Article(id=1321426295989322493, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321426285826519296, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.16.001, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1758556800000, acceptedDateStr=2025-09-23, onlineDate=1792982179876, onlineDateStr=2026-10-26, pubDate=1788019200000, pubDateStr=2026-08-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982179876, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982179876, creator=13701087609, updateTime=1792982179876, updator=13701087609, issue=Issue{id=1321426285826519296, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='16', pageStart='1681', pageEnd='1792', issueExtLink='null', onlineDate='null', pubDate='1788019200000', pubDateStr='2026-08-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982177454, creator='13701087609', updateTime=1792982881356, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321429238297776921, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321426285826519296, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321429238297776922, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321426285826519296, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1681, endPage=1688, ext={EN=ArticleExt(id=1321426296245175038, articleId=1321426295989322493, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Sphingosine-1-phosphate-targeted small molecule drugs for the treatment of multiple sclerosis and the patent research, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

In this paper, four sphingosine-1-phosphate (S1P) targeted small molecule drugs for the treatment of multiple sclerosis which have been marketed worldwide, and their patent information were unscrambled and researched. The development progress of fingolimod, siponimod, ozanimod and ponesimod, as well as their published patents about product, formulation, new use, et al, were studied and analyzed to provide effective patent information and references for pharmaceutical enterprises in China in the process of establishing and developing related drugs, as well as new patent mining, patent application and layout.

, authors=Hua JIANG^{1, 2}, Hong-tao JIAO³, Li-na QIAN^{2, *}, Lu HUANG^{1, 4, 5, 6, *}, authorsList=Hua JIANG, Hong-tao JIAO, Li-na QIAN, Lu HUANG, authorCompany=null, correspAuthors=Li-na QIAN, Lu HUANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321426296689771263, articleId=1321426295989322493, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=用于治疗多发性硬化症的S1P靶点小分子药物及其专利研究, columnId=1236331162679955859, journalTitle=中国新药杂志, columnName=新药述评与论坛, runingTitle=null, highlight=null, articleAbstract=

本文梳理了全球已获批上市与正在研发中的用于治疗多发性硬化症的鞘氨醇-1-磷酸（sphingosine-1-phosphate, S1P）靶点小分子药物品种情况，对其中4个已上市药物芬戈莫德、西尼莫德、奥扎莫德和珀奈莫德的研发进展以及涉及其化合物、药物制剂、新用途等不同技术主题已公开的专利进行研究和分析，以期为医药企业在进行立项与开发有关药物以及进行新的专利挖掘、专利申请与布局时，提供有效的产品信息和专利信息。

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姜华，女，工程师，主要从事生物医药企业知识产权工作。E-mail: 1013080702@qq.com。

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姜华，女，工程师，主要从事生物医药企业知识产权工作。E-mail: 1013080702@qq.com。

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