Article(id=1322127437429846122, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322127420036071763, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1629129600000, acceptedDateStr=2021-08-17, onlineDate=1793149345023, onlineDateStr=2026-10-28, pubDate=1640793600000, pubDateStr=2021-12-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793149345023, onlineIssueDateStr=2026-10-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793149345023, creator=13701087609, updateTime=1793149345023, updator=13701087609, issue=Issue{id=1322127420036071763, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='24', pageStart='2225', pageEnd='2327', issueExtLink='null', onlineDate='null', pubDate='1640793600000', pubDateStr='2021-12-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793149340876, creator='13701087609', updateTime=1793149575427, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322128403881374295, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322127420036071763, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322128403881374296, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322127420036071763, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2283, endPage=2287, ext={EN=ArticleExt(id=1322127437647949931, articleId=1322127437429846122, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Effect of butylphthalide on hsCRP and TNF-α in patients with anterior choroidal artery infarction with broadened therapeutic time window, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To observe the clinical efficacy and safety of butylphthalide injection in the treatment of patients with anterior choroidal artery infarction, as well as the changes of serum high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α).
Methods: Sixty-seven patients with anterior choroidal artery diagnosed in our hospital were selected and randomly divided into butylphthalide group (34 cases) and control group (33 cases). Both groups received antiplatelet aggregation and lipid-lowering therapy, and the butylphthalide group was treated with butylphthalide injection 25 mg (bid) in addition for 14 d. The patients were followed up for 3 month.
Results: The incidence of progressive stroke in the butylphthalide group was significantly lower than that in the control group. The National Institutes of Health Stroke Scale (NIHSS) scores of patients in the butylphthalide group 14 d after treatment were significantly lower than those in the control group. Three months later, the proportion of patients with good prognosis (mRS score≤1, Barthel index score≥90) was significantly higher than that of the control group (P<0.05). The levels of hs-CRP and TNF-α in the two groups were decreased on the 14th day, and the decrease in the butylphthalide group was more significant than that in the control group (P<0.05).
Conclusion: Butylphthalide injection can not only reduce the incidence of progression in patients with anterior choroidal artery infarction, but also has better long-term clinical efficacy and can bring higher quality of life to the patients. The mechanism may be related to reducing the levels of hs-CRP and TNF-α and inhibiting inflammatory reaction.
, authors=Jia-jun WANG, Ju GAO, Gang ZHOU, Zhan-chi XIAO, authorsList=Jia-jun WANG, Ju GAO, Gang ZHOU, Zhan-chi XIAO, authorCompany=null, correspAuthors=Zhan-chi XIAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322127437941551212, articleId=1322127437429846122, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=丁苯酞对超时间窗脉络膜前动脉梗死患者高敏C反应蛋白和肿瘤坏死因子-α的影响, columnId=1236331162205999476, journalTitle=中国新药杂志, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的： 观察丁苯酞注射液治疗脉络膜前动脉梗死患者的临床疗效、安全性以及血液高敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）的水平变化。
方法： 选取本院住院诊断为脉络膜前动脉梗死患者67例，用随机数字法分为丁苯酞组（34例）与对照组（33例），两组患者均给予抗血小板聚集、降脂等常规治疗，丁苯酞组在上述治疗的基础上加用丁苯酞注射液静滴25 mg，bid，连续治疗14 d，随访3个月，比较两组患者的疗效、安全性及随访康复情况。
结果： 丁苯酞组患者进展性卒中的发生率明显低于对照组，丁苯酞组患者治疗后14 d的美国国立卫生研究院卒中量表（NIHSS）评分均明显低于对照组，3个月后的预后良好，改良Rankin量表（mRS）评分≤1分、Barthel指数评分≥90分比例明显高于对照组，差异均有统计学意义（P<0.05）。两组患者d 14血液hs-CRP和TNF-α水平均降低，丁苯酞组较对照组降低更加显著，差异有统计学意义（P<0.05）。
结论： 在抗血小板聚集、降脂等常规基础治疗基础上加用丁苯酞注射液治疗脉络膜前动脉梗死患者，不仅能降低进展发生率，而且远期临床疗效更好，患者生活质量更高，其机制可能与降低血液hs-CRP和TNF-α水平、抑制炎症反应有关。
, authors=王佳君, 高聚, 周刚, 肖展翅, authorsList=王佳君, 高聚, 周刚, 肖展翅, authorCompany=null, correspAuthors=肖展翅, authorNote=
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王佳君，男，主治医师，主要从事脑血管病新药研究及临床研究。联系电话：(0713)8395027，E-mail：hgdoctor@126.com。
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王佳君，男，主治医师，主要从事脑血管病新药研究及临床研究。联系电话：(0713)8395027，E-mail：hgdoctor@126.com。
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journalId=1235980733773295621, articleId=1322127437429846122, language=CN, orderNo=4, keyword=临床疗效), Keyword(id=1322127440235835534, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, language=CN, orderNo=5, keyword=C反应蛋白), Keyword(id=1322127440323915919, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, language=CN, orderNo=6, keyword=肿瘤坏死因子-α)], refs=[Reference(id=1322127440441356432, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=null, journalName=null, refType=null, unstructuredReference=CHAUSSON N, JOUX J, SAINT-VIL M,
et al. Infarction in the anterior choroidal artery territory: clinical progression and prognosis factors[J].
