Article(id=1322246423635145105, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322246381633389353, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1581696000000, acceptedDateStr=2020-02-15, onlineDate=1793177713545, onlineDateStr=2026-10-28, pubDate=1623686400000, pubDateStr=2021-06-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793177713545, onlineIssueDateStr=2026-10-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793177713545, creator=13701087609, updateTime=1793177713545, updator=13701087609, issue=Issue{id=1322246381633389353, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='11', pageStart='961', pageEnd='1056', issueExtLink='null', onlineDate='null', pubDate='1623686400000', pubDateStr='2021-06-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793177703531, creator='13701087609', updateTime=1793178125547, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322248152208486593, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322246381633389353, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322248152212680898, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322246381633389353, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1053, endPage=1056, ext={EN=ArticleExt(id=1322246424151044498, articleId=1322246423635145105, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Influence factors on blood concentration of tacrolimus in patients with nephritic syndrome, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective:

To investigate the influence factors of blood concentration of tacrolimus, and to provide reference for clinical use of tacrolimus (FK506).

Methods:

66 patients with nephrotic syndrome, who received hospitalized treatment in nephrology department of our hospital were enrolled in this study. The blood concentration of FK506, general data and laboratory testing values and so on, were recorded and analyzed using multiple linear regression method by SPSS 17.0 software.

Results:

Among the 66 patients, 40.91% patients' FK506 concentration fell in the effective range, 54.55% below the effective range, and 4.55% above the effective range. Correlations were found in unit dose of blood concentration for tacrolimus with total cholesterol (CHO) combination with drugs that increase the FK506 blood concentration, and serum creatinine (P<0.01).

Conclusion:

The FK506 blood concentration in patients with nephrotic syndrome patients is greatly varied between individuals, and CHO, drugs that increase FK506 concentration and CK are main factors affecting FK506 blood concentration in nephrotic syndrome patients.

, authors=Chun-yan ZHANG, Lin HUANG, Xiao-lei REN, Yu-fei FENG, authorsList=Chun-yan ZHANG, Lin HUANG, Xiao-lei REN, Yu-fei FENG, authorCompany=null, correspAuthors=Yu-fei FENG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322246424968933779, articleId=1322246423635145105, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=肾病综合征患者他克莫司血药浓度影响因素研究, columnId=1236331163573342670, journalTitle=中国新药杂志, columnName=药物安全与合理应用, runingTitle=null, highlight=null, articleAbstract=
目的:

对肾病患综合征患者他克莫司(FK506)血药浓度监测结果进行分析,并探讨其影响因素。

方法:

采用回顾性调查方法,查阅我院肾内科口服FK506治疗的住院患者病历,记录血药浓度、患者一般资料、用药情况及实验室检测指标,应用SPSS 17.0统计软件对数据进行多元线性回归分析。

结果:

66例使用FK506治疗的患者,血药浓度在有效范围内的占40.91%,低于有效浓度范围的占54.55%,高于有效浓度范围的占4.55%。多元线性回归结果显示肾病综合征患者FK506剂量校正血药浓度与患者总胆固醇、可升高FK506血药浓度的合并用药及肌酸激酶之间存在具有统计学意义的相关性(P<0.01)。

结论:

肾病综合征患者FK506血药浓度个体差异大,总胆固醇、可升高FK506血药浓度的药物及肌酸激酶是其血药浓度主要影响因素。

, authors=张春燕, 黄琳, 任晓蕾, 封宇飞, authorsList=张春燕, 黄琳, 任晓蕾, 封宇飞, authorCompany=null, correspAuthors=封宇飞, authorNote=

张春燕,女,副主任药师,研究方向:肾内药物使用、循证药学。E-mail:。

, correspAuthorsNote=
封宇飞,男,硕士,主任药师,研究方向:药物经济学、循证药学。联系电话:(010)88325752,E-mail:。
, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=2VAk5BqB7dVmSs6aC4aSig==, magXml=mLOGh3Qg2o5zDMAnttCmjw==, pdfUrl=null, pdf=8QDig8jfRTYaWGSO3mZFqQ==, pdfFileSize=796386, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=fJ9SewOdxDAgjlR79UF10A==, mapNumber=null, fund=null)}, authors=[Author(id=1322246428257268120, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=zhangchy66@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322246428349542810, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, authorId=1322246428257268120, language=EN, stringName=Chun-yan ZHANG, firstName=Chun-yan, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Pharmacy, People's Hospital, Peking University, Beijing 100044, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322246428429234587, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, authorId=1322246428257268120, language=CN, stringName=张春燕, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=北京大学人民医院药剂科,北京 100044, bio={"content":"

