Article(id=1322180263619183256, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322180233244038010, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1620316800000, acceptedDateStr=2021-05-07, onlineDate=1793161939767, onlineDateStr=2026-10-28, pubDate=1631635200000, pubDateStr=2021-09-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793161939767, onlineIssueDateStr=2026-10-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793161939767, creator=13701087609, updateTime=1793161939767, updator=13701087609, issue=Issue{id=1322180233244038010, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='17', pageStart='1537', pageEnd='1632', issueExtLink='null', onlineDate='null', pubDate='1631635200000', pubDateStr='2021-09-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793161932525, creator='13701087609', updateTime=1793162118166, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322181011941732619, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322180233244038010, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322181011945926924, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322180233244038010, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1616, endPage=1620, ext={EN=ArticleExt(id=1322180263786955417, articleId=1322180263619183256, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=The effect of solvent on crystal transformation process of prasugrel hydrogen sulfate and its mechanism, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To determine the stable relationship of the polymorph system of prasugrel hydrogen sulfate, to clarify the influence rule of solvent on the polymorph nucleation of prasugrel hydrogen sulfate, and to reveal the crystal transformation mechanism of prasugrel hydrogen sulfate.
Methods: In this study, crystal forms Ⅰ and Ⅱ of prasugrel hydrogen sulfate were selected as the research subjects, focusing on their solvent-mediated transcrystallisation proces, the off-line monitoring of the crystal form composition of suspended solid phase and the change of the solution concentration with time during the crystallization process. The influence mechanism of solvent on the crystal transformation process was also revealed.
Results: Solvent-mediated crystallization of Prasugrel hydrogen sulfate form Ⅰ to form Ⅱ was monitored by X-ray diffraction, the results of which indicated that the rate-determining step during this process was the nucleation and growth of the prasugrel hydrogen sulfate form Ⅱ.
Conclusion: Consider the crystal transformation rate of prasugrel hydrogen sulfate in three solvents, including butanone, MIK and methyl acetate, and the solubility relationship of crystal form Ⅱ in them, it can be concluded that the nucleation process of prasugrel hydrogen sulfate form Ⅱ is affected not only by solubility, but also by the strength of hydrogen bond between the molecules.
, authors=Min LU
1, Yue GONG
1, Wei DU
1, Xue-kui WANG
1, Na TANG
1, Qiu-xiang YIN
2, authorsList=Min LU, Yue GONG, Wei DU, Xue-kui WANG, Na TANG, Qiu-xiang YIN, authorCompany=null, correspAuthors=Wei DU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322180264105722522, articleId=1322180263619183256, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=溶剂对普拉格雷硫酸氢盐晶型转变过程的影响机制, columnId=1236330556003242277, journalTitle=中国新药杂志, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的： 为了确定普拉格雷硫酸氢盐多晶型体系的稳定性关系，阐明溶剂对其多晶型成核的影响规律，并揭示普拉格雷硫酸氢盐的转晶机制。
方法： 本文以普拉格雷硫酸氢盐晶型Ⅰ和晶型Ⅱ为研究对象，聚焦其溶剂介导的转晶过程，离线监测了转晶过程中悬浮固相的晶型组成和溶液浓度随时间的变化趋势，并揭示溶剂对其晶型转变过程的影响机制。
结果： 通过X-射线衍射法测定了普拉格雷硫酸氢盐Ⅰ晶型向Ⅱ晶型的溶剂介导转晶过程，结果表明该转晶过程的速率控制步骤为普拉格雷硫酸氢盐Ⅱ晶型的成核与生长。
结论： 综合考虑普拉格雷硫酸氢盐在丁酮、乙酸甲酯、甲基异丁基甲酮3种溶剂的转晶速率以及Ⅱ晶型在3种溶剂中的溶解度关系可知，普拉格雷硫酸氢盐Ⅱ晶型的成核过程除了受到溶解度的影响，还与普拉格雷硫酸氢盐分子和溶剂分子间氢键的强弱有关。
, authors=卢敏
1, 宫月
1, 杜威
1, 王学魁
1, 唐娜
1, 尹秋响
2, authorsList=卢敏, 宫月, 杜威, 王学魁, 唐娜, 尹秋响, authorCompany=null, correspAuthors=杜威, authorNote=
, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=rJBXtE5nWaqtr53oEQveYg==, magXml=i+3C+jGJLE7Iu9Af5zoI6Q==, pdfUrl=null, pdf=CNb8FXphxuAdfkW5ZfjUQw==, pdfFileSize=1447796, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=bzntORPK5ZfdqYaD5iTJUA==, mapNumber=null, fund=null)}, authors=[Author(id=1322180265988965026, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=282303158@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322180266089628324, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, authorId=1322180265988965026, language=EN, stringName=Min LU, firstName=Min, middleName=null, lastName=LU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1Tianjin University of Science and Technology, College of Chemical Engineering and Materials Science, Tianjin 300457, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322180266169320101, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, authorId=1322180265988965026, language=CN, stringName=卢敏, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1天津科技大学化工与材料学院，天津 300457, bio={"content":"
卢敏，女，硕士研究生，研究方向：盐化工及晶体形貌。E-mail：282303158@qq.com。
"}, bioImg=null, bioContent=
