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Article(id=1322180365805011298, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322180330556076791, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1610553600000, acceptedDateStr=2021-01-14, onlineDate=1793161964131, onlineDateStr=2026-10-28, pubDate=1628956800000, pubDateStr=2021-08-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793161964131, onlineIssueDateStr=2026-10-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793161964131, creator=13701087609, updateTime=1793161964131, updator=13701087609, issue=Issue{id=1322180330556076791, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='15', pageStart='1345', pageEnd='1440', issueExtLink='null', onlineDate='null', pubDate='1628956800000', pubDateStr='2021-08-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793161955726, creator='13701087609', updateTime=1793162082189, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322180861076816464, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322180330556076791, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322180861076816465, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322180330556076791, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1413, endPage=1420, ext={EN=ArticleExt(id=1322180365972783459, articleId=1322180365805011298, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Preparation of glycyrrhizic acid-loaded F127/TPGS mixed nanomicelles and its therapeutic effects on atopic dermatitis in mice, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective:

To investigate the effect of glycyrrhizic acid (GL)-loaded F127/TPGS-MMs in mice model of atopic dermatitis (AD).

Methods:

GL-F127/TPGS-MMs was prepared by thin film dispersion method and characterized by particle size, entrapment efficiency, drug loading and morphology. A AD model was induced by 2, 4-dinitrochlorobenzene (DNCB) in female BALB/c mice. And then the mice were divided into 9 groups: normal control group, model group, dexamethasone positive group (30 mg·kg-1), low (25 mg·kg-1), medium (50 mg·kg-1) and high (100 mg·kg-1) doses of glycyrrhizic acid solution groups and GL-F127/TPGS-MMs group. After oral administration for 14 days, the mice's serum level of IgE, ear swelling degree, thymus index, spleen index, skin thickness, and pathological changes of skin lesions were detected to evaluate the therapeutic effects of GL-F127/TPGS-MMs on AD in mice.

Results:

Compared with the model group, the skin lesion scores of the GL-F127/TPGS-MMs groups significantly decreased on the 28th day of model establishment (P<0.05). After intragastric administration for 14 days, the levels of IgE, ear swelling degree, thymus index, spleen index and skin lesion thickness of mice in GL-F127/TPGS-MMs groups significantly decreased (P<0.05 or 0.01) compared with the model group. The thickness of the epidermis and dermis significantly increased in the model control group and significantly reduced in GL-F127/TPGS-MMs group according to the pathological changes of the skin lesions. Compared with the GL solution groups, the AD pathological changes of the mice in GL-F127/TPGS-MMs high-dose group were significantly improved, and the epidermal hyperplasia, dermal inflammatory infiltration, and intracellular and intercellular edema were significantly reduced.

Conclusion:

GL-F127/TPGS-MMs has a significant therapeutic effect on AD in mice.

, authors=Jun-jun ZHU1, 2, Cheng-ying SHEN1, 2, Jing WANG1, 2, Bao-de SHEN1, Bo DAI1, Hai-long YUAN1, authorsList=Jun-jun ZHU, Cheng-ying SHEN, Jing WANG, Bao-de SHEN, Bo DAI, Hai-long YUAN, authorCompany=null, correspAuthors=Hai-long YUAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322180366245413220, articleId=1322180365805011298, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=甘草酸载入普朗尼克F127/聚乙二醇1000维生素E琥珀酸酯混合纳米胶束的制备及对小鼠特应性皮炎的研究, columnId=1236330556003242277, journalTitle=中国新药杂志, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的：

研究甘草酸（glycyrrhizic acid，GL）载入普朗尼克F127/聚乙二醇1000维生素E琥珀酸酯（TPGS）混合纳米胶束（MMs）后对小鼠特应性皮炎（atopic dermatitis，AD）的治疗作用。