J Stroke Cerebrovasc Dis, 2014, 23(8): 2012-2017., articleTitle=null, refAbstract=null), Reference(id=1322127440525242513, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=王光胜, 胡婷, 杨金建, 等. 脉络膜前动脉供血区梗死: 梗死大小及其相关因素[J]. 国际脑血管病杂志, 2020, 28(5): 348-354., articleTitle=null, refAbstract=null), Reference(id=1322127440609128594, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=王拥军, 李子孝, 谷鸿秋, 等. 中国卒中报告2019(中文版)(3)[J]. 中国卒中杂志, 2020, 15(12): 1251-1263., articleTitle=null, refAbstract=null), Reference(id=1322127440697208979, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=郑迪, 周骏宇, 王亮. 丁苯酞对实验性脑梗死小鼠神经功能改善、脑保护及促进血管新生的作用[J]. 中国药师, 2019, 22(11): 2003-2007., articleTitle=null, refAbstract=null), Reference(id=1322127440793677972, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=朱以诚, 崔丽英, 高山, 等. 丁苯酞注射液治疗急性脑梗死的多中心、随机、双盲双模拟、对照Ⅲ期临床试验[J]. 中华神经科杂志, 2014, 47(2): 113-118., articleTitle=null, refAbstract=null), Reference(id=1322127440877564053, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=杨璟, 李凤, 石长青. 丁苯酞治疗进展性脑梗死患者疗效及对血清白细胞介素6和S100B蛋白表达的影响[J]. 中国新药杂志, 2020, 29(9): 1018-1022., articleTitle=null, refAbstract=null), Reference(id=1322127440953061526, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=彭斌, 吴波. 中国急性缺血性脑卒中诊治指南2018[J]. 中华神经科杂志, 2018, 51(9): 666-682., articleTitle=null, refAbstract=null), Reference(id=1322127441087279255, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=谢娜, 邓建中, 齐进兴, 等. 脉络膜前动脉梗死患者预后影响因素分析[J]. 新乡医学院学报, 2020, 37(1): 79-82., articleTitle=null, refAbstract=null), Reference(id=1322127441192136856, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=苏桐, 欧阳祖彬. 脉络膜前动脉解剖与功能的影像学研究进展[J]. 神经损伤与功能重建, 2020, 15(10): 579-581., articleTitle=null, refAbstract=null), Reference(id=1322127441355714713, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=芮德源, 陈立杰. 临床神经解剖学[M]. 北京: 人民卫生出版社, 2007: 534-536., articleTitle=null, refAbstract=null), Reference(id=1322127441489932442, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=YU J, XU N, ZHAO Y,
et al. Clinical importance of the anterior choroidal artery: a review of the literature[J].
Int J Med Sci, 2018, 15(4): 368-375., articleTitle=null, refAbstract=null), Reference(id=1322127441578012827, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=宋兆慧, 童燕娜, 杨延通, 等. 74例脉络膜前动脉脑梗死临床特点分析[J]. 实用心脑肺血管病杂志, 2018, 26(z1): 86-87., articleTitle=null, refAbstract=null), Reference(id=1322127441649315996, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=GONS RAR, DE LAAT KF, VAN NORDEN AGW,
et al. Hypertension and cerebral diffusion tensor imaging in small vessel disease[J].
Stroke, 2010, 41(12): 2801-2806., articleTitle=null, refAbstract=null), Reference(id=1322127441712230557, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=null, journalName=null, refType=null, unstructuredReference=SOHN H, KANG DW, KWON SU,
et al. Anterior choroidal artery territory infarction: lesions confined to versus beyond the internal capsule[J].
