首页 期刊 论文 学科刊群 资讯 加盟 关于
EN
image
Article(id=1321425921576386958, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425881147495164, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.18.011, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1777305600000, acceptedDateStr=2026-04-28, onlineDate=1792982090609, onlineDateStr=2026-10-26, pubDate=1790697600000, pubDateStr=2026-09-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982090609, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982090609, creator=13701087609, updateTime=1792982090609, updator=13701087609, issue=Issue{id=1321425881147495164, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='18', pageStart='1905', pageEnd='2016', issueExtLink='null', onlineDate='null', pubDate='1790697600000', pubDateStr='2026-09-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982080970, creator='13701087609', updateTime=1792982834300, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321429040930599029, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425881147495164, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321429040930599030, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425881147495164, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1988, endPage=1998, ext={EN=ArticleExt(id=1321425921748353423, articleId=1321425921576386958, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=A comprehensive clinical evaluation of rIX-FP for the treatment of hemophilia B, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective:

To conduct a comprehensive clinical evaluation of albutrepenonacog alfa (rIX-FP) for the treatment of hemophilia B.

Methods:

Based on guidelines, literature, and publicly available data, and following the PICOS principle, rIX-FP was compared with plasma-derived FIX, standard half-life recombinant FIX (SHL rFIX), and extended half-life recombinant FIX (EHL rFIX) across five dimensions: efficacy, safety, suitability, innovation, and economy.

Results:

The evaluation results indicate that rIX-FP has potential advantages over other FIX preparations in terms of reducing the annualized bleeding rate, increasing the proportion of patients with zero bleeding events, and improving joint health, with consistent trends observed in the pediatric subgroup. The safety profile of rIX-FP is comparable to that of other recombinant FIX preparations, with no unmanageable safety risks observed. Regarding suitability, rIX-FP is available in five dosage specifications, offers flexible dosing options, and requires no special storage conditions. In terms of innovation, it utilizes albumin fusion technology to extend the half-life, thereby reducing dosing frequency and increasing trough levels. As for economy, although not yet marketed in China, international data suggest that long-term treatment (≥3 years) with rIX-FP has a cost advantage compared to SHL rFIX and rFIXFc.

Conclusion:

Based on available evidence, rIX-FP demonstrates certain clinical advantages in the treatment of hemophilia B. However, head-to-head comparative studies and local pharmacoeconomic evaluations are still warranted.

, authors=Cai-hua YANG1, Yuan-yuan QI2, Zhuo-yun WANG3, Yun-cui YU4, Zheng-li DAI5, Qi-wei WANG5, Yuan-yuan WANG2, Juan CHEN1, Ping ZHENG1, Xiao-ling WANG4, *, Yi-lei LI1, *, authorsList=Cai-hua YANG, Yuan-yuan QI, Zhuo-yun WANG, Yun-cui YU, Zheng-li DAI, Qi-wei WANG, Yuan-yuan WANG, Juan CHEN, Ping ZHENG, Xiao-ling WANG, Yi-lei LI, authorCompany=null, correspAuthors=Xiao-ling WANG, Yi-lei LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425922050343312, articleId=1321425921576386958, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=rIX-FP用于血友病B治疗的临床综合评价, columnId=1236331163573342670, journalTitle=中国新药杂志, columnName=药物安全与合理应用, runingTitle=null, highlight=null, articleAbstract=
目的：

开展albutrepenonacog alfa（rIX-FP）治疗血友病B的临床综合评价。

方法：

基于指南、文献及公开数据，按PICOS原则，从有效性、安全性、适宜性、创新性和经济性5个维度，将rIX-FP与血源性凝血因子IX（coagulation factor IX, FIX）、标准半衰期重组FIX（standard half-life recombinant factor IX, SHL rFIX）和延长半衰期重组FIX（extend half-life recombinant factor IX, EHL rFIX）进行比较分析。

结果：

评价结果显示，有效性方面，rIX-FP在降低年化出血率、提高零出血患者比例及改善关节健康方面，相较于其他FIX制剂具有潜在优势，儿童亚组趋势一致。其安全性与其他重组FIX相当，未发现不可管理的安全风险。适宜性方面，提供5种规格，剂量选择灵活，无须特殊储存。创新性方面，依托白蛋白融合技术延长半衰期，减少给药频次，提升谷浓度。经济性方面，未在国内上市，国际数据显示长期治疗（≥3年）相较于SHL rFIX及rFIXFc具有成本优势。

