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Article(id=1322246406664991028, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322246381633389353, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1611244800000, acceptedDateStr=2021-01-22, onlineDate=1793177709498, onlineDateStr=2026-10-28, pubDate=1623686400000, pubDateStr=2021-06-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793177709498, onlineIssueDateStr=2026-10-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793177709498, creator=13701087609, updateTime=1793177709498, updator=13701087609, issue=Issue{id=1322246381633389353, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='11', pageStart='961', pageEnd='1056', issueExtLink='null', onlineDate='null', pubDate='1623686400000', pubDateStr='2021-06-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793177703531, creator='13701087609', updateTime=1793178125547, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322248152208486593, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322246381633389353, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322248152212680898, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322246381633389353, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1001, endPage=1007, ext={EN=ArticleExt(id=1322246408644702517, articleId=1322246406664991028, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=The anti-fibrosis effect of Shuganning Zhusheye in vitro, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective:

To examine the effect of Shuganning Zhusheye on the growth of human hepatic stellate cells LX2 (HSC-LX2), and to explore its anti-fibrosis mechanism.

Methods:

The HSC-LX2 cells were treated with Shuganning Zhusheye and the absorbance of the cells was measured by the CCK8 assay to calculate the cell proliferation rate. The expression levels of mRNA and protein such as collagen Ⅰ, collagen Ⅲ and TGF-β were detected by fluorescence quantitative PCR and Western Blot. The effect of Shuganning Zhusheye on the cell cycle distribution and apoptotic rate of HSC-LX2 cell was detected by flow cytometry.

Results:

Compared to the untreated group, the inhibition rates of the low, medium and high concentrations of Shuganning Zhusheye on HSC-LX2 cells for 120 h were 14.27%, 16.37% and 18.67% respectively (P<0.05). The quantitative results showed that the mRNA levels and the protein expression levels of collagen Ⅰ and collagen Ⅲ in HSC-LX2 cells were lower than those in the untreated group (P<0.05). Shuganning Zhusheye blocked the cycle of HSC-LX2 cells in G2/M phase and induced the early and late apoptosis of the cells with a maximum apoptosis rate of 2.69%. And the effect of inducing apoptosis was concentration-dependent (P<0.05).

Conclusion:

Shuganning Zhusheye inhibited cell proliferation by blocking the cell cycle, and promoted the early and late cell apoptosis. At the same time, it downregulated the expression levels of mRNA and protein regarding collagen Ⅰ and collagen Ⅲ, so as to play an anti-fibrosis effect.

, authors=Lan-lan SI1, Zhao-fang BAI2, Fei-lin GE2, Le LI1, Rong-juan CHEN1, Jia-bo WANG2, Dong-ping XU1, Xiao-he XIAO2, Yan LIU1, authorsList=Lan-lan SI, Zhao-fang BAI, Fei-lin GE, Le LI, Rong-juan CHEN, Jia-bo WANG, Dong-ping XU, Xiao-he XIAO, Yan LIU, authorCompany=null, correspAuthors=Xiao-he XIAO, Yan LIU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322246409080910134, articleId=1322246406664991028, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=舒肝宁注射液体外抗纤维化作用实验研究, columnId=1236331161786569054, journalTitle=中国新药杂志, columnName=重大新药创制专项巡礼, runingTitle=null, highlight=null, articleAbstract=
目的：

研究舒肝宁注射液对人肝星状细胞LX2（HSC-LX2）细胞生长的影响，探讨其抗纤维化机制。

方法：

使用舒肝宁注射液处理HSC-LX2细胞，用细胞计数试剂盒-8（CCK8）法测定细胞的吸光度值，计算细胞增殖率。荧光定量聚合酶链式反应（PCR）法和免疫印迹法分别检测Ⅰ型胶原蛋白、Ⅲ型胶原蛋白和转化生长因子-β（TGF-β）的mRNA和蛋白水平。流式细胞术检测细胞周期分布及细胞凋亡率。

结果：

与未用药组比较，低、中、高浓度的舒肝宁注射液处理HSC-LX2细胞120 h对细胞增殖的抑制率分别为14.27%，16.37和18.67%（P<0.05）。舒肝宁注射液处理组细胞Ⅰ型胶原蛋白和Ⅲ型胶原蛋白的mRNA和蛋白水平较未用药组明显降低（P<0.05）。舒肝宁注射液阻滞细胞周期在G2/M期，诱导细胞的早期和晚期凋亡，最大凋亡率达到2.69%，诱导凋亡作用呈浓度依赖性（P<0.05）。