Cerebrovasc Dis, 2013, 35(3): 228-234., articleTitle=null, refAbstract=null), Reference(id=1322127441791922334, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=null, journalName=null, refType=null, unstructuredReference=杨光, 程越朋, 孙鑫. 脉络膜前动脉梗死的临床特征及预后分析[J]. 中国现代医学杂志, 2019, 29(10): 113-116., articleTitle=null, refAbstract=null), Reference(id=1322127441867419807, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=null, journalName=null, refType=null, unstructuredReference=韩西娟, 贾建平, 孙永馨. 腔隙性脑梗死与分支动脉粥样硬化病[J]. 临床神经病学杂志, 2015, 28(2): 146-148., articleTitle=null, refAbstract=null), Reference(id=1322127441934528672, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=null, journalName=null, refType=null, unstructuredReference=谷楠, 李靓, 孙勇, 等. 动脉粥样硬化与炎症关系研究的进展[J]. 心血管康复医学杂志, 2020, 29(6): 714-717., articleTitle=null, refAbstract=null), Reference(id=1322127442010026145, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=null, journalName=null, refType=null, unstructuredReference=TABAS I, GARCÍA-CARDEÑA G, OWENS GK. Recent insights into the cellular biology of atherosclerosis[J].
J Cell Biol, 2015, 209(1): 13-22., articleTitle=null, refAbstract=null), Reference(id=1322127442081329314, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[19], rfOrder=18, authorNames=null, journalName=null, refType=null, unstructuredReference=LI Y, ZHONG X, CHENG G,
et al. Hs-CRP and all-cause, cardiovascular, and cancer mortality risk: a meta-analysis[J].
Atherosclerosis, 2017, 259: 75-82., articleTitle=null, refAbstract=null), Reference(id=1322127442161021091, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[20], rfOrder=19, authorNames=null, journalName=null, refType=null, unstructuredReference=于源东. 急性脑梗死患者血清hs-CRP水平与颈动脉粥样硬化斑块的相关性研究[J]. 中西医结合心脑血管病杂志, 2015, 13(3): 396-397., articleTitle=null, refAbstract=null), Reference(id=1322127442249101476, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[21], rfOrder=20, authorNames=null, journalName=null, refType=null, unstructuredReference=张凯. 动脉粥样硬化大血管和微血管病变的干预靶点研究[D]. 济南: 山东大学, 2014: 27-29., articleTitle=null, refAbstract=null), Reference(id=1322127442467205285, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[22], rfOrder=21, authorNames=null, journalName=null, refType=null, unstructuredReference=刘清霞, 张宏颖, 徐利霞, 等. 动脉粥样硬化斑块中TNF-α的表达与斑块稳定性的关系[J]. 中国循证心血管医学杂志, 2019, 11(4): 441-444., articleTitle=null, refAbstract=null), Reference(id=1322127442538508454, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[23], rfOrder=22, authorNames=null, journalName=null, refType=null, unstructuredReference=郑昌柱, 任雨笙, 李兰蓀, 等. 血脂、LP(a)及TNF-α水平变化及在动脉粥样硬化过程中的作用[J]. 重庆医学, 2015, 44(2): 171-173., articleTitle=null, refAbstract=null), Reference(id=1322127442689503399, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[24], rfOrder=23, authorNames=null, journalName=null, refType=null, unstructuredReference=卢柳, 谢娟, 郭书英. 丁苯酞软胶囊治疗进展性卒中的系统评价[J]. 中国现代应用药学, 2020, 37(9): 1121-1128., articleTitle=null, refAbstract=null), Reference(id=1322127442785972392, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[25], rfOrder=24, authorNames=null, journalName=null, refType=null, unstructuredReference=巴雪, 刘烨妹. 丁苯酞在急性脑梗死患者中的疗效与安全性研究[J]. 今日药学, 2019, 29(5): 321-324., articleTitle=null, refAbstract=null), Reference(id=1322127442882441385, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[26], rfOrder=25, authorNames=null, journalName=null, refType=null, unstructuredReference=高明, 张力辉, 白笑梅, 等. 丁苯酞对糖尿病小鼠学习记忆功能和海马炎症反应的影响[J]. 中国临床药理学杂志, 2019, 35(22): 2868-2871., articleTitle=null, refAbstract=null), Reference(id=1322127442995687594, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[27], rfOrder=26, authorNames=null, journalName=null, refType=null, unstructuredReference=赵冬凤, 刘强. 丁苯酞注射液对急性脑梗死不同OCSP分型的疗效及对Hs-CRP、FIB水平的影响[J]. 中风与神经疾病杂志, 2020, 37(9): 797-800., articleTitle=null, refAbstract=null), Reference(id=1322127443092156587, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127437429846122, doi=null, pmid=null, pmcid=null, year=null, 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