方法：

采用薄膜分散法制备GL-F127/TPGS-MMs，并对其粒径、包封率、形态等进行表征。用2，4-二硝基氯苯（2，4-dinitrochlorobenzene，DNCB）对雌性BALB/c小鼠建立特应性皮炎模型。小鼠分为9组：空白对照组、模型对照组、地塞米松组（30 mg·kg-1）、GL溶液低、中、高剂量组（25，50，100 mg·kg-1）、GL-F127/TPGS-MMs低、中、高剂量组（25，50，100 mg·kg-1）。灌胃给药14 d，检测小鼠血清免疫球蛋白E（IgE）水平、耳肿胀度、胸腺指数、脾脏指数、皮肤厚度、皮损组织病理变化等指标，评价GL-F127/TPGS-MMs对小鼠特应性皮炎的治疗效果。

结果：

与模型组比较，造模d 28 GL-F127/TPGS-MMs组皮损评分均显著降低（P<0.05）。灌胃给药14 d，与模型组比较，GL-F127/TPGS-MMs各剂量组小鼠IgE含量、耳肿胀度、胸腺指数、脾脏指数、皮损厚度显著降低（P<0.05或0.01）。通过观察皮损组织病理变化，模型对照组的表皮和真皮的厚度明显增加，GL-F127/TPGS-MMs治疗组的表皮和真皮厚度明显变薄。与GL溶液组相比，GL-F127/TPGS-MMs高剂量组小鼠AD病理变化明显改善，表皮增生、真皮炎性浸润和细胞内及细胞间的水肿程度明显减轻。

结论：

GL-F127/TPGS-MMs对小鼠特应性皮炎具有显著的治疗作用。

, authors=朱君君1, 2, 沈成英1, 2, 王镜1, 2, 申宝德1, 戴博1, 袁海龙1, authorsList=朱君君, 沈成英, 王镜, 申宝德, 戴博, 袁海龙, authorCompany=null, correspAuthors=袁海龙, authorNote=

朱君君，女，硕士研究生，研究方向：中药新制剂、新剂型、新技术。联系电话：（010）66928506，E-mail：。

, correspAuthorsNote=
袁海龙，男，博士，研究员，博士生导师，研究方向：中药新型给药系统。联系电话：（010）66928505，E-mail：。
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2成都中医药大学药学院，成都　611137, bio={"content":"

朱君君，女，硕士研究生，研究方向：中药新制剂、新剂型、新技术。联系电话：（010）66928506，E-mail：。

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朱君君，女，硕士研究生，研究方向：中药新制剂、新剂型、新技术。联系电话：（010）66928506，E-mail：。

