首页 期刊 论文 学科刊群 资讯 加盟 关于
EN
image
Article(id=1322127363182280939, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322127297054888908, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1633276800000, acceptedDateStr=2021-10-04, onlineDate=1793149327321, onlineDateStr=2026-10-28, pubDate=1639497600000, pubDateStr=2021-12-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793149327321, onlineIssueDateStr=2026-10-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793149327321, creator=13701087609, updateTime=1793149327321, updator=13701087609, issue=Issue{id=1322127297054888908, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='23', pageStart='2121', pageEnd='2224', issueExtLink='null', onlineDate='null', pubDate='1639497600000', pubDateStr='2021-12-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793149311555, creator='13701087609', updateTime=1793149538282, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322128248071369266, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322127297054888908, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322128248075563571, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322127297054888908, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2194, endPage=2202, ext={EN=ArticleExt(id=1322127363631071469, articleId=1322127363182280939, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Injectable cefoperazone sodium and tazobactam sodium (6∶1) in the treatment of moderate to severe acute respiratory bacterial infections: a blind, randomized controlled, multi-center clinical trial, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective:

To evaluate the efficacy and safety of injectable cefoperazone sodium and tazobactam sodium (6∶1) for the treatment of moderate to severe acute respiratory bacterial infections.

Methods:

Totally 237 patients with respiratory tract infections were enrolled in a randomized, double blind, multi-centerand, parallel controlled study, in which 179 in experimental group and 58 in control group ([injectable cefoperazone sodium and tazobactam sodium (4∶1)]. During the screening period, cefoperazone sodium was uniformly injected for 3 d. During the treatment period, the experimental group was given the test drug 3.0 g by intravenous drip twice a day, and the control group was given 2.0 g of control drug by intravenous drip 3 times a day. The results of symptoms, signs, laboratory examination, chest X-ray examination and sputum bacterial culture were observed before and after treatment.

Results:

In experiment group and control group, the clinical cure rates were 87.65% and 78.85%, respectively. The bacterial clearance rates were 97.89% and 97.06%. Comprehensive efficacies were 86.32% and 73.53%. Incidences of adverse reaction were 13.79% (24/174 patients) in the test group and 14.29% (8/56 patients) in the control group. The main manifestations were elevated transaminase, leucopenia, eosinophilia and so on. All patients returned to normal after follow-up.

Conclusion:

Injectable cefoperazone sodium and tazobactam sodium (6∶1) is proved to be safe and effective in the treatment of moderate to severe acute bacterial infection of respiratory system after large-scale phase Ⅲ clinical trial, providing an effective drug for the control of drug-resistant bacterial infection.

, authors=Feng CHEN1, Hai-ying YU2, Bi-wen MO1, Ji-fang SHENG2, Lian-ming DING3, Chong LI4, Qi YIN5, Wen-yuan LIU6, Xiu-hua FU7, authorsList=Feng CHEN, Hai-ying YU, Bi-wen MO, Ji-fang SHENG, Lian-ming DING, Chong LI, Qi YIN, Wen-yuan LIU, Xiu-hua FU, authorCompany=null, correspAuthors=Xiu-hua FU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322127364465737966, articleId=1322127363182280939, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=注射用头孢哌酮钠他唑巴坦钠（6∶1）治疗中重度呼吸系统急性细菌性感染的多中心随机对照临床试验, columnId=1236331162205999476, journalTitle=中国新药杂志, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的：

评价注射用头孢哌酮钠他唑巴坦钠（6∶1）在呼吸系统感染受试人群中的有效性和安全性。

方法：

采用多中心、随机、盲法、阳性药物平行对照。共237例患者纳入试验，其中试验组179例，用头孢哌酮钠他唑巴坦钠（6∶1），对照组58例用注射用头孢哌酮钠他唑巴坦钠（4∶1）。筛选期统一接受注射用头孢哌酮钠单药治疗3 d，治疗期试验组给予试验药3.0 g，bid静脉滴注；对照组给予对照药2.0 g，tid静脉滴注。观察两组治疗前后症状、体征、实验室检查、胸部X线检查、痰细菌培养等的变化。

结果：

两组临床治愈率分别为87.65%和78.85%；细菌清除率分别为97.89%和97.06%；综合疗效分别为86.32%和73.53%；不良反应发生率为13.79%（24/174例）、14.29%（8/56例），主要表现为转氨酶升高、白细胞减少、嗜酸性粒细胞增多等，随访均恢复正常。

结论：

经过大规模Ш期临床试验证明，注射用头孢哌酮钠他唑巴坦钠（6∶1）用于治疗中、重度呼吸系统急性细菌性感染安全有效，为遏制耐药菌感染提供了可选的有效药物。

, authors=陈峰1, 俞海英2, 莫碧文1, 盛吉芳2, 丁连明3, 李翀4, 尹琦5, 刘文媛6, 付秀华7, authorsList=陈峰, 俞海英, 莫碧文, 盛吉芳, 丁连明, 李翀, 尹琦, 刘文媛, 付秀华, authorCompany=null, correspAuthors=付秀华, authorNote=

