Article(id=1321425718349778961, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425717926154257, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.12.003, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1755187200000, acceptedDateStr=2025-08-15, onlineDate=1792982042157, onlineDateStr=2026-10-26, pubDate=1782748800000, pubDateStr=2026-06-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982042157, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982042157, creator=13701087609, updateTime=1792982042157, updator=13701087609, issue=Issue{id=1321425717926154257, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='12', pageStart='1233', pageEnd='1344', issueExtLink='null', onlineDate='null', pubDate='1782748800000', pubDateStr='2026-06-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982042056, creator='13701087609', updateTime=1792982988069, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321429686186529703, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425717926154257, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321429686186529704, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425717926154257, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1251, endPage=1256, ext={EN=ArticleExt(id=1321425718551105554, articleId=1321425718349778961, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Progress in research and application of organoid technology in drug research and development, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Drug development is a complex and time-consuming process, and traditional drug research models have obvious limitations, and there is an urgent need to establish a new model system. Organoids are three-dimensional tissue analogues derived from stem cells that have attracted attention for their excellent physiological relevance. Organoid technology has shown great application potential in the fields of disease modeling, drug screening, toxicity testing, and personalized medicine, and can also be combined with organ-on-a-chip technologies to provide a new platform for the construction of complex physiological correlation models and the study of multi-organ interactions. This article reviews the development history of organoid technology and the progress in its research and application in drug development, discusses the challenges and development directions, to provide references for the key process of drug development and help promote the application and development of organoid technology in drug research and development.

, authors=Hao-dong ZHONG^{1, 2}, Qian-yi NIU^{1, 3}, Tian LIN^{1, 2}, Rui-qiu ZHANG^{1, 4}, Man-man ZHAO^{1, 5, *}, Xiao-bing ZHOU^{1, 5, *}, authorsList=Hao-dong ZHONG, Qian-yi NIU, Tian LIN, Rui-qiu ZHANG, Man-man ZHAO, Xiao-bing ZHOU, authorCompany=null, correspAuthors=Man-man ZHAO, Xiao-bing ZHOU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425718815346708, articleId=1321425718349778961, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=类器官技术在药物研发中的研究和应用进展, columnId=1321425718622408723, journalTitle=中国新药杂志, columnName=类器官技术研究进展专栏, runingTitle=null, highlight=null, articleAbstract=

药物研发是一个复杂且耗时的过程，而传统药物研究模型存在明显局限性，迫切需要建立新的模型系统。类器官是由干细胞衍生的三维组织类似物，因其出色的生理相关性而备受关注。类器官技术在疾病建模、药物筛选、毒性测试及个性化医疗领域展现出巨大应用潜力，还可与器官芯片等技术相结合，为复杂生理相关性模型构建及多器官互作研究提供了新的平台。本文综述类器官技术的发展历程及其在药物研发中的研究和应用进展，探讨类器官技术面临的挑战及发展方向，以期为药物研发的关键过程提供参考，助力推动类器官技术在药物研发中的应用和发展。

, authors=钟浩东^{1, 2}, 牛茜怡^{1, 3}, 林钿^{1, 2}, 张瑞秋^{1, 4}, 赵曼曼^{1, 5, *}, 周晓冰^{1, 5, *}, authorsList=钟浩东, 牛茜怡, 林钿, 张瑞秋, 赵曼曼, 周晓冰, authorCompany=null, correspAuthors=赵曼曼, 周晓冰, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=BOwZTM2/VCc3pj/IIbuRAg==, magXml=PYTY743wZBNaQDZBC7toFA==, pdfUrl=null, pdf=EZctiL5LDMF5KzLsOhcOHg==, pdfFileSize=1222172, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=xXPmRBzQfslRuCuMjqNnWg==, mapNumber=null, fund=null)}, authors=[Author(id=1321425719431909413, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425718349778961, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=3323071873@stu.cpu.edu.cn, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425719507406888, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425718349778961, authorId=1321425719431909413, language=EN, stringName=Hao-dong ZHONG, firstName=Hao-dong, middleName=null, lastName=ZHONG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=¹Institute for Safety Evaluation, National Institutes for Food and Drug Control, Beijing Key Laboratory for Safety Evaluation of Drugs, Beijing 100176, China
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²中国药科大学，南京 211198, bio={"content":"

钟浩东，男，硕士研究生，研究方向：新药临床前评价。E-mail: 3323071873@stu.cpu.edu.cn。

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钟浩东，男，硕士研究生，研究方向：新药临床前评价。E-mail: 3323071873@stu.cpu.edu.cn。

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