Article(id=1321426287000933307, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321426285826519296, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.16.005, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1761494400000, acceptedDateStr=2025-10-27, onlineDate=1792982177733, onlineDateStr=2026-10-26, pubDate=1788019200000, pubDateStr=2026-08-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982177733, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982177733, creator=13701087609, updateTime=1792982177733, updator=13701087609, issue=Issue{id=1321426285826519296, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='16', pageStart='1681', pageEnd='1792', issueExtLink='null', onlineDate='null', pubDate='1788019200000', pubDateStr='2026-08-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982177454, creator='13701087609', updateTime=1792982881356, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321429238297776921, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321426285826519296, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321429238297776922, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321426285826519296, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1712, endPage=1719, ext={EN=ArticleExt(id=1321426287219037116, articleId=1321426287000933307, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Research advances in molecular imaging probes targeting CLDN18.2 in tumors, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Claudin 18.2 (CLDN18.2) has emerged as a promising molecular target for anti-tumor therapy, drawing considerable attention in recent years. Although several CLDN18.2-targeted therapeutics have already entered clinical practice and shown good efficacy, their efficacy is closely correlated with the expression level of the target. Consequently, the development of molecular imaging probes with high sensitivity and specificity for CLDN18.2 is of great significance for the early detection of tumors, stratification of patients, and real-time monitoring of therapeutic response. This review systematically summarizes recent advances in the development of CLDN18.2-targeted molecular imaging probes, aiming to provide a theoretical framework to support the future design and clinical translation of diagnostic radiopharmaceuticals.

, authors=Hao-qun MA^{1, 2}, Xuan-hui PENG^{1, 2}, Meng ZHENG^{1, 2}, Yan WANG^{1, 2}, Li-yan MIAO^{1, 2, *}, authorsList=Hao-qun MA, Xuan-hui PENG, Meng ZHENG, Yan WANG, Li-yan MIAO, authorCompany=null, correspAuthors=Li-yan MIAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321426287755908029, articleId=1321426287000933307, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=靶向肿瘤CLDN18.2分子影像探针的研究进展, columnId=1236330553964810454, journalTitle=中国新药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

近年来，以Claudin 18.2（CLDN18.2）为靶点的抗肿瘤治疗已成为研究热点。尽管部分靶向CLDN18.2的药物已进入临床应用，并展现出良好的疗效，但其疗效高度依赖于靶点的表达水平。因此，开发具有高灵敏性与高特异性的CLDN18.2分子影像探针，对于实现肿瘤的早期发现、患者筛选与分层治疗以及疗效的动态监测具有重要意义。本文系统梳理了近年来围绕CLDN18.2靶点开发的分子影像探针的研究进展，旨在为该类诊断型药物的持续优化及其临床转化提供理论支持与实践参考。

, authors=麻浩群^{1, 2}, 彭渲惠^{1, 2}, 郑梦^{1, 2}, 王燕^{1, 2}, 缪丽燕^{1, 2, *}, authorsList=麻浩群, 彭渲惠, 郑梦, 王燕, 缪丽燕, authorCompany=null, correspAuthors=缪丽燕, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=NuX4mZOCdQrQn9tSsP+uDQ==, magXml=AURCFjtRThPVSqcShEMdpg==, pdfUrl=null, pdf=flT3WUZ9w+whwGXgtydThA==, pdfFileSize=2833081, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=C97um7pawUmisxoUfDKzbw==, mapNumber=null, fund=null)}, authors=[Author(id=1321426289400075205, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=mahaoqun0926@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321426289509127112, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, authorId=1321426289400075205, language=EN, stringName=Hao-qun MA, firstName=Hao-qun, middleName=null, lastName=MA, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=¹Clinical Pharmacology Research Laboratory, the First Affiliated Hospital of Suzhou University, Suzhou 215006, China
²College of Pharmaceutical Sciences, Suzhou University, Suzhou 215123, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321426289605596105, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, authorId=1321426289400075205, language=CN, stringName=麻浩群, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=¹苏州大学附属第一医院临床药理实验室，苏州 215006
²苏州大学药学院，苏州 215123, bio={"content":"

