Article(id=1322181150248906778, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322181102488375822, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1610553600000, acceptedDateStr=2021-01-14, onlineDate=1793162151156, onlineDateStr=2026-10-28, pubDate=1627574400000, pubDateStr=2021-07-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793162151156, onlineIssueDateStr=2026-10-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793162151156, creator=13701087609, updateTime=1793162151156, updator=13701087609, issue=Issue{id=1322181102488375822, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='14', pageStart='1249', pageEnd='1344', issueExtLink='null', onlineDate='null', pubDate='1627574400000', pubDateStr='2021-07-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793162139770, creator='13701087609', updateTime=1793162209831, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322181396408419308, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322181102488375822, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322181396408419309, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322181102488375822, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1334, endPage=1339, ext={EN=ArticleExt(id=1322181150479593499, articleId=1322181150248906778, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Comparison of different polymer detection methods and analysis of polymer impurities of cefathiamidine for injection, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To analyze polymer impurities in cefathiamidine for injection by different methods, and compare the advantages and disadvantages of the specificity of different methods.
Methods: By using Sephadex G-10 System, high performance gel chromatography and column switching-LC-MSn method, the polymers in cefathiamidine for injection from 11 manufacturers were analyzed.
Results: No polymer was detected by Sephadex G10 System, high performance gel chromatography could detect polymer impurities, the structure of the components separated by high performance gel chromatography system was confirmed by the column switching-LC-MSn method.
Conclusion: It was proved that there were some polymer impurities in cefathiamidine for injection, the Sephadex G10 System and high performance gel chromatography had poor specificity, and macromolecular polymers and small molecular impurities could not be separated and qualitatively analyzed. This study laid the foundation to further establish a better specificity method.
, authors=Xiao-meng CHONG, Ye TIAN, Shang-chen YAO, Li-hui YIN, Ying LIU, Ming-zhe XU, authorsList=Xiao-meng CHONG, Ye TIAN, Shang-chen YAO, Li-hui YIN, Ying LIU, Ming-zhe XU, authorCompany=null, correspAuthors=Ying LIU, Ming-zhe XU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322181150743834652, articleId=1322181150248906778, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=注射用头孢硫脒聚合物检测方法比较及聚合物杂质分析, columnId=1236330556003242277, journalTitle=中国新药杂志, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的： 本研究采用不同的方法对注射用头孢硫脒中聚合物杂质进行分析，比较不同方法专属性的优劣。
方法： 分别采用葡聚糖凝胶G10系统、高效凝胶色谱系统以及柱切换液质联用系统对11个厂家的注射用头孢硫脒中聚合物进行分析。
结果： 葡聚糖凝胶G10系统并未检出聚合物，高效凝胶色谱系统可检出聚合物，采用柱切换液质联用方法对高效凝胶色谱系统分离的组分进行了结构确认。
结论： 柱切换液质联用方法证明了注射用头孢硫脒中存在多种聚合物杂质，葡聚糖凝胶G10系统以及高效凝胶色谱系统专属性较差，无法将大分子聚合物和小分子杂质进行分离和定性，为进一步建立专属性更好的方法奠定了基础。
, authors=崇小萌, 田冶, 姚尚辰, 尹利辉, 刘颖, 许明哲, authorsList=崇小萌, 田冶, 姚尚辰, 尹利辉, 刘颖, 许明哲, authorCompany=null, correspAuthors=刘颖, 许明哲, authorNote=
, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=ukKPcF5GDVP+QRfDkrtCug==, magXml=5iFonEieKhkke6NlhdO3/g==, pdfUrl=null, pdf=APJGtZ9QfMZu+3QsTo1VcA==, pdfFileSize=1356461, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=R379u5CX+SPdhsqC/nFn+g==, mapNumber=null, fund=null)}, authors=[Author(id=1322181151079378977, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=chongxm@nifdc.org.cn, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322181151448477731, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, authorId=1322181151079378977, language=EN, stringName=Xiao-meng CHONG, firstName=Xiao-meng, middleName=null, lastName=CHONG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=National Institutes for Food and Drug Control, Beijing 102629, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322181153138782244, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, authorId=1322181151079378977, language=CN, stringName=崇小萌, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=中国食品药品检定研究院，北京 102629, bio={"content":"
崇小萌，女，副主任药师，主要从事抗生素药品质量控制及研究。联系电话：（010）53851538，E-mail：chongxm@nifdc.org.cn。
"}, bioImg=null, bioContent=
崇小萌，女，副主任药师，主要从事抗生素药品质量控制及研究。联系电话：（010）53851538，E-mail：chongxm@nifdc.org.cn。
, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322181150974521373, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, xref=null, ext=[AuthorCompanyExt(id=1322181150987104286, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, companyId=1322181150974521373, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=National Institutes for Food and Drug Control, Beijing 102629, China), AuthorCompanyExt(id=1322181150995492895, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, companyId=1322181150974521373, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=中国食品药品检定研究院，北京 102629)])]), Author(id=1322181153239445542, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=tianye@nifdc.org.cn, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322181153398829096, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, authorId=1322181153239445542, language=EN, stringName=Ye TIAN, firstName=Ye, middleName=null, lastName=TIAN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=National Institutes for Food and Drug Control, Beijing 102629, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322181153520463913, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, authorId=1322181153239445542, language=CN, stringName=田冶, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=中国食品药品检定研究院，北京 102629, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322181150974521373, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, xref=null, ext=[AuthorCompanyExt(id=1322181150987104286, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, companyId=1322181150974521373, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=National Institutes for Food and Drug Control, Beijing 102629, China), AuthorCompanyExt(id=1322181150995492895, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, companyId=1322181150974521373, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=中国食品药品检定研究院，北京 102629)])]), Author(id=1322181153612738603, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322181153725984813, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, authorId=1322181153612738603, language=EN, stringName=Shang-chen YAO, firstName=Shang-chen, middleName=null, lastName=YAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=National Institutes for Food and Drug Control, Beijing 102629, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322181153843425326, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, authorId=1322181153612738603, language=CN, stringName=姚尚辰, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=中国食品药品检定研究院，北京 102629, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322181150974521373, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, xref=null, ext=[AuthorCompanyExt(id=1322181150987104286, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, companyId=1322181150974521373, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=National Institutes for Food and Drug Control, Beijing 102629, China), AuthorCompanyExt(id=1322181150995492895, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, companyId=1322181150974521373, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=中国食品药品检定研究院，北京 102629)])]), Author(id=1322181153931505712, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322181154019586098, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, authorId=1322181153931505712, language=EN, stringName=Li-hui YIN, firstName=Li-hui, middleName=null, lastName=YIN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=National Institutes for Food and Drug Control, Beijing 102629, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322181154116055091, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, authorId=1322181153931505712, language=CN, stringName=尹利辉, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=中国食品药品检定研究院，北京 102629, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322181150974521373, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, xref=null, ext=[AuthorCompanyExt(id=1322181150987104286, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, companyId=1322181150974521373, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=National Institutes for Food and Drug Control, Beijing 102629, China), AuthorCompanyExt(id=1322181150995492895, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, companyId=1322181150974521373, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=中国食品药品检定研究院，北京 102629)])]), Author(id=1322181154195746869, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=liuyingly77@hotmail.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1322181154288021559, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, authorId=1322181154195746869, language=EN, stringName=Ying LIU, firstName=Ying, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=National Institutes for Food and Drug Control, Beijing 102629, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322181154397073464, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, authorId=1322181154195746869, language=CN, stringName=刘颖, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=中国食品药品检定研究院，北京 102629, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322181150974521373, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, xref=null, ext=[AuthorCompanyExt(id=1322181150987104286, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, companyId=1322181150974521373, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=National Institutes for Food and Drug Control, Beijing 102629, China), AuthorCompanyExt(id=1322181150995492895, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, companyId=1322181150974521373, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=中国食品药品检定研究院，北京 102629)])]), Author(id=1322181154573234234, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=xumzhe@nifdc.org.cn, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1322181154707451964, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, authorId=1322181154573234234, language=EN, stringName=Ming-zhe