结论：

基于现有证据，rIX-FP在血友病B治疗中展现出一定的临床优势，但仍需开展头对头比较研究及本土化药物经济性评价。

, authors=杨彩华1, 戚媛媛2, 王卓芸3, 尉耘翠4, 戴铮立5, 王奇巍5, 王媛媛2, 陈娟1, 郑萍1, 王晓玲4, *, 李亦蕾1, *, authorsList=杨彩华, 戚媛媛, 王卓芸, 尉耘翠, 戴铮立, 王奇巍, 王媛媛, 陈娟, 郑萍, 王晓玲, 李亦蕾, authorCompany=null, correspAuthors=王晓玲, 李亦蕾, authorNote=

杨彩华，女，硕士，主要从事临床药学合理用药研究。E-mail: 。

戚媛媛，女，硕士，主要从事临床药学合理用药研究。E-mail: 。

, correspAuthorsNote=
* 李亦蕾，女，主任药师，博士生导师，研究方向：药事管理与临床药学。E-mail: 。
* 王晓玲，女，主任药师，硕士生导师，研究方向：儿科药学。E-mail: 。
, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=5dJVP2AboA3sQqK0tj1P5g==, magXml=z008dtRTQl4P+j49UKBnnw==, pdfUrl=null, pdf=Y4kwtvieYzvZT+6h8wZVCA==, pdfFileSize=6389839, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=8A7rPygkZlhg0nw9XCAsxA==, mapNumber=null, fund=null)}, authors=[Author(id=1321425924227187105, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=xiaoyang856@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425924340433315, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425924227187105, language=EN, stringName=Cai-hua YANG, firstName=Cai-hua, middleName=null, lastName=YANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425924403347876, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425924227187105, language=CN, stringName=杨彩华, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1南方医科大学南方医院药学部，广州 510515, bio={"content":"

杨彩华，女，硕士，主要从事临床药学合理用药研究。E-mail: 。

"}, bioImg=null, bioContent=

杨彩华，女，硕士，主要从事临床药学合理用药研究。E-mail: 。

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425922268447121, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=1, ext=[AuthorCompanyExt(id=1321425922276835730, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922268447121, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China), AuthorCompanyExt(id=1321425922281030035, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922268447121, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1南方医科大学南方医院药学部，广州 510515)])]), Author(id=1321425924483039654, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=2993876234@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425924566925736, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425924483039654, language=EN, stringName=Yuan-yuan QI, firstName=Yuan-yuan, middleName=null, lastName=QI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2Department of Pharmacy, The Second Hospital of Anhui Medical University, Hefei 230601, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425924642423209, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425924483039654, language=CN, stringName=戚媛媛, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2安徽医科大学第二附属医院药学部，合肥 230601, bio={"content":"

戚媛媛，女，硕士，主要从事临床药学合理用药研究。E-mail: 。

"}, bioImg=null, bioContent=

戚媛媛，女，硕士，主要从事临床药学合理用药研究。E-mail: 。

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425922331361684, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=2, ext=[AuthorCompanyExt(id=1321425922335555989, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922331361684, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2Department of Pharmacy, The Second Hospital of Anhui Medical University, Hefei 230601, China), AuthorCompanyExt(id=1321425922343944598, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922331361684, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2安徽医科大学第二附属医院药学部，合肥 230601)])]), Author(id=1321425924717920683, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425924797612461, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425924717920683, language=EN, stringName=Zhuo-yun WANG, firstName=Zhuo-yun, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=3, address=3Department of Clinical Pharmacy, Anhui Children's Hospital, Hefei 230001, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425924873109934, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425924717920683, language=CN, stringName=王卓芸, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=3, address=3安徽省儿童医院临床药学部，合肥 230001, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425922406859159, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=3, ext=[AuthorCompanyExt(id=1321425922411053464, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922406859159, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3Department of Clinical Pharmacy, Anhui Children's Hospital, Hefei 230001, China), AuthorCompanyExt(id=1321425922419442073, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922406859159, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3安徽省儿童医院临床药学部，合肥 230001)])]), Author(id=1321425924940218800, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425925011521970, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425924940218800, language=EN, stringName=Yun-cui YU, firstName=Yun-cui, middleName=null, lastName=YU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=4, address=4Clinical Research Center, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425925082825139, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425924940218800, language=CN, stringName=尉耘翠, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=4, address=4首都医科大学附属北京儿童医院药学部，北京 100045, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425922473968026, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=4, ext=[AuthorCompanyExt(id=1321425922478162331, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922473968026, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4Clinical Research Center, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China), AuthorCompanyExt(id=1321425922486550940, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922473968026, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4首都医科大学附属北京儿童医院药学部，北京 100045)])]), Author(id=1321425925154128309, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425925229625783, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425925154128309, language=EN, stringName=Zheng-li DAI, firstName=Zheng-li, middleName=null, lastName=DAI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=5, address=5China Pharmaceutical Industry Information Center, Shanghai 200040, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425925296734648, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425925154128309, language=CN, stringName=戴铮立, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=5, address=5上海医药工业信息中心，上海 200040, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425922541076893, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=5, ext=[AuthorCompanyExt(id=1321425922549465502, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922541076893, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=5China Pharmaceutical Industry Information Center, Shanghai 200040, China), AuthorCompanyExt(id=1321425922557854111, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922541076893, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=5上海医药工业信息中心，上海 200040)])]), Author(id=1321425925355454906, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425925439340988, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425925355454906, language=EN, stringName=Qi-wei WANG, firstName=Qi-wei, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=5, address=5China Pharmaceutical Industry Information Center, Shanghai 200040, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425925510644157, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425925355454906, language=CN, stringName=王奇巍, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=5, address=5上海医药工业信息中心，上海 200040, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425922541076893, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=5, ext=[AuthorCompanyExt(id=1321425922549465502, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922541076893, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=5China Pharmaceutical Industry Information Center, Shanghai 200040, China), AuthorCompanyExt(id=1321425922557854111, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922541076893, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=5上海医药工业信息中心，上海 200040)])]), Author(id=1321425925590335935, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425925665833409, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425925590335935, language=EN, stringName=Yuan-yuan WANG, firstName=Yuan-yuan, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2Department of Pharmacy, The Second Hospital of Anhui Medical University, Hefei 230601, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425925741330882, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425925590335935, language=CN, stringName=王媛媛, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2安徽医科大学第二附属医院药学部，合肥 230601, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425922331361684, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=2, ext=[AuthorCompanyExt(id=1321425922335555989, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922331361684, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2Department of Pharmacy, The Second Hospital of Anhui Medical University, Hefei 230601, China), AuthorCompanyExt(id=1321425922343944598, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922331361684, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2安徽医科大学第二附属医院药学部，合肥 230601)])]), Author(id=1321425925829411268, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, orderNo=7, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425925921685958, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425925829411268, language=EN, stringName=Juan CHEN, firstName=Juan, middleName=null, lastName=CHEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425925988794823, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425925829411268, language=CN, stringName=陈娟, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1南方医科大学南方医院药学部，广州 510515, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425922268447121, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=1, ext=[AuthorCompanyExt(id=1321425922276835730, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922268447121, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China), AuthorCompanyExt(id=1321425922281030035, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922268447121, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1南方医科大学南方医院药学部，广州 