Article(id=1321425779175575882, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425776323449136, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.14.008, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1757260800000, acceptedDateStr=2025-09-08, onlineDate=1792982056658, onlineDateStr=2026-10-26, pubDate=1785340800000, pubDateStr=2026-07-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982056658, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982056658, creator=13701087609, updateTime=1792982056658, updator=13701087609, issue=Issue{id=1321425776323449136, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='14', pageStart='1457', pageEnd='1568', issueExtLink='null', onlineDate='null', pubDate='1785340800000', pubDateStr='2026-07-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982055979, creator='13701087609', updateTime=1792982930455, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321429444191966074, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425776323449136, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321429444196160379, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425776323449136, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1502, endPage=1509, ext={EN=ArticleExt(id=1321425780903629131, articleId=1321425779175575882, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Sodium zirconium cyclosilicate: research progress on a novel potassium binder, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

This paper reviews the research progress of sodium zirconium cyclosilicate, a novel potassium binder. Sodium zirconium cyclosilicate is a non-absorbed, insoluble, non-polymer inorganic crystalline powder with a uniform microporous structure, and functions as a highly selective inorganic cation exchanger. When taken orally, it captures potassium ions in the human intestinal tract, which are then excreted in the feces. By reducing potassium ion absorption, it lowers the potassium ion level in the blood, thereby treating hyperkalemia. Sodium zirconium cyclosilicate has a high affinity for potassium ions that is unaffected by other cations. Compared with existing treatments for hyperkalemia, it offers improved selectivity and speed in capturing excess potassium ions, providing a safe and effective option for the long-term management of hyperkalemia. This article describes in detail the chemical structure, mechanism of action, pharmacokinetic characteristics, clinical research progress and pharmaceutical research progress of sodium zirconium cyclosilicate. Studies have shown that sodium zirconium cyclosilicate demonstrates favorable efficacy and safety in the treatment of hyperkalemia, offering a new option for clinical practice.

, authors=Shi-jie YANG, Jie ZHUANG, Qian LIU, Jian-zhao NIU^*, authorsList=Shi-jie YANG, Jie ZHUANG, Qian LIU, Jian-zhao NIU, authorCompany=null, correspAuthors=Jian-zhao NIU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425781218201932, articleId=1321425779175575882, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=环硅酸锆钠：一种新型钾离子结合剂的研究进展, columnId=1236330553964810454, journalTitle=中国新药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

本文综述了新型钾离子结合剂环硅酸锆钠的研究进展。环硅酸锆钠是一种不吸收不溶解的非聚合物无机结晶性粉末，具有均匀的微孔结构，是一种高选择性的无机阳离子交换剂。其经口服，在人体肠道中捕获钾离子后经粪便排出体外，因而可以通过减少钾离子吸收，减少人体血液中钾离子的含量，治疗高钾血症。环硅酸锆钠对钾离子具有高度亲和力，不受其他阳离子的影响，与现有高钾血症治疗方案相比，提高了捕获过量钾离子选择性和速度的能力，为高钾血症长期治疗提供了安全有效的治疗选择。本文详细介绍了环硅酸锆钠的化学结构、作用机制、药动学特性、临床研究进展以及药学研究进展。研究表明，环硅酸锆钠在治疗高钾血症方面表现出良好的疗效和安全性，为临床治疗高钾血症提供了新选择。

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杨世婕，女，在读硕士，研究方向：药品检验研究。E-mail: 17302510892@163.com。

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杨世婕，女，在读硕士，研究方向：药品检验研究。E-mail: 17302510892@163.com。

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