Article(id=1322180241188049872, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322180233244038010, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1615478400000, acceptedDateStr=2021-03-12, onlineDate=1793161934420, onlineDateStr=2026-10-28, pubDate=1631635200000, pubDateStr=2021-09-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793161934420, onlineIssueDateStr=2026-10-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793161934420, creator=13701087609, updateTime=1793161934420, updator=13701087609, issue=Issue{id=1322180233244038010, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='17', pageStart='1537', pageEnd='1632', issueExtLink='null', onlineDate='null', pubDate='1631635200000', pubDateStr='2021-09-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793161932525, creator='13701087609', updateTime=1793162118166, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322181011941732619, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322180233244038010, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322181011945926924, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322180233244038010, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1537, endPage=1545, ext={EN=ArticleExt(id=1322180241355822033, articleId=1322180241188049872, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Research on technological innovation of tumor vaccine field based on patent analysis, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Tumor vaccines have great potential in tumor immunotherapy. Effective, controllable and long-acting tumor vaccine therapy will play a greater role in treating tumors, preventing tumor recurrence, prolonging patient survival and tumor prevention. This research analyzes the applications and grants of invention patents in the global tumor vaccine field, from the technology birthplaces, target markets, technology innovation entities, technology innovation topics and other aspects, to reveal the technology innovation trend. There are 5 635 invention patent applications in the global tumor vaccine field, with 1 839 having been granted, close to one third, indication that technological innovation is active. The United States and China are both the main technology birthplaces and also the target market. In addition, the markets in Europe and Japan are also attracting much attention. The global technological innovation entities in the field of tumor vaccines are mainly enterprises and universities/institutes. Immatics Biotechnologies in Germany, Oncotherapy Science in Japan, and Glaxo Smith Kline in the United Kingdom are leading the research and development of global tumor vaccines. The technological innovation entities in China are mainly universities/institutes, but enterprises are also beginning to play an important role. The technology innovation topics focus on antigens related to tumor vaccines, tumor immune activity, polypeptide modification, and vaccine-related biotechnology. This research analyzes the global invention patents in the field of tumor vaccines, reveals the trend and direction of technological innovation, and provides information support for tumor immunotherapy research. At the same time, it provides a new research perspective for technology development from the angle of information science.

, authors=Ting ZHANG, Juan CHEN, Zhao-lian OUYANG, authorsList=Ting ZHANG, Juan CHEN, Zhao-lian OUYANG, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322180241703949266, articleId=1322180241188049872, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=基于专利分析的肿瘤疫苗领域技术创新态势研究, columnId=1236331162679955859, journalTitle=中国新药杂志, columnName=新药述评与论坛, runingTitle=null, highlight=null, articleAbstract=

肿瘤疫苗在肿瘤免疫治疗中有巨大潜力，有效、可控和长效的肿瘤疫苗治疗将在治疗肿瘤、防止肿瘤复发、延长患者生存期及肿瘤预防方面发挥更大的作用。本研究通过全球肿瘤疫苗领域的发明专利申请与授权、技术发源地、目标市场、技术创新实体及技术创新主题等进行分析，揭示技术创新态势。研究结果显示，全球肿瘤疫苗领域共有发明专利申请5 635组，其中已获得授权的发明专利有1 839组，技术创新活跃；美国和中国是主要的技术发源地和目标市场；全球肿瘤疫苗领域的技术创新实体以企业和高校/研究所为主，德国Immatics Biotechnologies公司、日本Oncotherapy Science公司及英国葛兰素史克公司引领全球肿瘤疫苗研发；中国的技术创新实体以高校/研究所为主，但企业也开始发挥重要作用；技术创新主题聚焦于肿瘤疫苗相关的抗原研究、肿瘤免疫活性、多肽修饰技术、疫苗相关生物技术。本研究通过对全球肿瘤疫苗领域的发明专利进行分析，揭示技术创新态势，明确技术创新方向，为我国肿瘤免疫治疗研究提供信息服务支持，同时从情报学角度为技术开发提供新的研究视角。