510515)])]), Author(id=1321425926064292297, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, orderNo=8, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425926152372683, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425926064292297, language=EN, stringName=Ping ZHENG, firstName=Ping, middleName=null, lastName=ZHENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425926236258764, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425926064292297, language=CN, stringName=郑萍, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1南方医科大学南方医院药学部，广州 510515, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425922268447121, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=1, ext=[AuthorCompanyExt(id=1321425922276835730, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922268447121, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China), AuthorCompanyExt(id=1321425922281030035, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922268447121, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1南方医科大学南方医院药学部，广州 510515)])]), Author(id=1321425926336922062, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, orderNo=9, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=wangxiaoling@bch.com.cn, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1321425926416613840, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425926336922062, language=EN, stringName=Xiao-ling WANG, firstName=Xiao-ling, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=4, *, address=4Clinical Research Center, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425926475334097, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425926336922062, language=CN, stringName=王晓玲, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=4, *, address=4首都医科大学附属北京儿童医院药学部，北京 100045, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425922473968026, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=4, ext=[AuthorCompanyExt(id=1321425922478162331, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922473968026, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4Clinical Research Center, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China), AuthorCompanyExt(id=1321425922486550940, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922473968026, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4首都医科大学附属北京儿童医院药学部，北京 100045)])]), Author(id=1321425926550831571, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, orderNo=10, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=liyilei1975@163.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1321425926617940437, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425926550831571, language=EN, stringName=Yi-lei LI, firstName=Yi-lei, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, *, address=1Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425926680854998, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425926550831571, language=CN, stringName=李亦蕾, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, *, address=1南方医科大学南方医院药学部，广州 510515, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425922268447121, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=1, ext=[AuthorCompanyExt(id=1321425922276835730, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922268447121, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China), AuthorCompanyExt(id=1321425922281030035, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922268447121, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1南方医科大学南方医院药学部，广州 510515)])])], keywords=[Keyword(id=1321425926773129687, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, language=EN, orderNo=1, keyword=hemophilia B), Keyword(id=1321425926836044248, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, language=EN, orderNo=2, keyword=albutrepenonacog alfa), Keyword(id=1321425926911541721, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, language=EN, orderNo=3, keyword=extended half-life), Keyword(id=1321425926987039194, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, language=EN, orderNo=4, keyword=coagulation factor IX), Keyword(id=1321425927041565147, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, language=EN, orderNo=5, keyword=clinical comprehensive evaluation), Keyword(id=1321425928694120924, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, language=CN, orderNo=1, keyword=血友病B), Keyword(id=1321425928773812701, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, language=CN, orderNo=2, keyword=albutrepenonacog alfa), Keyword(id=1321425928836727262, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, language=CN, orderNo=3, keyword=延长半衰期), Keyword(id=1321425928895447519, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, language=CN, orderNo=4, keyword=凝血因子IX), Keyword(id=1321425928962556384, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, language=CN, orderNo=5, keyword=临床综合评价)], refs=null, funds=[Fund(id=1321425929063219681, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, awardId=2023YFC2706100, language=CN, fundingSource=国家重点研发计划资助项目(2023YFC2706100), fundOrder=null, country=null), Fund(id=1321425929126134242, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, awardId=2025ZD01904903, language=CN, fundingSource=新发突发与重大传染病防控国家科技重大专项资助项目(2025ZD01904903), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1321425922268447121, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=1, ext=[AuthorCompanyExt(id=1321425922276835730, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922268447121, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China), AuthorCompanyExt(id=1321425922281030035, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922268447121, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1南方医科大学南方医院药学部，广州 510515)]), AuthorCompany(id=1321425922331361684, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=2, ext=[AuthorCompanyExt(id=1321425922335555989, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922331361684, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2Department of Pharmacy, The Second Hospital of Anhui Medical University, Hefei 230601, China), AuthorCompanyExt(id=1321425922343944598, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922331361684, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2安徽医科大学第二附属医院药学部，合肥 230601)]), AuthorCompany(id=1321425922406859159, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=3, ext=[AuthorCompanyExt(id=1321425922411053464, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922406859159, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3Department of Clinical Pharmacy, Anhui Children's Hospital, Hefei 230001, China), AuthorCompanyExt(id=1321425922419442073, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922406859159, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3安徽省儿童医院临床药学部，合肥 230001)]), AuthorCompany(id=1321425922473968026, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=4, ext=[AuthorCompanyExt(id=1321425922478162331, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922473968026, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4Clinical Research