Article(id=1322245735614104006, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322245734427112160, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1612195200000, acceptedDateStr=2021-02-02, onlineDate=1793177549508, onlineDateStr=2026-10-28, pubDate=1622304000000, pubDateStr=2021-05-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793177549508, onlineIssueDateStr=2026-10-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793177549508, creator=13701087609, updateTime=1793177549508, updator=13701087609, issue=Issue{id=1322245734427112160, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='10', pageStart='865', pageEnd='960', issueExtLink='null', onlineDate='null', pubDate='1622304000000', pubDateStr='2021-05-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793177549225, creator='13701087609', updateTime=1793177686658, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322246311269740715, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322245734427112160, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322246311269740716, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322245734427112160, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=898, endPage=901, ext={EN=ArticleExt(id=1322245735823819207, articleId=1322245735614104006, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Investigation and considerations about clinical position and effect evaluation system and criterion suited for traditional Chinese medicine, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Clinical position and effect evaluation are the key points of new drug research and development. Traditional Chinese medicine (TCM) clinical research often have problems such as unclear clinical position, effect evaluation not targeted, or do not tally with the characteristics of drug and so on. Recently, extensive investigation has been carried out with questionnaire on the revision of “the general principle of clinical research of new drug of TCM” on “how to determine the clinical position with characteristics of TCM” and “how to build effect evaluation system and evaluation standard with characteristics of TCM”, and participate experts give constructive advices. This article summarizes and analyzes experts' opinions, and discusses the author's opinion of TCM clinical position and effect evaluation system.

, authors=Cai-mei SONG, Bing-lin LIU, Fei-ran XUE, Ling HAN, authorsList=Cai-mei SONG, Bing-lin LIU, Fei-ran XUE, Ling HAN, authorCompany=null, correspAuthors=Ling HAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322245736125809096, articleId=1322245735614104006, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=关于中药临床定位及疗效评价体系和标准的调研及思考, columnId=1236331159400018080, journalTitle=中国新药杂志, columnName=新药注册与审评技术, runingTitle=null, highlight=null, articleAbstract=

临床定位和疗效评价均是新药研发的关键点,中药临床研究中往往存在临床定位不清、疗效评价没有针对性或与药物作用特点不符等问题。近期,在一项关于《中药新药临床研究一般原则》修订的调查问卷中也对“如何确定具有中药特点的临床定位”和“如何构建具有中药特点的疗效评价体系和评价标准”进行了广泛调研,参与专家均给出了具有建设性的意见。本文对专家意见进行总结分析,并浅谈笔者对中药临床定位和疗效评价体系的思考。

, authors=宋彩梅, 刘炳林, 薛斐然, 韩玲, authorsList=宋彩梅, 刘炳林, 薛斐然, 韩玲, authorCompany=null, correspAuthors=韩玲, authorNote=

宋彩梅,女,审评员,主要从事中药新药临床技术审评工作。E-mail:。

, correspAuthorsNote=
韩玲,女,博士,主任药师,主要从事中药新药技术审评工作。联系电话:(010)85243109,E-mail:。
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宋彩梅,女,审评员,主要从事中药新药临床技术审评工作。E-mail:。

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宋彩梅,女,审评员,主要从事中药新药临床技术审评工作。E-mail:。

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unstructuredReference=陈科艳, 黄倩, 武江海, 等. 新形势下中药临床评价相关问题思考[J]. 中国中医药现代远程教育, 2019, 17(4): 150-154., articleTitle=null, refAbstract=null), Reference(id=1322245743491006955, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735614104006, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=中华医学会消化病学分会. 中国慢性胃炎共识意见(2017, 上海)[J]. 胃肠病学, 2017, 22(11): 670-687., articleTitle=null, refAbstract=null), Reference(id=1322245743570698732, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735614104006, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=刘炳林, 薛斐然. 中药新药临床试验及技术要求历史回顾与展望[J]. 中国新药杂志, 2020, 29(16): 1-6., articleTitle=null, refAbstract=null), Reference(id=1322245743654584813, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735614104006, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=国家食品药品监督管理局. 抗肿瘤药物终点技术指导原则[EB/OL]. (2012-05-15). http://www.cde.org.cn/zdyz.do?method=largePage&id=9cf18143e2f6c19d., articleTitle=null, refAbstract=null), Reference(id=1322245743734276590, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735614104006, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=国家食品药品监督管理总局. 中药新药治疗恶性肿瘤临床研究技术指导原则[EB/OL]. (2015-11-03). http://www.cde.org.cn/zdyz.do?method=largePage&id=e806afcc7fac7929., articleTitle=null, refAbstract=null), Reference(id=1322245743805579759, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735614104006, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA. Guidance.for. Industry. Patient-Reported Outcome Measures: Use in Medical Product Development to Support Labeling Claims[EB/OL]. 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关于中药临床定位及疗效评价体系和标准的调研及思考
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宋彩梅 , 刘炳林 , 薛斐然 , 韩玲
中国新药杂志 | 新药注册与审评技术 2021,30(10): 898-901
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中国新药杂志 |新药注册与审评技术 2021 , 30 (10) : 898 -901
关于中药临床定位及疗效评价体系和标准的调研及思考
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宋彩梅 , 刘炳林, 薛斐然, 韩玲
作者信息
  • 国家药品监督管理局药品审评中心,北京 100022
通讯作者:
韩玲,女,博士,主任药师,主要从事中药新药技术审评工作。联系电话:(010)85243109,E-mail:。
作者简介:

宋彩梅,女,审评员,主要从事中药新药临床技术审评工作。E-mail:。

Investigation and considerations about clinical position and effect evaluation system and criterion suited for traditional Chinese medicine
Cai-mei SONG , Bing-lin LIU, Fei-ran XUE, Ling HAN
Affiliations
  • Center for Drug Evaluation, National Medical Products Administration, Beijing 100022, China
出版时间: 2021-05-30
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临床定位和疗效评价均是新药研发的关键点,中药临床研究中往往存在临床定位不清、疗效评价没有针对性或与药物作用特点不符等问题。近期,在一项关于《中药新药临床研究一般原则》修订的调查问卷中也对“如何确定具有中药特点的临床定位”和“如何构建具有中药特点的疗效评价体系和评价标准”进行了广泛调研,参与专家均给出了具有建设性的意见。本文对专家意见进行总结分析,并浅谈笔者对中药临床定位和疗效评价体系的思考。

中药  /  临床定位  /  疗效评价  /  调研

Clinical position and effect evaluation are the key points of new drug research and development. Traditional Chinese medicine (TCM) clinical research often have problems such as unclear clinical position, effect evaluation not targeted, or do not tally with the characteristics of drug and so on. Recently, extensive investigation has been carried out with questionnaire on the revision of “the general principle of clinical research of new drug of TCM” on “how to determine the clinical position with characteristics of TCM” and “how to build effect evaluation system and evaluation standard with characteristics of TCM”, and participate experts give constructive advices. This article summarizes and analyzes experts' opinions, and discusses the author's opinion of TCM clinical position and effect evaluation system.

traditional Chinese medicine  /  clinical position  /  effect evaluation  /  investigation
宋彩梅, 刘炳林, 薛斐然, 韩玲. 关于中药临床定位及疗效评价体系和标准的调研及思考. 中国新药杂志, 2021 , 30 (10) : 898 -901 .
Cai-mei SONG, Bing-lin LIU, Fei-ran XUE, Ling HAN. Investigation and considerations about clinical position and effect evaluation system and criterion suited for traditional Chinese medicine[J]. Chinese Journal of New Drugs, 2021 , 30 (10) : 898 -901 .

参考文献 引证文献
排序方式:
[1]
刘炳林. 从临床角度看中药新药适应证的定位[J]. 中药新药与临床药理, 2011, 22(2): 226-227.
[2]
国家食品药品监督管理总局. 中药新药临床研究一般原则[S]. 2015.
[3]
陈科艳, 黄倩, 武江海, 等. 新形势下中药临床评价相关问题思考[J]. 中国中医药现代远程教育, 2019, 17(4): 150-154.
[4]
中华医学会消化病学分会. 中国慢性胃炎共识意见(2017, 上海)[J]. 胃肠病学, 2017, 22(11): 670-687.
[5]
刘炳林, 薛斐然. 中药新药临床试验及技术要求历史回顾与展望[J]. 中国新药杂志, 2020, 29(16): 1-6.
[6]
国家食品药品监督管理局. 抗肿瘤药物终点技术指导原则[EB/OL]. (2012-05-15). http://www.cde.org.cn/zdyz.do?method=largePage&id=9cf18143e2f6c19d.
[7]
国家食品药品监督管理总局. 中药新药治疗恶性肿瘤临床研究技术指导原则[EB/OL]. (2015-11-03). http://www.cde.org.cn/zdyz.do?method=largePage&id=e806afcc7fac7929.
[8]
FDA. Guidance.for. Industry. Patient-Reported Outcome Measures: Use in Medical Product Development to Support Labeling Claims[EB/OL]. [2009-12]. https://www.fda.gov/down-loads/drugs/guidance.compliancere.gulatory.information/guidances/ucm193282.pdf.
2021年第30卷第10期
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  • 首发时间:2026-10-28
  • 出版时间:2021-05-30
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  • 录用日期:2021-02-02
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    国家药品监督管理局药品审评中心,北京 100022

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韩玲,女,博士,主任药师,主要从事中药新药技术审评工作。联系电话:(010)85243109,E-mail:。
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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