XU, firstName=Ming-zhe, middleName=null, lastName=XU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=National Institutes for Food and Drug Control, Beijing 102629, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322181154816503869, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, authorId=1322181154573234234, language=CN, stringName=许明哲, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=中国食品药品检定研究院，北京 102629, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322181150974521373, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, xref=null, ext=[AuthorCompanyExt(id=1322181150987104286, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, companyId=1322181150974521373, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=National Institutes for Food and Drug Control, Beijing 102629, China), AuthorCompanyExt(id=1322181150995492895, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, companyId=1322181150974521373, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=中国食品药品检定研究院，北京 102629)])])], keywords=[Keyword(id=1322181155063967806, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, language=EN, orderNo=1, keyword=cefathiamidine for injection), Keyword(id=1322181155168825407, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, language=EN, orderNo=2, keyword=polymer), Keyword(id=1322181155273683008, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, language=EN, orderNo=3, keyword=the column switching-LC-MS
n), Keyword(id=1322181155349180481, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, language=CN, orderNo=1, keyword=注射用头孢硫脒), Keyword(id=1322181155420483650, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, language=CN, orderNo=2, keyword=聚合物), Keyword(id=1322181155617615939, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, language=CN, orderNo=3, keyword=柱切换液质联用)], refs=[Reference(id=1322181155785388100, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=null, journalName=null, refType=null, unstructuredReference=金少鸿. 头孢菌素过敏反应的研究进展[J]. 国外医药·抗生素分册, 1984, (3): 191-197., articleTitle=null, refAbstract=null), Reference(id=1322181155865079877, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=金少鸿. 抗生素的过敏反应-Ⅰ. β-内酰胺类抗生素的过敏反应[J]. 中国临床药理学杂志, 1986, 2(4): 251-257., articleTitle=null, refAbstract=null), Reference(id=1322181155944771654, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=金少鸿, 胡昌勤. β-内酰胺类抗生素过敏反应的研究[J]. 医学研究杂志, 2002, 31(4): 22-23., articleTitle=null, refAbstract=null), Reference(id=1322181157601521735, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=金少鸿. β-内酰胺类抗生素的质量和过敏反应关系的评述[J]. 中国抗生素杂志, 1988, 13(1): 65-71., articleTitle=null, refAbstract=null), Reference(id=1322181157702185032, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=陈启立. 头孢菌素类仿制药的杂质谱研究[D]. 北京: 北京协和医学院, 2016., articleTitle=null, refAbstract=null), Reference(id=1322181157815431241, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=李进, 姚尚辰, 尹利辉, 等. 头孢噻肟钠原料的聚合物杂质分析[J]. 中国抗生素杂志, 2020, 45(9): 883-892., articleTitle=null, refAbstract=null), Reference(id=1322181157932871754, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=李进, 姚尚辰, 尹利辉, 等. 头孢他啶原料及制剂的聚合物杂质分析[J]. 药学学报, 2020, 55(8): 1889-1896., articleTitle=null, refAbstract=null), Reference(id=1322181158054506571, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=胡昌勤. β-内酰胺类抗生素聚合物杂质控制策略的形成与发展[J]. 中国新药杂志, 2020, 29(11): 1231-1244., articleTitle=null, refAbstract=null), Reference(id=1322181158155169868, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=黄每裕. 走出深闺人方识-广州白云山制药总厂开发独家产品头孢硫脒纪实[J]. 中国药业, 2003, 12(11): 17-19., articleTitle=null, refAbstract=null), Reference(id=1322181158247444557, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=陈红英, 张静, 胡海容, 等. 快速HPLC法测定头孢硫脒有关物质[J]. 中国新药杂志, 2016, 25(15): 1784-1787., articleTitle=null, refAbstract=null), Reference(id=1322181158327136334, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=王文梅, 我国自行研制的头孢菌素——头孢硫脒[J]. 世界临床药物, 2003, 24(3): 179-181., articleTitle=null, refAbstract=null)], funds=null, companyList=[AuthorCompany(id=1322181150974521373, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, xref=null, ext=[AuthorCompanyExt(id=1322181150987104286, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, companyId=1322181150974521373, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=National Institutes for Food and Drug Control, Beijing 102629, China), AuthorCompanyExt(id=1322181150995492895, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322181150248906778, companyId=1322181150974521373, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=中国食品药品检定研究院，北京 102629)])], figs=null, attaches=null, journal=Journal(id=1235980159023624194, delFlag=0, nameCn=中国新药杂志, nameEn=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, issn=1003-3734, eissn=null, cn=11-2850/R, coden=ZXZHA6, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of New