Article(id=1322180329440395335, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322180288214577608, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1610640000000, acceptedDateStr=2021-01-15, onlineDate=1793161955461, onlineDateStr=2026-10-28, pubDate=1630252800000, pubDateStr=2021-08-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793161955461, onlineIssueDateStr=2026-10-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793161955461, creator=13701087609, updateTime=1793161955461, updator=13701087609, issue=Issue{id=1322180288214577608, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='16', pageStart='1441', pageEnd='1536', issueExtLink='null', onlineDate='null', pubDate='1630252800000', pubDateStr='2021-08-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793161945632, creator='13701087609', updateTime=1793162101003, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322180940143644721, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322180288214577608, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322180940147839026, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322180288214577608, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1451, endPage=1455, ext={EN=ArticleExt(id=1322180329608167496, articleId=1322180329440395335, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=A new therapeutic agent for adult chronic idiopathic constipation, lactitol, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Lactotol was first registered by Novartis in Switzerland in 1985. Its trade name is Importal. It is used for the treatment of hyperammonemia caused by hepatic encephalopathy. On February 12, 2020, it was approved by the US FDA for the treatment of chronic idiopathic constipation in adults. Its trade name is Pizensy. Latitol can increase the defecation frequency of patients, and the treatment efficacy for chronic idiopathic constipation in adults is not inferior to that of rubiprostone. The most common adverse reactions are upper respiratory tract infection, abdominal distension and diarrhea. The mechanism of action, pharmacokinetics, effectiveness, and safety of lactitol were reviewed in this article.

, authors=Shao-qiang LI^{1, 2}, Jian-chun LI¹, Ya-tong ZHANG², Xin HU², authorsList=Shao-qiang LI, Jian-chun LI, Ya-tong ZHANG, Xin HU, authorCompany=null, correspAuthors=Xin HU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322180329864020041, articleId=1322180329440395335, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=新型成人慢性特发性便秘治疗药物乳糖醇, columnId=1236331162679955859, journalTitle=中国新药杂志, columnName=新药述评与论坛, runingTitle=null, highlight=null, articleAbstract=

乳糖醇（lactitol）于1985年由诺华公司首次在瑞士注册，商品名为Importal，用于肝性脑病引起的高氨血症。2020年2月12日获美国FDA批准用于治疗成人慢性特发性便秘，商品名为Pizensy。lactitol可增加患者排便频率，治疗成人慢性特发性便秘不劣于鲁比前列酮。其最常见的不良反应为上呼吸道感染、腹胀、腹泻等。本文对lactitol的作用机制、药动学、有效性、安全性等进行综述。

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²北京医院药学部，国家老年医学中心，药物临床风险与个体化应用评价北京市重点实验室，北京　100730, bio={"content":"

李少强，男，硕士研究生，研究方向：医院药学。E-mail：1811210147@pku.edu.cn。

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李少强，男，硕士研究生，研究方向：医院药学。E-mail：1811210147@pku.edu.cn。

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Embryotoxicity and teratogenicity studies with lactitol in rats[J]. Int J Toxicol, 1992, 11(2): 249-257., articleTitle=null, refAbstract=null), Reference(id=1322180334117044342, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180329440395335, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=SINKELDAM EJ. Multigeneration reproduction study of lactitol in rats[J]. 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