Article(id=1321425863028101799, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425847911830056, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.17.014, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1760976000000, acceptedDateStr=2025-10-21, onlineDate=1792982076651, onlineDateStr=2026-10-26, pubDate=1789401600000, pubDateStr=2026-09-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982076651, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982076651, creator=13701087609, updateTime=1792982076651, updator=13701087609, issue=Issue{id=1321425847911830056, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='17', pageStart='1793', pageEnd='1904', issueExtLink='null', onlineDate='null', pubDate='1789401600000', pubDateStr='2026-09-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982073047, creator='13701087609', updateTime=1792982858328, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321429141673586821, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425847911830056, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321429141673586822, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425847911830056, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1898, endPage=1904, ext={EN=ArticleExt(id=1321425863212651176, articleId=1321425863028101799, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Cost-effectiveness analysis of the combination of enfortumab vedotin and pembrolizumab in first-line treatment of previously untreated advanced urothelial carcinoma, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: From the perspective of the Chinese healthcare system, to evaluate the cost-effectiveness of enfortumab vedotin and pembrolizumab in the treatment of advanced urothelial carcinoma.
Methods: A dynamic Markov model was constructed based on data from the EV-302 trial, and cost-utility analysis (CUA) was used for economic evaluation. Deterministic (one-way) sensitivity analysis and probabilistic sensitivity analysis (PSA) were conducted on main parameters to verify the robustness of the base-case analysis results.
Results: The analysis showed that for every additional quality-adjusted life year (QALY) in the enfortumab vedotin plus pembrolizumab group compared to the standard chemotherapy group, an additional cost of 2 358 823.11 yuan was required. The results of the deterministic sensitivity analysis showed that the most influential factors on incremental cost-effectiveness ratio (ICER) were the utility value of the progression-free state and the cost of enfortumab vedotin. The probabilistic sensitivity analysis results indicated that the combination of enfortumab vedotin and pembrolizumab was not cost-effective at a willingness-to-pay threshold equivalent to three times China's 2024 per capita GDP.
Conclusion: The combination of enfortumab vedotin and pembrolizumab does not represent a cost-effectiveness strategy compared with the standard chemotherapy group in the treatment of advanced urothelial carcinoma.
, authors=Xin-xin LI, Hong-li MOU, Si-chen LI, Shu-lin WANG
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目的： 从中国卫生体系角度出发，评估维恩妥尤联合帕博利珠单抗在治疗晚期尿路上皮癌方面的经济性。
方法： 基于EV-302的临床试验数据构建动态Markov模型，采用成本-效用分析进行经济性评价，并对主要参数进行单因素敏感性分析和概率敏感性分析验证基础分析结果的稳健性。
结果： 研究结果显示，维恩妥尤联合帕博利珠单抗组较标准化疗组每多获得一个质量调整生命年（quality-adjusted life year, QALYs），需额外花费2 358 823.11元。单因素敏感性分析结果显示，对增量-成本效果比（incremental cost-effectiveness ratio, ICER）影响程度较大的参数是无进展状态效用值和维恩妥尤单抗成本。概率敏感性分析结果显示，维恩妥尤单抗联合帕博利珠单抗组在支付意愿阈值为我国2024年3倍人均GDP下不具有经济性。
结论： 维恩妥尤单抗联合帕博利珠单抗组对比标准化疗剂组在治疗晚期尿路上皮癌上不具备经济性优势。
, authors=利欣欣, 牟洪利, 李思陈, 王淑玲
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利欣欣，女，研究生，研究方向：药物经济学，药事管理与法规。E-mail: 3039440636@qq.com。
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