卢敏，女，硕士研究生，研究方向：盐化工及晶体形貌。E-mail：282303158@qq.com。
, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322180264311243419, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, xref=1, ext=[AuthorCompanyExt(id=1322180264323826332, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, companyId=1322180264311243419, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1Tianjin University of Science and Technology, College of Chemical Engineering and Materials Science, Tianjin 300457, China), AuthorCompanyExt(id=1322180264336409245, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, companyId=1322180264311243419, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1天津科技大学化工与材料学院，天津 300457)])]), Author(id=1322180266249011879, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322180266341286569, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, authorId=1322180266249011879, language=EN, stringName=Yue GONG, firstName=Yue, middleName=null, lastName=GONG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1Tianjin University of Science and Technology, College of Chemical Engineering and Materials Science, Tianjin 300457, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322180266416784042, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, authorId=1322180266249011879, language=CN, stringName=宫月, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1天津科技大学化工与材料学院，天津 300457, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322180264311243419, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, xref=1, ext=[AuthorCompanyExt(id=1322180264323826332, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, companyId=1322180264311243419, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1Tianjin University of Science and Technology, College of Chemical Engineering and Materials Science, Tianjin 300457, China), AuthorCompanyExt(id=1322180264336409245, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, companyId=1322180264311243419, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1天津科技大学化工与材料学院，天津 300457)])]), Author(id=1322180266496475820, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=duwei@tust.edu.cn, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1322180266571973294, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, authorId=1322180266496475820, language=EN, stringName=Wei DU, firstName=Wei, middleName=null, lastName=DU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1Tianjin University of Science and Technology, College of Chemical Engineering and Materials Science, Tianjin 300457, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322180266643276463, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, authorId=1322180266496475820, language=CN, stringName=杜威, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1天津科技大学化工与材料学院，天津 300457, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322180264311243419, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, xref=1, ext=[AuthorCompanyExt(id=1322180264323826332, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, companyId=1322180264311243419, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1Tianjin University of Science and Technology, College of Chemical Engineering and Materials Science, Tianjin 300457, China), AuthorCompanyExt(id=1322180264336409245, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, companyId=1322180264311243419, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1天津科技大学化工与材料学院，天津 300457)])]), Author(id=1322180266722968241, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322180266794271411, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, authorId=1322180266722968241, language=EN, stringName=Xue-kui WANG, firstName=Xue-kui, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1Tianjin University of Science and Technology, College of Chemical Engineering and Materials Science, Tianjin 300457, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322180266865574580, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, authorId=1322180266722968241, language=CN, stringName=王学魁, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1天津科技大学化工与材料学院，天津 300457, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322180264311243419, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, xref=1, ext=[AuthorCompanyExt(id=1322180264323826332, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, companyId=1322180264311243419, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1Tianjin University of Science and Technology, College of Chemical Engineering and Materials Science, Tianjin 300457, China), AuthorCompanyExt(id=1322180264336409245, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, companyId=1322180264311243419, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1天津科技大学化工与材料学院，天津 300457)])]), Author(id=1322180266932683446, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322180267020763832, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, authorId=1322180266932683446, language=EN, stringName=Na