Article(id=1322127318831714472, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322127297054888908, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1620921600000, acceptedDateStr=2021-05-14, onlineDate=1793149316747, onlineDateStr=2026-10-28, pubDate=1639497600000, pubDateStr=2021-12-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793149316747, onlineIssueDateStr=2026-10-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793149316747, creator=13701087609, updateTime=1793149316747, updator=13701087609, issue=Issue{id=1322127297054888908, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='23', pageStart='2121', pageEnd='2224', issueExtLink='null', onlineDate='null', pubDate='1639497600000', pubDateStr='2021-12-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793149311555, creator='13701087609', updateTime=1793149538282, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322128248071369266, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322127297054888908, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322128248075563571, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322127297054888908, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2189, endPage=2193, ext={EN=ArticleExt(id=1322127319007875241, articleId=1322127318831714472, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Research and development advancement of anti-cancer inhibitors targeting KRAS signaling pathway, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Based on the universality and significance of KRAS mutation in human cancer in recent years, the development of drugs targeting KRAS and KRAS-related drug screening have become the current research hotspots. The research strategies and development status of small-molecule KRAS inhibitors as well as existing effective small-molecule KRAS inhibitors were reviewed in this paper, in favor of providing new ideas and strategies for new drug development of KRAS mutated tumors.

, authors=Jia-ruo XU, Yu-ying ZHU, Guang-tao YAO, Jian-ge ZHANG, authorsList=Jia-ruo XU, Yu-ying ZHU, Guang-tao YAO, Jian-ge ZHANG, authorCompany=null, correspAuthors=Guang-tao YAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322127319242756266, articleId=1322127318831714472, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=靶向KRAS信号通路的抗肿瘤抑制剂研发现状, columnId=1236330553964810454, journalTitle=中国新药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

近年来，基于KRAS突变在人类癌症中的普遍性与重要性，靶向KRAS药物开发以及KRAS相关作用药物筛选已成为当前研究的热点。通过对KRAS小分子抑制剂的研究策略、发展现状以及现有药效较好的KRAS小分子抑制剂进行综述，为开发治疗KRAS突变肿瘤新药提供新的思路与方法。

, authors=徐嘉若, 朱玉莹, 姚广涛, 张建革, authorsList=徐嘉若, 朱玉莹, 姚广涛, 张建革, authorCompany=null, correspAuthors=姚广涛, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=NK3xKp3xEclTIveW6wlW/A==, magXml=7ZviocWqwBlTGYUPcPmTNQ==, pdfUrl=null, pdf=apnATv2Hk2KftYuyEBkeKA==, pdfFileSize=2674396, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=qsFLObaLQerE7sFnC7zOVQ==, mapNumber=null, fund=null)}, authors=[Author(id=1322127319532163247, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127318831714472, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=516413756@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322127319653798065, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127318831714472, authorId=1322127319532163247, language=EN, stringName=Jia-ruo XU, firstName=Jia-ruo, middleName=null, lastName=XU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322127319729295538, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322127318831714472, authorId=1322127319532163247, language=CN, stringName=徐嘉若, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=上海中医药大学，上海　201203, bio={"content":"

徐嘉若，女，硕士研究生；研究方向：抗肿瘤作用机制研究。E-mail：516413756@qq.com。

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徐嘉若，女，硕士研究生；研究方向：抗肿瘤作用机制研究。E-mail：516413756@qq.com。

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