张春燕,女,副主任药师,研究方向:肾内药物使用、循证药学。E-mail:。

"}, bioImg=null, bioContent=

张春燕,女,副主任药师,研究方向:肾内药物使用、循证药学。E-mail:。

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322246427481321876, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, xref=null, ext=[AuthorCompanyExt(id=1322246427825254805, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, companyId=1322246427481321876, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Pharmacy, People's Hospital, Peking University, Beijing 100044, China), AuthorCompanyExt(id=1322246427854614934, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, companyId=1322246427481321876, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=北京大学人民医院药剂科,北京 100044)])]), Author(id=1322246428500537757, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322246428647338399, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, authorId=1322246428500537757, language=EN, stringName=Lin HUANG, firstName=Lin, middleName=null, lastName=HUANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Pharmacy, People's Hospital, Peking University, Beijing 100044, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322246428752196000, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, authorId=1322246428500537757, language=CN, stringName=黄琳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=北京大学人民医院药剂科,北京 100044, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322246427481321876, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, xref=null, ext=[AuthorCompanyExt(id=1322246427825254805, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, companyId=1322246427481321876, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Pharmacy, People's Hospital, Peking University, Beijing 100044, China), AuthorCompanyExt(id=1322246427854614934, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, companyId=1322246427481321876, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=北京大学人民医院药剂科,北京 100044)])]), Author(id=1322246428852859298, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322246428928356772, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, authorId=1322246428852859298, language=EN, stringName=Xiao-lei REN, firstName=Xiao-lei, middleName=null, lastName=REN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Pharmacy, People's Hospital, Peking University, Beijing 100044, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322246429213569445, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, authorId=1322246428852859298, language=CN, stringName=任晓蕾, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=北京大学人民医院药剂科,北京 100044, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322246427481321876, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, xref=null, ext=[AuthorCompanyExt(id=1322246427825254805, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, companyId=1322246427481321876, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Pharmacy, People's Hospital, Peking University, Beijing 100044, China), AuthorCompanyExt(id=1322246427854614934, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, companyId=1322246427481321876, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=北京大学人民医院药剂科,北京 100044)])]), Author(id=1322246430832570791, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=fengyufei@126.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1322246430933234089, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, authorId=1322246430832570791, language=EN, stringName=Yu-fei FENG, firstName=Yu-fei, middleName=null, lastName=FENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Pharmacy, People's Hospital, Peking University, Beijing 100044, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322246431017120170, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, authorId=1322246430832570791, language=CN, stringName=封宇飞, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=北京大学人民医院药剂科,北京 100044, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322246427481321876, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, xref=null, ext=[AuthorCompanyExt(id=1322246427825254805, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, companyId=1322246427481321876, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Pharmacy, People's Hospital, Peking University, Beijing 100044, China), AuthorCompanyExt(id=1322246427854614934, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, companyId=1322246427481321876, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=北京大学人民医院药剂科,北京 100044)])])], keywords=[Keyword(id=1322246431201669547, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, language=EN, orderNo=1, keyword=tacrolimus), Keyword(id=1322246431344275884, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, language=EN, orderNo=2, keyword=blood concentration), Keyword(id=1322246431591739821, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, language=EN, orderNo=3, keyword=influencing factors), Keyword(id=1322246431679820206, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, language=EN, orderNo=4, keyword=nephrotic syndrome), Keyword(id=1322246431805649327, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, language=CN, orderNo=1, keyword=他克莫司), Keyword(id=1322246432006975920, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, language=CN, orderNo=2, keyword=血药浓度), Keyword(id=1322246432078279089, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, language=CN, orderNo=3, keyword=影响因素), Keyword(id=1322246432149582258, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, language=CN, orderNo=4, keyword=肾病综合征)], refs=[Reference(id=1322246432262828467, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=null, journalName=null, refType=null, unstructuredReference=朱旭, 路童, 印紫薇, 等. 