Article(id=1321426310333842284, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321426285826519296, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.16.009, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1776009600000, acceptedDateStr=2026-04-13, onlineDate=1792982183297, onlineDateStr=2026-10-26, pubDate=1788019200000, pubDateStr=2026-08-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982183297, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982183297, creator=13701087609, updateTime=1792982183297, updator=13701087609, issue=Issue{id=1321426285826519296, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='16', pageStart='1681', pageEnd='1792', issueExtLink='null', onlineDate='null', pubDate='1788019200000', pubDateStr='2026-08-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982177454, creator='13701087609', updateTime=1792982881356, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321429238297776921, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321426285826519296, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321429238297776922, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321426285826519296, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1745, endPage=1750, ext={EN=ArticleExt(id=1321426310644220782, articleId=1321426310333842284, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=A new drug for treating small cell lung cancer: tarlatamab, a DLL3/CD3-targeted bispecific T-cell engage, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Tarlatamab is an innovative targeted immunotherapy agent that simultaneously binds to delta-like ligand 3 (DLL3) expressed on tumor cell surfaces and CD3 expressed on cytotoxic T-cell surfaces. As a DLL3/CD3-targeted bispecific T-cell engager (BiTE), it activates T cells to release inflammatory cytokines, thereby killing tumor cells expressing DLL3 protein. In May 2024, tarlatamab received accelerated approval from the U.S. FDA for the treatment of adult patients with extensive-stage small cell lung cancer that has progressed during or after platinum-based chemotherapy. This article provides an overview of tarlatamab's basic information, mechanism of action, pharmacokinetics, clinical trials, and safety, to provide a reference for clinical application.

, authors=Xin-ling WANG, Qing-hua HU, Xiu-hua LU^*, authorsList=Xin-ling WANG, Qing-hua HU, Xiu-hua LU, authorCompany=null, correspAuthors=Xiu-hua LU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321426312724595567, articleId=1321426310333842284, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=小细胞肺癌治疗新药：塔拉妥单抗靶向DLL3/CD3双特异性T细胞衔接器, columnId=1236330553964810454, journalTitle=中国新药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

塔拉妥单抗（tarlatamab）是一款创新靶向免疫药物，能够同时结合肿瘤细胞表面表达的δ样配体3（delta-like ligand 3, DLL3）和细胞毒性T细胞表面表达的CD3，是靶向DLL3/CD3的双特异性T细胞衔接器，能够激活T细胞释放炎性细胞因子，从而杀伤表达DLL3蛋白的肿瘤细胞。2024年5月，tarlatamab获美国FDA加速批准，用于治疗在铂类化疗期间或之后进展的广泛期小细胞肺癌（extensive stage small cell lung cancer, ES-SCLC）成人患者。本文就tarlatamab的基本信息、作用机制、药动学、临床试验研究、安全性进行概述，以期为临床应用提供参考。

, authors=王新玲, 胡庆花, 卢秀花^*, authorsList=王新玲, 胡庆花, 卢秀花, authorCompany=null, correspAuthors=卢秀花, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=m1kZSbV73/hNtp8pSzsAww==, magXml=9jHZYu/t6ISLy4rjFItEAg==, pdfUrl=null, pdf=jwwLMmO6ByoB9CZ7k6ni3w==, pdfFileSize=1570752, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=kpNifKpAQEYBTVu/wDIBwQ==, mapNumber=null, fund=null)}, authors=[Author(id=1321426313039168372, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426310333842284, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=haijianlong@126.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321426313139831670, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426310333842284, authorId=1321426313039168372, language=EN, stringName=Xin-ling WANG, firstName=Xin-ling, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Pharmacy, Linyi Central Hospital, Linyi 276400, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321426313240494967, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426310333842284, authorId=1321426313039168372, language=CN, stringName=王新玲, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=临沂市中心医院药学部，临沂 276400, bio={"content":"

王新玲，女，本科，主管药师，主要从事新药研究相关工作。联系电话：（0539）2263614，E-mail: haijianlong@126.com。

"}, bioImg=null, bioContent=

王新玲，女，本科，主管药师，主要从事新药研究相关工作。联系电话：（0539）2263614，E-mail: haijianlong@126.com。

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