结论：

舒肝宁注射液通过阻滞细胞周期进而抑制细胞增殖，同时促进细胞早期和晚期凋亡，下调Ⅰ型胶原蛋白和Ⅲ型胶原蛋白mRNA和蛋白表达水平，从而起到抗纤维化作用。

, authors=思兰兰1, 柏兆方2, 葛斐林2, 李乐1, 陈容娟1, 王伽伯2, 徐东平1, 肖小河2, 刘妍1, authorsList=思兰兰, 柏兆方, 葛斐林, 李乐, 陈容娟, 王伽伯, 徐东平, 肖小河, 刘妍, authorCompany=null, correspAuthors=肖小河, 刘妍, authorNote=

思兰兰，女，硕士研究生，主要从事抗病毒、抗肿瘤、抗纤维化药物功能及机制的研究。联系电话：（010）66933392，E-mail：。

, correspAuthorsNote=
刘妍，女，博士，副研究员，主要从事乙型肝炎病毒感染慢性化重症化机制及抗HBV治疗研究。联系电话：（010）66933392，E-mail：。
肖小河，男，博士生导师，研究员，主要从事中药鉴定学和临床中药学研究。联系电话：（010）66933322，E-mail：。
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思兰兰，女，硕士研究生，主要从事抗病毒、抗肿瘤、抗纤维化药物功能及机制的研究。联系电话：（010）66933392，E-mail：。

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思兰兰，女，硕士研究生，主要从事抗病毒、抗肿瘤、抗纤维化药物功能及机制的研究。联系电话：（010）66933392，E-mail：。

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舒肝宁注射液体外抗纤维化作用实验研究
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思兰兰 1 , 柏兆方 2 , 葛斐林 2 , 李乐 1 , 陈容娟 1 , 王伽伯 2 , 徐东平 1 , 肖小河 2 , 刘妍 1
中国新药杂志 | 重大新药创制专项巡礼 2021,30(11): 1001-1007
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中国新药杂志 |重大新药创制专项巡礼 2021 , 30 (11) : 1001 -1007
舒肝宁注射液体外抗纤维化作用实验研究
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思兰兰，女，硕士研究生，主要从事抗病毒、抗肿瘤、抗纤维化药物功能及机制的研究。联系电话：（010）66933392，E-mail：。

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思兰兰，女，硕士研究生，主要从事抗病毒、抗肿瘤、抗纤维化药物功能及机制的研究。联系电话：（010）66933392，E-mail：。

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思兰兰1 , 柏兆方2, 葛斐林2, 李乐1, 陈容娟1, 王伽伯2, 徐东平1, 肖小河2 , 刘妍1
作者信息
  • 1解放军总医院第五医学中心　感染病医学部，北京　100039
  • 2解放军总医院第五医学中心　肝病医学部，北京　100039
通讯作者:
刘妍，女，博士，副研究员，主要从事乙型肝炎病毒感染慢性化重症化机制及抗HBV治疗研究。联系电话：（010）66933392，E-mail：。
肖小河，男，博士生导师，研究员，主要从事中药鉴定学和临床中药学研究。联系电话：（010）66933322，E-mail：。
作者简介:

思兰兰，女，硕士研究生，主要从事抗病毒、抗肿瘤、抗纤维化药物功能及机制的研究。联系电话：（010）66933392，E-mail：。

The anti-fibrosis effect of Shuganning Zhusheye in vitro
Lan-lan SI1 , Zhao-fang BAI2, Fei-lin GE2, Le LI1, Rong-juan CHEN1, Jia-bo WANG2, Dong-ping XU1, Xiao-he XIAO2 , Yan LIU1
Affiliations
  • 1The Fifth Medical Center of Chinese PLA General Hospital Department of Infectious Diseases, Beijing 100039, China
  • 2The Fifth Medical Center of Chinese PLA General Hospital Department of Hepatology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China
出版时间: 2021-06-15
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摘要
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目的：

研究舒肝宁注射液对人肝星状细胞LX2（HSC-LX2）细胞生长的影响，探讨其抗纤维化机制。

方法：

使用舒肝宁注射液处理HSC-LX2细胞，用细胞计数试剂盒-8（CCK8）法测定细胞的吸光度值，计算细胞增殖率。荧光定量聚合酶链式反应（PCR）法和免疫印迹法分别检测Ⅰ型胶原蛋白、Ⅲ型胶原蛋白和转化生长因子-β（TGF-β）的mRNA和蛋白水平。流式细胞术检测细胞周期分布及细胞凋亡率。

结果：

与未用药组比较，低、中、高浓度的舒肝宁注射液处理HSC-LX2细胞120 h对细胞增殖的抑制率分别为14.27%，16.37和18.67%（P<0.05）。舒肝宁注射液处理组细胞Ⅰ型胶原蛋白和Ⅲ型胶原蛋白的mRNA和蛋白水平较未用药组明显降低（P<0.05）。舒肝宁注射液阻滞细胞周期在G2/M期，诱导细胞的早期和晚期凋亡，最大凋亡率达到2.69%，诱导凋亡作用呈浓度依赖性（P<0.05）。