肾病综合症患者他克莫司血药浓度影响因素分析[J]. 中国临床药理学杂志, 2017, 33(18): 1810-1816., articleTitle=null, refAbstract=null), Reference(id=1322246432371880372, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=宋艳, 成璐, 贾淼鑫, 等. 肾病综合症患者他克莫司血药浓度监测的回顾性分析与评价[J]. 中国医院药学杂志, 2017, 37(7): 654-658., articleTitle=null, refAbstract=null), Reference(id=1322246432489320885, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=何艳玲, 莫小兰, 吴端仪, 等. 肾病综合症患儿他克莫司血药浓度影响因素分析[J]. 今日药学, 2016, 26(1): 46-50., articleTitle=null, refAbstract=null), Reference(id=1322246432619344310, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=钱卿, 韩睿, 胡楠, 等. 他克莫司治疗肾小球疾病的血药浓度监测及疗效影响因素分析[J]. 药学与临床研究, 2017, 25(5): 435-438., articleTitle=null, refAbstract=null), Reference(id=1322246432728396215, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=王琳娜. 他克莫司不同血药浓度对肾病综合症治疗效果的影响[J]. 北方药学, 2019, 16(4): 142-143., articleTitle=null, refAbstract=null), Reference(id=1322246432845836728, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=郭景鸽. 他克莫司治疗成人激素抵抗型肾病综合征血药浓度与临床效果及不良反应的相关性分析[J]. 中国药物与临床, 2019, 19(5): 773-775., articleTitle=null, refAbstract=null), Reference(id=1322246432971665849, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=凌静, 蒋艳, 邹素兰, 等. 肾病综合征患者他克莫司的群体药动学研究[J]. 中国现代应用药学, 2020, 37(24): 79-84., articleTitle=null, refAbstract=null), Reference(id=1322246433055551930, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=金萍, 李燕. 肾病综合症治疗药物的研究进展[J]. 国外医学泌尿系统分册, 2001, 21(4): 145-147., articleTitle=null, refAbstract=null), Reference(id=1322246433152020923, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=王化英, 周广宇, 王艺璇, 等. 他克莫司治疗难治性肾病综合征的新进展[J]. 中华肾病研究电子杂志, 2018, 7(4): 186-189., articleTitle=null, refAbstract=null), Reference(id=1322246433235907004, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=张建荣, 王利新, 王志伟, 等. 肝移植术后他克莫司血药浓度与血糖、血脂的相关关系探讨[J]. 宁夏医学杂志, 2007, 29(12): 1099-1100., articleTitle=null, refAbstract=null), Reference(id=1322246433336570301, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=米丽, 李敬超, 陆嘉君, 等. 五酯胶囊对他克莫司在肝移植患者体内的药代动力学的影响[J]. 海军医学杂志, 2020, 41(3): 299-302., articleTitle=null, refAbstract=null), Reference(id=1322246433428844990, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=陈万杰, 张琳. 五酯胶囊对肾移植受者他克莫司全血浓度及维持剂量影响的Meta分析[J]. 世界最新医学信息文摘, 2018, 18(104): 1-3., articleTitle=null, refAbstract=null), Reference(id=1322246433512731071, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=许建文, 黄品芳, 韩文迪, 等. CYP3A5*3基因多态性与他克莫司血药浓度及临床疗效的相关性研究[J]. 中国现代应用药学, 2020, 37(18): 64-68., articleTitle=null, refAbstract=null)], funds=null, companyList=[AuthorCompany(id=1322246427481321876, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, xref=null, ext=[AuthorCompanyExt(id=1322246427825254805, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, companyId=1322246427481321876, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Pharmacy, People's Hospital, Peking University, Beijing 100044, China), AuthorCompanyExt(id=1322246427854614934, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, companyId=1322246427481321876, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=北京大学人民医院药剂科,北京 100044)])], figs=null, attaches=null, journal=Journal(id=1235980159023624194, delFlag=0, nameCn=中国新药杂志, nameEn=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, issn=1003-3734, eissn=null, cn=11-2850/R, coden=ZXZHA6, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of New Drugs, journalRemark=null, publicationField=null, createdTime=1772610233314, updatedTime=1788948968376, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=ohPEEN//Vz1tDT3ZBNTp4Q==, picEn=f9WK9bvTM4guTmS/iGhOMg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509780974924039, language=CN, name=中国新药杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948968404, updatedTime=1788948968404, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304509781025255688, language=EN, name=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948968416, updatedTime=1788948968416, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1235980733773295621, websiteList=[Website(id=1235982099191222761, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/CN, language=CN, createTime=1772610695884, createBy=18614031015, updateTime=1772610860397, updateBy=18614031015, name=中国新药杂志-中文, tplId=1146099689490845704, title=中国新药杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983918629966444, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=articleTextType, value=kx, createTime=1772611129672, updateTime=1772611129672, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918604800617, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=banner, value=null, createTime=1772611129666, updateTime=1772611129666, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918655132271, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=grayFlag, value=0, createTime=1772611129678, updateTime=1772611129678, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918596412008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611129664, updateTime=1772611129664, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918667715185, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=minRunFlag, value=0, createTime=1772611129681, updateTime=1772611129681, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918617383531, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic, createTime=1772611129669, updateTime=1772611129669, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918659326576, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=silenceFlag, value=0, createTime=1772611129679, updateTime=1772611129679, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918613189226, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1772611129668, updateTime=1772611129668, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918634160749, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeColor, value=null, createTime=1772611129673, updateTime=1772611129673, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918646743662, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeStyle, value=null, createTime=1772611129676, updateTime=1772611129676, creator=18614031015, updator=18614031015)]), Website(id=1235982099270914542, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/EN, language=EN, createTime=1772610695903, createBy=18614031015, updateTime=1772610875891, updateBy=18614031015, name=中国新药杂志-英文, tplId=1146101810881728533, title=Chinese Journal of New Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983955829248630, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=articleTextType, value=kx, createTime=1772611138541, updateTime=1772611138541, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955804082803, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=banner, value=null, createTime=1772611138535, updateTime=1772611138535, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955854414457, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=grayFlag, value=0, createTime=1772611138547, updateTime=1772611138547, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955795694194, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611138533, updateTime=1772611138533, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955866997371, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=minRunFlag, value=0, createTime=1772611138550, updateTime=1772611138550, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955820860021, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic, createTime=1772611138539, updateTime=1772611138539, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955862803066, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=silenceFlag, value=0, createTime=1772611138549, updateTime=1772611138549, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955812471412, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1772611138537, updateTime=1772611138537, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955837637239, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeColor, value=null, createTime=1772611138543, updateTime=1772611138543, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955846025848, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeStyle, value=null, createTime=1772611138545, updateTime=1772611138545, creator=18614031015, updator=18614031015)])], journalTitle=中国新药杂志, weixinUrl=null, journalUrl=http://www.newdrug.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of New Drugs, journalPhotoCn=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPhotoEn=f9WK9bvTM4guTmS/iGhOMg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/Y2021/V30/I11/1053, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/Y2021/V30/I11/1053, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/PDF/Y2021/V30/I11/1053, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/PDF/Y2021/V30/I11/1053, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1623686400000, fullTextJson=null, articleText=null, reference=null)
收藏切换
肾病综合征患者他克莫司血药浓度影响因素研究
收藏切换
PDF下载
张春燕 , 黄琳 , 任晓蕾 , 封宇飞
中国新药杂志 | 药物安全与合理应用 2021,30(11): 1053-1056
收起
收藏切换
中国新药杂志 |药物安全与合理应用 2021 , 30 (11) : 1053 -1056
肾病综合征患者他克莫司血药浓度影响因素研究
全屏
[Author(id=1322246428257268120, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=zhangchy66@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322246428349542810, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, authorId=1322246428257268120, language=EN, stringName=Chun-yan ZHANG, firstName=Chun-yan, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Pharmacy, People's Hospital, Peking University, Beijing 100044, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322246428429234587, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, authorId=1322246428257268120, language=CN, stringName=张春燕, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=北京大学人民医院药剂科,北京 100044, bio={"content":"

