Blot法测定结果显示LBP1和LBP2诱导RAW264.7细胞产生免疫应答与特异性激活JNK MAPK通路相关。此外，在对RAW264.7细胞的刺激作用基础上，LBP1的调节作用明显优于LBP2。
结论： LBP对RAW264.7巨噬细胞的免疫调节作用可能与其特异性激活JNK MAPK信号转导通路相关，且其活性强弱与LBP分子量表现出较大的关联性。
, authors=王莹
1, 金红宇
1, 李耀磊
1, 董晓旭
2, 昝珂
1, 马双成
1, authorsList=王莹, 金红宇, 李耀磊, 董晓旭, 昝珂, 马双成, authorCompany=null, correspAuthors=董晓旭, 昝珂, authorNote=
, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=rNON/xTIUce/m7u9soP3mw==, magXml=3tpuXoMITMS4VggWWP39tw==, pdfUrl=null, pdf=cdaVvbVn7aHVi4UnR5HjiQ==, pdfFileSize=1776166, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=uWud3OYO3dYN8C/iSN3JJQ==, mapNumber=null, fund=null)}, authors=[Author(id=1322246491159245647, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=wayi_1986@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322246491247326033, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, authorId=1322246491159245647, language=EN, stringName=Ying WANG, firstName=Ying, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1National Institutes for Food and Drug Control, Beijing 100050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322246491352183634, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, authorId=1322246491159245647, language=CN, stringName=王莹, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1中国食品药品检定研究院，北京 100050, bio={"content":"
王莹，女，博士，副研究员，主要从事中药质量控制及安全检测研究。联系电话：（010）53852484，E-mail：wayi_1986@163.com。
"}, bioImg=null, bioContent=
王莹，女，博士，副研究员，主要从事中药质量控制及安全检测研究。联系电话：（010）53852484，E-mail：wayi_1986@163.com。
, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322246490966307656, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, xref=1, ext=[AuthorCompanyExt(id=1322246490974696265, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, companyId=1322246490966307656, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1National Institutes for Food and Drug Control, Beijing 100050, China), AuthorCompanyExt(id=1322246490987279178, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, companyId=1322246490966307656, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1中国食品药品检定研究院，北京 100050)])]), Author(id=1322246491419292500, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322246491507372886, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, authorId=1322246491419292500, language=EN, stringName=Hong-yu JIN, firstName=Hong-yu, middleName=null, lastName=JIN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1National Institutes for Food and Drug Control, Beijing 100050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322246491599647575, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, authorId=1322246491419292500, language=CN, stringName=金红宇, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1中国食品药品检定研究院，北京 100050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322246490966307656, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, xref=1, ext=[AuthorCompanyExt(id=1322246490974696265, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, companyId=1322246490966307656, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1National Institutes for Food and Drug Control, Beijing 100050, China), AuthorCompanyExt(id=1322246490987279178, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, companyId=1322246490966307656, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1中国食品药品检定研究院，北京 100050)])]), Author(id=1322246491666756441, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322246491733865307, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, authorId=1322246491666756441, language=EN, stringName=Yao-lei LI, firstName=Yao-lei, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1National Institutes for Food and Drug Control, Beijing 100050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322246491985523548, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, authorId=1322246491666756441, language=CN, stringName=李耀磊, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1中国食品药品检定研究院，北京 100050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322246490966307656, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, xref=1, ext=[AuthorCompanyExt(id=1322246490974696265, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, companyId=1322246490966307656, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1National Institutes for Food and Drug Control, Beijing 100050, China), AuthorCompanyExt(id=1322246490987279178, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, companyId=1322246490966307656, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1中国食品药品检定研究院，北京 100050)])]), Author(id=1322246492081992542, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=dxiaoxv@163.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1322246492153295712, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, authorId=1322246492081992542, language=EN, stringName=Xiao-xu DONG, firstName=Xiao-xu, middleName=null, lastName=DONG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=
2Beijing University of Chinese Medicine, Beijing 100029, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322246492451091297, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, authorId=1322246492081992542, language=CN, stringName=董晓旭, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=
