Article(id=1321426291530772765, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321426285826519296, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.16.007, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1759939200000, acceptedDateStr=2025-10-09, onlineDate=1792982178814, onlineDateStr=2026-10-26, pubDate=1788019200000, pubDateStr=2026-08-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982178814, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982178814, creator=13701087609, updateTime=1792982178814, updator=13701087609, issue=Issue{id=1321426285826519296, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='16', pageStart='1681', pageEnd='1792', issueExtLink='null', onlineDate='null', pubDate='1788019200000', pubDateStr='2026-08-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982177454, creator='13701087609', updateTime=1792982881356, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321429238297776921, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321426285826519296, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321429238297776922, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321426285826519296, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1728, endPage=1735, ext={EN=ArticleExt(id=1321426291778236702, articleId=1321426291530772765, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Advances in κ-opioid receptor selective agonist analgesics, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

To identify safer and more effective opioid analgesics, κ-opioid receptor (KOR) selective agonists have been widely investigated for their potent analgesic properties and lack of the abuse liability typically associated with μ-opioid receptor activation. The clinical approval of the peptide-based drug difelikefalin (Korsuva) established a pivotal milestone, creating new pathways for the therapeutic application of KOR-selective agonists. Subsequently, diverse compound scaffolds, including small molecules and peptides, along with innovative research approaches, have been systematically explored through experimental studies. This review examines the latest chemical advancements and challenges related to KOR agonists, as well as their clinical and potential applications.

, authors=Ming YUAN^{1, 2}, Qing LI², Chao WANG², Wei-guo SHI^{2, *}, Chun HU^{1, *}, authorsList=Ming YUAN, Qing LI, Chao WANG, Wei-guo SHI, Chun HU, authorCompany=null, correspAuthors=Wei-guo SHI, Chun HU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321426292138946847, articleId=1321426291530772765, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=κ-阿片受体选择性激动剂类镇痛药物研究进展, columnId=1236330553964810454, journalTitle=中国新药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

为了开发更安全有效的新型阿片类镇痛药物，κ-阿片受体（κ-opioid receptor, KOR）选择性激动剂因其显著的镇痛效果和避免μ-阿片受体相关的滥用风险而备受瞩目。多肽类药物地非法林（difelikefalin，商品名为Korsuva）的上市为KOR选择性激动剂的临床应用开辟了新的领域，更多的小分子和多肽等新化合物的结构和研究策略逐渐受到重视。本文综述了KOR激动剂的最新化学进展和面临挑战，并探讨其临床应用和潜在的治疗前景，以期为后续的阿片受体新药设计提供新的选择。

, authors=袁明^{1, 2}, 李晴², 王潮², 史卫国^{2, *}, 胡春^{1, *}, authorsList=袁明, 李晴, 王潮, 史卫国, 胡春, authorCompany=null, correspAuthors=史卫国, 胡春, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=7agqgZyoxkdENgvT7jQj3Q==, magXml=tkJ8wuMo/yzkegAHagPfcg==, pdfUrl=null, pdf=VFAkoE/yFQMLCML6LHKiIw==, pdfFileSize=9032390, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=6VKmVvqgAw+6B71L9JQavg==, mapNumber=null, fund=null)}, authors=[Author(id=1321426292591931687, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426291530772765, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=18698437226@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321426292696789290, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426291530772765, authorId=1321426292591931687, language=EN, stringName=Ming YUAN, firstName=Ming, middleName=null, lastName=YUAN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=¹Shenyang Pharmaceutical University, Shenyang 117004, China
²Academy of Military Medical Sciences, Beijing 100850, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321426294370316587, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426291530772765, authorId=1321426292591931687, language=CN, stringName=袁明, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=¹沈阳药科大学，沈阳 117004
²军事医学研究院，北京 100850, bio={"content":"

袁明，男，硕士研究生，研究方向：多肽药物的药物化学研究。E-mail: 18698437226@163.com。

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袁明，男，硕士研究生，研究方向：多肽药物的药物化学研究。E-mail: 18698437226@163.com。

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