Article(id=1322245735077237688, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322245734427112160, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1609171200000, acceptedDateStr=2020-12-29, onlineDate=1793177549379, onlineDateStr=2026-10-28, pubDate=1622304000000, pubDateStr=2021-05-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793177549379, onlineIssueDateStr=2026-10-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793177549379, creator=13701087609, updateTime=1793177549379, updator=13701087609, issue=Issue{id=1322245734427112160, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='10', pageStart='865', pageEnd='960', issueExtLink='null', onlineDate='null', pubDate='1622304000000', pubDateStr='2021-05-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793177549225, creator='13701087609', updateTime=1793177686658, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322246311269740715, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322245734427112160, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322246311269740716, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322245734427112160, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=865, endPage=870, ext={EN=ArticleExt(id=1322245735245009849, articleId=1322245735077237688, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=An overview of nonclinical study and evaluation of diagnostic radiopharmaceuticals approved for marketing in the United States in the last two decades, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

In recent years, with the development of radiochemistry, nuclear medicine and molecular biology technology and the interdisciplinary integration, diagnostic radiopharmaceuticals have become a hot field of drug research and development at home and abroad. In the past two decades, the US FDA has approved a number of new diagnostic radiopharmaceuticals for the diagnosis of tumor, cardiovascular disease, Parkinson's syndrome and other diseases. The nonclinical study of drugs is a key part of drug development. This paper sorted out the nonclinical study information of FDA-approved diagnostic radiopharmaceuticals and summarized the focus of nonclinical study and evaluation, aiming to provide information for such drugs' development in China.

, authors=Ai-fang LI, Hong-mei GUANG, Qing-li WANG, authorsList=Ai-fang LI, Hong-mei GUANG, Qing-li WANG, authorCompany=null, correspAuthors=Hong-mei GUANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322245735580554170, articleId=1322245735077237688, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=美国近20年批准上市的放射性诊断药物的非临床研究评价概述, columnId=1236331159400018080, journalTitle=中国新药杂志, columnName=新药注册与审评技术, runingTitle=null, highlight=null, articleAbstract=

近年，随着放射性化学、核医学、分子生物学技术的发展和学科交叉融合，放射性诊断药物已成为国内外药品研发的热门领域。美国FDA近20年批准了多个新型放射性诊断药物上市，适应证涉及肿瘤、心血管疾病、帕金森综合征等诊断领域。药物的非临床研究是药物研发的关键部分，本文将梳理FDA批准上市的放射性诊断药物的非临床研究信息，总结非临床研究评价关注点，为国内该类药物的研发提供参考。

, authors=李艾芳, 光红梅, 王庆利, authorsList=李艾芳, 光红梅, 王庆利, authorCompany=null, correspAuthors=光红梅, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=UYlSDBinxmWy19xujQT0NA==, magXml=RO6VgGvbyhFD5ECL0BXpRw==, pdfUrl=null, pdf=uR5eajn2YbQyK3DWxgliSw==, pdfFileSize=1086771, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=WYrbpxoupBtHi72hozGevw==, mapNumber=null, fund=null)}, authors=[Author(id=1322245736146785215, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735077237688, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=behealthy@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322245736243254209, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735077237688, authorId=1322245736146785215, language=EN, stringName=Ai-fang LI, firstName=Ai-fang, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Center for Drug Evaluation, National Medical Products Administration, Beijing 100022, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322245736314557378, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735077237688, authorId=1322245736146785215, language=CN, stringName=李艾芳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=国家药品监督管理局药品审评中心，北京　100022, bio={"content":"

李艾芳，女，助理研究员，研究方向：药物非临床研究评价。E-mail：behealthy@163.com。

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李艾芳，女，助理研究员，研究方向：药物非临床研究评价。E-mail：behealthy@163.com。

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Tauvid US label[S]. 2020., articleTitle=null, refAbstract=null), Reference(id=1322245740861182932, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735077237688, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA. Tauvid Intergrated Review (NDA 212123)[R]. 2020., articleTitle=null, refAbstract=null), Reference(id=1322245742538904533, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735077237688, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA. Cerianna US label[S]. 2020., articleTitle=null, refAbstract=null), Reference(id=1322245742643762134, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735077237688, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA. Cerianna Multi-Discipline Review (NDA 212155)[R]. 2020., articleTitle=null, refAbstract=null), Reference(id=1322245742731842519, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735077237688, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA. Fluorodopa F18 Injection US label[S]. 2019., articleTitle=null, refAbstract=null), Reference(id=1322245742819922904, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735077237688, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA. Fluorodopa F18 Injection Multi-Discipline Review (NDA 200655)[R]. 2019., articleTitle=null, refAbstract=null), Reference(id=1322245742916391897, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735077237688, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA. GA 68 Dotatoc Injection US label[S]. 2019., articleTitle=null, refAbstract=null), Reference(id=1322245742987695066, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735077237688, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA. GA 68 Dotatoc Injection Multi-Discipline Review (NDA 210828)[R]. 2019., articleTitle=null, refAbstract=null), Reference(id=1322245743071581147, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735077237688, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA. Netspot US label[S]. 2018., articleTitle=null, refAbstract=null), Reference(id=1322245743142884316, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735077237688, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA. Netspot Pharmacology Review (NDA 208547)[R]. 2016., articleTitle=null, refAbstract=null), Reference(id=1322245743230964701, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735077237688, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA. Axumin US label[S]. 2016., articleTitle=null, refAbstract=null), Reference(id=1322245743411319774, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735077237688, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA. Axumin Pharmacology Review (NDA 208054)[R]. 2016., articleTitle=null, refAbstract=null), Reference(id=1322245743486817247, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735077237688, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA. Neuraceq US label[S]. 2020., articleTitle=null, refAbstract=null), Reference(id=1322245743604257760, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735077237688, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA. Neuraceq Pharmacology Review (NDA 204677)[R]. 2014., articleTitle=null, refAbstract=null), Reference(id=1322245743709115361, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735077237688, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA. Vizamyl US label[S]. 2019., articleTitle=null, refAbstract=null), Reference(id=1322245743784612834, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735077237688, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA. Vizamyl Pharmacology Review (NDA 203137)[R]. 2013., articleTitle=null, refAbstract=null), Reference(id=1322245743860110307, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735077237688, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA. Choline C11 Injection US label[S]. 2012., articleTitle=null, refAbstract=null), Reference(id=1322245743935607780, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735077237688, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA. Choline C11 Injection Pharmacology Review (NDA 203155)[R]. 2012., articleTitle=null, refAbstract=null), Reference(id=1322245744023688165, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735077237688, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[19], rfOrder=18, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA. Amyvid US label[S]. 2019., articleTitle=null, refAbstract=null), Reference(id=1322245744099185638, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735077237688, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[20], rfOrder=19, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA. Amyvid Pharmacology Review (NDA 202008)[R]. 2012., articleTitle=null, refAbstract=null), Reference(id=1322245744191460327, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735077237688, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[21], rfOrder=20, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA. 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AdreView US label[S]. 2020., articleTitle=null, refAbstract=null), Reference(id=1322245744434729962, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735077237688, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[24], rfOrder=23, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA. AdreView Pharmacology Review (NDA 22-290)[R]. 2008., articleTitle=null, refAbstract=null), Reference(id=1322245744514421739, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735077237688, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[25], rfOrder=24, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA. Ammonia N13 Injection label[S]. 2011., articleTitle=null, refAbstract=null), Reference(id=1322245744585724908, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322245735077237688, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[26], rfOrder=25, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA. 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