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issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=null, journalName=null, refType=null, unstructuredReference=TORRES T, FERREIRA EO, GONÇALO M, et al. Update on atopic dermatitis[J]. Acta Med Port, 2019, 32(9): 606-613., articleTitle=null, refAbstract=null), Reference(id=1322180370796233114, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180365805011298, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=MOUNSEY SJ, AGIUS E. Atopic dermatitis[J]. Br J Hosp Med (Lond), 2017, 78(12): C183-C187., articleTitle=null, refAbstract=null), Reference(id=1322180370859147675, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180365805011298, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=NGUYEN HL, ANDERSON KR, TOLLEFSON MM. New and emerging therapies for pediatric atopic dermatitis[J]. Paediatr Drugs, 2019, 21(4): 239-260., articleTitle=null, refAbstract=null), Reference(id=1322180370917867932, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180365805011298, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=PENG W, NOVAK N. Pathogenesis of atopic dermatitis[J]. Clin Exp Allergy, 2015, 45(3): 566-574., articleTitle=null, refAbstract=null), Reference(id=1322180370980782493, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180365805011298, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=谭琦, 甘立强, 任发亮, 等. 甘草酸对小鼠特应性皮炎炎症的影响及机制研究[J]. 重庆医科大学学报, 2017, 42(12): 1536-1539., articleTitle=null, refAbstract=null), Reference(id=1322180371077251486, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180365805011298, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=刘斌, 李静, 胡惠清, 等. 白芍总苷对Nc/Nga小鼠特应性皮炎的保护作用[J]. 中国麻风皮肤病杂志, 2017, 33(1): 31-33., articleTitle=null, refAbstract=null), Reference(id=1322180371173720479, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180365805011298, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=张丽霞, 王倩, 赵蓓, 等. 雷公藤多苷与复方甘草酸苷配合抗组胺药治疗特应性皮炎疗效对比[J]. 中国美容医学, 2019, 28(2): 73-77., articleTitle=null, refAbstract=null), Reference(id=1322180371240829344, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180365805011298, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=CHEN T, FU LX, GUO ZP, et al. Involvement of high mobility group box-1 in imiquimod-induced psoriasis-like mice model[J]. J Dermatol, 2017, 44(5): 573-581., articleTitle=null, refAbstract=null), Reference(id=1322180372926939553, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180365805011298, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=黄金花, 马俐, 杜芬, 等. 甘草酸对动脉粥样硬化斑块的消退作用[J]. 中国医院药学杂志, 2015, 35(7): 571-575., articleTitle=null, refAbstract=null), Reference(id=1322180373023408546, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180365805011298, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=KANG DG, SOHN EJ, MUN YJ, et al. Glycyrrhizin ameliorates renal function defects in the early-phase of ischemia-induced acute renal failure[J]. Phytother Res, 2003, 17(8): 947-951., articleTitle=null, refAbstract=null), Reference(id=1322180373094711715, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180365805011298, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=ASHFAQ UA, MASOUD MS, NAWAZ Z, et al. Glycyrrhizin as antiviral agent against Hepatitis C Virus[J]. J Transl Med, 2011, 9(4): 112., articleTitle=null, refAbstract=null), Reference(id=1322180373161820580, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180365805011298, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=WANG Y, ZHANG Y, PENG G, et al. Glycyrrhizin ameliorates atopic dermatitis-like symptoms through inhibition of HMGB1[J]. Int Immunopharmacol, 2018, 60(16): 9-17., articleTitle=null, refAbstract=null), Reference(id=1322180373241512357, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180365805011298, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=蔡夏叶, 徐恩国, 唐梦丹, 等. 复方甘草酸苷调控SDF-1/CXCR-4轴治疗特应性皮炎小鼠的作用机制[J]. 中国药师, 2020, 23(4): 638-642., articleTitle=null, refAbstract=null), Reference(id=1322180373358952870, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180365805011298, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=null, journalName=null, refType=null, unstructuredReference=SHEN CY, ZHU JJ, SONG JW, et al. Formulation of pluronic F127/TPGS mixed micelles to improve the oral absorption of glycyrrhizic acid[J]. Drug Dev Ind Pharm, 2020, 46(7): 1100-1107., articleTitle=null, refAbstract=null), Reference(id=1322180373447033255, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180365805011298, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=null, journalName=null, refType=null, unstructuredReference=朱君君, 沈成英, 王镜, 等. 甘草酸-F127/TPGS混合纳米胶束的制备及其大鼠在体肠吸收研究[J]. 中草药, 2020, 51(7): 1845-1851., articleTitle=null, refAbstract=null), Reference(id=1322180373518336424, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180365805011298, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=null, journalName=null, refType=null, unstructuredReference=袁艳丽, 梁艳粉, 李刚刚, 等. 