俞海英，女，博士，副主任医师，主要从事感染性疾病诊断和治疗研究。E-mail：。

陈峰，男，副主任医师，主要从事呼吸系统疾病诊断和治疗研究。联系电话：13977325396，E-mail：。

, correspAuthorsNote=
付秀华，女，教授，主任医师，主要从事呼吸系统疾病诊断和治疗研究。E-mail：。
, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=DDvKSOiLZiIkMYME44r9+g==, magXml=xJKiL/3iRz5ieQJqWXjBDg==, pdfUrl=null, pdf=8AxjGIs+NsFgZxN3LKmcRg==, pdfFileSize=3186639, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=wdqI7T8/GDk8WRyml4DsYQ==, mapNumber=null, fund=null)}, authors=[Author(id=1322127367011680518, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=cf19781732@163.com.cn, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322127367091372296, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127367011680518, language=EN, stringName=Feng CHEN, firstName=Feng, middleName=null, lastName=CHEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1Affiliated Hospital of Guilin Medical University, Guilin 541000, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322127367208812809, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127367011680518, language=CN, stringName=陈峰, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1桂林医学院附属医院，桂林　541000, bio={"content":"

陈峰，男，副主任医师，主要从事呼吸系统疾病诊断和治疗研究。联系电话：13977325396，E-mail：。

"}, bioImg=null, bioContent=

陈峰，男，副主任医师，主要从事呼吸系统疾病诊断和治疗研究。联系电话：13977325396，E-mail：。

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322127365300404463, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, xref=1, ext=[AuthorCompanyExt(id=1322127365317181680, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127365300404463, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Affiliated Hospital of Guilin Medical University, Guilin 541000, China), AuthorCompanyExt(id=1322127365338153201, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127365300404463, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1桂林医学院附属医院，桂林　541000)])]), Author(id=1322127367355613451, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=yuhaiying@zju.edu.cn, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322127367431110925, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127367355613451, language=EN, stringName=Hai-ying YU, firstName=Hai-ying, middleName=null, lastName=YU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2The First Affiliated Hospital of of Zhejiang University, Hangzhou 310003, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322127367494025486, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127367355613451, language=CN, stringName=俞海英, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2浙江大学医学院附属第一医院，杭州　310003, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322127365686280435, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, xref=2, ext=[AuthorCompanyExt(id=1322127365698863348, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127365686280435, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2The First Affiliated Hospital of of Zhejiang University, Hangzhou 310003, China), AuthorCompanyExt(id=1322127365711446261, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127365686280435, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2浙江大学医学院附属第一医院，杭州　310003)])]), Author(id=1322127367586300176, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322127367842152722, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127367586300176, language=EN, stringName=Bi-wen MO, firstName=Bi-wen, middleName=null, lastName=MO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1Affiliated Hospital of Guilin Medical University, Guilin 541000, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322127367909261587, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127367586300176, language=CN, stringName=莫碧文, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1桂林医学院附属医院，桂林　541000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322127365300404463, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, xref=1, ext=[AuthorCompanyExt(id=1322127365317181680, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127365300404463, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Affiliated Hospital of Guilin Medical University, Guilin 541000, China), AuthorCompanyExt(id=1322127365338153201, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127365300404463, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1桂林医学院附属医院，桂林　541000)])]), Author(id=1322127367984759061, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322127368198668567, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127367984759061, language=EN, stringName=Ji-fang SHENG, firstName=Ji-fang, middleName=null, lastName=SHENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2The First Affiliated Hospital of of Zhejiang University, Hangzhou 310003, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322127368274166040, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127367984759061, language=CN, stringName=盛吉芳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2浙江大学医学院附属第一医院，杭州　310003, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322127365686280435, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, xref=2, ext=[AuthorCompanyExt(id=1322127365698863348, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127365686280435, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2The First Affiliated Hospital of of Zhejiang University, Hangzhou 310003, China), AuthorCompanyExt(id=1322127365711446261, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127365686280435, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2浙江大学医学院附属第一医院，杭州　310003)])]), Author(id=1322127368349663514, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322127368441938204, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127368349663514, language=EN, stringName=Lian-ming DING, firstName=Lian-ming, middleName=null, lastName=DING, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=3, address=3The 81st Group Army Hospital of the Chinese People's Liberation Army (The 251st Hospital of the Chinese People's Liberation Army), Zhangjiakou 075000, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322127368613904669, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127368349663514, language=CN, stringName=丁连明, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=3, address=3中国人民解放军陆军第81集团军医院（中国人民解放军第二五一医院），张家口　075000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322127365812109558, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, xref=3, ext=[AuthorCompanyExt(id=1322127365828886775, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127365812109558, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3The 81st Group Army Hospital of the Chinese People's Liberation Army (The 251st Hospital of the Chinese People's Liberation Army), Zhangjiakou 075000, China), AuthorCompanyExt(id=1322127365837275384, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127365812109558, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3中国人民解放军陆军第81集团军医院（中国人民解放军第二五一医院），张家口　075000)])]), Author(id=1322127368681013535, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322127368756511009, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127368681013535, language=EN, stringName=Chong