麻浩群，女，硕士，研究方向：分子影像与临床药学。E-mail: mahaoqun0926@163.com。

"}, bioImg=null, bioContent=

麻浩群，女，硕士，研究方向：分子影像与临床药学。E-mail: mahaoqun0926@163.com。

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321426288036926398, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, xref=1, ext=[AuthorCompanyExt(id=1321426288045315007, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, companyId=1321426288036926398, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹Clinical Pharmacology Research Laboratory, the First Affiliated Hospital of Suzhou University, Suzhou 215006, China), AuthorCompanyExt(id=1321426288049509312, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, companyId=1321426288036926398, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹苏州大学附属第一医院临床药理实验室，苏州 215006)]), AuthorCompany(id=1321426289295217601, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, xref=2, ext=[AuthorCompanyExt(id=1321426289299411906, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, companyId=1321426289295217601, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²College of Pharmaceutical Sciences, Suzhou University, Suzhou 215123, China), AuthorCompanyExt(id=1321426289307800515, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, companyId=1321426289295217601, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²苏州大学药学院，苏州 215123)])]), Author(id=1321426289693676491, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321426289819505614, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, authorId=1321426289693676491, language=EN, stringName=Xuan-hui PENG, firstName=Xuan-hui, middleName=null, lastName=PENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=¹Clinical Pharmacology Research Laboratory, the First Affiliated Hospital of Suzhou University, Suzhou 215006, China
²College of Pharmaceutical Sciences, Suzhou University, Suzhou 215123, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321426289903391695, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, authorId=1321426289693676491, language=CN, stringName=彭渲惠, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=¹苏州大学附属第一医院临床药理实验室，苏州 215006
²苏州大学药学院，苏州 215123, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321426288036926398, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, xref=1, ext=[AuthorCompanyExt(id=1321426288045315007, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, companyId=1321426288036926398, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹Clinical Pharmacology Research Laboratory, the First Affiliated Hospital of Suzhou University, Suzhou 215006, China), AuthorCompanyExt(id=1321426288049509312, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, companyId=1321426288036926398, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹苏州大学附属第一医院临床药理实验室，苏州 215006)]), AuthorCompany(id=1321426289295217601, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, xref=2, ext=[AuthorCompanyExt(id=1321426289299411906, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, companyId=1321426289295217601, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²College of Pharmaceutical Sciences, Suzhou University, Suzhou 215123, China), AuthorCompanyExt(id=1321426289307800515, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, companyId=1321426289295217601, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²苏州大学药学院，苏州 215123)])]), Author(id=1321426290012443601, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321426290108912596, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, authorId=1321426290012443601, language=EN, stringName=Meng ZHENG, firstName=Meng, middleName=null, lastName=ZHENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=¹Clinical Pharmacology Research Laboratory, the First Affiliated Hospital of Suzhou University, Suzhou 215006, China
²College of Pharmaceutical Sciences, Suzhou University, Suzhou 215123, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321426290188604373, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, authorId=1321426290012443601, language=CN, stringName=郑梦, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=¹苏州大学附属第一医院临床药理实验室，苏州 215006
²苏州大学药学院，苏州 215123, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321426288036926398, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, xref=1, ext=[AuthorCompanyExt(id=1321426288045315007, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, companyId=1321426288036926398, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹Clinical Pharmacology Research Laboratory, the First Affiliated Hospital of Suzhou University, Suzhou 215006, China), AuthorCompanyExt(id=1321426288049509312, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, companyId=1321426288036926398, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹苏州大学附属第一医院临床药理实验室，苏州 215006)]), AuthorCompany(id=1321426289295217601, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, xref=2, ext=[AuthorCompanyExt(id=1321426289299411906, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, companyId=1321426289295217601, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²College of Pharmaceutical Sciences, Suzhou University, Suzhou 215123, China), AuthorCompanyExt(id=1321426289307800515, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, companyId=1321426289295217601, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²苏州大学药学院，苏州 215123)])]), Author(id=1321426290293461975, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321426290394125274, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, authorId=1321426290293461975, language=EN, stringName=Yan WANG, firstName=Yan, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=¹Clinical Pharmacology Research Laboratory, the First Affiliated Hospital of Suzhou University, Suzhou 215006, China
²College of Pharmaceutical Sciences, Suzhou University, Suzhou 215123, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321426290486399963, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, authorId=1321426290293461975, language=CN, stringName=王燕, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=¹苏州大学附属第一医院临床药理实验室，苏州 215006