2北京中医药大学，北京 100029, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322246491062776651, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, xref=2, ext=[AuthorCompanyExt(id=1322246491071165260, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, companyId=1322246491062776651, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2Beijing University of Chinese Medicine, Beijing 100029, China), AuthorCompanyExt(id=1322246491079553869, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, companyId=1322246491062776651, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2北京中医药大学，北京 100029)])]), Author(id=1322246492530783075, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=6206310@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1322246492610474853, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, authorId=1322246492530783075, language=EN, stringName=Ke ZAN, firstName=Ke, middleName=null, lastName=ZAN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1National Institutes for Food and Drug Control, Beijing 100050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322246492685972326, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, authorId=1322246492530783075, language=CN, stringName=昝珂, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1中国食品药品检定研究院，北京 100050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322246490966307656, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, xref=1, ext=[AuthorCompanyExt(id=1322246490974696265, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, companyId=1322246490966307656, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1National Institutes for Food and Drug Control, Beijing 100050, China), AuthorCompanyExt(id=1322246490987279178, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, companyId=1322246490966307656, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1中国食品药品检定研究院，北京 100050)])]), Author(id=1322246492765664104, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322246492836967274, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, authorId=1322246492765664104, language=EN, stringName=Shuang-cheng MA, firstName=Shuang-cheng, middleName=null, lastName=MA, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1National Institutes for Food and Drug Control, Beijing 100050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322246492895687531, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, authorId=1322246492765664104, language=CN, stringName=马双成, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1中国食品药品检定研究院，北京 100050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322246490966307656, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, xref=1, ext=[AuthorCompanyExt(id=1322246490974696265, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, companyId=1322246490966307656, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1National Institutes for Food and Drug Control, Beijing 100050, China), AuthorCompanyExt(id=1322246490987279178, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, companyId=1322246490966307656, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1中国食品药品检定研究院，北京 100050)])])], keywords=[Keyword(id=1322246492987962220, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, language=EN, orderNo=1, keyword=polysaccharide of lycium barbarum), Keyword(id=1322246493063459693, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, language=EN, orderNo=2, keyword=immunomodulation), Keyword(id=1322246493117985646, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, language=EN, orderNo=3, keyword=RAW264.7 macrophage cell), Keyword(id=1322246493185094511, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, language=EN, orderNo=4, keyword=mitogen-activated protein kinase (MAPK)), Keyword(id=1322246493252203376, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, language=EN, orderNo=5, keyword=cytokine), Keyword(id=1322246493319312241, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, language=CN, orderNo=1, keyword=枸杞多糖), Keyword(id=1322246493382226802, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, language=CN, orderNo=2, keyword=免疫功能), Keyword(id=1322246493461918579, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, language=CN, orderNo=3, keyword=RAW264.7巨噬细胞), Keyword(id=1322246493524833140, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, language=CN, orderNo=4, keyword=丝裂原活化蛋白激酶), Keyword(id=1322246493596136309, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, language=CN, orderNo=5, keyword=细胞因子)], refs=[Reference(id=1322246493780685687, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHANG ZP, LIU XM, WU T,
et al. Selective suppression of cervical cancer Hela cells by 2-O-β-D-glucopyranosyl-L-ascorbic acid isolated from the fruit of
Lycium barbarum L[J].
Cell Biol Toxicol, 2011, 27(2): 107-121., articleTitle=null, refAbstract=null), Reference(id=1322246493843600248, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHANG XR, QI CH, CHENG JP,
et al.
Lycium barbarum polysaccharide LBPF4-OL may be a new Toll-like receptor 4/MD2-MAPK signaling pathway activator and inducer[J].
Int Immunopharmacol, 2014, 19(1): 132-141., articleTitle=null, refAbstract=null), Reference(id=1322246493906514809, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=NAN Y, WANG R, YUAN L,
et al. Effects of
Lycium barbarum polysaccharides (LBP) on immune function of mice[J].
Afr J Microbiol Res, 2012, 6(2): 4757-4760., articleTitle=null, refAbstract=null), Reference(id=1322246493965235066, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=LUO Q, CAI YZ, YAN J,
et al. Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from
Lycium barbarum[J].
Life Sci, 2004, 76(2): 137-149., articleTitle=null, refAbstract=null), Reference(id=1322246494040732539, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=JANEWAU CA Jr, MEDZHITOV R. Innate immune recognition[J].
Annu Rev Immunol, 2002, 20(1): 197-216., articleTitle=null, refAbstract=null), Reference(id=1322246494099452796, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=UTHAISANGSOOK S, DAY NK, BAHNA SL,
et al. Innate immunity and its role against infections[J].