LI, firstName=Chong, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=4, address=4The First People's Hospital of Changzhou, Changzhou 213003, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322127368832008482, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127368681013535, language=CN, stringName=李翀, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=4, address=4常州市第一人民医院，常州　213003, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322127366147653881, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, xref=4, ext=[AuthorCompanyExt(id=1322127366151848186, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127366147653881, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4The First People's Hospital of Changzhou, Changzhou 213003, China), AuthorCompanyExt(id=1322127366160236795, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127366147653881, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4常州市第一人民医院，常州　213003)])]), Author(id=1322127368899117348, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322127369033335078, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127368899117348, language=EN, stringName=Qi YIN, firstName=Qi, middleName=null, lastName=YIN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=5, address=5Dongfang Hospital Affiliated to Tongji University, Shanghai 200120, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322127369100443943, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127368899117348, language=CN, stringName=尹琦, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=5, address=5同济大学附属东方医院，上海　200120, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322127366235734268, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, xref=5, ext=[AuthorCompanyExt(id=1322127366239928573, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127366235734268, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=5Dongfang Hospital Affiliated to Tongji University, Shanghai 200120, China), AuthorCompanyExt(id=1322127366512558334, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127366235734268, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=5同济大学附属东方医院，上海　200120)])]), Author(id=1322127369167552809, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, orderNo=7, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322127369243050283, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127369167552809, language=EN, stringName=Wen-yuan LIU, firstName=Wen-yuan, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=6, address=6Sichuan Provincial People's Hospital, Chengdu 610072, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322127369305964844, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127369167552809, language=CN, stringName=刘文媛, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=6, address=6四川省人民医院，成都　610072, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322127366592250111, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, xref=6, ext=[AuthorCompanyExt(id=1322127366600638720, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127366592250111, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=6Sichuan Provincial People's Hospital, Chengdu 610072, China), AuthorCompanyExt(id=1322127366609027329, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127366592250111, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=6四川省人民医院，成都　610072)])]), Author(id=1322127369377268014, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, orderNo=8, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=fuxiuhua555@sohu.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1322127369519874352, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127369377268014, language=EN, stringName=Xiu-hua FU, firstName=Xiu-hua, middleName=null, lastName=FU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=7, address=7The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 10050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322127369591177521, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127369377268014, language=CN, stringName=付秀华, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=7, address=7内蒙古医学院附属医院，呼和浩特　10050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322127366671941890, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, xref=7, ext=[AuthorCompanyExt(id=1322127366927794435, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127366671941890, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=7The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 10050, China), AuthorCompanyExt(id=1322127366936183044, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127366671941890, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=7内蒙古医学院附属医院，呼和浩特　10050)])])], keywords=[Keyword(id=1322127369721200946, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, language=EN, orderNo=1, keyword=cefoperazone sodium and tazobactam sodium for injection (6∶1)), Keyword(id=1322127369872195891, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, language=EN, orderNo=2, keyword=drug-resistant bacteria infection), Keyword(id=1322127369977053492, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, language=EN, orderNo=3, keyword=acute respiratory bacterial infections), Keyword(id=1322127370065133877, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, language=EN, orderNo=4, keyword=blind), Keyword(id=1322127370132242742, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, language=EN, orderNo=5, keyword=randomized controlled), Keyword(id=1322127370199351607, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, language=EN, orderNo=6, keyword=multi-center clinical trial), Keyword(id=1322127370295820600, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, language=CN, orderNo=1, keyword=注射用头孢哌酮钠他唑巴坦钠（6∶1）), Keyword(id=1322127370358735161, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, language=CN, orderNo=2, keyword=耐药菌感染), Keyword(id=1322127370430038330, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, language=CN, orderNo=3, keyword=呼吸系统), Keyword(id=1322127370501341499, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, language=CN, orderNo=4, keyword=盲法), Keyword(id=1322127370593616188, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, language=CN, orderNo=5, keyword=随机对照), Keyword(id=1322127370702668093, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, language=CN, orderNo=6, keyword=多中心临床试验)], refs=[Reference(id=1322127370899800383, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=null, journalName=null, refType=null, unstructuredReference=胡付品, 郭燕, 吴湜, 等. CHINET中国细菌耐药监测结果[EB/OL]. (2021-02-22). http://www.chinets.com/Document., articleTitle=null, refAbstract=null), Reference(id=1322127370962714944, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=WHO. 2020 antibacterial agents in clinical and preclinical development: an overview and analysis[EB/OL]. (2021-04-15). https://www.who.int/publications/i/item/9789240021303., articleTitle=null, refAbstract=null), Reference(id=1322127371038212417, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA CDER. Guidance for industry antibacterial drug products: use of noninferiority trials to support approval[EB/OL]. (2010-11-29). https://www.fda.gov/regulatory-information/search-fda-guidance-documents/antibacterial-drug-products-use-noninferiority-studies-support-approval., articleTitle=null, refAbstract=null), Reference(id=1322127371189207362, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=NMPA CDE. 