, authors=张婷, 陈娟, 欧阳昭连, authorsList=张婷, 陈娟, 欧阳昭连, authorCompany=null, correspAuthors=null, authorNote=, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=YyP0JRb5L7hYvbMkfw3kEA==, magXml=UONjgWUuAdf/0qrQV9z7Tw==, pdfUrl=null, pdf=OsecrvdoR7X2AKP6q0z8RQ==, pdfFileSize=2172768, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=A9QNSYzhF1WwaXeQVgB0vQ==, mapNumber=null, fund=null)}, authors=[Author(id=1322180243545248728, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=brendatingting@126.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322180243624940506, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, authorId=1322180243545248728, language=EN, stringName=Ting ZHANG, firstName=Ting, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Institute of Medical Information/Medical Library, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100020, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322180243700437979, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, authorId=1322180243545248728, language=CN, stringName=张婷, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=中国医学科学院/北京协和医学院　医学信息研究所/图书馆，北京　100020, bio={"content":"

张婷，女，理学博士，副研究员，主要从事药物专利分析、技术预测、战略情报等研究。联系电话：（010）52328705，E-mail：brendatingting@126.com。

"}, bioImg=null, bioContent=

张婷，女，理学博士，副研究员，主要从事药物专利分析、技术预测、战略情报等研究。联系电话：（010）52328705，E-mail：brendatingting@126.com。

