Article(id=1322246436876571277, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322246381633389353, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1594051200000, acceptedDateStr=2020-07-07, onlineDate=1793177716702, onlineDateStr=2026-10-28, pubDate=1623686400000, pubDateStr=2021-06-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793177716702, onlineIssueDateStr=2026-10-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793177716702, creator=13701087609, updateTime=1793177716702, updator=13701087609, issue=Issue{id=1322246381633389353, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='11', pageStart='961', pageEnd='1056', issueExtLink='null', onlineDate='null', pubDate='1623686400000', pubDateStr='2021-06-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793177703531, creator='13701087609', updateTime=1793178125547, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322248152208486593, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322246381633389353, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322248152212680898, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322246381633389353, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1017, endPage=1021, ext={EN=ArticleExt(id=1322246437077897870, articleId=1322246436876571277, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Design, synthesis and antitumor activity of vanillin derivatives, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To design and synthesize novel vanillin derivatives and evaluate their anti-proliferation effect against HeLa cells.
Methods: Taking vanillin derivative SBE-13 as lead, 2-chloroquinoline fragment were introduced into the new compounds by the methods of electronic isosteric and skeleton transition. 2-Chloro-3-chloromethylquinoline and vanillin were used as raw materials to obtain the target compounds 4a~4k by etherification and reductive amination.
Results: A total of 11 novel vanillin derivatives were designed and synthesized, and their structures were confirmed by 1H NMR and ESI-MS. Most of the compounds exhibited good antiproliferative activities against HeLa cells. Notably, compound 4b potently inhibited HeLa cells with an IC50=9.79 μmol·L-1, a 10-fold improvement over SBE-13 (IC50=78.30 μmol·L-1).
Conclusion: Compound 4b displayed significant antiproliferative effect in vitro, which is worthy of further study.
, authors=Ya BAO
1, 2, 3, Min-ru JIAO
2, 3, Jian-qi LI
2, 3, Qing-wei ZHANG
2, 3, authorsList=Ya BAO, Min-ru JIAO, Jian-qi LI, Qing-wei ZHANG, authorCompany=null, correspAuthors=Qing-wei ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322246437337944719, articleId=1322246436876571277, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=香兰素衍生物的设计、合成及抗肿瘤活性, columnId=1236330556003242277, journalTitle=中国新药杂志, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的： 设计合成系列香兰素衍生物，并测试化合物体外抗HeLa细胞（人宫颈癌细胞）增殖活性。
方法： 以香草素衍生物SBE-13为先导，采用电子等排、骨架迁越等方法引入2-氯喹啉片段设计新结构类型化合物。以2-氯-3-氯甲基喹啉与香兰素为原料，经醚化、还原胺化合成目标化合物4a~4k。
结果： 共合成11个未见文献报道的香兰素衍生物，结构经1H-NMR和MS确证，体外抗HeLa细胞增殖活性实验显示大部分化合物具有较好的抗肿瘤细胞增殖活性，其中化合物4b的活性相比SBE-13提高10倍。
结论： 香兰素衍生物4b具有较好的抗HeLa细胞增殖活性，值得进一步深入研究。
, authors=包亚
1, 2, 3, 焦民茹
2, 3, 李建其
2, 3, 张庆伟
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包亚，女，硕士研究生，主要从事抗肿瘤新化合物设计与合成研究。联系电话：（021）20572000-5060，E-mail：baoyaar@163.com。
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包亚，女，硕士研究生，主要从事抗肿瘤新化合物设计与合成研究。联系电话：（021）20572000-5060，E-mail：baoyaar@163.com。
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包亚，女，硕士研究生，主要从事抗肿瘤新化合物设计与合成研究。联系电话：（021）20572000-5060，E-mail：baoyaar@163.com。
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2中国医药工业研究总院上海医药工业研究院化学制药新技术中心，上海 201203
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2Novel Technology Center of Pharmaceutical Chemistry, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 201203, China
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2中国医药工业研究总院上海医药工业研究院化学制药新技术中心，上海 201203
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J Nat Prod, 2020, 83(3): 770-803., articleTitle=null, refAbstract=null), Reference(id=1322246446309561022, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246436876571277, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=HUANG GC, CHEN LB. Recombinant human endostatin improves anti-tumor efficacy of paclitaxel by normalizing tumor vasculature in Lewis lung carcinoma[J].
