Article(id=1322180313288135086, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322180288214577608, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1621785600000, acceptedDateStr=2021-05-24, onlineDate=1793161951610, onlineDateStr=2026-10-28, pubDate=1630252800000, pubDateStr=2021-08-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793161951610, onlineIssueDateStr=2026-10-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793161951610, creator=13701087609, updateTime=1793161951610, updator=13701087609, issue=Issue{id=1322180288214577608, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='16', pageStart='1441', pageEnd='1536', issueExtLink='null', onlineDate='null', pubDate='1630252800000', pubDateStr='2021-08-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793161945632, creator='13701087609', updateTime=1793162101003, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322180940143644721, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322180288214577608, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322180940147839026, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322180288214577608, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1489, endPage=1497, ext={EN=ArticleExt(id=1322180315024576944, articleId=1322180313288135086, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Research progress in improving water solubility and targeting of paclitaxel by prodrugs, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Paclitaxel, the first natural plant-derived chemical approved by the US FDA, is a broad-spectrum antitumor drug with good antitumor activity. However, due to its complex chemical structure, disadvantages such as poor water solubility and poor absorption limit its widespread clinical application. Therefore, how to improve its water solubility, bioavailability and targeting effect in tumor tissues has been a difficult and important issue to be solved. In this article, we briefly reviewed the research progress of paclitaxel prodrugs that improve its water solubility and targeting in recent years.

, authors=Jing-jing MA, Zheng YANG, Hui GUO, Ying-ying ZHANG, Li-xiang LIU, Jing ZHOU, Ru-yi JIN, Zhi LI, Yu-ping TANG, authorsList=Jing-jing MA, Zheng YANG, Hui GUO, Ying-ying ZHANG, Li-xiang LIU, Jing ZHOU, Ru-yi JIN, Zhi LI, Yu-ping TANG, authorCompany=null, correspAuthors=Hui GUO, Yu-ping TANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322180315355926961, articleId=1322180313288135086, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=水溶性及靶向性紫杉醇前药的研究进展, columnId=1236330553964810454, journalTitle=中国新药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

获得美国FDA批准的第一个来自天然植物的化学药物紫杉醇（paclitaxel，PTX）是一个广谱抗肿瘤药物，具有良好的抗肿瘤活性。但由于其本身复杂的化学结构、水溶性差、吸收不好等缺点限制了其在临床上的广泛应用。因此，如何改善其水溶性，提高生物利用度及其在肿瘤组织的靶向性，是近年来亟待解决的难点与重点。本文就近年来以改善其水溶性及靶向性的紫杉醇前药的研究进展进行简单综述。

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马晶晶，女，硕士研究生，研究方向：天然药物化学。E-mail：1152996783@qq.com。

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马晶晶，女，硕士研究生，研究方向：天然药物化学。E-mail：1152996783@qq.com。

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杨政，男，硕士研究生，研究方向：天然药物化学。E-mail：1308162478@qq.com。

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杨政，男，硕士研究生，研究方向：天然药物化学。E-mail：1308162478@qq.com。

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