Article(id=1321425887225036886, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425812331549069, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.15.012, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1761840000000, acceptedDateStr=2025-10-31, onlineDate=1792982082420, onlineDateStr=2026-10-26, pubDate=1786723200000, pubDateStr=2026-08-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982082420, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982082420, creator=13701087609, updateTime=1792982082420, updator=13701087609, issue=Issue{id=1321425812331549069, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='15', pageStart='1569', pageEnd='1680', issueExtLink='null', onlineDate='null', pubDate='1786723200000', pubDateStr='2026-08-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982064564, creator='13701087609', updateTime=1792982904202, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321429334083097400, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425812331549069, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321429334087291705, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425812331549069, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1657, endPage=1662, ext={EN=ArticleExt(id=1321425888370081879, articleId=1321425887225036886, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Study on the anti-inflammatory and analgesic effects of Naizilai Granules and their mechanisms, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To evaluate the anti-inflammatory and analgesic effects of Naizilai Granules (NZL) and to preliminarily investigate the underlying mechanisms.
Methods: The anti-inflammatory and analgesic effects of NZL were evaluated in mice using the acetic acid-induced writhing test as well as the egg white-induced paw edema model. Serum levels of tumor necrosis factor-α (TNF-α), interleukin-12 (IL-12), and interleukin-1 beta (IL-1β) were quantified by enzyme-linked immunosorbent assay (ELISA). In lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages, the inhibitory effect of NZL on inflammation was assessed. Additionally, the cytokine levels (IL-12, IL-1β and TNF-α) in cell supernatants were measured, and the protein expression of cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) was detected by Western blot (WB).
Results: The acetic acid-induced writhing test demonstrated a significant reduction in the number of writhes in NZL-treat groups compared to the model group. In the egg white-induced paw edema model, NZL treatment groups showed markedly decreased paw swelling compared to the model group. Furthermore, NZL effectively inhibited the LPS-induced inflammation in RAW264.7 cells and decreased the expression levels of IL-12, IL-1β, and TNF-α in cell supernatants. Additionally, there was a marked reduction in the expression of COX-2 and PGE2.
Conclusions: NZL exhibits analgesic and anti-inflammatory effects.
, authors=Wei-yi ZHANG
1, 2, ShuLiPan-MuLaTi
2, Lei HUANG
1, Ju CHEN
1, Xu YAO
1, Jun LI
1, *, AJiAiKeBaiEr-AiSa
1, 2, *, authorsList=Wei-yi ZHANG, ShuLiPan-MuLaTi, Lei HUANG, Ju CHEN, Xu YAO, Jun LI, AJiAiKeBaiEr-AiSa, authorCompany=null, correspAuthors=Jun LI, AJiAiKeBaiEr-AiSa, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425889158611032, articleId=1321425887225036886, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=乃孜来颗粒的抗炎与镇痛作用及机制研究, columnId=1236330556003242277, journalTitle=中国新药杂志, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的： 评价乃孜来颗粒的抗炎、镇痛作用，并初步探讨其作用机制。
方法： 采用冰醋酸致小鼠扭体和蛋清致小鼠足趾肿胀实验观察乃孜来颗粒的抗炎、镇痛作用，并测定小鼠血清中肿瘤坏死因子-α（tumor necrosis factor-α, TNF-α）、白细胞介素-12（interleukin-12, IL-12）和白细胞介素-1β（interleukin-1β, IL-1β）的含量；观察乃孜来颗粒对脂多糖（lipopolysaccharide, LPS）致炎RAW264.7细胞的抑制作用及其上清液中炎症因子IL-12、IL-1β、TNF-α的表达，并通过蛋白免疫印迹法（Western blot, WB）检测环氧合酶-2（cyclooxygenase-2, COX-2）和前列腺素E2（prostaglandin E2, PGE2）蛋白的表达。
结果： 冰醋酸致小鼠扭体实验结果显示，与模型组相比，乃孜来颗粒高、中、低剂量组小鼠扭体次数均显著减少；蛋清致小鼠足趾肿胀实验结果显示，与模型组相比，乃孜来颗粒高、中、低剂量组小鼠足趾肿胀程度显著降低；乃孜来颗粒抑制LPS致炎后RAW264.7细胞的增殖，降低上清液中IL-12、IL-1β、TNF-α的含量。此外，乃孜来颗粒显著降低COX-2和PGE2的含量。
, authors=张伟怡
1, 2, 曙丽盼·木拉提
2, 黄磊
1, 陈菊
1, 姚旭
1, 李俊
1, *, 阿吉艾克拜尔·艾萨
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1Xinjiang Yindolan Pharmaceutical Co., Ltd., Urumchi 830011, China
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1新疆银朵兰药业股份有限公司，乌鲁木齐 830011
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张伟怡，女，博士，副教授，主要从事天然小分子化合物药物研发。E-mail: zwy13132150812@163.com。
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张伟怡，女，博士，副教授，主要从事天然小分子化合物药物研发。E-mail: zwy13132150812@163.com。
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