抗菌药物非劣效临床试验设计技术指导原则[S]. 2012., articleTitle=null, refAbstract=null), Reference(id=1322127371260510531, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=NMPA CDE. 抗菌药物临床试验技术指导原则[S]. 2015., articleTitle=null, refAbstract=null), Reference(id=1322127371323425092, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=NMPA CDE. 社区获得性细菌性肺炎抗菌药物临床试验技术指导原则[S]. 2020., articleTitle=null, refAbstract=null), Reference(id=1322127371428282693, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=JACKSON EA, CARDONI AA, LYON JA. Cefoperazone (cefobid, pfizer)[J]. Drug Intell Clin Pharm, 1983, 17(1): 7-11., articleTitle=null, refAbstract=null), Reference(id=1322127371558306118, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=CRAIG WA, GERBER AU. Pharmacokinetics of cefoperazone: a review[J]. Drugs, 1981, 22(1): 35-45., articleTitle=null, refAbstract=null), Reference(id=1322127371621220679, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=ARONOFF SC, JACOBS MR, JOHENNING S, et al. Comparative activities of the beta-lactamase inhibitors YTR 830, sodium clavulanate, and sulbactam combined with amoxicillin or ampicillin[J]. Antimicrob Agents Chemother, 1984, 26(4): 580-582., articleTitle=null, refAbstract=null), Reference(id=1322127371696718152, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=APPELBAUM PC, JACOBS MR, SPANGLER SK, et al. Comparative activity of beta-lactamase inhibitors YTR 830, clavulanate, and sulbactam combined with beta-lactams against beta-lactamase-producing anaerobes[J]. Antimicrob Agents Chemother, 1986, 30(5): 789-791., articleTitle=null, refAbstract=null), Reference(id=1322127371960959305, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=BHATTACHARYA S, PADHI AK, JUNGHARE V, et al. Understanding the molecular interactions of inhibitors against Bla1 beta-lactamase towards unraveling the mechanism of antimicrobial resistance[J]. Int J Biol Macromol, 2021, 177: 337-350., articleTitle=null, refAbstract=null), Reference(id=1322127372065816906, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA. 头孢哌酮钠(CEFOBID®)说明书[EB/OL]. [2021-06-25]. https://s3-us-west-2.amazonaws.com/drugbank/fda_labels/DB01329.pdf?1559236712., articleTitle=null, refAbstract=null), Reference(id=1322127372145508683, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=刘毅, 付四海, 高太平, 等. 头孢哌酮与β-内酰胺酶抑制剂复方研究进展[J]. 国外医药(抗生素分册), 2018, 39(2): 135-140., articleTitle=null, refAbstract=null), Reference(id=1322127372485247308, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=null, journalName=null, refType=null, unstructuredReference=FDA CDER. Community-acquired bacterial pneumonia: developing drugs for treatment guidance for industry[EB/OL]. (2020-06-24). https://www.fda.gov/media/75149/download., articleTitle=null, refAbstract=null), Reference(id=1322127372577521997, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=null, journalName=null, refType=null, unstructuredReference=赵磊, 何晓静, 李晓冰, 等. 临床常用头孢菌素类抗菌药物药品说明书评价[J]. 中国现代应用药学, 2020, 37(15): 1872-1876., articleTitle=null, refAbstract=null)], funds=[Fund(id=1322127370811719998, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, awardId=2013ZX09301303, language=CN, fundingSource=国家“重大新药创制”科技重大专项基金资助项目(2013ZX09301303), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1322127365300404463, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, xref=1, ext=[AuthorCompanyExt(id=1322127365317181680, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127365300404463, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Affiliated Hospital of Guilin Medical University, Guilin 541000, China), AuthorCompanyExt(id=1322127365338153201, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127365300404463, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1桂林医学院附属医院，桂林　541000)]), AuthorCompany(id=1322127365686280435, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, xref=2, ext=[AuthorCompanyExt(id=1322127365698863348, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127365686280435, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2The First Affiliated Hospital of of Zhejiang University, Hangzhou 310003, China), AuthorCompanyExt(id=1322127365711446261, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127365686280435, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2浙江大学医学院附属第一医院，杭州　310003)]), AuthorCompany(id=1322127365812109558, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, xref=3, ext=[AuthorCompanyExt(id=1322127365828886775, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127365812109558, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3The 81st Group Army Hospital of the Chinese People's Liberation Army (The 251st Hospital of the Chinese People's Liberation Army), Zhangjiakou 075000, China), AuthorCompanyExt(id=1322127365837275384, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127365812109558, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3中国人民解放军陆军第81集团军医院（中国人民解放军第二五一医院），张家口　075000)]), AuthorCompany(id=1322127366147653881, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, xref=4, ext=[AuthorCompanyExt(id=1322127366151848186, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127366147653881, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4The First People's Hospital of Changzhou, Changzhou 213003, China), AuthorCompanyExt(id=1322127366160236795, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127366147653881, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4常州市第一人民医院，常州　213003)]), AuthorCompany(id=1322127366235734268, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, xref=5, ext=[AuthorCompanyExt(id=1322127366239928573, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127366235734268, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=5Dongfang Hospital Affiliated to Tongji University, Shanghai 200120, China), AuthorCompanyExt(id=1322127366512558334, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127366235734268, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=5同济大学附属东方医院，上海　200120)]), AuthorCompany(id=1322127366592250111, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, xref=6, ext=[AuthorCompanyExt(id=1322127366600638720, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127366592250111, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=6Sichuan Provincial People's Hospital, Chengdu 610072, China), AuthorCompanyExt(id=1322127366609027329, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127366592250111, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=6四川省人民医院，成都　610072)]), AuthorCompany(id=1322127366671941890, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, xref=7, ext=[AuthorCompanyExt(id=1322127366927794435, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127366671941890, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=7The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 