²苏州大学药学院，苏州 215123, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321426288036926398, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, xref=1, ext=[AuthorCompanyExt(id=1321426288045315007, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, companyId=1321426288036926398, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹Clinical Pharmacology Research Laboratory, the First Affiliated Hospital of Suzhou University, Suzhou 215006, China), AuthorCompanyExt(id=1321426288049509312, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, companyId=1321426288036926398, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹苏州大学附属第一医院临床药理实验室，苏州 215006)]), AuthorCompany(id=1321426289295217601, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, xref=2, ext=[AuthorCompanyExt(id=1321426289299411906, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, companyId=1321426289295217601, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²College of Pharmaceutical Sciences, Suzhou University, Suzhou 215123, China), AuthorCompanyExt(id=1321426289307800515, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, companyId=1321426289295217601, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²苏州大学药学院，苏州 215123)])]), Author(id=1321426290570286045, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=miaolysuzhou@163.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1321426290662560736, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, authorId=1321426290570286045, language=EN, stringName=Li-yan MIAO, firstName=Li-yan, middleName=null, lastName=MIAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2, *}, address=¹Clinical Pharmacology Research Laboratory, the First Affiliated Hospital of Suzhou University, Suzhou 215006, China
²College of Pharmaceutical Sciences, Suzhou University, Suzhou 215123, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321426290746446817, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, authorId=1321426290570286045, language=CN, stringName=缪丽燕, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2, *}, address=¹苏州大学附属第一医院临床药理实验室，苏州 215006
²苏州大学药学院，苏州 215123, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321426288036926398, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, xref=1, ext=[AuthorCompanyExt(id=1321426288045315007, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, companyId=1321426288036926398, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹Clinical Pharmacology Research Laboratory, the First Affiliated Hospital of Suzhou University, Suzhou 215006, China), AuthorCompanyExt(id=1321426288049509312, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, companyId=1321426288036926398, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹苏州大学附属第一医院临床药理实验室，苏州 215006)]), AuthorCompany(id=1321426289295217601, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, xref=2, ext=[AuthorCompanyExt(id=1321426289299411906, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, companyId=1321426289295217601, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²College of Pharmaceutical Sciences, Suzhou University, Suzhou 215123, China), AuthorCompanyExt(id=1321426289307800515, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, companyId=1321426289295217601, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²苏州大学药学院，苏州 215123)])])], keywords=[Keyword(id=1321426290880664546, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, language=EN, orderNo=1, keyword=CLDN18.2), Keyword(id=1321426290964550627, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, language=EN, orderNo=2, keyword=molecular imaging probe), Keyword(id=1321426291056825316, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, language=EN, orderNo=3, keyword=radionuclide), Keyword(id=1321426291140711397, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, language=EN, orderNo=4, keyword=tumor diagnosis), Keyword(id=1321426291216208870, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, language=EN, orderNo=5, keyword=targeted therapy), Keyword(id=1321426291312677863, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, language=EN, orderNo=6, keyword=clinical application), Keyword(id=1321426291413341160, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, language=CN, orderNo=1, keyword=CLDN18.2), Keyword(id=1321426291501421545, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, language=CN, orderNo=2, keyword=分子影像探针), Keyword(id=1321426291576919018, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, language=CN, orderNo=3, keyword=放射性核素), Keyword(id=1321426291669193707, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, language=CN, orderNo=4, keyword=肿瘤诊断), Keyword(id=1321426291757274092, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, language=CN, orderNo=5, keyword=靶向治疗), Keyword(id=1321426291828577261, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, language=CN, orderNo=6, keyword=临床应用)], refs=null, funds=[Fund(id=1321426291958600686, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, awardId=U24A20765, language=CN, fundingSource=国家自然科学基金区域重点资助项目(U24A20765), fundOrder=null, country=null), Fund(id=1321426292088624111, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, awardId=KJXW2023004, language=CN, fundingSource=苏州市“科教兴卫”青年科技项目(KJXW2023004), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1321426288036926398, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, xref=1, ext=[AuthorCompanyExt(id=1321426288045315007, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, companyId=1321426288036926398, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹Clinical Pharmacology Research Laboratory, the First Affiliated Hospital of Suzhou University, Suzhou 215006, China), AuthorCompanyExt(id=1321426288049509312, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, companyId=1321426288036926398, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹苏州大学附属第一医院临床药理实验室，苏州 215006)]), AuthorCompany(id=1321426289295217601, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, xref=2, ext=[AuthorCompanyExt(id=1321426289299411906, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, companyId=1321426289295217601, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²College of Pharmaceutical Sciences, Suzhou