结论：

舒肝宁注射液通过阻滞细胞周期进而抑制细胞增殖，同时促进细胞早期和晚期凋亡，下调Ⅰ型胶原蛋白和Ⅲ型胶原蛋白mRNA和蛋白表达水平，从而起到抗纤维化作用。

舒肝宁注射液  /  人肝星状细胞  /  肝纤维化  /  Ⅰ型胶原蛋白  /  Ⅲ型胶原蛋白
Objective:

To examine the effect of Shuganning Zhusheye on the growth of human hepatic stellate cells LX2 (HSC-LX2), and to explore its anti-fibrosis mechanism.

Methods:

The HSC-LX2 cells were treated with Shuganning Zhusheye and the absorbance of the cells was measured by the CCK8 assay to calculate the cell proliferation rate. The expression levels of mRNA and protein such as collagen Ⅰ, collagen Ⅲ and TGF-β were detected by fluorescence quantitative PCR and Western Blot. The effect of Shuganning Zhusheye on the cell cycle distribution and apoptotic rate of HSC-LX2 cell was detected by flow cytometry.

Results:

Compared to the untreated group, the inhibition rates of the low, medium and high concentrations of Shuganning Zhusheye on HSC-LX2 cells for 120 h were 14.27%, 16.37% and 18.67% respectively (P<0.05). The quantitative results showed that the mRNA levels and the protein expression levels of collagen Ⅰ and collagen Ⅲ in HSC-LX2 cells were lower than those in the untreated group (P<0.05). Shuganning Zhusheye blocked the cycle of HSC-LX2 cells in G2/M phase and induced the early and late apoptosis of the cells with a maximum apoptosis rate of 2.69%. And the effect of inducing apoptosis was concentration-dependent (P<0.05).

Conclusion:

Shuganning Zhusheye inhibited cell proliferation by blocking the cell cycle, and promoted the early and late cell apoptosis. At the same time, it downregulated the expression levels of mRNA and protein regarding collagen Ⅰ and collagen Ⅲ, so as to play an anti-fibrosis effect.

Shuganning Zhusheye  /  human hepatic stellate cell  /  hepatic fibrosis  /  collagen Ⅰ  /  collagen Ⅲ
思兰兰, 柏兆方, 葛斐林, 李乐, 陈容娟, 王伽伯, 徐东平, 肖小河, 刘妍. 舒肝宁注射液体外抗纤维化作用实验研究. 中国新药杂志, 2021 , 30 (11) : 1001 -1007 .
Lan-lan SI, Zhao-fang BAI, Fei-lin GE, Le LI, Rong-juan CHEN, Jia-bo WANG, Dong-ping XU, Xiao-he XIAO, Yan LIU. The anti-fibrosis effect of Shuganning Zhusheye in vitro[J]. Chinese Journal of New Drugs, 2021 , 30 (11) : 1001 -1007 .
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  • 国家“重大新药创制”科技重大专项资助项目(2017ZX09301022)
  • 国家自然科学基金面上资助项目(81573676)
  • 国家自然科学基金重点资助项目(81930110)
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HU NH, WANG C, DAI XY, et al. Phillygenin inhibits LPS-induced activation and inflammation of LX2 cells by TLR4/MyD88/NF-κB signaling pathway[J]. J Ethnopharmacol, 2020, 248: 112361.
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ZHOU Y, WU R, CAI FF, et al. Xiaoyaosan decoction alleviated rat liver fibrosis via the TGFβ/Smad and Akt/FoxO3 signaling pathways based on network pharmacology analysis[J]. J Ethnopharmacol, 2021, 264: 113021.
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2021年第30卷第11期
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  • 首发时间：2026-10-28
  • 出版时间：2021-06-15
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  • 录用日期：2021-01-22
基金
国家“重大新药创制”科技重大专项资助项目(2017ZX09301022)
国家自然科学基金面上资助项目(81573676)
国家自然科学基金重点资助项目(81930110)
作者信息
    1解放军总医院第五医学中心　感染病医学部，北京　100039
    2解放军总医院第五医学中心　肝病医学部，北京　100039

通讯作者:

刘妍，女，博士，副研究员，主要从事乙型肝炎病毒感染慢性化重症化机制及抗HBV治疗研究。联系电话：（010）66933392，E-mail：。
肖小河，男，博士生导师，研究员，主要从事中药鉴定学和临床中药学研究。联系电话：（010）66933322，E-mail：。
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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