Center, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China), AuthorCompanyExt(id=1321425922486550940, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922473968026, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4首都医科大学附属北京儿童医院药学部，北京 100045)]), AuthorCompany(id=1321425922541076893, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=5, ext=[AuthorCompanyExt(id=1321425922549465502, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922541076893, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=5China Pharmaceutical Industry Information Center, Shanghai 200040, China), AuthorCompanyExt(id=1321425922557854111, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922541076893, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=5上海医药工业信息中心，上海 200040)])], figs=null, attaches=null, journal=Journal(id=1235980159023624194, delFlag=0, nameCn=中国新药杂志, nameEn=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, issn=1003-3734, eissn=null, cn=11-2850/R, coden=ZXZHA6, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of New Drugs, journalRemark=null, publicationField=null, createdTime=1772610233314, updatedTime=1788948968376, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=ohPEEN//Vz1tDT3ZBNTp4Q==, picEn=f9WK9bvTM4guTmS/iGhOMg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509780974924039, language=CN, name=中国新药杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948968404, updatedTime=1788948968404, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304509781025255688, language=EN, name=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948968416, updatedTime=1788948968416, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1235980733773295621, websiteList=[Website(id=1235982099191222761, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/CN, language=CN, createTime=1772610695884, createBy=18614031015, updateTime=1772610860397, updateBy=18614031015, name=中国新药杂志-中文, tplId=1146099689490845704, title=中国新药杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983918629966444, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=articleTextType, value=kx, createTime=1772611129672, updateTime=1772611129672, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918604800617, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=banner, value=null, createTime=1772611129666, updateTime=1772611129666, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918655132271, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=grayFlag, value=0, createTime=1772611129678, updateTime=1772611129678, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918596412008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611129664, updateTime=1772611129664, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918667715185, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=minRunFlag, value=0, createTime=1772611129681, updateTime=1772611129681, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918617383531, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic, createTime=1772611129669, updateTime=1772611129669, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918659326576, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=silenceFlag, value=0, createTime=1772611129679, updateTime=1772611129679, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918613189226, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1772611129668, updateTime=1772611129668, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918634160749, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeColor, value=null, createTime=1772611129673, updateTime=1772611129673, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918646743662, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeStyle, value=null, createTime=1772611129676, updateTime=1772611129676, creator=18614031015, updator=18614031015)]), Website(id=1235982099270914542, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/EN, language=EN, createTime=1772610695903, createBy=18614031015, updateTime=1772610875891, updateBy=18614031015, name=中国新药杂志-英文, tplId=1146101810881728533, title=Chinese Journal of New Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983955829248630, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=articleTextType, value=kx, createTime=1772611138541, updateTime=1772611138541, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955804082803, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=banner, value=null, createTime=1772611138535, updateTime=1772611138535, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955854414457, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=grayFlag, value=0, createTime=1772611138547, updateTime=1772611138547, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955795694194, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611138533, updateTime=1772611138533, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955866997371, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=minRunFlag, value=0, createTime=1772611138550, updateTime=1772611138550, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955820860021, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic, createTime=1772611138539, updateTime=1772611138539, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955862803066, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=silenceFlag, value=0, createTime=1772611138549, updateTime=1772611138549, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955812471412, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1772611138537, updateTime=1772611138537, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955837637239, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeColor, value=null, createTime=1772611138543, updateTime=1772611138543, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955846025848, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeStyle, value=null, createTime=1772611138545, updateTime=1772611138545, creator=18614031015, updator=18614031015)])], journalTitle=中国新药杂志, weixinUrl=null, journalUrl=http://www.newdrug.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of New Drugs, journalPhotoCn=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPhotoEn=f9WK9bvTM4guTmS/iGhOMg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/10.20251/j.cnki.1003-3734.2026.18.011, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/10.20251/j.cnki.1003-3734.2026.18.011, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/PDF/10.20251/j.cnki.1003-3734.2026.18.011, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/PDF/10.20251/j.cnki.1003-3734.2026.18.011, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1790697600000, fullTextJson=null, articleText=null, reference=null)
收藏切换
rIX-FP用于血友病B治疗的临床综合评价
收藏切换
PDF下载
杨彩华 1 , 戚媛媛 2 , 王卓芸 3 , 尉耘翠 4 , 戴铮立 5 , 王奇巍 5 , 王媛媛 2 , 陈娟 1 , 郑萍 1 , 王晓玲 4, * , 李亦蕾 1, *
中国新药杂志 | 药物安全与合理应用 2026,35(18): 1988-1998
收起
收藏切换
中国新药杂志 |药物安全与合理应用 2026 , 35 (18) : 1988 -1998
rIX-FP用于血友病B治疗的临床综合评价
全屏
[Author(id=1321425924227187105, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=xiaoyang856@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425924340433315, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425924227187105, language=EN, stringName=Cai-hua YANG, firstName=Cai-hua, middleName=null, lastName=YANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425924403347876, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425924227187105, language=CN, stringName=杨彩华, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1南方医科大学南方医院药学部，广州 510515, bio={"content":"

