Article(id=1321425900349014220, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425847911830056, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.17.006, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1773244800000, acceptedDateStr=2026-03-12, onlineDate=1792982085548, onlineDateStr=2026-10-26, pubDate=1789401600000, pubDateStr=2026-09-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982085548, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982085548, creator=13701087609, updateTime=1792982085548, updator=13701087609, issue=Issue{id=1321425847911830056, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='17', pageStart='1793', pageEnd='1904', issueExtLink='null', onlineDate='null', pubDate='1789401600000', pubDateStr='2026-09-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982073047, creator='13701087609', updateTime=1792982858328, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321429141673586821, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425847911830056, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321429141673586822, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425847911830056, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1828, endPage=1835, ext={EN=ArticleExt(id=1321425901896712397, articleId=1321425900349014220, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Progress on the application of nanotechnology in tumor diagnosis and targeted therapy, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Early screening and precise treatment of malignant tumors are critical for reducing mortality rates. Nanotechnology, owing to its tunable physicochemical properties and biocompatibility, has shown significant potential in the field of tumor diagnosis and therapy. This review systematically summarizes the innovative applications of nanotechnology, with a focus on its advancements in two key areas: tumor screening and targeted therapy. In terms of tumor screening, nanoprobes have markedly enhanced the sensitivity and specificity of detecting circulating tumor cells, exosomes, and tumor biomarkers, thereby promoting the development of multimodal imaging and liquid biopsy. In the realm of targeted therapy, nanocarriers achieve precise drug delivery via passive or active targeting strategies, while intelligent responsive systems further promote the development of theranostic integration. This review also analyzes existing challenges in clinical translation, including safety and standardized manufacturing, and provides perspectives on future directions involving the integration of nanotechnology with cutting-edge fields such as artificial intelligence and immunotherapy.

, authors=Zi-hao LIU1, Xiao YE1, Bo-wen GUAN2, Ying LIU1, *, authorsList=Zi-hao LIU, Xiao YE, Bo-wen GUAN, Ying LIU, authorCompany=null, correspAuthors=Ying LIU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425902144176334, articleId=1321425900349014220, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=纳米技术在肿瘤诊断与靶向治疗中的应用研究进展, columnId=1236330553964810454, journalTitle=中国新药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

恶性肿瘤的早期筛查与精准治疗是降低死亡率的关键。纳米技术因其可调控物理化学性质与生物相容性,在肿瘤诊疗领域展现出巨大的应用潜力。本文系统综述了纳米技术的创新应用,重点分析其在肿瘤筛查与靶向治疗两方面的进展。在肿瘤筛查方面,纳米探针显著提升了循环肿瘤细胞、外泌体及肿瘤标志物检测的灵敏度与特异性,推动了多模态成像与液体活检技术的发展;在靶向治疗方面,纳米载体通过被动靶向或主动靶向策略实现药物的精准递送,而智能响应型系统则进一步促进了诊疗一体化的发展。本文分析了该技术在临床转化中面临的安全性、标准化生产等挑战,并展望了其与人工智能、免疫治疗等前沿领域融合的未来发展方向。

, authors=刘子豪1, 叶潇1, 关博文2, 刘颖1, *, authorsList=刘子豪, 叶潇, 关博文, 刘颖, authorCompany=null, correspAuthors=刘颖, authorNote=

叶潇,女,博士,主要从事药动学研究。E-mail: 。

刘子豪,男,本科,主要从事药物递送研究。E-mail: 。

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* 刘颖,女,研究员,主要从事药物质量控制研究。E-mail: 。
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刘子豪,男,本科,主要从事药物递送研究。E-mail: 。

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刘子豪,男,本科,主要从事药物递送研究。E-mail: 。

