Article(id=1321425800159670439, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425746170597545, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.13.015, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1761408000000, acceptedDateStr=2025-10-26, onlineDate=1792982061661, onlineDateStr=2026-10-26, pubDate=1784044800000, pubDateStr=2026-07-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982061661, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982061661, creator=13701087609, updateTime=1792982061661, updator=13701087609, issue=Issue{id=1321425746170597545, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='13', pageStart='1345', pageEnd='1456', issueExtLink='null', onlineDate='null', pubDate='1784044800000', pubDateStr='2026-07-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982048790, creator='13701087609', updateTime=1792982953102, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321429539205534609, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425746170597545, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321429539205534610, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425746170597545, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1447, endPage=1456, ext={EN=ArticleExt(id=1321425800335831208, articleId=1321425800159670439, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Systematic review and pharmacoeconomic evaluation of tirzepatide for the treatment of overweight/obesity, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To evaluate the efficacy, safety, and economics of tirzepatide in the treatment of overweight/obesity.
Methods: A comprehensive comparison of the efficacy of tirzepatide and semaglutide in the treatment of overweight/obesity was performed using reticulated Meta-analysis (NMA), and cost-effectiveness analysis was used for pharmacoeconomic evaluation.
Results: A total of 14 randomized controlled trials were searched. The NMA showed that for efficacy, the tirzepatide group was significantly better than the simelglutide group in terms of weight loss (MD=-6.50%, 95%CI: -8.13% to -4.87%), waist circumference reduction (MD=-5.40%), and the attainment rate of >15% weight loss (RR=1.28) (P<0.001), but the glycemic control was not statistically different. For safety, the overall incidence of gastrointestinal adverse events was similar in both groups, with a lower risk of vomiting with telbivudine (RR=0.70, 95%CI: 0.55~0.89). For the pharmacoeconomics, the ICER value of 87 714.55 yuan was well below the willingness-to-pay threshold, suggesting that tirzepatide was more cost-effective compared with semaglutide.
Conclusion: The weight loss efficacy and economy of tirzepatide are significantly better than those of semaglutide, and its long-term safety needs to be further verified in the future.
, authors=Hong-ye GENG, Li-xuan LI, Cheng-yuan LU, Shu-ling WANG
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目的： 评估替尔泊肽治疗超重/肥胖的有效性、安全性和经济性。
方法： 采用网状Meta分析（network Meta-analysis, NMA）综合比较替尔泊肽与司美格鲁肽治疗超重/肥胖的疗效，并采用成本效果分析进行药物经济学评价。
结果： 系统检索14项随机对照试验。NMA显示，疗效上替尔泊肽组的减重幅度[均数差（mean difference, MD）=-6.50%，95%CI：-8.13%~-4.87%]、腰围缩减（MD=-5.40%）及体质量降幅>15%的达标率[风险比（relative risk, RR）=1.28均显著优于司美格鲁肽组（P<0.001）]，但血糖控制无统计学差异。安全性方面，两组胃肠道不良事件总体发生率相近，替尔泊肽的呕吐风险更低（RR=0.70, 95%CI：0.55~0.89）。药物经济学结果显示，增量成本效果比（incremental cost-effectiveness ratio, ICER）值为87 714.55元，远低于意愿支付阈值，说明替尔泊肽相比于司美格鲁肽更具有经济性。
结论： 替尔泊肽的减重疗效和经济性均显著优于司美格鲁肽，未来需进一步验证其长期安全性。
, authors=耿宏业, 李俐萱, 陆成远, 王淑玲
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耿宏业，女，硕士研究生，主要从事药物经济学研究。E-mail: g067043@outlook.com。
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耿宏业，女，硕士研究生，主要从事药物经济学研究。E-mail: g067043@outlook.com。
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