雷帕霉素软膏对Nc/Nga小鼠特应性皮炎的治疗作用及相关机制研究[J]. 临床和实验医学杂志, 2017, 16(24): 2419-2422., articleTitle=null, refAbstract=null), Reference(id=1322180373585445289, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180365805011298, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=null, journalName=null, refType=null, unstructuredReference=KU JM, HONG SH, KIM HI, et al. Effects of angelicae dahuricae Radix on 2, 4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice model[J]. BMC Complement Altern Med, 2017, 17(1): 98., articleTitle=null, refAbstract=null), Reference(id=1322180373673525674, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180365805011298, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=null, journalName=null, refType=null, unstructuredReference=YU HY, LI HY, LI YX, et al. Effect of isoliquiritigenin for the treatment of atopic dermatitis-like skin lesions in mice[J]. Arch Dermatol Res, 2017, 309(10): 805-813., articleTitle=null, refAbstract=null), Reference(id=1322180373740634539, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180365805011298, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[19], rfOrder=18, authorNames=null, journalName=null, refType=null, unstructuredReference=BORDBAR N, KARIMI MH, AMIRGHOFRAN Z. The effect of glycyrrhizin on maturation and T cell stimulating activity of dendritic cells[J]. Cell Immunol, 2012, 280(1): 44-49., articleTitle=null, refAbstract=null), Reference(id=1322180373807743404, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180365805011298, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[20], rfOrder=19, authorNames=null, journalName=null, refType=null, unstructuredReference=GUTERMUTH J, OLLERT M, RING J, et al. Mouse models of atopic eczema critically evaluated[J]. Int Arch Allergy Immunol, 2004, 135(3): 262-276., articleTitle=null, refAbstract=null), Reference(id=1322180373895823789, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180365805011298, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[21], rfOrder=20, authorNames=null, journalName=null, refType=null, unstructuredReference=JIN H, HE R, OYOSHI M, et al. Animal models of atopic dermatitis[J]. J Invest Dermatol, 2009, 129(1): 31-40., articleTitle=null, refAbstract=null), Reference(id=1322180374009069998, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180365805011298, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[22], rfOrder=21, authorNames=null, journalName=null, refType=null, unstructuredReference=纪莲, 马铁, 狄正鸿, 等. 小鼠特应性皮炎建模方法的改进[J]. 实验动物与比较医学, 2018, 38(4): 267-271., articleTitle=null, refAbstract=null), Reference(id=1322180374109733295, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180365805011298, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[23], rfOrder=22, authorNames=null, journalName=null, refType=null, unstructuredReference=王欣欣, 李思佳, 关洪全, 等. DNCB对BALB/c小鼠特应性皮炎的诱导作用及其机制[J]. 吉林大学学报(医学版), 2020, 46(3): 439-443, 669., articleTitle=null, refAbstract=null), Reference(id=1322180374189425072, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180365805011298, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[24], rfOrder=23, authorNames=null, journalName=null, refType=null, unstructuredReference=LIN L, ZHOU YW, LI HF, et al. Polysaccharide extracted from Chinese white wax scale ameliorates 2, 4-dinitrochlorobenzene-induced atopic dermatitis-like symptoms in BALB/c mice[J]. Saudi Pharm J, 2017, 25(4): 625-632., articleTitle=null, refAbstract=null), Reference(id=1322180374281699761, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180365805011298, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[25], rfOrder=24, authorNames=null, journalName=null, refType=null, unstructuredReference=吴春燕, 白方树, 徐晓静. 益肤透明质酸凝胶配合复方甘草酸苷治疗过敏性皮肤病的疗效观察及对外周血T淋巴细胞平衡的影响[J]. 世界临床药物, 2020(6): 451-455., articleTitle=null, refAbstract=null), Reference(id=1322180374361391538, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180365805011298, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[26], rfOrder=25, authorNames=null, journalName=null, refType=null, unstructuredReference=CHEN C, WANG LS, CAO FR, et al. Formulation of 20(S)-protopanaxadiol nanocrystals to improve oral bioavailability and brain delivery[J]. 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甘草酸载入普朗尼克F127/聚乙二醇1000维生素E琥珀酸酯混合纳米胶束的制备及对小鼠特应性皮炎的研究
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朱君君 1, 2 , 沈成英 1, 2 , 王镜 1, 2 , 申宝德 1 , 戴博 1 , 袁海龙 1
中国新药杂志 | 实验研究 2021,30(15): 1413-1420
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中国新药杂志 |实验研究 2021 , 30 (15) : 1413 -1420
甘草酸载入普朗尼克F127/聚乙二醇1000维生素E琥珀酸酯混合纳米胶束的制备及对小鼠特应性皮炎的研究
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朱君君，女，硕士研究生，研究方向：中药新制剂、新剂型、新技术。联系电话：（010）66928506，E-mail：。

