Article(id=1322180255041827087, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322180233244038010, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1613923200000, acceptedDateStr=2021-02-22, onlineDate=1793161937722, onlineDateStr=2026-10-28, pubDate=1631635200000, pubDateStr=2021-09-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793161937722, onlineIssueDateStr=2026-10-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793161937722, creator=13701087609, updateTime=1793161937722, updator=13701087609, issue=Issue{id=1322180233244038010, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='17', pageStart='1537', pageEnd='1632', issueExtLink='null', onlineDate='null', pubDate='1631635200000', pubDateStr='2021-09-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793161932525, creator='13701087609', updateTime=1793162118166, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322181011941732619, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322180233244038010, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322181011945926924, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322180233244038010, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1600, endPage=1604, ext={EN=ArticleExt(id=1322180255217987856, articleId=1322180255041827087, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Research progress in the influence of carrier materials on the dissolution behavior of solid dispersion and its mechanism, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Solid dispersion (SD) is one of the most valuable methods to improve the solubility, dissolution rate and oral bioavailability of poorly soluble drugs. SD disperses poorly soluble drugs into carrier materials, and improves the solubility and dissolution of drugs by changing their dispersion state, increasing specific surface area, increasing wettability, and so on, so as to improve the bioavailability. Dissolution is one of the most important pharmacological properties of SD and is the basis for determining whether it can successfully improve the bioavailability for the poorly soluble drugs. In SD, the carrier material is the largest component in the formulation, and the nature of it is an important factor that affects the dissolution process and dissolution behavior. Based on these, this article reviews the effects of carrier materials on the dissolution behavior and saturation solubility of SD, and provides references of selecting a suitable carrier material for SD.

, authors=Ping CAI, Li-quan OU, Guo-wei ZHAO, Qing-yun ZENG, Xin-li LIANG, Wei DONG, Zheng-gen LIAO, authorsList=Ping CAI, Li-quan OU, Guo-wei ZHAO, Qing-yun ZENG, Xin-li LIANG, Wei DONG, Zheng-gen LIAO, authorCompany=null, correspAuthors=Guo-wei ZHAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322180257206087953, articleId=1322180255041827087, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=载体材料对固体分散体溶出行为的影响及机制研究进展, columnId=1236330553964810454, journalTitle=中国新药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

固体分散体（solid dispersion，SD）是提高难溶性药物溶解度、溶出速率及改善其口服生物利用度最具有应用价值的方法之一。SD将难溶性药物分散到载体材料中，通过改变药物分散状态、增加比表面积、增加润湿性等来改善药物的溶解度和溶出行为，进而提高药物的生物利用度。溶出是SD最重要的药剂学性质之一，是决定SD能否成功改善难溶性药物生物利用度的基础。在SD中，载体材料是配方中最大的组成部分，载体材料的性质是影响溶解过程和溶出行为的重要因素之一。基于此，本文综述了载体材料对SD溶出行为、饱和溶解度等方面的影响，为SD选择合适的载体材料提供参考。

, authors=蔡萍, 欧丽泉, 赵国巍, 曾庆云, 梁新丽, 董伟, 廖正根, authorsList=蔡萍, 欧丽泉, 赵国巍, 曾庆云, 梁新丽, 董伟, 廖正根, authorCompany=null, correspAuthors=赵国巍, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=0pVWxsG9PSEa1XuqKRIWTw==, magXml=54G+W5x5K1wa1cBrwZiPew==, pdfUrl=null, pdf=ELhUmUtY/PRAD9DhZkQsJQ==, pdfFileSize=1259633, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=+Kw5f2De2ezV5dUIJ2SKlA==, mapNumber=null, fund=null)}, authors=[Author(id=1322180257508077846, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180255041827087, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=499369329@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322180257596158232, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180255041827087, authorId=1322180257508077846, language=EN, stringName=Ping CAI, firstName=Ping, middleName=null, lastName=CAI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322180257667461401, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180255041827087, authorId=1322180257508077846, language=CN, stringName=蔡萍, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=江西中医药大学现代中药制剂教育部重点实验室，南昌　330004, bio={"content":"

蔡萍，女，硕士研究生，研究方向：中药药剂学。E-mail：499369329@qq.com。

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蔡萍，女，硕士研究生，研究方向：中药药剂学。E-mail：499369329@qq.com。

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