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322180241930441683, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, xref=null, ext=[AuthorCompanyExt(id=1322180241943024596, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, companyId=1322180241930441683, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Institute of Medical Information/Medical Library, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100020, China), AuthorCompanyExt(id=1322180241951413205, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, companyId=1322180241930441683, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=中国医学科学院/北京协和医学院　医学信息研究所/图书馆，北京　100020)])]), Author(id=1322180243767546845, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322180243855627231, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, authorId=1322180243767546845, language=EN, stringName=Juan CHEN, firstName=Juan, middleName=null, lastName=CHEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Institute of Medical Information/Medical Library, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100020, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322180243926930400, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, authorId=1322180243767546845, language=CN, stringName=陈娟, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=中国医学科学院/北京协和医学院　医学信息研究所/图书馆，北京　100020, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322180241930441683, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, xref=null, ext=[AuthorCompanyExt(id=1322180241943024596, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, companyId=1322180241930441683, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Institute of Medical Information/Medical Library, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100020, China), AuthorCompanyExt(id=1322180241951413205, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, companyId=1322180241930441683, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=中国医学科学院/北京协和医学院　医学信息研究所/图书馆，北京　100020)])]), Author(id=1322180243985650658, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322180244069536740, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, authorId=1322180243985650658, language=EN, stringName=Zhao-lian OUYANG, firstName=Zhao-lian, middleName=null, lastName=OUYANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Institute of Medical Information/Medical Library, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100020, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322180244157617125, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, authorId=1322180243985650658, language=CN, stringName=欧阳昭连, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=中国医学科学院/北京协和医学院　医学信息研究所/图书馆，北京　100020, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322180241930441683, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, xref=null, ext=[AuthorCompanyExt(id=1322180241943024596, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, companyId=1322180241930441683, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Institute of Medical Information/Medical Library, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100020, China), AuthorCompanyExt(id=1322180241951413205, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, companyId=1322180241930441683, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=中国医学科学院/北京协和医学院　医学信息研究所/图书馆，北京　100020)])])], keywords=[Keyword(id=1322180244258280422, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, language=EN, orderNo=1, keyword=tumor vaccine), Keyword(id=1322180244363138023, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, language=EN, orderNo=2, keyword=invention patent), Keyword(id=1322180244455412712, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, language=EN, orderNo=3, keyword=patent analysis), Keyword(id=1322180244547687401, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, language=EN, orderNo=4, keyword=technological innovation), Keyword(id=1322180244631573482, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, language=CN, orderNo=1, keyword=肿瘤疫苗), Keyword(id=1322180244715459563, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, language=CN, orderNo=2, keyword=发明专利), Keyword(id=1322180244803539948, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, language=CN, orderNo=3, keyword=专利分析), Keyword(id=1322180244900008941, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, language=CN, orderNo=4, keyword=技术创新)], refs=[Reference(id=1322180245445268466, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=null, journalName=null, refType=null, unstructuredReference=SIEGEL RL, MILLER KD, JEMAL A. Cancer statistics, 2019[J]. CA Cancer J Clin, 2019, 69(1): 7-34., articleTitle=null, refAbstract=null), Reference(id=1322180245516571635, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=DONG HD, MARKOVIC SN. The basics of cancer immunotherapy[M]. Cham: Springer International Publishing, 2018., articleTitle=null, refAbstract=null), Reference(id=1322180245583680500, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=张婷, 欧阳昭连. 基于cortellis数据库的肿瘤免疫治疗药物研发态势分析[J]. 中国新药杂志, 2019, 28(1): 1-9., articleTitle=null, refAbstract=null), Reference(id=1322180245692732405, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=袁瑕, 王琳, 涂杰霞, 等. 1例COVID-19危重型患者免疫治疗的疗效评估[J]. 今日药学, 2021, 31(1): 53-56., articleTitle=null, refAbstract=null), Reference(id=1322180245785007094, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=梁霄, 陈枢青. 新生抗原在精准肿瘤免疫治疗中的研究进展[J]. 中国现代应用药学, 2021, 38(8): 897-903., articleTitle=null, refAbstract=null), Reference(id=1322180245910836215, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=殷保兵, 彭智主译. 肿瘤免疫治疗概要[M]. 北京: 北京科学技术出版社, 2019., articleTitle=null, refAbstract=null), Reference(id=1322180245982139384, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=贺庆, 高华, 王军志. 个体化治疗性肿瘤疫苗的临床前药效学研究进展[J]. 中国新药杂志, 2020, 29(21): 2401-2409., articleTitle=null, refAbstract=null), Reference(id=1322180246053442553, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=IGARASHI Y, SASADA T. Cancer vaccines: toward the next breakthrough in cancer immunotherapy[J]. J Immunol Res, 2020(5): 5825401., articleTitle=null, refAbstract=null), Reference(id=1322180246137328634, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=张婷, 卢岩, 陈娟, 等. 我国生物医药领域技术创新态势研究[J]. 中国新药杂志, 2020, 29(22): 2521-2527., articleTitle=null, refAbstract=null), Reference(id=1322180246208631803, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=张婷, 欧阳昭连. 基于专利分析及可视化的抗肿瘤药竞争态势研究[J]. 中国新药杂志, 2018, 27(20): 2337-2345., articleTitle=null, refAbstract=null), Reference(id=1322180246296712188, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=张婷, 卢岩, 陈娟, 等. PD-1/PD-L1抑制剂领域技术创新态势及其科学基础研究[J]. 中国药事, 2020, 34(10): 1171-1179., articleTitle=null, refAbstract=null), Reference(id=1322180246388986877, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHANG T, CHEN J, OUYANG Z. Key fields and key technical points of pharmaceuticals: a perspective from patent analysis. BIBE 2018. International Conference on Biological Information and Biomedical Engineering[C]. 2018: 1-13., articleTitle=null, refAbstract=null), Reference(id=1322180248045736958, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=RANGANATHAN B, MILLER C, SINSKEY A. Biocompatible synthetic and semi-synthetic polymers-A patent analysis[J]. Pharm Nanotechnol, 2018, 6(1): 28-37., articleTitle=null, refAbstract=null), Reference(id=1322180248138011647, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=null, journalName=null, refType=null, unstructuredReference=ZHANG T, CHEN J, JIA X. Identification of the key fields and their key technical points of oncology by patent analysis[J]. PLoS One, 2015, 10(11): e0143573., articleTitle=null, refAbstract=null), Reference(id=1322180248221897728, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=null, journalName=null, refType=null, unstructuredReference=黄可, 周俊, 李玉杰, 等. 基于市场与专利分析的肿瘤疫苗发展趋势研究[J]. 