Drugs, journalRemark=null, publicationField=null, createdTime=1772610233314, updatedTime=1788948968376, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=ohPEEN//Vz1tDT3ZBNTp4Q==, picEn=f9WK9bvTM4guTmS/iGhOMg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509780974924039, language=CN, name=中国新药杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948968404, updatedTime=1788948968404, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304509781025255688, language=EN, name=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948968416, updatedTime=1788948968416, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1235980733773295621, websiteList=[Website(id=1235982099191222761, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/CN, language=CN, createTime=1772610695884, createBy=18614031015, updateTime=1772610860397, updateBy=18614031015, name=中国新药杂志-中文, tplId=1146099689490845704, title=中国新药杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983918629966444, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=articleTextType, value=kx, createTime=1772611129672, updateTime=1772611129672, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918604800617, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=banner, value=null, createTime=1772611129666, updateTime=1772611129666, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918655132271, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=grayFlag, value=0, createTime=1772611129678, updateTime=1772611129678, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918596412008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611129664, updateTime=1772611129664, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918667715185, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=minRunFlag, value=0, createTime=1772611129681, updateTime=1772611129681, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918617383531, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic, createTime=1772611129669, updateTime=1772611129669, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918659326576, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=silenceFlag, value=0, createTime=1772611129679, updateTime=1772611129679, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918613189226, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1772611129668, updateTime=1772611129668, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918634160749, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeColor, value=null, createTime=1772611129673, updateTime=1772611129673, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918646743662, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeStyle, value=null, createTime=1772611129676, updateTime=1772611129676, creator=18614031015, updator=18614031015)]), Website(id=1235982099270914542, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/EN, language=EN, createTime=1772610695903, createBy=18614031015, updateTime=1772610875891, updateBy=18614031015, name=中国新药杂志-英文, tplId=1146101810881728533, title=Chinese Journal of New Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983955829248630, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=articleTextType, value=kx, createTime=1772611138541, updateTime=1772611138541, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955804082803, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=banner, value=null, createTime=1772611138535, updateTime=1772611138535, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955854414457, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=grayFlag, value=0, createTime=1772611138547, updateTime=1772611138547, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955795694194, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611138533, updateTime=1772611138533, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955866997371, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=minRunFlag, value=0, createTime=1772611138550, updateTime=1772611138550, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955820860021, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic, createTime=1772611138539, updateTime=1772611138539, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955862803066, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=silenceFlag, value=0, createTime=1772611138549, updateTime=1772611138549, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955812471412, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1772611138537, updateTime=1772611138537, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955837637239, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeColor, value=null, createTime=1772611138543, updateTime=1772611138543, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955846025848, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeStyle, value=null, createTime=1772611138545, updateTime=1772611138545, creator=18614031015, updator=18614031015)])], journalTitle=中国新药杂志, weixinUrl=null, journalUrl=http://www.newdrug.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of New Drugs, journalPhotoCn=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPhotoEn=f9WK9bvTM4guTmS/iGhOMg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/Y2021/V30/I14/1334, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/Y2021/V30/I14/1334, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/PDF/Y2021/V30/I14/1334, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/PDF/Y2021/V30/I14/1334, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1627574400000, fullTextJson=null, articleText=null, reference=null)
全屏
文章导航
PDF下载
16
4
关闭全屏
北京市海淀区学院南路86号
010-62662699（运营及技术支持）
qkjq@cast.org.cn