University, Suzhou 215123, China), AuthorCompanyExt(id=1321426289307800515, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321426287000933307, companyId=1321426289295217601, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²苏州大学药学院，苏州 215123)])], figs=null, attaches=null, journal=Journal(id=1235980159023624194, delFlag=0, nameCn=中国新药杂志, nameEn=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, issn=1003-3734, eissn=null, cn=11-2850/R, coden=ZXZHA6, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of New Drugs, journalRemark=null, publicationField=null, createdTime=1772610233314, updatedTime=1788948968376, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=ohPEEN//Vz1tDT3ZBNTp4Q==, picEn=f9WK9bvTM4guTmS/iGhOMg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509780974924039, language=CN, name=中国新药杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948968404, updatedTime=1788948968404, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304509781025255688, language=EN, name=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948968416, updatedTime=1788948968416, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1235980733773295621, websiteList=[Website(id=1235982099191222761, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/CN, language=CN, createTime=1772610695884, createBy=18614031015, updateTime=1772610860397, updateBy=18614031015, name=中国新药杂志-中文, tplId=1146099689490845704, title=中国新药杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983918629966444, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=articleTextType, value=kx, createTime=1772611129672, updateTime=1772611129672, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918604800617, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=banner, value=null, createTime=1772611129666, updateTime=1772611129666, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918655132271, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=grayFlag, value=0, createTime=1772611129678, updateTime=1772611129678, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918596412008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611129664, updateTime=1772611129664, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918667715185, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=minRunFlag, value=0, createTime=1772611129681, updateTime=1772611129681, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918617383531, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic, createTime=1772611129669, updateTime=1772611129669, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918659326576, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=silenceFlag, value=0, createTime=1772611129679, updateTime=1772611129679, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918613189226, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1772611129668, updateTime=1772611129668, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918634160749, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeColor, value=null, createTime=1772611129673, updateTime=1772611129673, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918646743662, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeStyle, value=null, createTime=1772611129676, updateTime=1772611129676, creator=18614031015, updator=18614031015)]), Website(id=1235982099270914542, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/EN, language=EN, createTime=1772610695903, createBy=18614031015, updateTime=1772610875891, updateBy=18614031015, name=中国新药杂志-英文, tplId=1146101810881728533, title=Chinese Journal of New Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983955829248630, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=articleTextType, value=kx, createTime=1772611138541, updateTime=1772611138541, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955804082803, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=banner, value=null, createTime=1772611138535, updateTime=1772611138535, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955854414457, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=grayFlag, value=0, createTime=1772611138547, updateTime=1772611138547, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955795694194, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611138533, updateTime=1772611138533, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955866997371, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=minRunFlag, value=0, createTime=1772611138550, updateTime=1772611138550, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955820860021, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic, createTime=1772611138539, updateTime=1772611138539, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955862803066, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=silenceFlag, value=0, createTime=1772611138549, updateTime=1772611138549, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955812471412, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1772611138537, updateTime=1772611138537, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955837637239, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeColor, value=null, createTime=1772611138543, updateTime=1772611138543, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955846025848, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeStyle, value=null, createTime=1772611138545, updateTime=1772611138545, creator=18614031015, updator=18614031015)])], journalTitle=中国新药杂志, weixinUrl=null, journalUrl=http://www.newdrug.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of New Drugs, journalPhotoCn=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPhotoEn=f9WK9bvTM4guTmS/iGhOMg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/10.20251/j.cnki.1003-3734.2026.16.005, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/10.20251/j.cnki.1003-3734.2026.16.005, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/PDF/10.20251/j.cnki.1003-3734.2026.16.005, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/PDF/10.20251/j.cnki.1003-3734.2026.16.005, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1788019200000, fullTextJson=null, articleText=null, reference=null)