TANG, firstName=Na, middleName=null, lastName=TANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1Tianjin University of Science and Technology, College of Chemical Engineering and Materials Science, Tianjin 300457, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322180267096261305, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, authorId=1322180266932683446, language=CN, stringName=唐娜, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1天津科技大学化工与材料学院，天津 300457, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322180264311243419, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, xref=1, ext=[AuthorCompanyExt(id=1322180264323826332, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, companyId=1322180264311243419, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1Tianjin University of Science and Technology, College of Chemical Engineering and Materials Science, Tianjin 300457, China), AuthorCompanyExt(id=1322180264336409245, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, companyId=1322180264311243419, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1天津科技大学化工与材料学院，天津 300457)])]), Author(id=1322180267171758779, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322180267238867645, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, authorId=1322180267171758779, language=EN, stringName=Qiu-xiang YIN, firstName=Qiu-xiang, middleName=null, lastName=YIN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=
2School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322180267314365118, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, authorId=1322180267171758779, language=CN, stringName=尹秋响, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=
2天津大学化工学院，天津 300072, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322180265879913118, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, xref=2, ext=[AuthorCompanyExt(id=1322180265888301727, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, companyId=1322180265879913118, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China), AuthorCompanyExt(id=1322180265896690336, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, companyId=1322180265879913118, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2天津大学化工学院，天津 300072)])])], keywords=[Keyword(id=1322180267423417023, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, language=EN, orderNo=1, keyword=prasugrel hydrogen sulfate), Keyword(id=1322180267511497408, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, language=EN, orderNo=2, keyword=polymorphs), Keyword(id=1322180267586994881, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, language=EN, orderNo=3, keyword=solvent-mediated polymorphic transformation), Keyword(id=1322180267662492354, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, language=EN, orderNo=4, keyword=X-ray diffraction), Keyword(id=1322180267750572739, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, language=EN, orderNo=5, keyword=nucleation and growth), Keyword(id=1322180267817681604, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, language=CN, orderNo=1, keyword=普拉格雷硫酸氢盐), Keyword(id=1322180267888984773, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, language=CN, orderNo=2, keyword=多晶型), Keyword(id=1322180267977065158, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, language=CN, orderNo=3, keyword=溶剂介导转晶), Keyword(id=1322180268048368327, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, language=CN, orderNo=4, keyword=X-射线衍射), Keyword(id=1322180268128060104, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, language=CN, orderNo=5, keyword=成核生长)], refs=[Reference(id=1322180268371329739, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=null, journalName=null, refType=null, unstructuredReference=周云松, 王平保, 刘颖, 等. 噻吩并四氢吡啶衍生物的合成及其抗血小板聚集活性研究[J]. 药学学报, 2011, 46(1): 70-74., articleTitle=null, refAbstract=null), Reference(id=1322180268446827212, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=何雷, 魏娜, 丁长坤, 等. 普拉格雷有关物质的合成[J]. 中国医药工业杂志, 2018, 49(1): 57-61., articleTitle=null, refAbstract=null), Reference(id=1322180268509741773, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHAO ZQ. The hydrosulfate of prasugrel, its pharmaceutical combination and use thereof: US, 20110124675[P]. 2011-05-26., articleTitle=null, refAbstract=null), Reference(id=1322180268572656334, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=HANMI HOLDINGS CO, LTD. PARK, CHANG HEE BAEK,
et al. Novel polymorphic form of Prasugrel-hydrogen sulfate: US, WO2010KR05632[P]. 2011-03-10., articleTitle=null, refAbstract=null), Reference(id=1322180268664931023, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=TUKSAR M, BILJAN T, ZEGARAC M. Crystalline forms of prasugrel salts: US, 9012641[P]. 2015-04-21., articleTitle=null, refAbstract=null), Reference(id=1322180270325875409, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=BECHTLOFF B, NORDHOFF S, ULRICH J. Pseudopolymorphs in industrial use[J].