10050, China), AuthorCompanyExt(id=1322127366936183044, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127366671941890, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=7内蒙古医学院附属医院，呼和浩特　10050)])], figs=null, attaches=null, journal=Journal(id=1235980159023624194, delFlag=0, nameCn=中国新药杂志, nameEn=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, issn=1003-3734, eissn=null, cn=11-2850/R, coden=ZXZHA6, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of New Drugs, journalRemark=null, publicationField=null, createdTime=1772610233314, updatedTime=1788948968376, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=ohPEEN//Vz1tDT3ZBNTp4Q==, picEn=f9WK9bvTM4guTmS/iGhOMg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509780974924039, language=CN, name=中国新药杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948968404, updatedTime=1788948968404, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304509781025255688, language=EN, name=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948968416, updatedTime=1788948968416, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1235980733773295621, websiteList=[Website(id=1235982099191222761, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/CN, language=CN, createTime=1772610695884, createBy=18614031015, updateTime=1772610860397, updateBy=18614031015, name=中国新药杂志-中文, tplId=1146099689490845704, title=中国新药杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983918629966444, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=articleTextType, value=kx, createTime=1772611129672, updateTime=1772611129672, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918604800617, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=banner, value=null, createTime=1772611129666, updateTime=1772611129666, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918655132271, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=grayFlag, value=0, createTime=1772611129678, updateTime=1772611129678, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918596412008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611129664, updateTime=1772611129664, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918667715185, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=minRunFlag, value=0, createTime=1772611129681, updateTime=1772611129681, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918617383531, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic, createTime=1772611129669, updateTime=1772611129669, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918659326576, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=silenceFlag, value=0, createTime=1772611129679, updateTime=1772611129679, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918613189226, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1772611129668, updateTime=1772611129668, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918634160749, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeColor, value=null, createTime=1772611129673, updateTime=1772611129673, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918646743662, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeStyle, value=null, createTime=1772611129676, updateTime=1772611129676, creator=18614031015, updator=18614031015)]), Website(id=1235982099270914542, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/EN, language=EN, createTime=1772610695903, createBy=18614031015, updateTime=1772610875891, updateBy=18614031015, name=中国新药杂志-英文, tplId=1146101810881728533, title=Chinese Journal of New Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983955829248630, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=articleTextType, value=kx, createTime=1772611138541, updateTime=1772611138541, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955804082803, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=banner, value=null, createTime=1772611138535, updateTime=1772611138535, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955854414457, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=grayFlag, value=0, createTime=1772611138547, updateTime=1772611138547, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955795694194, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611138533, updateTime=1772611138533, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955866997371, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=minRunFlag, value=0, createTime=1772611138550, updateTime=1772611138550, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955820860021, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic, createTime=1772611138539, updateTime=1772611138539, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955862803066, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=silenceFlag, value=0, createTime=1772611138549, updateTime=1772611138549, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955812471412, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1772611138537, updateTime=1772611138537, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955837637239, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeColor, value=null, createTime=1772611138543, updateTime=1772611138543, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955846025848, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeStyle, value=null, createTime=1772611138545, updateTime=1772611138545, creator=18614031015, updator=18614031015)])], journalTitle=中国新药杂志, weixinUrl=null, journalUrl=http://www.newdrug.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of New Drugs, journalPhotoCn=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPhotoEn=f9WK9bvTM4guTmS/iGhOMg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/Y2021/V30/I23/2194, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/Y2021/V30/I23/2194, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/PDF/Y2021/V30/I23/2194, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/PDF/Y2021/V30/I23/2194, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1639497600000, fullTextJson=null, articleText=null, reference=null)
收藏切换
注射用头孢哌酮钠他唑巴坦钠（6∶1）治疗中重度呼吸系统急性细菌性感染的多中心随机对照临床试验
收藏切换
PDF下载
陈峰 1 , 俞海英 2 , 莫碧文 1 , 盛吉芳 2 , 丁连明 3 , 李翀 4 , 尹琦 5 , 刘文媛 6 , 付秀华 7
中国新药杂志 | 临床研究 2021,30(23): 2194-2202
收起
收藏切换
中国新药杂志 |临床研究 2021 , 30 (23) : 2194 -2202
注射用头孢哌酮钠他唑巴坦钠（6∶1）治疗中重度呼吸系统急性细菌性感染的多中心随机对照临床试验
全屏
[Author(id=1322127367011680518, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=cf19781732@163.com.cn, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322127367091372296, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127367011680518, language=EN, stringName=Feng CHEN, firstName=Feng, middleName=null, lastName=CHEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1Affiliated Hospital of Guilin Medical University, Guilin 541000, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322127367208812809, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127367011680518, language=CN, stringName=陈峰, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1桂林医学院附属医院，桂林　541000, bio={"content":"