Ann Allergy Asthma Immunol, 2002, 88(3): 253-264., articleTitle=null, refAbstract=null), Reference(id=1322246494158173053, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHANG L, WANG CC. Inflammatory response of macrophages in infection[J].
Hepatobiliary Pancreat Dis Int, 2014, 13(2): 138-152., articleTitle=null, refAbstract=null), Reference(id=1322246494229476222, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=尚京迎, 付海田, 邓超, 等. 基于巨噬细胞模型的竹荪多糖的免疫功能[J]. 食品与生物技术学报, 2016, 40(8): 849-854., articleTitle=null, refAbstract=null), Reference(id=1322246494288196479, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=苗月, 任桂红, 甄东, 等. 蛹虫草多糖调节小鼠巨噬细胞RAW264.7免疫活性的分子机制[J]. 食品科学, 2019, 35(9): 188-194., articleTitle=null, refAbstract=null), Reference(id=1322246494367888256, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHU J, LIU W, YU J,
et al. Characterization and hypoglycemic effect of a polysaccharide extracted from the fruit of
Lycium barbarum L[J].
Carbohydr Polym, 2013, 98(1): 8-16., articleTitle=null, refAbstract=null), Reference(id=1322246494426608513, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=国家药典委员会. 中华人民共和国药典[S]. 2015年版. 一部. 北京: 中国医药科技出版社, 2015., articleTitle=null, refAbstract=null), Reference(id=1322246494493717378, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=张倩, 张民, 王超, 等. 枸杞多糖的分离纯化及结构研究[J]. 食品与发酵工业, 2014, 40(12): 41-47., articleTitle=null, refAbstract=null), Reference(id=1322246494560826243, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=WANG Y, JIN HY, DONG XX,
et al. Quality evaluation of Lycium barbarum (wolfberry) from different regions in China based on the structure, yield and bioactivities of polysaccharides[J].
Chin Med, 2019, 14(1): 1-10., articleTitle=null, refAbstract=null), Reference(id=1322246494640518020, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=null, journalName=null, refType=null, unstructuredReference=祖丽胡玛尔·阿卜杜合力力, 帕丽达·阿不力孜, 木尼萨·迪力夏提, 等. 阿里红多糖组分对RAW264.7巨噬细胞免疫功能的影响[J]. 食品安全质量检测学报, 2017, 8(12): 4638-4644., articleTitle=null, refAbstract=null), Reference(id=1322246494711821189, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=null, journalName=null, refType=null, unstructuredReference=CHEN H, JIAO HW, CHENG Y,
et al.
In vitro and
in vivo immunomodulatory activity of okra (
Abelmoschus esculentus L.) polysaccharides[J].
J Med Food, 2016, 19(3): 253-265., articleTitle=null, refAbstract=null), Reference(id=1322246494791512966, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=null, journalName=null, refType=null, unstructuredReference=祖丽胡玛尔·阿卜杜合力力, 帕丽达·阿不力孜, 木尼萨·迪力夏提, 等. 阿里红多糖组分对RAW264.7巨噬细胞免疫功能的影响[J]. 食品安全质量检测学报, 2017, 8(12): 4638-4644., articleTitle=null, refAbstract=null), Reference(id=1322246494862816135, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=null, journalName=null, refType=null, unstructuredReference=WEI W, XIAO HT, BAO WR,
et al. TLR-4 may mediate signaling pathways of
Astragalus polysaccharide RAP induced cytokine expression of RAW264.7 cells[J].
J Ethnopharmacol, 2016, 179: 243-252., articleTitle=null, refAbstract=null), Reference(id=1322246494946702216, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=null, journalName=null, refType=null, unstructuredReference=董莎莎, 杨晓彤, 冯慧琴, 等. 云芝糖肽在ROS、p38信号通路中对巨噬细胞RAWA264.7的免疫调节作用[J]. 现代生物医学进展, 2011, 11(15): 2848-2850., articleTitle=null, refAbstract=null), Reference(id=1322246495030588297, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[19], rfOrder=18, authorNames=null, journalName=null, refType=null, unstructuredReference=查倩, 江琼, 伍亚民, 等. 黄芪多糖含药血清对神经干细胞增殖和分化的影响[J]. 中药材, 2015, 38(8): 1721-1723., articleTitle=null, refAbstract=null), Reference(id=1322246495110280074, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[20], rfOrder=19, authorNames=null, journalName=null, refType=null, unstructuredReference=张琪琳. 香菇多糖的结构鉴定及抗肿瘤作用机制研究[D]. 华中科技大学, 2015., articleTitle=null, refAbstract=null), Reference(id=1322246495248692107, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[21], rfOrder=20, authorNames=null, journalName=null, refType=null, unstructuredReference=TANG HL, CHEN C, WANG SK,
et al. Biochemical analysis and hypoglycemic activity of a polysaccharide isolated from the fruit of
Lycium barbarum L[J].