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朱君君，女，硕士研究生，研究方向：中药新制剂、新剂型、新技术。联系电话：（010）66928506，E-mail：。

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朱君君1, 2 , 沈成英1, 2, 王镜1, 2, 申宝德1, 戴博1, 袁海龙1
作者信息
  • 1空军特色医学中心药学部，北京　100142
  • 2成都中医药大学药学院，成都　611137
通讯作者:
袁海龙，男，博士，研究员，博士生导师，研究方向：中药新型给药系统。联系电话：（010）66928505，E-mail：。
作者简介:

朱君君，女，硕士研究生，研究方向：中药新制剂、新剂型、新技术。联系电话：（010）66928506，E-mail：。

Preparation of glycyrrhizic acid-loaded F127/TPGS mixed nanomicelles and its therapeutic effects on atopic dermatitis in mice
Jun-jun ZHU1, 2 , Cheng-ying SHEN1, 2, Jing WANG1, 2, Bao-de SHEN1, Bo DAI1, Hai-long YUAN1
Affiliations
  • 1Department of Pharmacy, Air Force Medical Center, Beijing 100142, China
  • 2College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
出版时间: 2021-08-15
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摘要
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目的：

研究甘草酸（glycyrrhizic acid，GL）载入普朗尼克F127/聚乙二醇1000维生素E琥珀酸酯（TPGS）混合纳米胶束（MMs）后对小鼠特应性皮炎（atopic dermatitis，AD）的治疗作用。

方法：

采用薄膜分散法制备GL-F127/TPGS-MMs，并对其粒径、包封率、形态等进行表征。用2，4-二硝基氯苯（2，4-dinitrochlorobenzene，DNCB）对雌性BALB/c小鼠建立特应性皮炎模型。小鼠分为9组：空白对照组、模型对照组、地塞米松组（30 mg·kg-1）、GL溶液低、中、高剂量组（25，50，100 mg·kg-1）、GL-F127/TPGS-MMs低、中、高剂量组（25，50，100 mg·kg-1）。灌胃给药14 d，检测小鼠血清免疫球蛋白E（IgE）水平、耳肿胀度、胸腺指数、脾脏指数、皮肤厚度、皮损组织病理变化等指标，评价GL-F127/TPGS-MMs对小鼠特应性皮炎的治疗效果。

结果：

与模型组比较，造模d 28 GL-F127/TPGS-MMs组皮损评分均显著降低（P<0.05）。灌胃给药14 d，与模型组比较，GL-F127/TPGS-MMs各剂量组小鼠IgE含量、耳肿胀度、胸腺指数、脾脏指数、皮损厚度显著降低（P<0.05或0.01）。通过观察皮损组织病理变化，模型对照组的表皮和真皮的厚度明显增加，GL-F127/TPGS-MMs治疗组的表皮和真皮厚度明显变薄。与GL溶液组相比，GL-F127/TPGS-MMs高剂量组小鼠AD病理变化明显改善，表皮增生、真皮炎性浸润和细胞内及细胞间的水肿程度明显减轻。

结论：

GL-F127/TPGS-MMs对小鼠特应性皮炎具有显著的治疗作用。

甘草酸  /  纳米胶束  /  特应性皮炎  /  炎症  /  皮肤
Objective:

To investigate the effect of glycyrrhizic acid (GL)-loaded F127/TPGS-MMs in mice model of atopic dermatitis (AD).

Methods:

GL-F127/TPGS-MMs was prepared by thin film dispersion method and characterized by particle size, entrapment efficiency, drug loading and morphology. A AD model was induced by 2, 4-dinitrochlorobenzene (DNCB) in female BALB/c mice. And then the mice were divided into 9 groups: normal control group, model group, dexamethasone positive group (30 mg·kg-1), low (25 mg·kg-1), medium (50 mg·kg-1) and high (100 mg·kg-1) doses of glycyrrhizic acid solution groups and GL-F127/TPGS-MMs group. After oral administration for 14 days, the mice's serum level of IgE, ear swelling degree, thymus index, spleen index, skin thickness, and pathological changes of skin lesions were detected to evaluate the therapeutic effects of GL-F127/TPGS-MMs on AD in mice.