陈峰，男，副主任医师，主要从事呼吸系统疾病诊断和治疗研究。联系电话：13977325396，E-mail：。

"}, bioImg=null, bioContent=

陈峰，男，副主任医师，主要从事呼吸系统疾病诊断和治疗研究。联系电话：13977325396，E-mail：。

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322127365300404463, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, xref=1, ext=[AuthorCompanyExt(id=1322127365317181680, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127365300404463, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Affiliated Hospital of Guilin Medical University, Guilin 541000, China), AuthorCompanyExt(id=1322127365338153201, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127365300404463, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1桂林医学院附属医院，桂林　541000)])]), Author(id=1322127367355613451, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=yuhaiying@zju.edu.cn, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322127367431110925, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127367355613451, language=EN, stringName=Hai-ying YU, firstName=Hai-ying, middleName=null, lastName=YU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2The First Affiliated Hospital of of Zhejiang University, Hangzhou 310003, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322127367494025486, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127367355613451, language=CN, stringName=俞海英, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2浙江大学医学院附属第一医院，杭州　310003, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322127365686280435, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, xref=2, ext=[AuthorCompanyExt(id=1322127365698863348, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127365686280435, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2The First Affiliated Hospital of of Zhejiang University, Hangzhou 310003, China), AuthorCompanyExt(id=1322127365711446261, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127365686280435, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2浙江大学医学院附属第一医院，杭州　310003)])]), Author(id=1322127367586300176, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322127367842152722, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127367586300176, language=EN, stringName=Bi-wen MO, firstName=Bi-wen, middleName=null, lastName=MO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1Affiliated Hospital of Guilin Medical University, Guilin 541000, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322127367909261587, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127367586300176, language=CN, stringName=莫碧文, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1桂林医学院附属医院，桂林　541000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322127365300404463, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, xref=1, ext=[AuthorCompanyExt(id=1322127365317181680, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127365300404463, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Affiliated Hospital of Guilin Medical University, Guilin 541000, China), AuthorCompanyExt(id=1322127365338153201, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127365300404463, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1桂林医学院附属医院，桂林　541000)])]), Author(id=1322127367984759061, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322127368198668567, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127367984759061, language=EN, stringName=Ji-fang SHENG, firstName=Ji-fang, middleName=null, lastName=SHENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2The First Affiliated Hospital of of Zhejiang University, Hangzhou 310003, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322127368274166040, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127367984759061, language=CN, stringName=盛吉芳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2浙江大学医学院附属第一医院，杭州　310003, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322127365686280435, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, xref=2, ext=[AuthorCompanyExt(id=1322127365698863348, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127365686280435, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2The First Affiliated Hospital of of Zhejiang University, Hangzhou 310003, China), AuthorCompanyExt(id=1322127365711446261, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127365686280435, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2浙江大学医学院附属第一医院，杭州　310003)])]), Author(id=1322127368349663514, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322127368441938204, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127368349663514, language=EN, stringName=Lian-ming DING, firstName=Lian-ming, middleName=null, lastName=DING, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=3, address=3The 81st Group Army Hospital of the Chinese People's Liberation Army (The 251st Hospital of the Chinese People's Liberation Army), Zhangjiakou 075000, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322127368613904669, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127368349663514, language=CN, stringName=丁连明, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=3, address=3中国人民解放军陆军第81集团军医院（中国人民解放军第二五一医院），张家口　075000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322127365812109558, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, xref=3, ext=[AuthorCompanyExt(id=1322127365828886775, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127365812109558, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3The 81st Group Army Hospital of the Chinese People's Liberation Army (The 251st Hospital of the Chinese People's Liberation Army), Zhangjiakou 075000, China), AuthorCompanyExt(id=1322127365837275384, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127365812109558, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3中国人民解放军陆军第81集团军医院（中国人民解放军第二五一医院），张家口　075000)])]), Author(id=1322127368681013535, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322127368756511009, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127368681013535, language=EN, stringName=Chong LI, firstName=Chong, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=4, address=4The First People's Hospital of Changzhou, Changzhou 213003, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322127368832008482, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127368681013535, language=CN, stringName=李翀, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=4, address=4常州市第一人民医院，常州　213003, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322127366147653881, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, xref=4, ext=[AuthorCompanyExt(id=1322127366151848186, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127366147653881, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4The First People's Hospital of Changzhou, Changzhou 213003, China), AuthorCompanyExt(id=1322127366160236795, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127366147653881, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4常州市第一人民医院，常州　213003)])]), Author(id=1322127368899117348, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322127369033335078, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127368899117348, language=EN, stringName=Qi YIN, firstName=Qi, middleName=null, lastName=YIN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=5, address=5Dongfang Hospital Affiliated to Tongji University, Shanghai 200120, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322127369100443943, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127368899117348, language=CN, stringName=尹琦, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=5, address=5同济大学附属东方医院，上海　200120, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322127366235734268, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, xref=5, ext=[AuthorCompanyExt(id=1322127366239928573, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127366235734268, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=5Dongfang Hospital Affiliated to Tongji University, Shanghai 200120, China), AuthorCompanyExt(id=1322127366512558334, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127366235734268, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=5同济大学附属东方医院，上海　200120)])]), Author(id=1322127369167552809, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, orderNo=7, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322127369243050283, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127369167552809, language=EN, stringName=Wen-yuan LIU, firstName=Wen-yuan, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=6, address=6Sichuan Provincial People's Hospital, Chengdu 610072, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322127369305964844, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127369167552809, language=CN, stringName=刘文媛, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=6, address=6四川省人民医院，成都　610072, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322127366592250111, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, xref=6, ext=[AuthorCompanyExt(id=1322127366600638720, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127366592250111, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=6Sichuan Provincial People's Hospital, Chengdu 610072, China), AuthorCompanyExt(id=1322127366609027329, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127366592250111, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=6四川省人民医院，成都　610072)])]), Author(id=1322127369377268014, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, orderNo=8, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=fuxiuhua555@sohu.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1322127369519874352, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127369377268014, language=EN, stringName=Xiu-hua FU, firstName=Xiu-hua, middleName=null, lastName=FU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=7, address=7The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 10050, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322127369591177521, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, authorId=1322127369377268014, language=CN, stringName=付秀华, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=7, address=7内蒙古医学院附属医院，呼和浩特　10050, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322127366671941890, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, xref=7, ext=[AuthorCompanyExt(id=1322127366927794435, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127366671941890, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=7The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 10050, China), AuthorCompanyExt(id=1322127366936183044, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127363182280939, companyId=1322127366671941890, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=7内蒙古医学院附属医院，呼和浩特　10050)])])]
陈峰1 , 俞海英2 , 莫碧文1, 盛吉芳2, 丁连明3, 李翀4, 尹琦5, 刘文媛6, 付秀华7
作者信息
  • 1桂林医学院附属医院，桂林　541000
  • 2浙江大学医学院附属第一医院，杭州　310003
  • 3中国人民解放军陆军第81集团军医院（中国人民解放军第二五一医院），张家口　075000
  • 4常州市第一人民医院，常州　213003
  • 5同济大学附属东方医院，上海　200120
  • 6四川省人民医院，成都　610072
  • 7内蒙古医学院附属医院，呼和浩特　10050
通讯作者:
付秀华，女，教授，主任医师，主要从事呼吸系统疾病诊断和治疗研究。E-mail：。
作者简介:

