Article(id=1322245690034602383, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322245649572156020, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1601222400000, acceptedDateStr=2020-09-28, onlineDate=1793177538640, onlineDateStr=2026-10-28, pubDate=1619712000000, pubDateStr=2021-04-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793177538640, onlineIssueDateStr=2026-10-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793177538640, creator=13701087609, updateTime=1793177538640, updator=13701087609, issue=Issue{id=1322245649572156020, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='8', pageStart='673', pageEnd='768', issueExtLink='null', onlineDate='null', pubDate='1619712000000', pubDateStr='2021-04-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793177528994, creator='13701087609', updateTime=1793177643007, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322246127831863562, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322245649572156020, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322246127831863563, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322245649572156020, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=754, endPage=759, ext={EN=ArticleExt(id=1322245690273677712, articleId=1322245690034602383, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Study on synthesis and performance of PEG-Bola nonionic surfactant, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective:

To synthesize a series of Bola type nonionic surfactants using 1, 12-dodecanediol and undecenoic acid as raw materials, characterize the products and evaluate the safety.

Methods:

Dodecyl Di-10-undecenoate was prepared by esterification, epoxidation was conducted on the product followed by ring opening to prepare disubstituted polyoxyethylene undecanoate dodecyl with different degrees of polymerization glycol ester, and the products were compared with the nonionic surfactant Tween 80 in terms of surface activity, solubilization, hemolysis, etc.

Results:

The safe and effective index of PUDD-800 was 10 times that of Tween 80.

Conclusion:

PUDD-800 can replace the commercially available surfactants and has the potential for further application in the development of injection formulations.

, authors=Chang-lin HUA, Rui ZHANG, Xin-quan RAO, Yan-ting ZHANG, authorsList=Chang-lin HUA, Rui ZHANG, Xin-quan RAO, Yan-ting ZHANG, authorCompany=null, correspAuthors=Rui ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322245690546307473, articleId=1322245690034602383, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=PEG-Bola型非离子表面活性剂的合成与性能研究, columnId=1236330556003242277, journalTitle=中国新药杂志, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的:

以1,12-十二醇为连接基,10-十一烯酸为原料,合成了系列Bola型非离子表面活性剂,并对产物进行了表征和安全性评价。

方法:

首先通过酯化制备二-10-十一烯酸十二烷基二醇酯,对产物进行环氧化反应,然后开环制得不同聚合度的二取代聚氧乙烯十一烷酸十二烷基二醇酯,并与非离子表面活性剂Tween 80在表面活性、增溶性、溶血性等方面进行了对比。

结果:

PUDD-800的安全有效指数是Tween 80的10倍,可代替现有市售表面活性剂,并在注射剂配方开发中具有进一步应用的潜力。

, authors=花昌林, 张锐, 饶信权, 张艳婷, authorsList=花昌林, 张锐, 饶信权, 张艳婷, authorCompany=null, correspAuthors=张锐, authorNote=

花昌林,男,硕士研究生,研究方向为药用辅料的设计合成与安全性评价。E-mail:。

, correspAuthorsNote=
张锐,男,博士,副教授,研究方向为药用辅料的设计合成与评价。E-mail:。
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花昌林,男,硕士研究生,研究方向为药用辅料的设计合成与安全性评价。E-mail:。

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花昌林,男,硕士研究生,研究方向为药用辅料的设计合成与安全性评价。E-mail:。

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PEG-Bola型非离子表面活性剂的合成与性能研究
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花昌林 , 张锐 , 饶信权 , 张艳婷
中国新药杂志 | 实验研究 2021,30(8): 754-759
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中国新药杂志 |实验研究 2021 , 30 (8) : 754 -759
PEG-Bola型非离子表面活性剂的合成与性能研究
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花昌林 , 张锐 , 饶信权, 张艳婷
作者信息
  • 江西中医药大学现代中药制剂教育部重点实验室,南昌 330004
通讯作者:
张锐,男,博士,副教授,研究方向为药用辅料的设计合成与评价。E-mail:。
作者简介:

花昌林,男,硕士研究生,研究方向为药用辅料的设计合成与安全性评价。E-mail:。

Study on synthesis and performance of PEG-Bola nonionic surfactant
Chang-lin HUA , Rui ZHANG , Xin-quan RAO, Yan-ting ZHANG
Affiliations
  • Jiangxi University of Traditional Chinese Medicine, Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Nanchang 330004, China
出版时间: 2021-04-30
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目的:

以1,12-十二醇为连接基,10-十一烯酸为原料,合成了系列Bola型非离子表面活性剂,并对产物进行了表征和安全性评价。

方法:

首先通过酯化制备二-10-十一烯酸十二烷基二醇酯,对产物进行环氧化反应,然后开环制得不同聚合度的二取代聚氧乙烯十一烷酸十二烷基二醇酯,并与非离子表面活性剂Tween 80在表面活性、增溶性、溶血性等方面进行了对比。

结果:

PUDD-800的安全有效指数是Tween 80的10倍,可代替现有市售表面活性剂,并在注射剂配方开发中具有进一步应用的潜力。

PEG-Bola型非离子表面活性剂  /  合成  /  增溶  /  溶血
Objective:

To synthesize a series of Bola type nonionic surfactants using 1, 12-dodecanediol and undecenoic acid as raw materials, characterize the products and evaluate the safety.

Methods:

Dodecyl Di-10-undecenoate was prepared by esterification, epoxidation was conducted on the product followed by ring opening to prepare disubstituted polyoxyethylene undecanoate dodecyl with different degrees of polymerization glycol ester, and the products were compared with the nonionic surfactant Tween 80 in terms of surface activity, solubilization, hemolysis, etc.

Results:

The safe and effective index of PUDD-800 was 10 times that of Tween 80.

Conclusion:

PUDD-800 can replace the commercially available surfactants and has the potential for further application in the development of injection formulations.

PEG-Bola nonionic surfactant  /  synthesis  /  solubilization  /  hemolysis
花昌林, 张锐, 饶信权, 张艳婷. PEG-Bola型非离子表面活性剂的合成与性能研究. 中国新药杂志, 2021 , 30 (8) : 754 -759 .
Chang-lin HUA, Rui ZHANG, Xin-quan RAO, Yan-ting ZHANG. Study on synthesis and performance of PEG-Bola nonionic surfactant[J]. Chinese Journal of New Drugs, 2021 , 30 (8) : 754 -759 .
  • 国家自然科学基金项目(81560579)
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2021年第30卷第8期
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  • 首发时间:2026-10-28
  • 出版时间:2021-04-30
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  • 录用日期:2020-09-28
基金
国家自然科学基金项目(81560579)
作者信息
    江西中医药大学现代中药制剂教育部重点实验室,南昌 330004

通讯作者:

张锐,男,博士,副教授,研究方向为药用辅料的设计合成与评价。E-mail:。
参考文献
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2种不同金属材料的力学参数
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属
Genus
种数
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species
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Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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