Results:

Compared with the model group, the skin lesion scores of the GL-F127/TPGS-MMs groups significantly decreased on the 28th day of model establishment (P<0.05). After intragastric administration for 14 days, the levels of IgE, ear swelling degree, thymus index, spleen index and skin lesion thickness of mice in GL-F127/TPGS-MMs groups significantly decreased (P<0.05 or 0.01) compared with the model group. The thickness of the epidermis and dermis significantly increased in the model control group and significantly reduced in GL-F127/TPGS-MMs group according to the pathological changes of the skin lesions. Compared with the GL solution groups, the AD pathological changes of the mice in GL-F127/TPGS-MMs high-dose group were significantly improved, and the epidermal hyperplasia, dermal inflammatory infiltration, and intracellular and intercellular edema were significantly reduced.

Conclusion:

GL-F127/TPGS-MMs has a significant therapeutic effect on AD in mice.

glycyrrhizic acid  /  nanomicelles  /  atopic dermatitis  /  inflammation  /  skin
朱君君, 沈成英, 王镜, 申宝德, 戴博, 袁海龙. 甘草酸载入普朗尼克F127/聚乙二醇1000维生素E琥珀酸酯混合纳米胶束的制备及对小鼠特应性皮炎的研究. 中国新药杂志, 2021 , 30 (15) : 1413 -1420 .
Jun-jun ZHU, Cheng-ying SHEN, Jing WANG, Bao-de SHEN, Bo DAI, Hai-long YUAN. Preparation of glycyrrhizic acid-loaded F127/TPGS mixed nanomicelles and its therapeutic effects on atopic dermatitis in mice[J]. Chinese Journal of New Drugs, 2021 , 30 (15) : 1413 -1420 .
基金
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  • 国家自然科学基金资助项目(81803741)
  • 北京市科委重点资助项目(Z171100001717026)
  • 军事飞行人员用药目录研究资助项目(BKJ15J005)
文献
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参考文献 引证文献
排序方式：
[1]
TORRES T, FERREIRA EO, GONÇALO M, et al. Update on atopic dermatitis[J]. Acta Med Port, 2019, 32(9): 606-613.
[2]
MOUNSEY SJ, AGIUS E. Atopic dermatitis[J]. Br J Hosp Med (Lond), 2017, 78(12): C183-C187.
[3]
NGUYEN HL, ANDERSON KR, TOLLEFSON MM. New and emerging therapies for pediatric atopic dermatitis[J]. Paediatr Drugs, 2019, 21(4): 239-260.
[4]
PENG W, NOVAK N. Pathogenesis of atopic dermatitis[J]. Clin Exp Allergy, 2015, 45(3): 566-574.
[5]
谭琦, 甘立强, 任发亮, 等. 甘草酸对小鼠特应性皮炎炎症的影响及机制研究[J]. 重庆医科大学学报, 2017, 42(12): 1536-1539.
[6]
刘斌, 李静, 胡惠清, 等. 白芍总苷对Nc/Nga小鼠特应性皮炎的保护作用[J]. 中国麻风皮肤病杂志, 2017, 33(1): 31-33.
[7]
张丽霞, 王倩, 赵蓓, 等. 雷公藤多苷与复方甘草酸苷配合抗组胺药治疗特应性皮炎疗效对比[J]. 中国美容医学, 2019, 28(2): 73-77.
[8]
CHEN T, FU LX, GUO ZP, et al. Involvement of high mobility group box-1 in imiquimod-induced psoriasis-like mice model[J]. J Dermatol, 2017, 44(5): 573-581.
[9]
黄金花, 马俐, 杜芬, 等. 甘草酸对动脉粥样硬化斑块的消退作用[J]. 中国医院药学杂志, 2015, 35(7): 571-575.
[10]
KANG DG, SOHN EJ, MUN YJ, et al. Glycyrrhizin ameliorates renal function defects in the early-phase of ischemia-induced acute renal failure[J]. Phytother Res, 2003, 17(8): 947-951.
[11]