俞海英，女，博士，副主任医师，主要从事感染性疾病诊断和治疗研究。E-mail：。

陈峰，男，副主任医师，主要从事呼吸系统疾病诊断和治疗研究。联系电话：13977325396，E-mail：。

Injectable cefoperazone sodium and tazobactam sodium (6∶1) in the treatment of moderate to severe acute respiratory bacterial infections: a blind, randomized controlled, multi-center clinical trial
Feng CHEN1 , Hai-ying YU2 , Bi-wen MO1, Ji-fang SHENG2, Lian-ming DING3, Chong LI4, Qi YIN5, Wen-yuan LIU6, Xiu-hua FU7
Affiliations
  • 1Affiliated Hospital of Guilin Medical University, Guilin 541000, China
  • 2The First Affiliated Hospital of of Zhejiang University, Hangzhou 310003, China
  • 3The 81st Group Army Hospital of the Chinese People's Liberation Army (The 251st Hospital of the Chinese People's Liberation Army), Zhangjiakou 075000, China
  • 4The First People's Hospital of Changzhou, Changzhou 213003, China
  • 5Dongfang Hospital Affiliated to Tongji University, Shanghai 200120, China
  • 6Sichuan Provincial People's Hospital, Chengdu 610072, China
  • 7The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 10050, China
出版时间: 2021-12-15
文章导航
收藏切换
摘要
收起
目的：

评价注射用头孢哌酮钠他唑巴坦钠（6∶1）在呼吸系统感染受试人群中的有效性和安全性。

方法：

采用多中心、随机、盲法、阳性药物平行对照。共237例患者纳入试验，其中试验组179例，用头孢哌酮钠他唑巴坦钠（6∶1），对照组58例用注射用头孢哌酮钠他唑巴坦钠（4∶1）。筛选期统一接受注射用头孢哌酮钠单药治疗3 d，治疗期试验组给予试验药3.0 g，bid静脉滴注；对照组给予对照药2.0 g，tid静脉滴注。观察两组治疗前后症状、体征、实验室检查、胸部X线检查、痰细菌培养等的变化。

结果：

两组临床治愈率分别为87.65%和78.85%；细菌清除率分别为97.89%和97.06%；综合疗效分别为86.32%和73.53%；不良反应发生率为13.79%（24/174例）、14.29%（8/56例），主要表现为转氨酶升高、白细胞减少、嗜酸性粒细胞增多等，随访均恢复正常。

结论：

经过大规模Ш期临床试验证明，注射用头孢哌酮钠他唑巴坦钠（6∶1）用于治疗中、重度呼吸系统急性细菌性感染安全有效，为遏制耐药菌感染提供了可选的有效药物。

注射用头孢哌酮钠他唑巴坦钠（6∶1）  /  耐药菌感染  /  呼吸系统  /  盲法  /  随机对照  /  多中心临床试验
Objective:

To evaluate the efficacy and safety of injectable cefoperazone sodium and tazobactam sodium (6∶1) for the treatment of moderate to severe acute respiratory bacterial infections.

Methods:

Totally 237 patients with respiratory tract infections were enrolled in a randomized, double blind, multi-centerand, parallel controlled study, in which 179 in experimental group and 58 in control group ([injectable cefoperazone sodium and tazobactam sodium (4∶1)]. During the screening period, cefoperazone sodium was uniformly injected for 3 d. During the treatment period, the experimental group was given the test drug 3.0 g by intravenous drip twice a day, and the control group was given 2.0 g of control drug by intravenous drip 3 times a day. The results of symptoms, signs, laboratory examination, chest X-ray examination and sputum bacterial culture were observed before and after treatment.

Results:

In experiment group and control group, the clinical cure rates were 87.65% and 78.85%, respectively. The bacterial clearance rates were 97.89% and 97.06%. Comprehensive efficacies were 86.32% and 73.53%. Incidences of adverse reaction were 13.79% (24/174 patients) in the test group and 14.29% (8/56 patients) in the control group. The main manifestations were elevated transaminase, leucopenia, eosinophilia and so on. All patients returned to normal after follow-up.