Int J Biol Macromol, 2015, 77: 235-242., articleTitle=null, refAbstract=null), Reference(id=1322246495336772492, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[22], rfOrder=21, authorNames=null, journalName=null, refType=null, unstructuredReference=岳雨曦, 王小燕, 柏丁丁, 等. 野阳合多糖及其纯化组分对胆汁酸的结合能力[J]. 食品科学, 2018, 39(12): 154-160., articleTitle=null, refAbstract=null), Reference(id=1322246495399687053, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[23], rfOrder=22, authorNames=null, journalName=null, refType=null, unstructuredReference=崔石阳, 姜帆, 韩建春, 等. 北五味子多糖对RAW264.7细胞的免疫调节作用[J]. 食品科学, 2017, 38(19): 201-205., articleTitle=null, refAbstract=null), Reference(id=1322246495466795918, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[24], rfOrder=23, authorNames=null, journalName=null, refType=null, unstructuredReference=LEE SB, LEE WS, SHIN JS,
et al. Xanthotoxin suppresses LPS induced expression of iNOS, COX-2, TNF-alpha, and IL-6 via AP-1, NF-kappaB, and JAK-STAT inactivation in RAW 264.7 macrophages[J].
Int Immunopharmacol, 2017, 49: 21-29., articleTitle=null, refAbstract=null), Reference(id=1322246495546487695, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[25], rfOrder=24, authorNames=null, journalName=null, refType=null, unstructuredReference=吴静, 胡居吾, 熊伟, 等. 樟树果实多糖对巨噬细胞RAW264.7的免疫调节作用[J]. 现代食品科技, 2018, 34(9): 12-18., articleTitle=null, refAbstract=null), Reference(id=1322246495609402256, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[26], rfOrder=25, authorNames=null, journalName=null, refType=null, unstructuredReference=杨青. 枸杞多糖通过诱导巨噬细胞极化抗胰腺癌的实验研究[D]. 锦州: 锦州医科大学, 2016., articleTitle=null, refAbstract=null), Reference(id=1322246495663928209, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[27], rfOrder=26, authorNames=null, journalName=null, refType=null, unstructuredReference=张小锐. 枸杞多糖LBPF4-OL免疫调节靶细胞及其作用位点研究[D]. 北京: 中国人民解放军军事医学科学院, 2011., articleTitle=null, refAbstract=null), Reference(id=1322246495731037074, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[28], rfOrder=27, authorNames=null, journalName=null, refType=null, unstructuredReference=谢燕霞, 安利国, 杨桂文. 植物多糖对巨噬细胞的免疫调节作用[J]. 中国生物化学与分子生物学报, 2008, 24(4): 307-314., articleTitle=null, refAbstract=null), Reference(id=1322246495793951635, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[29], rfOrder=28, authorNames=null, journalName=null, refType=null, unstructuredReference=LONG T, LIU Z, SHANG J,
et al.
Polygonatum sibiricum polysaccharides play anti-cancer effect through TLR4-MAPK/NF-κB signaling pathways[J].
Int J Biol Macromol, 2018, 111: 813-821., articleTitle=null, refAbstract=null), Reference(id=1322246495869449108, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[30], rfOrder=29, authorNames=null, journalName=null, refType=null, unstructuredReference=XU DD, WANG H Y, ZHENG W,
et al. Charaterization and immunomodulatory activities of polysaccharide isolated from
Pleurotus eryngii[J].
