Article(id=1322246436364861598, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322246421869346895, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1600099200000, acceptedDateStr=2020-09-15, onlineDate=1793177716579, onlineDateStr=2026-10-28, pubDate=1624982400000, pubDateStr=2021-06-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793177716579, onlineIssueDateStr=2026-10-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793177716579, creator=13701087609, updateTime=1793177716579, updator=13701087609, issue=Issue{id=1322246421869346895, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='12', pageStart='1057', pageEnd='1152', issueExtLink='null', onlineDate='null', pubDate='1624982400000', pubDateStr='2021-06-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793177713123, creator='13701087609', updateTime=1793178158604, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322248290402414824, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322246421869346895, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322248290402414825, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322246421869346895, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1103, endPage=1109, ext={EN=ArticleExt(id=1322246436545216671, articleId=1322246436364861598, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Protective effect of gardenoside on dementia-like mice induced by tail intravenous injection of streptozotocin, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To investigate the protective effect of gardenoside on dementia-like mice induced by tail intravenous injection of streptozotocin (STZ).
Methods: Mice receiving STZ tail intravenous injection were randomly divided into model group (Model), low-dose gardenoside group (GL), high-dose gardenoside group (GH), and solvent control group (Vehicle). Blood glucose level was monitored every two weeks. After administration of the drug, a glucose tolerance test was conducted, and serum insulin levels were detected by ELASA. Morris water maze test was used to test the learning and memory ability of mice in each group, and Contextual fear system was used to test the ability of fear memory regression of mice in each group. Western blot was used to detect the expression of GSK-3β and phosphorylated GSK-3β (P-GSK3β) protein in hippocampus and cortical tissues.
Results: Compared with the Vehicle group, the blood glucose level in the Model group was significantly increased (P<0.001). The spatial learning and memory function as shown by Morris water maze detection were significantly impaired (P<0.05). In the episodic fear memory experiment, there were disorder in the extinction of fear memory in mice (P<0.01) and significant decrease in serum insulin (P<0.05), while serum insulin resistance index increased significantly (P<0.001). The expression level of GSK3β remained unchanged in hippocampus and cortex, while the expression level of P-GSK3β decreased significantly (P<0.05). All abnormal indexes in the GH group were improve (P<0.05). In the GL group, some abnormal indexes were improved to a certain extent.
Conclusion: Gardenoside can improve spatial learning and memory impairment and fear memory extinction disorders in mice receiving STZ tail intravenous injection. The mechanism may be increasing P-GSK3β to inhibit GSK-3β activation, thereby protecting nerve cells.
, authors=Jia-qing HUANG, Wu WEN, Xin LÜ, Meng-meng JIANG, Wang-li DING, Jia-hui ZHAO, Yue-song GONG, authorsList=Jia-qing HUANG, Wu WEN, Xin LÜ, Meng-meng JIANG, Wang-li DING, Jia-hui ZHAO, Yue-song GONG, authorCompany=null, correspAuthors=Yue-song GONG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322246437040144544, articleId=1322246436364861598, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=栀子苷对尾静脉注射链脲佐菌素引起的痴呆样小鼠的保护作用, columnId=1236330556003242277, journalTitle=中国新药杂志, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的： 探究栀子苷对尾静脉注射链脲佐菌素（streptozotocin，STZ）引起的痴呆样小鼠的保护作用。
方法： 随机分配STZ尾静脉注射小鼠为模型组（Model）、栀子苷低剂量组（GL）和栀子苷高剂量组（GH），另设溶剂对照组（Vehicle）。每2周监测一次血糖，给药结束后进行糖耐量实验，ELASA检测血清胰岛素水平。Morris水迷宫检测各组小鼠的学习记忆能力，条件恐惧系统检测各组小鼠的恐惧记忆消退能力；Western Blot检测海马体和皮层组织中糖原合成酶激酶3β（GSK-3β）、磷酸化GSK-3β（P-GSK3β）蛋白的表达。
结果： 与Vehicle组比较，Model组小鼠血糖明显升高（P<0.001）；Morris水迷宫检测的空间学习记忆功能明显损伤（P<0.05）；条件恐惧记忆实验中小鼠恐惧记忆消退出现障碍（P<0.001）；糖耐受显著降低（P<0.001）；血清胰岛素明显下降（P<0.05），血清胰岛素抵抗指数明显增高（P<0.001）；海马体和皮层GSK-3β表达水平不变，P-GSK3β表达水平明显下降（P<0.05）。而GH组均能改善各异常指标（P<0.05），GL组在一定程度上改善某些异常指标。
结论： 栀子苷可以改善尾静脉注射STZ小鼠的空间学习记忆损伤和恐惧记忆消退障碍，其机制可能与P-GSK3β活性增强抑制GSK-3β的激活从而保护神经细胞有关。
, authors=黄家情, 闻妩, 吕馨, 蒋蒙蒙, 丁网丽, 赵佳惠, 贡岳松, authorsList=黄家情, 闻妩, 吕馨, 蒋蒙蒙, 丁网丽, 赵佳惠, 贡岳松, authorCompany=null, correspAuthors=贡岳松, authorNote=
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黄家情，女，硕士研究生，主要从事糖代谢与阿尔茨海默病药理学研究。E-mail：hjqnzy@njucm.edu.cn。
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黄家情，女，硕士研究生，主要从事糖代谢与阿尔茨海默病药理学研究。E-mail：hjqnzy@njucm.edu.cn。
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