科技通报, 2019, 35(5): 225-229., articleTitle=null, refAbstract=null), Reference(id=1322180248301588480, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=null, journalName=null, refType=null, unstructuredReference=黄聪, 白丽. 树突状细胞肿瘤疫苗及其联合应用的研究进展[J]. 细胞与分子免疫学杂志, 2019, 35(12): 1141-1145., articleTitle=null, refAbstract=null), Reference(id=1322180248381280257, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=null, journalName=null, refType=null, unstructuredReference=张叔人. 肿瘤免疫治疗进展[M]. 北京: 中国协和医科大学出版社, 2017., articleTitle=null, refAbstract=null), Reference(id=1322180248456777730, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=null, journalName=null, refType=null, unstructuredReference=闻玉梅. 治疗性疫苗[M]. 第2版. 北京: 科学出版社, 2020., articleTitle=null, refAbstract=null)], funds=[Fund(id=1322180245025838062, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, awardId=null, language=CN, fundingSource=中国工程院咨询研究项目“天津市生物医药创新与产业发展战略研究”, fundOrder=null, country=null), Fund(id=1322180245130695663, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, awardId=2016YFC0104805, language=CN, fundingSource=国家重点研发计划(2016YFC0104805), fundOrder=null, country=null), Fund(id=1322180245227164656, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, awardId=2020XG010, language=CN, fundingSource=中国医学科学院/北京协和医学院医学信息研究所/图书馆新冠肺炎疫情专项课题(2020XG010), fundOrder=null, country=null), Fund(id=1322180245332022257, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, awardId=2020XG012, language=CN, fundingSource=中国医学科学院/北京协和医学院医学信息研究所/图书馆新冠肺炎疫情专项课题(2020XG012), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1322180241930441683, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, xref=null, ext=[AuthorCompanyExt(id=1322180241943024596, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, companyId=1322180241930441683, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Institute of Medical Information/Medical Library, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100020, China), AuthorCompanyExt(id=1322180241951413205, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322180241188049872, companyId=1322180241930441683, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=中国医学科学院/北京协和医学院　医学信息研究所/图书馆，北京　100020)])], figs=null, attaches=null, journal=Journal(id=1235980159023624194, delFlag=0, nameCn=中国新药杂志, nameEn=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, issn=1003-3734, eissn=null, cn=11-2850/R, coden=ZXZHA6, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of New Drugs, journalRemark=null, publicationField=null, createdTime=1772610233314, updatedTime=1788948968376, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=ohPEEN//Vz1tDT3ZBNTp4Q==, picEn=f9WK9bvTM4guTmS/iGhOMg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509780974924039, language=CN, name=中国新药杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948968404, updatedTime=1788948968404, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304509781025255688, language=EN, name=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948968416, updatedTime=1788948968416, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1235980733773295621, websiteList=[Website(id=1235982099191222761, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/CN, language=CN, createTime=1772610695884, createBy=18614031015, updateTime=1772610860397, updateBy=18614031015, name=中国新药杂志-中文, tplId=1146099689490845704, title=中国新药杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983918629966444, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=articleTextType, value=kx, createTime=1772611129672, updateTime=1772611129672, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918604800617, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=banner, value=null, createTime=1772611129666, updateTime=1772611129666, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918655132271, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=grayFlag, value=0, createTime=1772611129678, updateTime=1772611129678, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918596412008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611129664, updateTime=1772611129664, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918667715185, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=minRunFlag, value=0, createTime=1772611129681, updateTime=1772611129681, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918617383531, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic, createTime=1772611129669, updateTime=1772611129669, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918659326576, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=silenceFlag, value=0, createTime=1772611129679, updateTime=1772611129679, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918613189226, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1772611129668, updateTime=1772611129668, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918634160749, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeColor, value=null, createTime=1772611129673, updateTime=1772611129673, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918646743662, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeStyle, value=null, createTime=1772611129676, updateTime=1772611129676, creator=18614031015, updator=18614031015)]), Website(id=1235982099270914542, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/EN, language=EN, createTime=1772610695903, createBy=18614031015, updateTime=1772610875891, updateBy=18614031015, name=中国新药杂志-英文, tplId=1146101810881728533, title=Chinese Journal of New Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983955829248630, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=articleTextType, value=kx, createTime=1772611138541, updateTime=1772611138541, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955804082803, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=banner, value=null, createTime=1772611138535, updateTime=1772611138535, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955854414457, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=grayFlag, value=0, createTime=1772611138547, updateTime=1772611138547, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955795694194, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611138533, updateTime=1772611138533, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955866997371, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=minRunFlag, value=0, createTime=1772611138550, updateTime=1772611138550, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955820860021, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic, createTime=1772611138539, updateTime=1772611138539, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955862803066, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=silenceFlag, value=0, createTime=1772611138549, updateTime=1772611138549, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955812471412, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1772611138537, updateTime=1772611138537, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955837637239, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeColor, value=null, createTime=1772611138543, updateTime=1772611138543, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955846025848, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeStyle, value=null, createTime=1772611138545, updateTime=1772611138545, creator=18614031015, updator=18614031015)])], journalTitle=中国新药杂志, weixinUrl=null, journalUrl=http://www.newdrug.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of New Drugs, journalPhotoCn=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPhotoEn=f9WK9bvTM4guTmS/iGhOMg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/Y2021/V30/I17/1537, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/Y2021/V30/I17/1537, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/PDF/Y2021/V30/I17/1537, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/PDF/Y2021/V30/I17/1537, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1631635200000, fullTextJson=null, articleText=null, reference=null)