Cryst Res Technol, 2001, 36(12): 1315-1328., articleTitle=null, refAbstract=null), Reference(id=1322180270430733010, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=王娜, 陶晓龙, 史欢欢, 等. 过程分析技术在晶体多晶型研究中的应用[J]. 化学工业与工程, 2017, 34(2): 1-9., articleTitle=null, refAbstract=null), Reference(id=1322180270514619091, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=汤伟伟, 李斯, 龚俊波. 有机晶体成核分子机理研究进展[J]. 化学工业与工程, 2018, 35(3): 2-11., articleTitle=null, refAbstract=null), Reference(id=1322180270615282388, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=肖燕, 王静康, 尹秋响, 等. 固体药物晶型定量分析方法[J]. 石油化工, 2015, 44(1): 11-18, 10., articleTitle=null, refAbstract=null), Reference(id=1322180270703362773, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=马乐伟, 杜葳, 赵春顺. 药物晶型定量分析方法的研究进展[J]. 药学学报, 2011, 46(8): 896-903., articleTitle=null, refAbstract=null), Reference(id=1322180270787248854, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=DU W, YIN QX, HAO HX,
et al. Solution-mediated polymorphic transformation of prasugrel hydrochloride from form Ⅱ to form Ⅰ[J].
Ind Eng Chem Res, 2014, 53(14): 5652-5659., articleTitle=null, refAbstract=null), Reference(id=1322180270850163415, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=GU CH, YOUNG V, GRANT DJ. Polymorph screening: influence of solvents on the rate of solvent-mediated polymorphic transformation[J].
J Pharm Sci, 2001, 90(11): 1878-1890., articleTitle=null, refAbstract=null), Reference(id=1322180270929855192, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=KHAMAR D, ZEGLINSKI J, MEALEY D,
et al. Investigating the role of solvent-solute interaction in crystal nucleation of salicylic acid from organic solvents[J].
J Am Chem Soc, 2014, 136(33): 11664-11673., articleTitle=null, refAbstract=null), Reference(id=1322180270996964057, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=null, journalName=null, refType=null, unstructuredReference=MURPHY D, RODRÍGUEZ-CINTRÓN F, LANGEVIN B,
et al. Solution-mediated phase transformation of anhydrous to dihydrate carbamazepine and the effect of lattice disorder[J].
Int J Pharm, 2002, 246(1-2): 121-134., articleTitle=null, refAbstract=null), Reference(id=1322180271076655834, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=null, journalName=null, refType=null, unstructuredReference=GIORDANO F. Polymorphism in pharmaceutical solids[J].
J Control Release, 2001, 71(3): 354-355., articleTitle=null, refAbstract=null), Reference(id=1322180271139570395, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=null, journalName=null, refType=null, unstructuredReference=YANG LQ, YIN QX, HOU BH,
et al. Solubility and thermodynamic stability of the enantiotropic polymorphs of 2, 3, 5-trimethyl-1, 4-diacetoxybenzene[J].
Ind Eng Chem Res, 2013, 52(7): 2477-2485., articleTitle=null, refAbstract=null), Reference(id=1322180271219262172, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=null, journalName=null, refType=null, unstructuredReference=GU CH, YOUNG V, GRANT DJ. Polymorph screening: influence of solvents on the rate of solvent-mediated polymorphic transformation[J].
J Pharm Sci, 2001, 90(11): 1878-1890., articleTitle=null, refAbstract=null), Reference(id=1322180271298953949, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=null, journalName=null, refType=null, unstructuredReference=MAHER A, CROKER DM, RASMUSON ÅC,
et al. Solution mediated polymorphic transformation: form Ⅱ to form Ⅲ piracetam in ethanol[J].
Cryst Growth Des, 2012, 12(12): 6151-6157., articleTitle=null, refAbstract=null), Reference(id=1322180271361868510, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[19], rfOrder=18, authorNames=null, journalName=null, refType=null, unstructuredReference=CROKER D, HODNETT BK. Mechanistic features of polymorphic transformations: the role of surfaces[J].
