Article(id=1321425829406556788, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425746170597545, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.13.006, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1767974400000, acceptedDateStr=2026-01-10, onlineDate=1792982068635, onlineDateStr=2026-10-26, pubDate=1784044800000, pubDateStr=2026-07-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982068635, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982068635, creator=13701087609, updateTime=1792982068635, updator=13701087609, issue=Issue{id=1321425746170597545, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='13', pageStart='1345', pageEnd='1456', issueExtLink='null', onlineDate='null', pubDate='1784044800000', pubDateStr='2026-07-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982048790, creator='13701087609', updateTime=1792982953102, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321429539205534609, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425746170597545, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321429539205534610, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425746170597545, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1378, endPage=1388, ext={EN=ArticleExt(id=1321425829612077685, articleId=1321425829406556788, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Prediction and analysis of Q-Marker for Shenge Bushen Capsules based on chemical composition and network pharmacology, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Shenge Bushen Capsule is a traditional Chinese medicine (TCM) compound preparation developed under the guidance of TCM theory and combined with modern pharmaceutical technology. It is indicated for mild to moderate depression of TCM syndrome of qi and yin deficiency, and kidney qi deficiency. Based on a summary of the chemical constituents of Shenge Bushen Capsule, this study applied network pharmacology methods and integrated the core concept of quality marker (Q-Marker) to predict and analyze the Q-Marker of Shenge Bushen Capsule. The results showed that formononetin, 3'-methoxydaidzein, daidzein-4,7-diglucoside, puerarin, icariin, anhydroicaritin, chrysoseriol, kaempferol, luteolin, and quercetin are the key active components of Shenge Bushen Capsules and can serve as its Q-Marker. Which can provide a reference for establishing a comprehensive quality standard for Shenge Bushen Capsule.

, authors=Pei-jin YOU, Shi-xian HU, Chang-bing PU, Juan HAO, Zhi-yuan LÜ*, authorsList=Pei-jin YOU, Shi-xian HU, Chang-bing PU, Juan HAO, Zhi-yuan LÜ, authorCompany=null, correspAuthors=Zhi-yuan LÜ, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425829809209974, articleId=1321425829406556788, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=基于化学成分、网络药理学的参葛补肾胶囊质量标志物预测分析, columnId=1236330553964810454, journalTitle=中国新药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

参葛补肾胶囊是在中医传统理论指导下,结合现代制药工艺研制而成的中药复方制剂,适用于轻、中度抑郁症中医辨证属气阴两虚、肾气不足证。本文在总结参葛补肾胶囊化学成分的基础上,应用网络药理学的研究方法并结合质量标志物(Q-Marker)的核心理论,对参葛补肾胶囊的Q-Marker进行预测分析。芒柄花素、3′-甲氧基黄豆苷元、大豆苷元4,7-二葡萄糖苷、葛根素、淫羊藿苷、脱水淫羊藿素、金圣草素、山柰酚、木犀草素、槲皮素等是参葛补肾胶囊的关键活性成分且可作为参葛补肾胶囊的Q-Marker,为参葛补肾胶囊建立全方位的质量标准提供参考依据。

, authors=游佩进, 胡时先, 蒲长兵, 郝娟, 吕志远*, authorsList=游佩进, 胡时先, 蒲长兵, 郝娟, 吕志远, authorCompany=null, correspAuthors=吕志远, authorNote=

游佩进,男,硕士,研究方向:中药新药研发。E-mail: 。

, correspAuthorsNote=
* 吕志远,男,硕士,研究方向:中草药提取物药理活性研究。E-mail: 。
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游佩进,男,硕士,研究方向:中药新药研发。E-mail: 。

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游佩进,男,硕士,研究方向:中药新药研发。E-mail: 。

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基于化学成分、网络药理学的参葛补肾胶囊质量标志物预测分析
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游佩进 , 胡时先 , 蒲长兵 , 郝娟 , 吕志远 *
中国新药杂志 | 综述 2026,35(13): 1378-1388
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中国新药杂志 |综述 2026 , 35 (13) : 1378 -1388
基于化学成分、网络药理学的参葛补肾胶囊质量标志物预测分析
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游佩进 , 胡时先, 蒲长兵, 郝娟, 吕志远*
作者信息
  • 新疆华春药业医药研究院,乌鲁木齐 830000
通讯作者:
* 吕志远,男,硕士,研究方向:中草药提取物药理活性研究。E-mail: 。
作者简介:

游佩进,男,硕士,研究方向:中药新药研发。E-mail: 。

Prediction and analysis of Q-Marker for Shenge Bushen Capsules based on chemical composition and network pharmacology
Pei-jin YOU , Shi-xian HU, Chang-bing PU, Juan HAO, Zhi-yuan LÜ*
Affiliations
  • Xinjiang Huachun Research Institute of Pharmaceutical Sciences, Urumqi 830000, China
出版时间: 2026-07-15 doi: 10.20251/j.cnki.1003-3734.2026.13.006
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参葛补肾胶囊是在中医传统理论指导下,结合现代制药工艺研制而成的中药复方制剂,适用于轻、中度抑郁症中医辨证属气阴两虚、肾气不足证。本文在总结参葛补肾胶囊化学成分的基础上,应用网络药理学的研究方法并结合质量标志物(Q-Marker)的核心理论,对参葛补肾胶囊的Q-Marker进行预测分析。芒柄花素、3′-甲氧基黄豆苷元、大豆苷元4,7-二葡萄糖苷、葛根素、淫羊藿苷、脱水淫羊藿素、金圣草素、山柰酚、木犀草素、槲皮素等是参葛补肾胶囊的关键活性成分且可作为参葛补肾胶囊的Q-Marker,为参葛补肾胶囊建立全方位的质量标准提供参考依据。

参葛补肾胶囊  /  抑郁症  /  化学成分  /  网络药理学  /  质量标志物

Shenge Bushen Capsule is a traditional Chinese medicine (TCM) compound preparation developed under the guidance of TCM theory and combined with modern pharmaceutical technology. It is indicated for mild to moderate depression of TCM syndrome of qi and yin deficiency, and kidney qi deficiency. Based on a summary of the chemical constituents of Shenge Bushen Capsule, this study applied network pharmacology methods and integrated the core concept of quality marker (Q-Marker) to predict and analyze the Q-Marker of Shenge Bushen Capsule. The results showed that formononetin, 3'-methoxydaidzein, daidzein-4,7-diglucoside, puerarin, icariin, anhydroicaritin, chrysoseriol, kaempferol, luteolin, and quercetin are the key active components of Shenge Bushen Capsules and can serve as its Q-Marker. Which can provide a reference for establishing a comprehensive quality standard for Shenge Bushen Capsule.

Shenge Bushen Capsule  /  depression  /  chemical composition  /  network pharmacology  /  Q-Marker
游佩进, 胡时先, 蒲长兵, 郝娟, 吕志远. 基于化学成分、网络药理学的参葛补肾胶囊质量标志物预测分析. 中国新药杂志, 2026 , 35 (13) : 1378 -1388 . DOI: 10.20251/j.cnki.1003-3734.2026.13.006
Pei-jin YOU, Shi-xian HU, Chang-bing PU, Juan HAO, Zhi-yuan LÜ. Prediction and analysis of Q-Marker for Shenge Bushen Capsules based on chemical composition and network pharmacology[J]. Chinese Journal of New Drugs, 2026 , 35 (13) : 1378 -1388 . DOI: 10.20251/j.cnki.1003-3734.2026.13.006
  • 乌鲁木齐市“红山英才”计划资助项目(20251219)
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2026年第35卷第13期
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doi: 10.20251/j.cnki.1003-3734.2026.13.006
  • 首发时间:2026-10-26
  • 出版时间:2026-07-15
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  • 录用日期:2026-01-10
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乌鲁木齐市“红山英才”计划资助项目(20251219)
作者信息
    新疆华春药业医药研究院,乌鲁木齐 830000

通讯作者:

* 吕志远,男,硕士,研究方向:中草药提取物药理活性研究。E-mail: 。
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2种不同金属材料的力学参数
科
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genus
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属
Genus
种数
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species
占总种数比例
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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