Article(id=1321425929507815908, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425881147495164, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.18.009, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1767542400000, acceptedDateStr=2026-01-05, onlineDate=1792982092500, onlineDateStr=2026-10-26, pubDate=1790697600000, pubDateStr=2026-09-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982092500, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982092500, creator=13701087609, updateTime=1792982092500, updator=13701087609, issue=Issue{id=1321425881147495164, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='18', pageStart='1905', pageEnd='2016', issueExtLink='null', onlineDate='null', pubDate='1790697600000', pubDateStr='2026-09-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982080970, creator='13701087609', updateTime=1792982834300, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321429040930599029, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425881147495164, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321429040930599030, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425881147495164, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1968, endPage=1976, ext={EN=ArticleExt(id=1321425929658810853, articleId=1321425929507815908, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Investigating the mechanisms of total alkaloids of Strychnos against myasthenia gravis in a rat model, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To investigate the therapeutic effect of MQZZJ (total alkaloids of Strychnos) on experimental autoimmune myasthenia gravis (EAMG) rats and to elucidate its underlying mechanisms.
Methods: The EAMG rat model was established by immunizing female Lewis rats with the R97-116 peptide fragment. Rats were assigned to different groups and treated with MQZZJ (0.35, 0.7, and 1.4 mg·kg-1) or prednisone (4.2 mg·kg-1). The therapeutic effects and potential mechanisms were evaluated by monitoring the Lennon score and rotarod falling speed, measuring serum levels of acetylcholine receptor antibody (AChR-Ab), IgG, IgG1, IgG2b, IFN-γ, IL-17, and TGF-β, and detecting the CD4+/CD8+ ratio in peripheral blood lymphocytes.
Results: MQZZJ significantly reduced the Lennon score, increased the rotarod falling speed, and reduced serum levels of AChR-Ab, IgG, and the IgG2b subtype. It also significantly decreased serum IL-17 and IFN-γ levels, increased serum TGF-β levels, and reduced the CD4+/CD8+ ratio.
Conclusion: MQZZJ can markedly ameliorate myasthenic symptoms in EAMG rats. The mechanism may be related to inhibiting AChR-Ab production, reducing the CD4+/CD8+ ratio, modulating immune dysfunction, and alleviating abnormal inflammation.
, authors=Han-xing LIU
1, Xing HUANG
1, Xue-chun WU
1, Lu LI
1, Bin-bin DAI
1, Xin-zhuang ZHANG
1, Liang CAO
1, Yong-wen ZHANG
2, Wei XIAO
1, *, authorsList=Han-xing LIU, Xing HUANG, Xue-chun WU, Lu LI, Bin-bin DAI, Xin-zhuang ZHANG, Liang CAO, Yong-wen ZHANG, Wei XIAO, authorCompany=null, correspAuthors=Wei XIAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425929931440614, articleId=1321425929507815908, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=马钱子总碱治疗重症肌无力大鼠模型的机制研究, columnId=1236330556003242277, journalTitle=中国新药杂志, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的： 探讨马钱子总碱对实验性自身免疫性重症肌无力（experimental autoimmune myasthenia gravis, EAMG）大鼠的疗效及其作用机制。
方法： Lewis雌性大鼠采用R97-116肽段免疫法构建EAMG模型，马钱子总碱（0.35、0.7、1.4 mg·kg-1）和泼尼松（4.2 mg·kg-1）分别对其进行分组给药治疗。通过记录大鼠Lennon评分和跌落时的转棒速度，测定血清抗乙酰胆碱受体抗体（anti-acetylcholine receptor antibody, AChR-Ab）、免疫球蛋白G（immunoglobulin G, IgG）、免疫球蛋白G1（immunoglobulin G1, IgG1）、免疫球蛋白G2b（immunoglobulin G2b, IgG2b）、干扰素-γ（interferon-γ, IFN-γ）、白细胞介素-17（interleukin 17, IL-17）和转化生长因子-β（transforming growth factor-β, TGF-β）水平，检测外周血淋巴细胞CD4+/CD8+比例等相关指标，考察其药效并探究可能的作用机制。
结果： 马钱子总碱能显著降低Lennon评分，显著升高跌落时的转棒速度，显著降低血清AChR-Ab、IgG和IgG2b亚型水平。马钱子总碱显著降低了血清IL-17和IFN-γ含量，升高血清TGF-β含量，显著降低外周血淋巴细胞CD4+/CD8+比例。
结论： 马钱子总碱能明显改善EAMG大鼠肌无力的症状，其作用机制可能与抑制AChR-Ab的生成、降低CD4+/CD8+比例、调节免疫功能紊乱和机体异常炎性状态有关。
, authors=刘涵星
1, 黄醒
1, 吴雪纯
1, 李璐
1, 代斌斌
1, 张新庄
1, 曹亮
1, 张永文
2, 肖伟
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刘涵星，男，硕士，主要从事中药新药药理毒理研究。E-mail: 2864111766@qq.com。
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刘涵星，男，硕士，主要从事中药新药药理毒理研究。E-mail: 2864111766@qq.com。
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1中药制药过程控制与智能制造技术全国重点实验室（江苏康缘药业股份有限公司），南京 211112)])]), Author(id=1321425930766107128, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425929507815908, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425930854187514, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425929507815908, authorId=1321425930766107128, language=EN, stringName=Xue-chun WU, firstName=Xue-chun, middleName=null, lastName=WU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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1State Key Laboratory of Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture (Jiangsu Kanion Pharmaceutical Co., Ltd.), Nanjing 211112, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425930929684987, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425929507815908, authorId=1321425930766107128, language=CN, stringName=吴雪纯, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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1中药制药过程控制与智能制造技术全国重点实验室（江苏康缘药业股份有限公司），南京 211112, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425930141155815, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425929507815908, xref=1, ext=[AuthorCompanyExt(id=1321425930149544424, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425929507815908, companyId=1321425930141155815, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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1中药制药过程控制与智能制造技术全国重点实验室（江苏康缘药业股份有限公司），南京 211112, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425930141155815, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425929507815908, xref=1, ext=[AuthorCompanyExt(id=1321425930149544424, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425929507815908, companyId=1321425930141155815, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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1中药制药过程控制与智能制造技术全国重点实验室（江苏康缘药业股份有限公司），南京 211112)])]), Author(id=1321425931277812226, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425929507815908, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425931370086916, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425929507815908, authorId=1321425931277812226, language=EN, stringName=Bin-bin DAI, firstName=Bin-bin, middleName=null, lastName=DAI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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