张春燕,女,副主任药师,研究方向:肾内药物使用、循证药学。E-mail:。

"}, bioImg=null, bioContent=

张春燕,女,副主任药师,研究方向:肾内药物使用、循证药学。E-mail:。

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322246427481321876, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, xref=null, ext=[AuthorCompanyExt(id=1322246427825254805, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, companyId=1322246427481321876, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Pharmacy, People's Hospital, Peking University, Beijing 100044, China), AuthorCompanyExt(id=1322246427854614934, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, companyId=1322246427481321876, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=北京大学人民医院药剂科,北京 100044)])]), Author(id=1322246428500537757, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322246428647338399, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, authorId=1322246428500537757, language=EN, stringName=Lin HUANG, firstName=Lin, middleName=null, lastName=HUANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Pharmacy, People's Hospital, Peking University, Beijing 100044, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322246428752196000, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, authorId=1322246428500537757, language=CN, stringName=黄琳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=北京大学人民医院药剂科,北京 100044, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322246427481321876, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, xref=null, ext=[AuthorCompanyExt(id=1322246427825254805, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, companyId=1322246427481321876, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Pharmacy, People's Hospital, Peking University, Beijing 100044, China), AuthorCompanyExt(id=1322246427854614934, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, companyId=1322246427481321876, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=北京大学人民医院药剂科,北京 100044)])]), Author(id=1322246428852859298, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322246428928356772, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, authorId=1322246428852859298, language=EN, stringName=Xiao-lei REN, firstName=Xiao-lei, middleName=null, lastName=REN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Pharmacy, People's Hospital, Peking University, Beijing 100044, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322246429213569445, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, authorId=1322246428852859298, language=CN, stringName=任晓蕾, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=北京大学人民医院药剂科,北京 100044, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322246427481321876, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, xref=null, ext=[AuthorCompanyExt(id=1322246427825254805, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, companyId=1322246427481321876, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Pharmacy, People's Hospital, Peking University, Beijing 100044, China), AuthorCompanyExt(id=1322246427854614934, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, companyId=1322246427481321876, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=北京大学人民医院药剂科,北京 100044)])]), Author(id=1322246430832570791, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=fengyufei@126.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1322246430933234089, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, authorId=1322246430832570791, language=EN, stringName=Yu-fei FENG, firstName=Yu-fei, middleName=null, lastName=FENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Pharmacy, People's Hospital, Peking University, Beijing 100044, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322246431017120170, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, authorId=1322246430832570791, language=CN, stringName=封宇飞, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=北京大学人民医院药剂科,北京 100044, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322246427481321876, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, xref=null, ext=[AuthorCompanyExt(id=1322246427825254805, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, companyId=1322246427481321876, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Pharmacy, People's Hospital, Peking University, Beijing 100044, China), AuthorCompanyExt(id=1322246427854614934, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322246423635145105, companyId=1322246427481321876, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=北京大学人民医院药剂科,北京 100044)])])]
张春燕 , 黄琳, 任晓蕾, 封宇飞
作者信息
  • 北京大学人民医院药剂科,北京 100044
通讯作者:
封宇飞,男,硕士,主任药师,研究方向:药物经济学、循证药学。联系电话:(010)88325752,E-mail:。
作者简介:

张春燕,女,副主任药师,研究方向:肾内药物使用、循证药学。E-mail:。

Influence factors on blood concentration of tacrolimus in patients with nephritic syndrome
Chun-yan ZHANG , Lin HUANG, Xiao-lei REN, Yu-fei FENG
Affiliations
  • Department of Pharmacy, People's Hospital, Peking University, Beijing 100044, China
出版时间: 2021-06-15
文章导航
收藏切换
目的:

对肾病患综合征患者他克莫司(FK506)血药浓度监测结果进行分析,并探讨其影响因素。

方法:

采用回顾性调查方法,查阅我院肾内科口服FK506治疗的住院患者病历,记录血药浓度、患者一般资料、用药情况及实验室检测指标,应用SPSS 17.0统计软件对数据进行多元线性回归分析。

结果:

66例使用FK506治疗的患者,血药浓度在有效范围内的占40.91%,低于有效浓度范围的占54.55%,高于有效浓度范围的占4.55%。多元线性回归结果显示肾病综合征患者FK506剂量校正血药浓度与患者总胆固醇、可升高FK506血药浓度的合并用药及肌酸激酶之间存在具有统计学意义的相关性(P<0.01)。

结论:

肾病综合征患者FK506血药浓度个体差异大,总胆固醇、可升高FK506血药浓度的药物及肌酸激酶是其血药浓度主要影响因素。

他克莫司  /  血药浓度  /  影响因素  /  肾病综合征
Objective:

To investigate the influence factors of blood concentration of tacrolimus, and to provide reference for clinical use of tacrolimus (FK506).

Methods:

66 patients with nephrotic syndrome, who received hospitalized treatment in nephrology department of our hospital were enrolled in this study. The blood concentration of FK506, general data and laboratory testing values and so on, were recorded and analyzed using multiple linear regression method by SPSS 17.0 software.