Conclusion:

Injectable cefoperazone sodium and tazobactam sodium (6∶1) is proved to be safe and effective in the treatment of moderate to severe acute bacterial infection of respiratory system after large-scale phase Ⅲ clinical trial, providing an effective drug for the control of drug-resistant bacterial infection.

cefoperazone sodium and tazobactam sodium for injection (6∶1)  /  drug-resistant bacteria infection  /  acute respiratory bacterial infections  /  blind  /  randomized controlled  /  multi-center clinical trial
陈峰, 俞海英, 莫碧文, 盛吉芳, 丁连明, 李翀, 尹琦, 刘文媛, 付秀华. 注射用头孢哌酮钠他唑巴坦钠（6∶1）治疗中重度呼吸系统急性细菌性感染的多中心随机对照临床试验. 中国新药杂志, 2021 , 30 (23) : 2194 -2202 .
Feng CHEN, Hai-ying YU, Bi-wen MO, Ji-fang SHENG, Lian-ming DING, Chong LI, Qi YIN, Wen-yuan LIU, Xiu-hua FU. Injectable cefoperazone sodium and tazobactam sodium (6∶1) in the treatment of moderate to severe acute respiratory bacterial infections: a blind, randomized controlled, multi-center clinical trial[J]. Chinese Journal of New Drugs, 2021 , 30 (23) : 2194 -2202 .
基金
收起
  • 国家“重大新药创制”科技重大专项基金资助项目(2013ZX09301303)
文献
收起
参考文献 引证文献
排序方式：
[1]
胡付品, 郭燕, 吴湜, 等. CHINET中国细菌耐药监测结果[EB/OL]. (2021-02-22). http://www.chinets.com/Document.
[2]
WHO. 2020 antibacterial agents in clinical and preclinical development: an overview and analysis[EB/OL]. (2021-04-15). https://www.who.int/publications/i/item/9789240021303.
[3]
FDA CDER. Guidance for industry antibacterial drug products: use of noninferiority trials to support approval[EB/OL]. (2010-11-29). https://www.fda.gov/regulatory-information/search-fda-guidance-documents/antibacterial-drug-products-use-noninferiority-studies-support-approval.
[4]
NMPA CDE. 抗菌药物非劣效临床试验设计技术指导原则[S]. 2012.
[5]
NMPA CDE. 抗菌药物临床试验技术指导原则[S]. 2015.
[6]
NMPA CDE. 社区获得性细菌性肺炎抗菌药物临床试验技术指导原则[S]. 2020.
[7]
JACKSON EA, CARDONI AA, LYON JA. Cefoperazone (cefobid, pfizer)[J]. Drug Intell Clin Pharm, 1983, 17(1): 7-11.
[8]
CRAIG WA, GERBER AU. Pharmacokinetics of cefoperazone: a review[J]. Drugs, 1981, 22(1): 35-45.
[9]
ARONOFF SC, JACOBS MR, JOHENNING S, et al. Comparative activities of the beta-lactamase inhibitors YTR 830, sodium clavulanate, and sulbactam combined with amoxicillin or ampicillin[J]. Antimicrob Agents Chemother, 1984, 26(4): 580-582.
[10]
APPELBAUM PC, JACOBS MR, SPANGLER SK, et al. Comparative activity of beta-lactamase inhibitors YTR 830, clavulanate, and sulbactam combined with beta-lactams against beta-lactamase-producing anaerobes[J]. Antimicrob Agents Chemother, 1986, 30(5): 789-791.
[11]
BHATTACHARYA S, PADHI AK, JUNGHARE V, et al. Understanding the molecular interactions of inhibitors against Bla1 beta-lactamase towards unraveling the mechanism of antimicrobial resistance[J]. Int J Biol Macromol, 2021, 177: 337-350.
[12]
FDA. 头孢哌酮钠(CEFOBID®)说明书[EB/OL]. [2021-06-25]. https://s3-us-west-2.amazonaws.com/drugbank/fda_labels/DB01329.pdf?1559236712.
[13]
刘毅, 付四海, 高太平, 等. 头孢哌酮与β-内酰胺酶抑制剂复方研究进展[J]. 国外医药(抗生素分册), 2018, 39(2): 135-140.
[14]
FDA CDER. Community-acquired bacterial pneumonia: developing drugs for treatment guidance for industry[EB/OL]. (2020-06-24). https://www.fda.gov/media/75149/download.
[15]
赵磊, 何晓静, 李晓冰, 等. 临床常用头孢菌素类抗菌药物药品说明书评价[J]. 中国现代应用药学, 2020, 37(15): 1872-1876.
2021年第30卷第23期
PDF下载
15
2
引用本文
BibTeX
文章信息
  • 首发时间：2026-10-28
  • 出版时间：2021-12-15
补充材料
相关文章
文章信息
作者
出版历史
  • 录用日期：2021-10-04
基金
国家“重大新药创制”科技重大专项基金资助项目(2013ZX09301303)
作者信息
    1桂林医学院附属医院，桂林　541000
    2浙江大学医学院附属第一医院，杭州　310003
    3中国人民解放军陆军第81集团军医院（中国人民解放军第二五一医院），张家口　075000
    4常州市第一人民医院，常州　213003
    5同济大学附属东方医院，上海　200120
    6四川省人民医院，成都　610072
    7内蒙古医学院附属医院，呼和浩特　10050

通讯作者:

付秀华，女，教授，主任医师，主要从事呼吸系统疾病诊断和治疗研究。E-mail：。
参考文献
分享链接
https://castjournals.cast.org.cn/joweb/zgxyzz/CN/1322127363182280939
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
相关链接
论文
最新文章
热读文章
热点专题
内参
蓝皮书
产业发展报告
传播力报告
期刊分级目录
资讯
学术新闻
行业新闻
学术会议
行业会议
关于
关于我们
联系我们
北京市海淀区学院南路86号
100081
010-62662699（运营及技术支持）
qkjq@cast.org.cn

中国科学技术协会版权所有 京ICP 备10216604号-4 海淀分局备案 1101084647
科技导报社主办 中国科协信息中心技术支持