Cryst Growth Des, 2010, 10(6): 2806-2816., articleTitle=null, refAbstract=null)], funds=[Fund(id=1322180268216140489, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, awardId=21506162, language=CN, fundingSource=国家自然科学基金青年基金资助项目(21506162), fundOrder=null, country=null), Fund(id=1322180268283249354, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, awardId=17JCQNJC13200, language=CN, fundingSource=天津市自然科学基金青年基金资助项目(17JCQNJC13200), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1322180264311243419, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, xref=1, ext=[AuthorCompanyExt(id=1322180264323826332, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, companyId=1322180264311243419, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1Tianjin University of Science and Technology, College of Chemical Engineering and Materials Science, Tianjin 300457, China), AuthorCompanyExt(id=1322180264336409245, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, companyId=1322180264311243419, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1天津科技大学化工与材料学院，天津 300457)]), AuthorCompany(id=1322180265879913118, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, xref=2, ext=[AuthorCompanyExt(id=1322180265888301727, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, companyId=1322180265879913118, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China), AuthorCompanyExt(id=1322180265896690336, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180263619183256, companyId=1322180265879913118, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2天津大学化工学院，天津 300072)])], figs=null, attaches=null, journal=Journal(id=1235980159023624194, delFlag=0, nameCn=中国新药杂志, nameEn=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, issn=1003-3734, eissn=null, cn=11-2850/R, coden=ZXZHA6, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of New Drugs, journalRemark=null, publicationField=null, createdTime=1772610233314, updatedTime=1788948968376, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=ohPEEN//Vz1tDT3ZBNTp4Q==, picEn=f9WK9bvTM4guTmS/iGhOMg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509780974924039, language=CN, name=中国新药杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948968404, updatedTime=1788948968404, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304509781025255688, language=EN, name=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948968416, updatedTime=1788948968416, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1235980733773295621, websiteList=[Website(id=1235982099191222761, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/CN, language=CN, createTime=1772610695884, createBy=18614031015, updateTime=1772610860397, updateBy=18614031015, name=中国新药杂志-中文, tplId=1146099689490845704, title=中国新药杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983918629966444, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=articleTextType, value=kx, createTime=1772611129672, updateTime=1772611129672, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918604800617, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=banner, value=null, createTime=1772611129666, updateTime=1772611129666, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918655132271, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=grayFlag, value=0, createTime=1772611129678, updateTime=1772611129678, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918596412008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611129664, updateTime=1772611129664, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918667715185, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=minRunFlag, value=0, createTime=1772611129681, updateTime=1772611129681, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918617383531, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic, createTime=1772611129669, updateTime=1772611129669, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918659326576, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=silenceFlag, value=0, createTime=1772611129679, updateTime=1772611129679, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918613189226, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1772611129668, updateTime=1772611129668, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918634160749, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeColor, value=null, createTime=1772611129673, updateTime=1772611129673, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918646743662, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeStyle, value=null, createTime=1772611129676, updateTime=1772611129676, creator=18614031015, updator=18614031015)]), Website(id=1235982099270914542, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/EN, language=EN, createTime=1772610695903, createBy=18614031015, updateTime=1772610875891, updateBy=18614031015, name=中国新药杂志-英文, tplId=1146101810881728533, title=Chinese Journal of New Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983955829248630, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=articleTextType, value=kx, createTime=1772611138541, updateTime=1772611138541, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955804082803, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=banner, value=null, createTime=1772611138535, updateTime=1772611138535, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955854414457, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=grayFlag, value=0, createTime=1772611138547, updateTime=1772611138547, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955795694194, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611138533, updateTime=1772611138533, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955866997371, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=minRunFlag, value=0, createTime=1772611138550, updateTime=1772611138550, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955820860021, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic, createTime=1772611138539, updateTime=1772611138539, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955862803066, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=silenceFlag, value=0, createTime=1772611138549, updateTime=1772611138549, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955812471412, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1772611138537, updateTime=1772611138537, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955837637239, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeColor, value=null, createTime=1772611138543, updateTime=1772611138543, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955846025848, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeStyle, value=null, createTime=1772611138545, updateTime=1772611138545, creator=18614031015, updator=18614031015)])], journalTitle=中国新药杂志, weixinUrl=null, journalUrl=http://www.newdrug.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of New Drugs, journalPhotoCn=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPhotoEn=f9WK9bvTM4guTmS/iGhOMg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/Y2021/V30/I17/1616, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/Y2021/V30/I17/1616, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/PDF/Y2021/V30/I17/1616, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/PDF/Y2021/V30/I17/1616, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1631635200000, fullTextJson=null, articleText=null, reference=null)
全屏
文章导航
PDF下载
12
3
关闭全屏
北京市海淀区学院南路86号
010-62662699（运营及技术支持）
qkjq@cast.org.cn
