Article(id=1322127420690383187, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322127420036071763, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1620230400000, acceptedDateStr=2021-05-06, onlineDate=1793149341031, onlineDateStr=2026-10-28, pubDate=1640793600000, pubDateStr=2021-12-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793149341031, onlineIssueDateStr=2026-10-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793149341031, creator=13701087609, updateTime=1793149341031, updator=13701087609, issue=Issue{id=1322127420036071763, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='24', pageStart='2225', pageEnd='2327', issueExtLink='null', onlineDate='null', pubDate='1640793600000', pubDateStr='2021-12-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793149340876, creator='13701087609', updateTime=1793149575427, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322128403881374295, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322127420036071763, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322128403881374296, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322127420036071763, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2256, endPage=2261, ext={EN=ArticleExt(id=1322127420853961044, articleId=1322127420690383187, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Comparative study of two
in vitro experimental methods detecting cytokine release syndrome, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: A comparative study of two in vitro experimental methods detecting cytokine release was conducted for evaluating methodological choices on whether new drugs cause cytokine release.
Methods: Peripheral blood mononuclear cells were incubated with two different methods for 24 hours, after which the expression levels of four cytokines: IL-1β, IL-6, IL-8 and TNF-α were detected by cytometric bead assay.
Results: In solid phase method, IL-1β was significantly released only in OKT3 at 5 μg·well-1 (P<0.05). Significant release of IL-6 was found in two antibodies (P<0.05). There was a significant release of IL-8 and TNF-α at all concentrations of OKT3 and 5 μg·well-1 of TGN1412 (P<0.05). While in liquid phase method, significant release of IL-6 happened in 1 and 5 μg·well-1 of OKT3, as well as 5 μg·well-1 of TGN1412 (P<0.05). There was a significant release of IL-8 at 5 μg·well-1 of TGN1412 (P<0.05). Significant release of TNF-α was found in all concentrations of OKT3 and 5 μg·well-1 of TGN1412 (P<0.05).
Conclusion: The solid phase method is more suitable for T cell receptor monoclonal antibody drugs, the results of which are more reliable in preclinical evaluation. The liquid phase method is simpler to operate, and its simulated environment is closer to human body, but it has higher sensitivity for monoclonal antibodies whose target is not on T cells.
, authors=Jing-yi XU
1, 2, Jia-yi YU
1, 2, Jing MA
1, 2, authorsList=Jing-yi XU, Jia-yi YU, Jing MA, authorCompany=null, correspAuthors=Jing MA, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322127421101424981, articleId=1322127420690383187, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=细胞因子释放综合征的2种体外检测方法比较研究, columnId=1236330552693944345, journalTitle=中国新药杂志, columnName=生物医药前沿, runingTitle=null, highlight=null, articleAbstract=
目的： 对固相法及液相法2种体外细胞因子释放实验方法进行比较研究，为评价新药是否引起细胞因子释放方法学选择提供依据。
方法： 用2种不同方法与外周血单核细胞共同孵育24 h，流式细胞磁珠微阵列法检测白介素-1β（IL-1β）、IL-6、IL-8、肿瘤坏死因子-α（TNF-α）这4种细胞因子的表达水平。
结果： 固相法中，IL-1β仅在抗CD3单克隆抗体（OKT3）的5 μg·孔-1有显著性释放（P<0.05）；IL-6在2种抗体中均有显著性释放（P<0.05）；OKT3所有浓度及CD28超级激动剂TGN1412的5 μg·孔-1 IL-8与TNF-α有显著性释放（P<0.05）。液相法中，OKT3的1和5 μg·孔-1、TGN1412的5 μg·孔-1 IL-6有显著性释放（P<0.05）；TGN1412的5 μg·孔-1 IL-8有显著性释放（P<0.05）；OKT3所有浓度及TGN1412的5 μg·孔-1 TNF-α有显著性释放（P<0.05）。
结论： 固相法更适用于T细胞受体的单克隆抗体药物，在临床前评价中其结果可信度更高；液相法操作简单，并且其模拟的环境更接近于人体，对于靶点不在T细胞上的单克隆抗体有更高的灵敏度。
, authors=徐静怡
1, 2, 宇家仪
1, 2, 马璟
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