Int J Biol Macromol, 2016, 92: 30-36., articleTitle=null, refAbstract=null)], funds=[Fund(id=1322246493688410998, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, awardId=2018ZX09303-024, language=CN, fundingSource=国家“重大新药创制”科技重大专项资助项目(2018ZX09303-024), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1322246490966307656, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, xref=1, ext=[AuthorCompanyExt(id=1322246490974696265, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, companyId=1322246490966307656, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1National Institutes for Food and Drug Control, Beijing 100050, China), AuthorCompanyExt(id=1322246490987279178, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, companyId=1322246490966307656, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1中国食品药品检定研究院，北京 100050)]), AuthorCompany(id=1322246491062776651, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, xref=2, ext=[AuthorCompanyExt(id=1322246491071165260, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, companyId=1322246491062776651, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2Beijing University of Chinese Medicine, Beijing 100029, China), AuthorCompanyExt(id=1322246491079553869, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246490249081669, companyId=1322246491062776651, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2北京中医药大学，北京 100029)])], figs=null, attaches=null, journal=Journal(id=1235980159023624194, delFlag=0, nameCn=中国新药杂志, nameEn=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, issn=1003-3734, eissn=null, cn=11-2850/R, coden=ZXZHA6, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of New Drugs, journalRemark=null, publicationField=null, createdTime=1772610233314, updatedTime=1788948968376, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=ohPEEN//Vz1tDT3ZBNTp4Q==, picEn=f9WK9bvTM4guTmS/iGhOMg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509780974924039, language=CN, name=中国新药杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948968404, updatedTime=1788948968404, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304509781025255688, language=EN, name=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948968416, updatedTime=1788948968416, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1235980733773295621, websiteList=[Website(id=1235982099191222761, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/CN, language=CN, createTime=1772610695884, createBy=18614031015, updateTime=1772610860397, updateBy=18614031015, name=中国新药杂志-中文, tplId=1146099689490845704, title=中国新药杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983918629966444, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=articleTextType, value=kx, createTime=1772611129672, updateTime=1772611129672, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918604800617, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=banner, value=null, createTime=1772611129666, updateTime=1772611129666, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918655132271, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=grayFlag, value=0, createTime=1772611129678, updateTime=1772611129678, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918596412008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611129664, updateTime=1772611129664, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918667715185, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=minRunFlag, value=0, createTime=1772611129681, updateTime=1772611129681, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918617383531, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic, createTime=1772611129669, updateTime=1772611129669, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918659326576, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=silenceFlag, value=0, createTime=1772611129679, updateTime=1772611129679, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918613189226, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1772611129668, updateTime=1772611129668, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918634160749, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeColor, value=null, createTime=1772611129673, updateTime=1772611129673, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918646743662, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeStyle, value=null, createTime=1772611129676, updateTime=1772611129676, creator=18614031015, updator=18614031015)]), Website(id=1235982099270914542, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/EN, language=EN, createTime=1772610695903, createBy=18614031015, updateTime=1772610875891, updateBy=18614031015, name=中国新药杂志-英文, tplId=1146101810881728533, title=Chinese Journal of New Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983955829248630, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=articleTextType, value=kx, createTime=1772611138541, updateTime=1772611138541, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955804082803, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=banner, value=null, createTime=1772611138535, updateTime=1772611138535, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955854414457, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=grayFlag, value=0, createTime=1772611138547, updateTime=1772611138547, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955795694194, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611138533, updateTime=1772611138533, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955866997371, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=minRunFlag, value=0, createTime=1772611138550, updateTime=1772611138550, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955820860021, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic, createTime=1772611138539, updateTime=1772611138539, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955862803066, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=silenceFlag, value=0, createTime=1772611138549, updateTime=1772611138549, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955812471412, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1772611138537, updateTime=1772611138537, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955837637239, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeColor, value=null, createTime=1772611138543, updateTime=1772611138543, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955846025848, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeStyle, value=null, createTime=1772611138545, updateTime=1772611138545, creator=18614031015, updator=18614031015)])], journalTitle=中国新药杂志, weixinUrl=null, journalUrl=http://www.newdrug.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of New Drugs, journalPhotoCn=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPhotoEn=f9WK9bvTM4guTmS/iGhOMg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/Y2021/V30/I12/1079, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/Y2021/V30/I12/1079, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/PDF/Y2021/V30/I12/1079, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/PDF/Y2021/V30/I12/1079, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1624982400000, fullTextJson=null, articleText=null, reference=null)
PDF下载
全屏
17
4
关闭全屏
北京市海淀区学院南路86号
010-62662699（运营及技术支持）
qkjq@cast.org.cn
