Article(id=1322180303167271458, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322180288214577608, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1614528000000, acceptedDateStr=2021-03-01, onlineDate=1793161949196, onlineDateStr=2026-10-28, pubDate=1630252800000, pubDateStr=2021-08-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793161949196, onlineIssueDateStr=2026-10-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793161949196, creator=13701087609, updateTime=1793161949196, updator=13701087609, issue=Issue{id=1322180288214577608, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='16', pageStart='1441', pageEnd='1536', issueExtLink='null', onlineDate='null', pubDate='1630252800000', pubDateStr='2021-08-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793161945632, creator='13701087609', updateTime=1793162101003, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322180940143644721, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322180288214577608, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322180940147839026, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322180288214577608, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1498, endPage=1502, ext={EN=ArticleExt(id=1322180303351820835, articleId=1322180303167271458, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=The prospect of Janus kinase inhibitors in rheumatic diseases, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Rheumatism immunity disease is one of the chronic diseases which affect health seriously. A series of biological agents targeting cytokines have greatly improved the prognosis and quality of life of patients, but still can not meet the needs of disease treatment, thus searching new drugs has become an important task in the treatment of rheumatoid immune diseases. JAK-STAT is an important signaling pathway, which is involved in the development of many autoimmune diseases. JAK inhibitors can block the production of a variety of inflammatory cytokines and have anti-inflammatory and immunomodulatory effects. JAK inhibitors are gaining increasing attention in the field of rheumatologic disorders. In this review, the application status and prospect of these drugs in autoimmune diseases are summarized for the first time.

, authors=Qing-fang ZHOU, Yu XIA, authorsList=Qing-fang ZHOU, Yu XIA, authorCompany=null, correspAuthors=Yu XIA, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322180304136155684, articleId=1322180303167271458, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=Janus激酶抑制剂在风湿性疾病中的应用前景, columnId=1236330553964810454, journalTitle=中国新药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

风湿免疫性疾病是严重影响身体健康的慢性疾病之一。以细胞因子为靶标的一系列生物制剂极大地改善了患者的预后和生活质量，但仍不能满足疾病治疗的需要，寻找新的药物成为风湿性疾病治疗领域的重要任务。Janus酪氨酸激酶-信号转导及转录激活因子（JAK-STAT）是一类重要的信号传导通路，与许多免疫性疾病发生有关。JAK抑制剂可阻断多种炎症细胞因子的生成，有抗炎及调节免疫的作用。JAK抑制剂在风湿性疾病领域越来越受到重视，本文综述了该类药物在风湿性疾病中的应用现状及前景。

, authors=周青芳, 夏宇, authorsList=周青芳, 夏宇, authorCompany=null, correspAuthors=夏宇, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=azXYSFmmvB8WDn54vB7yIA==, magXml=0bTm2a4VJk/Gcxam3AlOgQ==, pdfUrl=null, pdf=Y91/m1kw6/P9zxkQE2y18A==, pdfFileSize=1285889, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=Ocqs07StB9UAK1XebPMCqw==, mapNumber=null, fund=null)}, authors=[Author(id=1322180306031981097, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180303167271458, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=462371620@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322180306111672875, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180303167271458, authorId=1322180306031981097, language=EN, stringName=Qing-fang ZHOU, firstName=Qing-fang, middleName=null, lastName=ZHOU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Rheumatology and Immunology, Shenzhen Children's Hospital of China Medical University, Shenzhen 518038, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322180306195558956, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180303167271458, authorId=1322180306031981097, language=CN, stringName=周青芳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=中国医科大学深圳市儿童医院风湿免疫科，深圳　518038, bio={"content":"

周青芳，女，硕士研究生，主要从事风湿免疫常见疾病研究。E-mail：462371620@qq.com。

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周青芳，女，硕士研究生，主要从事风湿免疫常见疾病研究。E-mail：462371620@qq.com。

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