Article(id=1321425887757710090, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425847911830056, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.17.007, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1760371200000, acceptedDateStr=2025-10-14, onlineDate=1792982082547, onlineDateStr=2026-10-26, pubDate=1789401600000, pubDateStr=2026-09-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982082547, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982082547, creator=13701087609, updateTime=1792982082547, updator=13701087609, issue=Issue{id=1321425847911830056, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='17', pageStart='1793', pageEnd='1904', issueExtLink='null', onlineDate='null', pubDate='1789401600000', pubDateStr='2026-09-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982073047, creator='13701087609', updateTime=1792982858328, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321429141673586821, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425847911830056, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321429141673586822, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425847911830056, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1836, endPage=1842, ext={EN=ArticleExt(id=1321425888365884171, articleId=1321425887757710090, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Advances in tumor-infiltrating lymphocyte therapy for ovarian cancer, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Ovarian cancer (OVCA) is a gynecological malignancy that poses a serious threat to women's health and life. Despite significant advances in modern medicine and surgery in recent years, the five-year survival rates for patients with stages Ⅲ and Ⅳ OVCA are only 27% and 13%, respectively. Tumor-infiltrating lymphocytes (TILs) are a type of immune cell that infiltrate the tumor parenchyma or stroma. Compared to non-tumor-infiltrating lymphocytes, TILs exhibit a stronger ability for antitumor immune responses. TIL therapy is an innovative cell-based treatment in which the therapeutic preparation is derived from the selection and expansion of autologous TILs obtained from the patient's own tumor tissue, offering potent antitumor activity and low off-target toxicity. Studies have shown that extensive TIL infiltration is associated with improved prognosis in OVCA patients after clinical treatment, and early-phase clinical trials have also demonstrated the feasibility of TIL therapy for OVCA. This review focuses on key TILs within the ovarian tumor microenvironment, the clinical translation of TIL therapy, and the potential challenges and optimization strategies for its clinical application, aiming to provide a scientific reference for TIL-based treatment of OVCA.

, authors=Quan-min LIU^{1, 2}, Ping HUANG^{1, 2}, Jia-chen SHI^{1, 2}, Lan WANG^{1, 2}, Yi-fang DENG^{1, 2, *}, authorsList=Quan-min LIU, Ping HUANG, Jia-chen SHI, Lan WANG, Yi-fang DENG, authorCompany=null, correspAuthors=Yi-fang DENG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425889657729804, articleId=1321425887757710090, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=基于肿瘤浸润淋巴细胞治疗卵巢癌的研究进展, columnId=1236330553964810454, journalTitle=中国新药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

卵巢癌（ovarian cancer, OVCA）是严重威胁女性的身体健康和生命安全的妇科恶性肿瘤，尽管近年来现代医学和外科手术取得了显著进步，Ⅲ期和Ⅳ期OVCA患者的5年生存率仅有27%和13%。肿瘤浸润淋巴细胞（tumor infiltrating lymphocytes, TIL）是一类浸润于肿瘤实质或间质中的免疫细胞，与非肿瘤浸润性淋巴细胞相比，TIL具有更高水平的抗肿瘤免疫应答能力。TIL疗法是创新的细胞疗法，其制剂由患者自体肿瘤中TIL筛选和扩增而来，具有强大的抗肿瘤活性和较低的脱靶毒性。研究发现，TIL大量浸润与OVCA患者接受临床治疗后更好的预后相关，早期临床试验亦证实了TIL疗法治疗OVCA的可行性。本文主要就卵巢肿瘤微环境中关键TIL、TIL疗法的临床转化以及临床应用可能面临的挑战与优化策略进行综述，以期为TIL疗法治疗OVCA提供科学参考。

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刘铨民，男，硕士研究生，研究方向：药理学。E-mail: liuquanmin1999@163.com。

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刘铨民，男，硕士研究生，研究方向：药理学。E-mail: liuquanmin1999@163.com。

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