中国新药杂志

外泌体miRNAs在抑郁症中的作用及作为其生物标志物的研究进展

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柴玉慧 ¹ , 蔡雅文 ¹ , 缪明星 ² , 颜天华 ¹

中国新药杂志 | 综述 2021,30(16): 1466-1470

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中国新药杂志 |综述 2021 , 30 (16) : 1466 -1470

外泌体miRNAs在抑郁症中的作用及作为其生物标志物的研究进展

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柴玉慧¹, 蔡雅文¹, 缪明星², 颜天华¹

作者信息

¹中国药科大学　基础医学与临床药学学院生理教研室，南京　210009

²中国药科大学　中国药科大学国家药学实验教学示范中心，南京　210009

通讯作者:

颜天华，男，副教授，研究方向：心血管药理学。E-mail：13016931191@126.com。

作者简介:

柴玉慧，女，硕士研究生，研究方向：心血管药理学。E-mail：2474951653@qq.com。

The role of exosomal miRNAs in depression and progress in research on it as biomarker

Yu-hui CHAI¹, Ya-wen CAI¹, Ming-xing MIAO², Tian-hua YAN¹

Affiliations

¹China Pharmaceutical University Department of Physiology and Pharmacology, College of Basic Medicine and Clinical Pharmacy, Nanjing 210009, China

²China Pharmaceutical University National Pharmacy Experimental Teaching Demonstration Center, Nanjing 210009, China

出版时间: 2021-08-30

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摘要

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抑郁症（depression）是一类严重危害人类身心健康的精神疾病，临床表现为显著而持久的心境低落、情绪低沉、思维迟缓等症状。然而，其发病机制仍不明确，治疗靶点仍不清晰。外泌体（exosome）是携带脂质、蛋白质、DNA、微小核糖核酸（miRNA）等生物信息分子的脂质双分子层囊性小泡，介导细胞间的信息传递并调控相关信号通路表达。目前，外泌体miRNA在抑郁症中的作用研究较为广泛，为抑郁症早期诊断和治疗提供了新的应用前景。本文就外泌体miRNA在抑郁症中的最新研究进展进行综述。

关键词

抑郁症 / 外泌体 / miRNA / 作用机制 / 生物标志物

Abstract

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Depression is a type of mental illness that seriously endangers the physical and mental health of humans. The clinical manifestations are marked and lasting symptoms such as depressed mood, low mood, slow thinking and other symptoms. However, its pathogenesis and the therapeutic target is still unclear. Exosomes are lipid bilayer cystic vesicles carrying biological information molecules such as lipids, proteins, DNA, and miRNAs, which mediate information transmission between cells and regulate the expression of related signal pathways. At present, the study of exosomal miRNAs in depression is relatively extensive, providing new application prospects for early diagnosis and treatment of depression. In this paper, we mainly reviewed the latest research progress in exosomal miRNAs in depression.

Key words

depression / exosomes / miRNA / mechanism / biomarker

引用本文

柴玉慧, 蔡雅文, 缪明星, 颜天华. 外泌体miRNAs在抑郁症中的作用及作为其生物标志物的研究进展. 中国新药杂志, 2021 , 30 (16) : 1466 -1470 .

Yu-hui CHAI, Ya-wen CAI, Ming-xing MIAO, Tian-hua YAN. The role of exosomal miRNAs in depression and progress in research on it as biomarker[J]. Chinese Journal of New Drugs, 2021 , 30 (16) : 1466 -1470 .

参考文献

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2021年第30卷第16期

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首发时间：2026-10-28
出版时间：2021-08-30

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录用日期：2020-11-18

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¹中国药科大学　基础医学与临床药学学院生理教研室，南京　210009

²中国药科大学　中国药科大学国家药学实验教学示范中心，南京　210009

通讯作者:

颜天华，男，副教授，研究方向：心血管药理学。E-mail：13016931191@126.com。

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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