J Cancer Res Clin Oncol, 2010, 136(8): 1201-1211., articleTitle=null, refAbstract=null), Reference(id=1322246446389252799, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246436876571277, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=ALLEN TM, NEWMAN MS, WOODLE MC,
et al. Pharmacokinetics and anti-tumor activity of vincristine encapsulated in sterically stabilized liposomes[J].
Int J Cancer, 1995, 62(2): 199-204., articleTitle=null, refAbstract=null), Reference(id=1322246446464750272, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246436876571277, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=IMBERT TF. Discovery of podophyllotoxins[J].
Biochimie, 1998, 80(3): 207-222., articleTitle=null, refAbstract=null), Reference(id=1322246446544442049, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246436876571277, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=杨文文, 吴秋林, 唐鸿志, 等. “香料皇后”: 天然香兰素生物合成的研究进展[J]. 微生物学通报, 2013, 40(6): 1087-1095., articleTitle=null, refAbstract=null), Reference(id=1322246446724797122, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246436876571277, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=BEZERRA CF, CAMILO CJ, DO NASCIMENTO SILVA MK,
et al. Vanillin selectively modulates the action of antibiotics against resistant bacteria[J].
Microb Pathog, 2017, 113: 265-268., articleTitle=null, refAbstract=null), Reference(id=1322246446812877507, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246436876571277, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=SUN J, LI M, WANG X,
et al. Vanillin derivatives as the selective small molecule inhibitors of FtsZ[J].
Mel Chem Res, 2014, 23(6): 2985-2994., articleTitle=null, refAbstract=null), Reference(id=1322246447152616132, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246436876571277, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=FACHE M, DARROMAN E, BESSE V,
et al. Vanillin, a promising biobased building-block for monomer synthesis[J].
Green Chem, 2014, 16(4): 1987-1998., articleTitle=null, refAbstract=null), Reference(id=1322246448809366213, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246436876571277, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=BURRI J, GRAF M, LAMBELET P,
et al. Vanillin: More than a flavouring agent: a potent antioxidant[J].
J Sci Food Agric, 1989, 48(1): 49-56., articleTitle=null, refAbstract=null), Reference(id=1322246448922612422, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246436876571277, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=BEZERRA DP, SOARES AKN, DE SOUSA DP. Overview of the role of vanillin on redox status and cancer development[J].
Oxidative Med Cell Longev, 2016, 2016: 1-9., articleTitle=null, refAbstract=null), Reference(id=1322246448989721287, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246436876571277, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=CARRASCO-GOMEZ R, KEPPNER-WITTER S, HIEKE M,
et al. Vanillin-derived antiproliferative compounds influence Plk1 activity[J].
Bioorg Med Chem Lett, 2014, 24(21): 5063-5069., articleTitle=null, refAbstract=null), Reference(id=1322246449073607368, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246436876571277, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=RAMESH V, ANANDA RAO B, SHARMA P,
et al. Synthesis and biological evaluation of new rhodanine analogues bearing 2-chloroquinoline and benzo[h]quinoline scaffolds as anticancer agents[J].
Eur J Med Chem, 2014, 83: 569-580., articleTitle=null, refAbstract=null), Reference(id=1322246449170076361, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246436876571277, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=MA J, GUAN R, SHEN H,
et al. Comparison of anticancer activity between lactoferrin nanoliposome and lactoferrin in Caco-2 cells
in vitro[J].
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