杨彩华，女，硕士，主要从事临床药学合理用药研究。E-mail: 。

"}, bioImg=null, bioContent=

杨彩华，女，硕士，主要从事临床药学合理用药研究。E-mail: 。

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425922268447121, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=1, ext=[AuthorCompanyExt(id=1321425922276835730, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922268447121, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China), AuthorCompanyExt(id=1321425922281030035, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922268447121, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1南方医科大学南方医院药学部，广州 510515)])]), Author(id=1321425924483039654, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=2993876234@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425924566925736, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425924483039654, language=EN, stringName=Yuan-yuan QI, firstName=Yuan-yuan, middleName=null, lastName=QI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2Department of Pharmacy, The Second Hospital of Anhui Medical University, Hefei 230601, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425924642423209, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425924483039654, language=CN, stringName=戚媛媛, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2安徽医科大学第二附属医院药学部，合肥 230601, bio={"content":"

戚媛媛，女，硕士，主要从事临床药学合理用药研究。E-mail: 。

"}, bioImg=null, bioContent=

戚媛媛，女，硕士，主要从事临床药学合理用药研究。E-mail: 。

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425922331361684, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=2, ext=[AuthorCompanyExt(id=1321425922335555989, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922331361684, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2Department of Pharmacy, The Second Hospital of Anhui Medical University, Hefei 230601, China), AuthorCompanyExt(id=1321425922343944598, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922331361684, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2安徽医科大学第二附属医院药学部，合肥 230601)])]), Author(id=1321425924717920683, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425924797612461, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425924717920683, language=EN, stringName=Zhuo-yun WANG, firstName=Zhuo-yun, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=3, address=3Department of Clinical Pharmacy, Anhui Children's Hospital, Hefei 230001, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425924873109934, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425924717920683, language=CN, stringName=王卓芸, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=3, address=3安徽省儿童医院临床药学部，合肥 230001, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425922406859159, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=3, ext=[AuthorCompanyExt(id=1321425922411053464, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922406859159, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3Department of Clinical Pharmacy, Anhui Children's Hospital, Hefei 230001, China), AuthorCompanyExt(id=1321425922419442073, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922406859159, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3安徽省儿童医院临床药学部，合肥 230001)])]), Author(id=1321425924940218800, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425925011521970, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425924940218800, language=EN, stringName=Yun-cui YU, firstName=Yun-cui, middleName=null, lastName=YU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=4, address=4Clinical Research Center, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425925082825139, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425924940218800, language=CN, stringName=尉耘翠, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=4, address=4首都医科大学附属北京儿童医院药学部，北京 100045, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425922473968026, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=4, ext=[AuthorCompanyExt(id=1321425922478162331, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922473968026, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4Clinical Research Center, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China), AuthorCompanyExt(id=1321425922486550940, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922473968026, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4首都医科大学附属北京儿童医院药学部，北京 100045)])]), Author(id=1321425925154128309, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425925229625783, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425925154128309, language=EN, stringName=Zheng-li DAI, firstName=Zheng-li, middleName=null, lastName=DAI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=5, address=5China Pharmaceutical Industry Information Center, Shanghai 200040, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425925296734648, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425925154128309, language=CN, stringName=戴铮立, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=5, address=5上海医药工业信息中心，上海 200040, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425922541076893, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=5, ext=[AuthorCompanyExt(id=1321425922549465502, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922541076893, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=5China Pharmaceutical Industry Information Center, Shanghai 200040, China), AuthorCompanyExt(id=1321425922557854111, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922541076893, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=5上海医药工业信息中心，上海 200040)])]), Author(id=1321425925355454906, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425925439340988, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425925355454906, language=EN, stringName=Qi-wei WANG, firstName=Qi-wei, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=5, address=5China Pharmaceutical Industry Information Center, Shanghai 200040, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425925510644157, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425925355454906, language=CN, stringName=王奇巍, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=5, address=5上海医药工业信息中心，上海 200040, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425922541076893, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=5, ext=[AuthorCompanyExt(id=1321425922549465502, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922541076893, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=5China Pharmaceutical Industry Information Center, Shanghai 200040, China), AuthorCompanyExt(id=1321425922557854111, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922541076893, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=5上海医药工业信息中心，上海 200040)])]), Author(id=1321425925590335935, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425925665833409, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425925590335935, language=EN, stringName=Yuan-yuan WANG, firstName=Yuan-yuan, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2Department of Pharmacy, The Second Hospital of Anhui Medical University, Hefei 230601, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425925741330882, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425925590335935, language=CN, stringName=王媛媛, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2安徽医科大学第二附属医院药学部，合肥 230601, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425922331361684, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=2, ext=[AuthorCompanyExt(id=1321425922335555989, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922331361684, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2Department of Pharmacy, The Second Hospital of Anhui Medical University, Hefei 230601, China), AuthorCompanyExt(id=1321425922343944598, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922331361684, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2安徽医科大学第二附属医院药学部，合肥 230601)])]), Author(id=1321425925829411268, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, orderNo=7, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425925921685958, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425925829411268, language=EN, stringName=Juan CHEN, firstName=Juan, middleName=null, lastName=CHEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425925988794823, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425925829411268, language=CN, stringName=陈娟, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1南方医科大学南方医院药学部，广州 510515, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425922268447121, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=1, ext=[AuthorCompanyExt(id=1321425922276835730, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922268447121, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China), AuthorCompanyExt(id=1321425922281030035, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922268447121, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1南方医科大学南方医院药学部，广州 510515)])]), Author(id=1321425926064292297, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, orderNo=8, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425926152372683, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425926064292297, language=EN, stringName=Ping ZHENG, firstName=Ping, middleName=null, lastName=ZHENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425926236258764, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425926064292297, language=CN, stringName=郑萍, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1南方医科大学南方医院药学部，广州 510515, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425922268447121, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=1, ext=[AuthorCompanyExt(id=1321425922276835730, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922268447121, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China), AuthorCompanyExt(id=1321425922281030035, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922268447121, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1南方医科大学南方医院药学部，广州 510515)])]), Author(id=1321425926336922062, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, orderNo=9, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=wangxiaoling@bch.com.cn, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1321425926416613840, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425926336922062, language=EN, stringName=Xiao-ling WANG, firstName=Xiao-ling, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=4, *, address=4Clinical Research Center, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425926475334097, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425926336922062, language=CN, stringName=王晓玲, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=4, *, address=4首都医科大学附属北京儿童医院药学部，北京 100045, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425922473968026, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=4, ext=[AuthorCompanyExt(id=1321425922478162331, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922473968026, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4Clinical Research Center, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China), AuthorCompanyExt(id=1321425922486550940, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922473968026, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4首都医科大学附属北京儿童医院药学部，北京 100045)])]), Author(id=1321425926550831571, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, orderNo=10, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=liyilei1975@163.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1321425926617940437, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425926550831571, language=EN, stringName=Yi-lei LI, firstName=Yi-lei, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, *, address=1Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425926680854998, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, authorId=1321425926550831571, language=CN, stringName=李亦蕾, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, *, address=1南方医科大学南方医院药学部，广州 510515, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425922268447121, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, xref=1, ext=[AuthorCompanyExt(id=1321425922276835730, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922268447121, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China), AuthorCompanyExt(id=1321425922281030035, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425921576386958, companyId=1321425922268447121, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1南方医科大学南方医院药学部，广州 510515)])])]
杨彩华1 , 戚媛媛2 , 王卓芸3, 尉耘翠4, 戴铮立5, 王奇巍5, 王媛媛2, 陈娟1, 郑萍1, 王晓玲4, * , 李亦蕾1, *
作者信息
  • 1南方医科大学南方医院药学部，广州 510515
  • 2安徽医科大学第二附属医院药学部，合肥 230601
  • 3安徽省儿童医院临床药学部，合肥 230001
  • 4首都医科大学附属北京儿童医院药学部，北京 100045
  • 5上海医药工业信息中心，上海 200040
通讯作者:
* 李亦蕾，女，主任药师，博士生导师，研究方向：药事管理与临床药学。E-mail: 。
* 王晓玲，女，主任药师，硕士生导师，研究方向：儿科药学。E-mail: 。
作者简介:

