Article(id=1322180311773983321, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322180288214577608, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1611763200000, acceptedDateStr=2021-01-28, onlineDate=1793161951249, onlineDateStr=2026-10-28, pubDate=1630252800000, pubDateStr=2021-08-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793161951249, onlineIssueDateStr=2026-10-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793161951249, creator=13701087609, updateTime=1793161951249, updator=13701087609, issue=Issue{id=1322180288214577608, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='16', pageStart='1441', pageEnd='1536', issueExtLink='null', onlineDate='null', pubDate='1630252800000', pubDateStr='2021-08-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793161945632, creator='13701087609', updateTime=1793162101003, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322180940143644721, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322180288214577608, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322180940147839026, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322180288214577608, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1524, endPage=1529, ext={EN=ArticleExt(id=1322180311958532698, articleId=1322180311773983321, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Formula optimization and evaluation of pulchinenoside B4-loaded long-circulation liposomes, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To optimize the formula of long-circulation liposomes loaded with pulchinenoside B4 (PB4-L) by central composite design-response surface method and characterize the liposomes.
Methods: PB4-L were prepared by ethanol injection and the encapsulation efficiency was determined by ultrafiltration centrifugation. The formula of PB4-L was optimized by the four-factor, three-level central composite design-response surface method. The particle size, zeta potential and morphology of PB4-L were characterized by laser particle zeta-sizer and transmission electron microscope. The stability of the liposomes was evaluated.
Results: The optimal formula of PB4-L was as follows: the phospholipid content was 2.4%, the weight ratio of phospholipids to cholesterol was 3∶1, the weight ratio of lipids to drug was 2∶1, and the DSPE-PEG2000 content was 2.4%. The encapsulation efficiency of PB4-L was 76.9%, with a mean particle size of (408.7±1.1) nm, polymer dispersity index (PDI) of 0.16, and zeta potential of (-45.2±0.2) mV. The morphology study of PB4-L showed that the liposomes were round-shaped with good dispersity. PB4-L was stable in 10% FBS-containing medium.
Conclusion: The formula of PB4-L was optimized by central composite design-response surface method. The liposomes were characterized by a high encapsulation efficiency, a uniform particle size distribution and a good serum stability in vitro.
, authors=Jun LIU
1, 2, Ying LUO
1, Jing ZHANG
1, Xiang LI
2, authorsList=Jun LIU, Ying LUO, Jing ZHANG, Xiang LI, authorCompany=null, correspAuthors=Jing ZHANG, Xiang LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322180312226968155, articleId=1322180311773983321, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=白头翁皂苷B4长循环脂质体的处方优化与评价, columnId=1236330556003242277, journalTitle=中国新药杂志, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的： 采用星点设计-效应面法优化白头翁皂苷B4长循环脂质体（long-circulation pulchinenoside B4-loaded liposomes，PB4-L）的处方并进行评价。
方法： 采用乙醇注入法制备脂质体，采用超滤离心法测定制剂包封率。采用4因素3水平星点设计-效应面法优化PB4-L的最佳处方；采用激光粒径仪和透射电镜对制剂的粒径、Zeta电位和形态特征进行表征，并对脂质体的稳定性进行评价。
结果： 星点设计-效应面法得到PB4-L最优处方如下：磷脂含量为2.4%，磷脂与胆固醇质量比为3∶1，脂药比为2∶1，DSPE-PEG2000含量为2.4%，在最佳制备工艺下，PB4-L的包封率为76.9%，平均粒径为（408.7±1.1）nm，聚合物分散性指数（PDI）为（0.16±0.08），Zeta电位为（-45.2±0.2）mV，透射电镜照片显示脂质体外观圆整，分散性较好；制剂在10%胎牛血清（FBS）培养基中稳定性良好。
结论： 采用星点设计-效应面法优化的PB4-L制备工艺可行，所得脂质体包封率高、粒径分布均匀，具有良好的体外血清稳定性。
, authors=刘骏
1, 2, 罗莹
1, 张婧
1, 李翔
2, authorsList=刘骏, 罗莹, 张婧, 李翔, authorCompany=null, correspAuthors=张婧, 李翔, authorNote=
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1Jiangxi University of Chinese Medicine Key Laboratory of Modern Preparation of Chinese Medicines, Ministry of Education, Nanchang 330006, China
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1江西中医药大学 现代中药制剂教育部重点实验室，南昌 330006
2江西中医药大学 中药固体制剂制造技术国家工程研究中心，南昌 330006, bio={"content":"
刘骏，男，硕士研究生，主要从事药物新剂型研究。联系电话：（0791）87119661，E-mail：2466714731@qq.com。
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刘骏，男，硕士研究生，主要从事药物新剂型研究。联系电话：（0791）87119661，E-mail：2466714731@qq.com。
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