Article(id=1322127443654193325, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322127420036071763, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1620921600000, acceptedDateStr=2021-05-14, onlineDate=1793149346506, onlineDateStr=2026-10-28, pubDate=1640793600000, pubDateStr=2021-12-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793149346506, onlineIssueDateStr=2026-10-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793149346506, creator=13701087609, updateTime=1793149346506, updator=13701087609, issue=Issue{id=1322127420036071763, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='24', pageStart='2225', pageEnd='2327', issueExtLink='null', onlineDate='null', pubDate='1640793600000', pubDateStr='2021-12-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793149340876, creator='13701087609', updateTime=1793149575427, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322128403881374295, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322127420036071763, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322128403881374296, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322127420036071763, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2300, endPage=2305, ext={EN=ArticleExt(id=1322127443821965486, articleId=1322127443654193325, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Preliminarily explore the effect of panax notoginseng saponins on differentiation of mouse treg cells and its mechanism, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To observe the effect of panax notoginseng saponins (PNS) on the differentiation of CD4+ T cells into regulatory T (Treg) cells and preliminarily explore its relationship with regulating cellular fatty acid oxidation metabolism.
Methods: The spleen cells of C57BL/6 mice were isolated and CD4+ T cells were cultured in vitro by magnetic beads sorting. The optimal concentration of PNS was screened by the CCK-8 method and its effect on cell viability was tested. Then the cells were divided into control group and PNS intervention groups (5, 10, 20 μg·mL-1). After corresponding drug intervention, the proportion of Treg cells was detected by using flow cytometry, the level of β-hydroxybutyric acid (BHBA) in the supernatant was measured by using ELISA, cellular carnitine palmitoyl transferase 1A (CPT-1A) mRNA expression was detected by using q-PCR, and the expression of CPT-1A protein was detected by using Western Blot method.
Results: The differentiation ratio of Treg cells and BHBA level in the supernatants significantly increased in the PNS intervention groups (5, 10, 20 μg·mL-1). The increasing expressions of CPT-1A mRNA and protein in the cells were also observed in the PNS intervention groups.
Conclusion: Certain concentrations of PNS can significantly promote the differentiation of mouse CD4+ T cells into Treg cells, and its mechanism may be related with promoting the fatty acid oxidation of CD4+ T cells.
, authors=Xiang WANG, Yu-xi DI, Mei-yu SHEN, Ming-fei ZHANG, A-lan XU, Ling-ling ZHOU, authorsList=Xiang WANG, Yu-xi DI, Mei-yu SHEN, Ming-fei ZHANG, A-lan XU, Ling-ling ZHOU, authorCompany=null, correspAuthors=Ling-ling ZHOU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322127444199452847, articleId=1322127443654193325, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=三七总皂苷对小鼠Treg细胞分化的影响及其机制初探, columnId=1236330556003242277, journalTitle=中国新药杂志, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的： 观察三七总皂苷（panax notoginseng saponins，PNS）对CD4+ T细胞向调节性T细胞（Treg）分化的影响，并初步探讨其效应与调节细胞脂肪酸氧化代谢的相关性。
方法： 分离C57BL/6小鼠的脾细胞并磁珠分选CD4+ T细胞进行体外培养，采用CCK-8法筛选PNS的最佳给药浓度并检测其对细胞活力的影响，之后分别设对照组、PNS干预组（5，10，20 μg·mL-1），相应药物干预后，流式细胞术检测Treg细胞的比例，ELISA方法检测上清液中β-羟基丁酸（BHBA）水平，q-PCR方法检测细胞肉毒碱棕榈酰转移酶1A（CPT-1A）mRNA表达水平，Western Blot法检测细胞中CPT-1A蛋白表达水平。
结果： 5，10，20 μg·mL-1的PNS可显著增加CD4+ T细胞向Treg细胞分化的比例，明显增加细胞上清液中BHBA水平，升高细胞中CPT-1A mRNA和CPT-1A蛋白的表达水平。
结论： 一定浓度的PNS可显著促进小鼠CD4+ T细胞向Treg细胞分化，其作用机制可能与提高CD4+ T细胞脂肪酸氧化代谢水平有关。
, authors=王祥, 狄昱希, 申美玉, 张明菲, 许阿兰, 周玲玲, authorsList=王祥, 狄昱希, 申美玉, 张明菲, 许阿兰, 周玲玲, authorCompany=null, correspAuthors=周玲玲, authorNote=
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王祥，男，硕士，主要从事抗炎免疫药理学研究。E-mail：2358359354@qq.com。
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王祥，男，硕士，主要从事抗炎免疫药理学研究。E-mail：2358359354@qq.com。
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