ASHFAQ UA, MASOUD MS, NAWAZ Z, et al. Glycyrrhizin as antiviral agent against Hepatitis C Virus[J]. J Transl Med, 2011, 9(4): 112.
[12]
WANG Y, ZHANG Y, PENG G, et al. Glycyrrhizin ameliorates atopic dermatitis-like symptoms through inhibition of HMGB1[J]. Int Immunopharmacol, 2018, 60(16): 9-17.
[13]
蔡夏叶, 徐恩国, 唐梦丹, 等. 复方甘草酸苷调控SDF-1/CXCR-4轴治疗特应性皮炎小鼠的作用机制[J]. 中国药师, 2020, 23(4): 638-642.
[14]
SHEN CY, ZHU JJ, SONG JW, et al. Formulation of pluronic F127/TPGS mixed micelles to improve the oral absorption of glycyrrhizic acid[J]. Drug Dev Ind Pharm, 2020, 46(7): 1100-1107.
[15]
朱君君, 沈成英, 王镜, 等. 甘草酸-F127/TPGS混合纳米胶束的制备及其大鼠在体肠吸收研究[J]. 中草药, 2020, 51(7): 1845-1851.
[16]
袁艳丽, 梁艳粉, 李刚刚, 等. 雷帕霉素软膏对Nc/Nga小鼠特应性皮炎的治疗作用及相关机制研究[J]. 临床和实验医学杂志, 2017, 16(24): 2419-2422.
[17]
KU JM, HONG SH, KIM HI, et al. Effects of angelicae dahuricae Radix on 2, 4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice model[J]. BMC Complement Altern Med, 2017, 17(1): 98.
[18]
YU HY, LI HY, LI YX, et al. Effect of isoliquiritigenin for the treatment of atopic dermatitis-like skin lesions in mice[J]. Arch Dermatol Res, 2017, 309(10): 805-813.
[19]
BORDBAR N, KARIMI MH, AMIRGHOFRAN Z. The effect of glycyrrhizin on maturation and T cell stimulating activity of dendritic cells[J]. Cell Immunol, 2012, 280(1): 44-49.
[20]
GUTERMUTH J, OLLERT M, RING J, et al. Mouse models of atopic eczema critically evaluated[J]. Int Arch Allergy Immunol, 2004, 135(3): 262-276.
[21]
JIN H, HE R, OYOSHI M, et al. Animal models of atopic dermatitis[J]. J Invest Dermatol, 2009, 129(1): 31-40.
[22]
纪莲, 马铁, 狄正鸿, 等. 小鼠特应性皮炎建模方法的改进[J]. 实验动物与比较医学, 2018, 38(4): 267-271.
[23]
王欣欣, 李思佳, 关洪全, 等. DNCB对BALB/c小鼠特应性皮炎的诱导作用及其机制[J]. 吉林大学学报(医学版), 2020, 46(3): 439-443, 669.
[24]
LIN L, ZHOU YW, LI HF, et al. Polysaccharide extracted from Chinese white wax scale ameliorates 2, 4-dinitrochlorobenzene-induced atopic dermatitis-like symptoms in BALB/c mice[J]. Saudi Pharm J, 2017, 25(4): 625-632.
[25]
吴春燕, 白方树, 徐晓静. 益肤透明质酸凝胶配合复方甘草酸苷治疗过敏性皮肤病的疗效观察及对外周血T淋巴细胞平衡的影响[J]. 世界临床药物, 2020(6): 451-455.
[26]
CHEN C, WANG LS, CAO FR, et al. Formulation of 20(S)-protopanaxadiol nanocrystals to improve oral bioavailability and brain delivery[J]. Int J Pharm, 2016, 497(1-2): 239-247.
2021年第30卷第15期
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  • 首发时间：2026-10-28
  • 出版时间：2021-08-15
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  • 录用日期：2021-01-14
基金
国家自然科学基金资助项目(81803741)
北京市科委重点资助项目(Z171100001717026)
军事飞行人员用药目录研究资助项目(BKJ15J005)
作者信息
    1空军特色医学中心药学部，北京　100142
    2成都中医药大学药学院，成都　611137

通讯作者:

袁海龙，男，博士，研究员，博士生导师，研究方向：中药新型给药系统。联系电话：（010）66928505，E-mail：。
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https://castjournals.cast.org.cn/joweb/zgxyzz/CN/1322180365805011298
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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