Article(id=1321425746619388073, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425746170597545, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.13.004, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1754755200000, acceptedDateStr=2025-08-10, onlineDate=1792982048897, onlineDateStr=2026-10-26, pubDate=1784044800000, pubDateStr=2026-07-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982048897, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982048897, creator=13701087609, updateTime=1792982048897, updator=13701087609, issue=Issue{id=1321425746170597545, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='13', pageStart='1345', pageEnd='1456', issueExtLink='null', onlineDate='null', pubDate='1784044800000', pubDateStr='2026-07-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982048790, creator='13701087609', updateTime=1792982953102, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321429539205534609, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425746170597545, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321429539205534610, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425746170597545, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1363, endPage=1371, ext={EN=ArticleExt(id=1321425746858463402, articleId=1321425746619388073, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Globally approved deuterated drugs and patent research thereof, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

This article reviews the patent information of seven deuterated drugs approved globally. It first briefly introduces, for each of the seven deuterated drugs, the originator and developing companies, the country and date of first approval, indications, main advantages, and inclusion status in China's National Reimbursement Drug List (NRDL). It then provides a detailed analysis and interpretation of the patents filed by the originator companies, developing companies, and other applicants in various technical fields, such as compounds, pharmaceutical formulations, pharmaceutical compositions, and new therapeutic uses. The analysis covers the information published on the China Patent Information Registration Platform for Marketed Drugs, the technical content, and the global patent portfolio strategies, with a focus on the basic information and legal status of patent applications in China in different technical fields. The article also analyzes the expiration dates of compound patent for deuterated drugs approved in China and identifies vulnerabilities in the associated patent technology landscapes, so as to provide an effective patent information reference for Chinese pharmaceutical enterprises in project selection, new development initiatives, patent mining, patent protection, and patent portfolio construction involving deuterated drugs.

, authors=Hong-fen MAO^{1, 2}, Tao-xi LIN^{1, 2, *}, Lu HUANG^{3, 4, 5, *}, authorsList=Hong-fen MAO, Tao-xi LIN, Lu HUANG, authorCompany=null, correspAuthors=Tao-xi LIN, Lu HUANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425747684741291, articleId=1321425746619388073, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=全球已上市的氘代药物及其专利分析, columnId=1236331162679955859, journalTitle=中国新药杂志, columnName=新药述评与论坛, runingTitle=null, highlight=null, articleAbstract=

本文对全球已上市的7个氘代药物及其专利信息分别进行了梳理。首先简要介绍7个氘代药物的原研厂家及开发厂家、首次批准国家及上市时间、适应证、主要优势以及在中国进入《国家基本医疗保险、工伤保险和生育保险药品目录》的情况；其次，详细分析和解读了原研厂家、开发厂家和其他申请人针对这些创新药物在不同技术主题如化合物、药物制剂、药物组合物、药物新用途等方面的专利情况，包括中国上市药品专利信息登记平台公示情况、技术内容、全球布局等，重点介绍了不同技术主题在中国的专利申请基本信息及法律状态，并分析了中国上市氘代药物的化合物专利到期日、相关药物专利技术布局的薄弱环节，以期为我国医药企业在进行氘代药物产品立项与开发以及进行新的专利挖掘、专利保护与布局时，提供有效的专利信息参考。

, authors=毛洪芬^{1, 2}, 林淘曦^{1, 2, *}, 黄璐^{3, 4, 5, *}, authorsList=毛洪芬, 林淘曦, 黄璐, authorCompany=null, correspAuthors=林淘曦, 黄璐, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=Y6sQv8wjJ+H02gneQwOCNQ==, magXml=8k7jPyqBQtmbnG/PSwDYPQ==, pdfUrl=null, pdf=PxZ+41cc0Q2TPZW87dTCUQ==, pdfFileSize=3328326, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=9UQykvqzJuMn44nFM5wpmA==, mapNumber=null, fund=null)}, authors=[Author(id=1321425749932888252, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425746619388073, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=394175262@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425750037745855, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425746619388073, authorId=1321425749932888252, language=EN, stringName=Hong-fen MAO, firstName=Hong-fen, middleName=null, lastName=MAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=¹Sunshine Lake Pharma Co., Ltd., Dongguan 523871, China
²State Key Laboratory of Anti-Infective Drug Discovery and Development, Dongguan 523871, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425750121631936, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425746619388073, authorId=1321425749932888252, language=CN, stringName=毛洪芬, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=¹广东东阳光药业股份有限公司，东莞 523871
²抗感染新药研发全国重点实验室，东莞 523871, bio={"content":"

毛洪芬，女，硕士，工程师，专利代理师，主要从事生物医药知识产权工作。E-mail: 394175262@qq.com。

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毛洪芬，女，硕士，工程师，专利代理师，主要从事生物医药知识产权工作。E-mail: 394175262@qq.com。

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