杨彩华，女，硕士，主要从事临床药学合理用药研究。E-mail: 。

戚媛媛，女，硕士，主要从事临床药学合理用药研究。E-mail: 。

A comprehensive clinical evaluation of rIX-FP for the treatment of hemophilia B
Cai-hua YANG1 , Yuan-yuan QI2 , Zhuo-yun WANG3, Yun-cui YU4, Zheng-li DAI5, Qi-wei WANG5, Yuan-yuan WANG2, Juan CHEN1, Ping ZHENG1, Xiao-ling WANG4, * , Yi-lei LI1, *
Affiliations
  • 1Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
  • 2Department of Pharmacy, The Second Hospital of Anhui Medical University, Hefei 230601, China
  • 3Department of Clinical Pharmacy, Anhui Children's Hospital, Hefei 230001, China
  • 4Clinical Research Center, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China
  • 5China Pharmaceutical Industry Information Center, Shanghai 200040, China
出版时间: 2026-09-30 doi: 10.20251/j.cnki.1003-3734.2026.18.011
文章导航
收藏切换
摘要
收起
目的：

开展albutrepenonacog alfa（rIX-FP）治疗血友病B的临床综合评价。

方法：

基于指南、文献及公开数据，按PICOS原则，从有效性、安全性、适宜性、创新性和经济性5个维度，将rIX-FP与血源性凝血因子IX（coagulation factor IX, FIX）、标准半衰期重组FIX（standard half-life recombinant factor IX, SHL rFIX）和延长半衰期重组FIX（extend half-life recombinant factor IX, EHL rFIX）进行比较分析。

结果：

评价结果显示，有效性方面，rIX-FP在降低年化出血率、提高零出血患者比例及改善关节健康方面，相较于其他FIX制剂具有潜在优势，儿童亚组趋势一致。其安全性与其他重组FIX相当，未发现不可管理的安全风险。适宜性方面，提供5种规格，剂量选择灵活，无须特殊储存。创新性方面，依托白蛋白融合技术延长半衰期，减少给药频次，提升谷浓度。经济性方面，未在国内上市，国际数据显示长期治疗（≥3年）相较于SHL rFIX及rFIXFc具有成本优势。

结论：

基于现有证据，rIX-FP在血友病B治疗中展现出一定的临床优势，但仍需开展头对头比较研究及本土化药物经济性评价。

血友病B  /  albutrepenonacog alfa  /  延长半衰期  /  凝血因子IX  /  临床综合评价
Objective:

To conduct a comprehensive clinical evaluation of albutrepenonacog alfa (rIX-FP) for the treatment of hemophilia B.

