Article(id=1322245749358834496, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322245734427112160, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1596211200000, acceptedDateStr=2020-08-01, onlineDate=1793177552785, onlineDateStr=2026-10-28, pubDate=1622304000000, pubDateStr=2021-05-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793177552785, onlineIssueDateStr=2026-10-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793177552785, creator=13701087609, updateTime=1793177552785, updator=13701087609, issue=Issue{id=1322245734427112160, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='10', pageStart='865', pageEnd='960', issueExtLink='null', onlineDate='null', pubDate='1622304000000', pubDateStr='2021-05-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793177549225, creator='13701087609', updateTime=1793177686658, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322246311269740715, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322245734427112160, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322246311269740716, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322245734427112160, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=929, endPage=936, ext={EN=ArticleExt(id=1322245749602104129, articleId=1322245749358834496, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=New progress in research on drugs for treatment of hyperuricemia, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Hyperuricemia results from excessive production of uric acid and/or physical excretion deficiency and is the core to formation and development of gout, which has caught attention of researchers due to increasing prevalence. The drugs currently used in clinic can control the development of gout, but still have various deficiencies. The hot spot of drugs under research is urate anion exchanger 1 (URAT1) inhibitor, but new conditions for old drug aiming at other targets are also worthy of attention. This article reviewed the progress in research on therapeutic drugs of hyperuricemia, aiming to provide reference for the development of new drugs.

, authors=Qi-meng ZHOU, Xiao-yue ZHAO, Yu LIANG, De-wen KONG, Sen ZHANG, Wen ZHANG, Jun-ke SONG, Guan-hua DU, authorsList=Qi-meng ZHOU, Xiao-yue ZHAO, Yu LIANG, De-wen KONG, Sen ZHANG, Wen ZHANG, Jun-ke SONG, Guan-hua DU, authorCompany=null, correspAuthors=Guan-hua DU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322245749853762370, articleId=1322245749358834496, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=治疗高尿酸血症相关药物研究新进展, columnId=1236330553964810454, journalTitle=中国新药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

高尿酸血症是尿酸在体内生成过多或排泄不足引发的疾病，也是痛风形成与发展的关键因素，日益增加的患者使其逐渐受到研究者的关注。临床治疗药物虽能控制部分病情但仍有各种不足。在研药物的热点是人尿酸盐转运蛋白1（URAT1）抑制剂，但老药新用及其他靶点的药物也值得关注。本文通过对治疗高尿酸血症相关药物研究进展进行综述，希望能为新药开发提供参考。

, authors=周启蒙, 赵晓悦, 梁宇, 孔德文, 张森, 张雯, 宋俊科, 杜冠华, authorsList=周启蒙, 赵晓悦, 梁宇, 孔德文, 张森, 张雯, 宋俊科, 杜冠华, authorCompany=null, correspAuthors=杜冠华, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=VPPosactjvptH1AgSVP3Fw==, magXml=xBfVr54VrbCreZKUqmO4hA==, pdfUrl=null, pdf=C/GVkxjrDs0tMV3Bp7808A==, pdfFileSize=1122988, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=yWHmSjxKEfiO9a2NXZPGuQ==, mapNumber=null, fund=null)}, authors=[Author(id=1322245751737004871, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245749358834496, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=tamias@imm.ac.cn, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322245751812502345, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245749358834496, authorId=1322245751737004871, language=EN, stringName=Qi-meng ZHOU, firstName=Qi-meng, middleName=null, lastName=ZHOU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322245751900582730, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245749358834496, authorId=1322245751737004871, language=CN, stringName=周启蒙, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=中国医学科学院北京协和医学院药物研究所，北京市药物靶点研究与新药筛选重点实验室，北京　100050, bio={"content":"

周启蒙，男，硕士研究生，主要从事代谢性疾病与新药发现研究。E-mail：tamias@imm.ac.cn。

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周启蒙，男，硕士研究生，主要从事代谢性疾病与新药发现研究。E-mail：tamias@imm.ac.cn。

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