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纳米技术在肿瘤诊断与靶向治疗中的应用研究进展
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刘子豪 1 , 叶潇 1 , 关博文 2 , 刘颖 1, *
中国新药杂志 | 综述 2026,35(17): 1828-1835
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中国新药杂志 |综述 2026 , 35 (17) : 1828 -1835
纳米技术在肿瘤诊断与靶向治疗中的应用研究进展
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刘子豪1 , 叶潇1 , 关博文2, 刘颖1, *
作者信息
  • 1中国药品检定研究院,北京 100176
  • 2北京工商大学,北京 100048
通讯作者:
* 刘颖,女,研究员,主要从事药物质量控制研究。E-mail: 。
作者简介:

叶潇,女,博士,主要从事药动学研究。E-mail: 。

刘子豪,男,本科,主要从事药物递送研究。E-mail: 。

Progress on the application of nanotechnology in tumor diagnosis and targeted therapy
Zi-hao LIU1 , Xiao YE1 , Bo-wen GUAN2, Ying LIU1, *
Affiliations
  • 1National Institutes for Drug Control, Beijing 100176, China
  • 2Beijing Technology and Business University, Beijing 100048, China
出版时间: 2026-09-15 doi: 10.20251/j.cnki.1003-3734.2026.17.006
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恶性肿瘤的早期筛查与精准治疗是降低死亡率的关键。纳米技术因其可调控物理化学性质与生物相容性,在肿瘤诊疗领域展现出巨大的应用潜力。本文系统综述了纳米技术的创新应用,重点分析其在肿瘤筛查与靶向治疗两方面的进展。在肿瘤筛查方面,纳米探针显著提升了循环肿瘤细胞、外泌体及肿瘤标志物检测的灵敏度与特异性,推动了多模态成像与液体活检技术的发展;在靶向治疗方面,纳米载体通过被动靶向或主动靶向策略实现药物的精准递送,而智能响应型系统则进一步促进了诊疗一体化的发展。本文分析了该技术在临床转化中面临的安全性、标准化生产等挑战,并展望了其与人工智能、免疫治疗等前沿领域融合的未来发展方向。

纳米技术  /  肿瘤筛查  /  靶向治疗  /  诊疗一体化

Early screening and precise treatment of malignant tumors are critical for reducing mortality rates. Nanotechnology, owing to its tunable physicochemical properties and biocompatibility, has shown significant potential in the field of tumor diagnosis and therapy. This review systematically summarizes the innovative applications of nanotechnology, with a focus on its advancements in two key areas: tumor screening and targeted therapy. In terms of tumor screening, nanoprobes have markedly enhanced the sensitivity and specificity of detecting circulating tumor cells, exosomes, and tumor biomarkers, thereby promoting the development of multimodal imaging and liquid biopsy. In the realm of targeted therapy, nanocarriers achieve precise drug delivery via passive or active targeting strategies, while intelligent responsive systems further promote the development of theranostic integration. This review also analyzes existing challenges in clinical translation, including safety and standardized manufacturing, and provides perspectives on future directions involving the integration of nanotechnology with cutting-edge fields such as artificial intelligence and immunotherapy.

nanotechnology  /  tumor screening  /  targeted therapy  /  theranostic
刘子豪, 叶潇, 关博文, 刘颖. 纳米技术在肿瘤诊断与靶向治疗中的应用研究进展. 中国新药杂志, 2026 , 35 (17) : 1828 -1835 . DOI: 10.20251/j.cnki.1003-3734.2026.17.006
Zi-hao LIU, Xiao YE, Bo-wen GUAN, Ying LIU. Progress on the application of nanotechnology in tumor diagnosis and targeted therapy[J]. Chinese Journal of New Drugs, 2026 , 35 (17) : 1828 -1835 . DOI: 10.20251/j.cnki.1003-3734.2026.17.006

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doi: 10.20251/j.cnki.1003-3734.2026.17.006
  • 首发时间:2026-10-26
  • 出版时间:2026-09-15
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  • 录用日期:2026-03-12
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    1中国药品检定研究院,北京 100176
    2北京工商大学,北京 100048

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* 刘颖,女,研究员,主要从事药物质量控制研究。E-mail: 。
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Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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