Results:

Among the 66 patients, 40.91% patients' FK506 concentration fell in the effective range, 54.55% below the effective range, and 4.55% above the effective range. Correlations were found in unit dose of blood concentration for tacrolimus with total cholesterol (CHO) combination with drugs that increase the FK506 blood concentration, and serum creatinine (P<0.01).

Conclusion:

The FK506 blood concentration in patients with nephrotic syndrome patients is greatly varied between individuals, and CHO, drugs that increase FK506 concentration and CK are main factors affecting FK506 blood concentration in nephrotic syndrome patients.

tacrolimus  /  blood concentration  /  influencing factors  /  nephrotic syndrome
张春燕, 黄琳, 任晓蕾, 封宇飞. 肾病综合征患者他克莫司血药浓度影响因素研究. 中国新药杂志, 2021 , 30 (11) : 1053 -1056 .
Chun-yan ZHANG, Lin HUANG, Xiao-lei REN, Yu-fei FENG. Influence factors on blood concentration of tacrolimus in patients with nephritic syndrome[J]. Chinese Journal of New Drugs, 2021 , 30 (11) : 1053 -1056 .

参考文献 引证文献
排序方式:
[1]
朱旭, 路童, 印紫薇, 等. 肾病综合症患者他克莫司血药浓度影响因素分析[J]. 中国临床药理学杂志, 2017, 33(18): 1810-1816.
[2]
宋艳, 成璐, 贾淼鑫, 等. 肾病综合症患者他克莫司血药浓度监测的回顾性分析与评价[J]. 中国医院药学杂志, 2017, 37(7): 654-658.
[3]
何艳玲, 莫小兰, 吴端仪, 等. 肾病综合症患儿他克莫司血药浓度影响因素分析[J]. 今日药学, 2016, 26(1): 46-50.
[4]
钱卿, 韩睿, 胡楠, 等. 他克莫司治疗肾小球疾病的血药浓度监测及疗效影响因素分析[J]. 药学与临床研究, 2017, 25(5): 435-438.
[5]
王琳娜. 他克莫司不同血药浓度对肾病综合症治疗效果的影响[J]. 北方药学, 2019, 16(4): 142-143.
[6]
郭景鸽. 他克莫司治疗成人激素抵抗型肾病综合征血药浓度与临床效果及不良反应的相关性分析[J]. 中国药物与临床, 2019, 19(5): 773-775.
[7]
凌静, 蒋艳, 邹素兰, 等. 肾病综合征患者他克莫司的群体药动学研究[J]. 中国现代应用药学, 2020, 37(24): 79-84.
[8]
金萍, 李燕. 肾病综合症治疗药物的研究进展[J]. 国外医学泌尿系统分册, 2001, 21(4): 145-147.
[9]
王化英, 周广宇, 王艺璇, 等. 他克莫司治疗难治性肾病综合征的新进展[J]. 中华肾病研究电子杂志, 2018, 7(4): 186-189.
[10]
张建荣, 王利新, 王志伟, 等. 肝移植术后他克莫司血药浓度与血糖、血脂的相关关系探讨[J]. 宁夏医学杂志, 2007, 29(12): 1099-1100.
[11]
米丽, 李敬超, 陆嘉君, 等. 五酯胶囊对他克莫司在肝移植患者体内的药代动力学的影响[J]. 海军医学杂志, 2020, 41(3): 299-302.
[12]
陈万杰, 张琳. 五酯胶囊对肾移植受者他克莫司全血浓度及维持剂量影响的Meta分析[J]. 世界最新医学信息文摘, 2018, 18(104): 1-3.
[13]
许建文, 黄品芳, 韩文迪, 等. CYP3A5*3基因多态性与他克莫司血药浓度及临床疗效的相关性研究[J]. 中国现代应用药学, 2020, 37(18): 64-68.
2021年第30卷第11期
PDF下载
18
7
引用本文
BibTeX
文章信息
  • 首发时间:2026-10-28
  • 出版时间:2021-06-15
补充材料
相关文章
文章信息
作者
出版历史
  • 录用日期:2020-02-15
基金
作者信息
    北京大学人民医院药剂科,北京 100044

通讯作者:

封宇飞,男,硕士,主任药师,研究方向:药物经济学、循证药学。联系电话:(010)88325752,E-mail:。
参考文献
分享链接
https://castjournals.cast.org.cn/joweb/zgxyzz/CN/1322246423635145105
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