Methods:

Based on guidelines, literature, and publicly available data, and following the PICOS principle, rIX-FP was compared with plasma-derived FIX, standard half-life recombinant FIX (SHL rFIX), and extended half-life recombinant FIX (EHL rFIX) across five dimensions: efficacy, safety, suitability, innovation, and economy.

Results:

The evaluation results indicate that rIX-FP has potential advantages over other FIX preparations in terms of reducing the annualized bleeding rate, increasing the proportion of patients with zero bleeding events, and improving joint health, with consistent trends observed in the pediatric subgroup. The safety profile of rIX-FP is comparable to that of other recombinant FIX preparations, with no unmanageable safety risks observed. Regarding suitability, rIX-FP is available in five dosage specifications, offers flexible dosing options, and requires no special storage conditions. In terms of innovation, it utilizes albumin fusion technology to extend the half-life, thereby reducing dosing frequency and increasing trough levels. As for economy, although not yet marketed in China, international data suggest that long-term treatment (≥3 years) with rIX-FP has a cost advantage compared to SHL rFIX and rFIXFc.

Conclusion:

Based on available evidence, rIX-FP demonstrates certain clinical advantages in the treatment of hemophilia B. However, head-to-head comparative studies and local pharmacoeconomic evaluations are still warranted.

hemophilia B  /  albutrepenonacog alfa  /  extended half-life  /  coagulation factor IX  /  clinical comprehensive evaluation
杨彩华, 戚媛媛, 王卓芸, 尉耘翠, 戴铮立, 王奇巍, 王媛媛, 陈娟, 郑萍, 王晓玲, 李亦蕾. rIX-FP用于血友病B治疗的临床综合评价. 中国新药杂志, 2026 , 35 (18) : 1988 -1998 . DOI: 10.20251/j.cnki.1003-3734.2026.18.011
Cai-hua YANG, Yuan-yuan QI, Zhuo-yun WANG, Yun-cui YU, Zheng-li DAI, Qi-wei WANG, Yuan-yuan WANG, Juan CHEN, Ping ZHENG, Xiao-ling WANG, Yi-lei LI. A comprehensive clinical evaluation of rIX-FP for the treatment of hemophilia B[J]. Chinese Journal of New Drugs, 2026 , 35 (18) : 1988 -1998 . DOI: 10.20251/j.cnki.1003-3734.2026.18.011
基金
收起
  • 国家重点研发计划资助项目(2023YFC2706100)
  • 新发突发与重大传染病防控国家科技重大专项资助项目(2025ZD01904903)
文献
收起
参考文献 引证文献
排序方式：
2026年第35卷第18期
PDF下载
30
5
引用本文
BibTeX
文章信息
doi: 10.20251/j.cnki.1003-3734.2026.18.011
  • 首发时间：2026-10-26
  • 出版时间：2026-09-30
补充材料
相关文章
文章信息
作者
出版历史
  • 录用日期：2026-04-28
基金
国家重点研发计划资助项目(2023YFC2706100)
新发突发与重大传染病防控国家科技重大专项资助项目(2025ZD01904903)
作者信息
    1南方医科大学南方医院药学部，广州 510515
    2安徽医科大学第二附属医院药学部，合肥 230601
    3安徽省儿童医院临床药学部，合肥 230001
    4首都医科大学附属北京儿童医院药学部，北京 100045
    5上海医药工业信息中心，上海 200040

通讯作者:

* 李亦蕾，女，主任药师，博士生导师，研究方向：药事管理与临床药学。E-mail: 。
* 王晓玲，女，主任药师，硕士生导师，研究方向：儿科药学。E-mail: 。
参考文献
分享链接
https://castjournals.cast.org.cn/joweb/zgxyzz/CN/10.20251/j.cnki.1003-3734.2026.18.011
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
相关链接
论文
最新文章
热读文章
热点专题
内参
蓝皮书
产业发展报告
传播力报告
期刊分级目录
资讯
学术新闻
行业新闻
学术会议
行业会议
关于
关于我们
联系我们
北京市海淀区学院南路86号
100081
010-62662699（运营及技术支持）
qkjq@cast.org.cn

中国科学技术协会版权所有 京ICP 备10216604号-4 海淀分局备案 1101084647
科技导报社主办 中国科协信息中心技术支持